Instrumentation for the continuous measurement of gas exchange and ventilation of infants during assisted ventilation.

abstract：OBJECTIVES:We recently reported that bacterial lipopolysaccharide stimulates release of tumor necrosis factor (TNF)-alpha from both human vascular tissue and cultured smooth muscle cells. In the current study, we tested the hypothesis that increased intracellular cyclic adenosine 3',5'-monophosphate (cAMP) could inhibi...

journal_title：Critical care medicine

authors： Zhang LM,Castresana MR,Shaker IJ,Dalton ML,Leeper-Woodford SK,Newman WH

更新日期：1997-11-01 00:00:00

abstract：:In a prospective randomized trial in patients with a history of preoperative pulmonary hypertension who were undergoing surgery for valvular replacement or annuloplasty, the effects of ketanserin (KET) (12 patients) and sodium nitroprusside (SNP) (14 patients) on the systemic and pulmonary circulation and pulmonary sh...

journal_title：Critical care medicine

authors： van der Starre PJ,Feld RJ,Reneman RS

更新日期：1989-07-01 00:00:00

abstract：OBJECTIVE:Most studies have assessed conflict between clinicians and surrogate decision makers in ICUs from only clinicians' perspectives. It is unknown if surrogates' perceptions differ from clinicians'. We sought to determine the degree of agreement between physicians and surrogates about conflict and to identify pre...

journal_title：Critical care medicine

authors： Schuster RA,Hong SY,Arnold RM,White DB

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:Although contraindicated, there are situations when a patient who has recently taken a phosphodiesterase 5 inhibitor (e.g., sildenafil) might need intravenous nitroglycerin (NTG) treatment. This study determined if, and at what dose, intravenous NTG could be administered safely to men with coronary artery dis...

journal_title：Critical care medicine

authors： Parker JD,Bart BA,Webb DJ,Koren MJ,Siegel RL,Wang H,Malhotra B,Jen F,Glue P

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVES:The Fragility Index, which represents the number of patients responsible for a statistically significant finding, has been suggested as an aid for interpreting the robustness of results from clinical trials. A small Fragility Index indicates that the statistical significance of a trial depends on only a few ...

journal_title：Critical care medicine

authors： Grolleau F,Collins GS,Smarandache A,Pirracchio R,Gakuba C,Boutron I,Busse JW,Devereaux PJ,Le Manach Y

更新日期：2019-03-01 00:00:00

abstract：OBJECTIVE:To describe the experience of pediatric intensive care hospitalization from the perspective of a parents of children with severe, antecedent disability. DESIGN:Qualitative analysis of data obtained through semistructured interviews. SETTING:Pediatric intensive care unit (PICU) in a children's hospital. SUB...

journal_title：Critical care medicine

authors： Graham RJ,Pemstein DM,Curley MA

更新日期：2009-06-01 00:00:00

abstract：:Over a 2-year period, 14 viable ventilator-dependent patients were transferred from the Medical Intensive Care Unit (MICU) to a general ward floor for nutritional support after failing to wean from mechanical ventilation (MV) while in the MICU. These patients were retrospectively grouped based on their ultimate abilit...

journal_title：Critical care medicine

authors： Larca L,Greenbaum DM

更新日期：1982-05-01 00:00:00

abstract：OBJECTIVES:To investigate whether admission B-type natriuretic peptide levels predict the development of acute kidney injury in acute coronary syndromes. DESIGN:Prospective study. SETTING:Single-center study, 13-bed intensive cardiac care unit at a University Cardiological Center. PATIENTS:Six-hundred thirty-nine ac...

journal_title：Critical care medicine

authors： Moltrasio M,Cabiati A,Milazzo V,Rubino M,De Metrio M,Discacciati A,Rumi P,Marana I,Marenzi G

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVE:To determine the functionality of identified polymorphisms in the promoter and upstream regions of the interleukin-10 gene in terms of release of interleukin-10 from lipopolysaccharide-stimulated whole blood from healthy volunteers and to evaluate the relationship of interleukin-10 polymorphisms to interleuki...

journal_title：Critical care medicine

authors： Lowe PR,Galley HF,Abdel-Fattah A,Webster NR

更新日期：2003-01-01 00:00:00

abstract：:The metabolic support of critically ill patients is a relatively new topic of active research and discussion, and surprisingly little is known about the effects of critical illness on metabolic physiology and activity. The metabolic changes seen in critical illness are highly complex, and how and when to treat them ar...

journal_title：Critical care medicine

authors： Vincent JL

更新日期：2007-09-01 00:00:00

abstract：OBJECTIVE:Acute lung injury is a detrimental complication for victims of burn accidents. Airway obstruction plays an important role in pulmonary dysfunction in these patients. In this study, we tested the hypothesis that aerosolized anticoagulants will reduce the degree of airway obstruction and improve pulmonary funct...

