Extracorporeal cell therapy with granulocytes in a pig model of Gram-positive sepsis.

abstract：OBJECTIVE:To review current knowledge about the impact of prolonged mechanical ventilation on diaphragmatic function and biology. MEASUREMENTS:Systematic literature review. CONCLUSIONS:Prolonged mechanical ventilation can promote diaphragmatic atrophy and contractile dysfunction. As few as 18 hrs of mechanical ventil...

journal_title：Critical care medicine

authors： Powers SK,Kavazis AN,Levine S

更新日期：2009-10-01 00:00:00

abstract：BACKGROUND:Increased intracranial pressure (ICP) worsens