journal_title：Critical care medicine

authors： Enkhbaatar P,Cox RA,Traber LD,Westphal M,Aimalohi E,Morita N,Prough DS,Herndon DN,Traber DL

更新日期：2007-12-01 00:00:00

abstract：:We investigated clinically the differences in respiratory work of patients imposed by three modes of one ventilator: the flow-by system, the demand valve system, and the pressure support system. Inspiratory work using flow-by and pressure support systems was reduced sufficiently when compared to the demand valve syste...

journal_title：Critical care medicine

authors： Saito S,Tokioka H,Kosaka F

更新日期：1990-06-01 00:00:00

abstract：:A patient with brainstem infarction met the clinical criteria for brain death but had persistent EEG activity, complicating our decision to withdraw life support. We evaluated cerebral blood flow with xenon-enhanced computed tomography (Xe/CT), which documented the absence of posterior circulation flow and persistent,...

journal_title：Critical care medicine

authors： Darby J,Yonas H,Brenner RP

更新日期：1987-05-01 00:00:00

abstract：:Medical technology is a two-edged sword, capable of saving and improving life but also of ending and harming life. Finding the right stance toward technology requires great balance and sensitivity. It has seductive powers because of its expected benefits, the social and professional pressures to use it, and a frequent...

journal_title：Critical care medicine

authors： Callahan D

更新日期：2003-05-01 00:00:00

abstract：OBJECTIVES:With the exception of a few single-center descriptive reports, data on critical care organizations are relatively sparse. The objectives of our study were to determine the structure, governance, and experience to date of established critical care organizations in North American academic medical centers. DES...

journal_title：Critical care medicine

authors： Pastores SM,Halpern NA,Oropello JM,Kostelecky N,Kvetan V

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:To determine whether plasma lipid hydroperoxides may be a useful marker for sepsis. DESIGN:Exploratory, open-label study. SETTING:Critical care unit at a university medical center. PATIENTS:Twelve patients with sepsis syndrome requiring hemodynamic monitoring with pulmonary artery catheters. Seven patients...

journal_title：Critical care medicine

authors： Keen RR,Stella L,Flanigan DP,Lands WE

更新日期：1991-09-01 00:00:00

abstract：OBJECTIVE:To identify factors associated with granting or refusing intensive care unit (ICU) admission, to analyze ICU characteristics and triage decisions, and to describe mortality in admitted and refused patients. DESIGN:Observational, prospective, multiple-center study. SETTING:Four university hospitals and seven...

journal_title：Critical care medicine

authors： Garrouste-Orgeas M,Montuclard L,Timsit JF,Reignier J,Desmettre T,Karoubi P,Moreau D,Montesino L,Duguet A,Boussat S,Ede C,Monseau Y,Paule T,Misset B,Carlet J,French ADMISSIONREA Study Group.

更新日期：2005-04-01 00:00:00

abstract：OBJECTIVES:Administration of eicosapentaenoic acid and docosahexanoic acid, omega-3 fatty acids in fish oil, has been associated with improved patient outcomes in acute lung injury when studied in a commercial enteral formula. However, fish oil has not been tested independently in acute lung injury. We therefore sought...

journal_title：Critical care medicine

authors： Stapleton RD,Martin TR,Weiss NS,Crowley JJ,Gundel SJ,Nathens AB,Akhtar SR,Ruzinski JT,Caldwell E,Curtis JR,Heyland DK,Watkins TR,Parsons PE,Martin JM,Wurfel MM,Hallstrand TS,Sims KA,Neff MJ

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVES:To assess in-hospital neurologic (CNS) complications in adult patients undergoing veno-venous extracorporeal membrane oxygenation for respiratory failure. DESIGN:Retrospective analysis of the Extracorporeal Life Support Organization's data registry. SETTING:Data reported to Extracorporeal Life Support Orga...

journal_title：Critical care medicine

authors： Lorusso R,Gelsomino S,Parise O,Di Mauro M,Barili F,Geskes G,Vizzardi E,Rycus PT,Muellenbach R,Mueller T,Pesenti A,Combes A,Peek G,Frenckner B,Di Nardo M,Swol J,Maessen J,Thiagarajan RR

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVES:a) To investigate whether the patient work of breathing needed to trigger inspiration is affected by the type of ventilator delivering pressure-support ventilation for mechanically ventilated pediatric patients. b) To determine whether changes in oxygen consumption (VO2) trend with changes in work of breathi...

journal_title：Critical care medicine

authors： el-Khatib MF,Chatburn RL,Potts DL,Blumer JL,Smith PG

更新日期：1994-12-01 00:00:00

abstract：:Capnography is a valuable tool in the management of cardiac arrest, since end-tidal CO2 (PetCO2) correlates well with cardiac output and there are no other suitable noninvasive ways to measure this important variable during resuscitation. Animal studies also suggest that PetCO2 correlates well with the likelihood of r...

journal_title：Critical care medicine

authors： Callaham M,Barton C

更新日期：1990-04-01 00:00:00

abstract：:An emergency cricothyrotomy device was placed in 11 anesthetized dogs in order to assess airway damage and problems in placement, ventilation, and design. Posterior airway perforation without esophageal damage occurred in three animals. Submucosal hematomas or cricoid cartilage injury occurred in seven animals. As pla...

journal_title：Critical care medicine

authors： Bjoraker DG,Kumar NB,Brown AC

更新日期：1987-02-01 00:00:00

abstract：OBJECTIVES:Granulocyte transfusions have been used to treat immune cell dysfunction in sepsis. As granulocyte transfusions can trigger tissue injury via local effects of neutrophils, we hypothesized that extracorporeal treatment of plasma using granulocytes would prove beneficial while having less side effects. DESIGN...

journal_title：Critical care medicine

authors： Sauer M,Altrichter J,Kreutzer HJ,Lögters T,Scholz M,Nöldge-Schomburg G,Schmidt R,Mitzner SR

更新日期：2009-02-01 00:00:00

abstract：OBJECTIVE:To compare the oxidative stress induced by IV iron infusion in critically ill patients and in healthy volunteers. DESIGN:Multicenter, interventional study. SETTING:Two ICUs and one clinical research center. SUBJECTS:Anemic critically ill patients treated with IV iron and healthy volunteers. INTERVENTIONS:...

journal_title：Critical care medicine

authors： Lasocki S,Piednoir P,Couffignal C,Rineau E,Dufour G,Lefebvre T,Puy H,Duval X,Driss F,Schilte C

更新日期：2016-03-01 00:00:00

abstract：OBJECTIVE:To evaluate the cardiopulmonary effects of the novel endothelin receptor antagonist tezosentan in endotoxin-induced lung injury in sheep and to assess the dose response to tezosentan and endothelin-1 in healthy sheep. DESIGN:Prospective, randomized, controlled experimental study. SETTING:University animal l...

journal_title：Critical care medicine

authors： Kuklin VN,Kirov MY,Evgenov OV,Sovershaev MA,Sjöberg J,Kirova SS,Bjertnaes LJ

更新日期：2004-03-01 00:00:00

abstract：OBJECTIVES:To compare the plasma volume (PV) expanding effect of a fast infusion rate with that of a slow infusion rate of a fixed volume of 5% albumin, of the synthetic colloids, 6% hydroxyethyl starch 130/0.4 and 4% gelatin, and of 0.9% NaCl in a rat sepsis model and to compare the plasma-expanding effect among these...

journal_title：Critical care medicine

authors： Bark BP,Persson J,Grände PO

更新日期：2013-03-01 00:00:00

abstract：OBJECTIVE:The goals of this review article are to review the importance and value of standardized definitions in clinical research, as well as to propose the necessary tools and infrastructure needed to advance nosology and medial taxonomy to improve the quality of clinical trials in the field of critical care. DATA S...

journal_title：Critical care medicine

authors： Singh JM,Ferguson ND

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVES:To measure pulmonary capillary pressure and pulmonary artery occlusion pressures both during control conditions and during acute lung injury and to evaluate the effects of inotropic therapy and volume loading on these measurements after lung injury. DESIGN:Prospective, randomized, controlled laboratory tria...

journal_title：Critical care medicine

authors： Pellett AA,Lord KC,Champagne MS,deBoisblanc BP,Johnson RW,Levitzky MG

更新日期：2002-02-01 00:00:00

abstract：OBJECTIVES:To compare sleep, work hours, and behavioral alertness in faculty and fellows during a randomized trial of nighttime in-hospital intensivist staffing compared with a standard daytime intensivist model. DESIGN:Prospective observational study. SETTING:Medical ICU of a tertiary care academic medical center du...

journal_title：Critical care medicine

authors： Bakhru RN,Basner M,Kerlin MP,Halpern SD,Hansen-Flaschen J,Rosen IM,Dinges DF,Schweickert WD

更新日期：2019-07-01 00:00:00

abstract：OBJECTIVES:The role of nitric oxide in mediating the early phase of hypotension and cardiovascular hyporeactivity in sepsis, and the cellular sources of inducible nitric oxide synthase expression under in vivo conditions, remain unclear. The objective of this study was to elucidate the time course and cellular location...

journal_title：Critical care medicine

authors： Liu SF,Barnes PJ,Evans TW

更新日期：1997-03-01 00:00:00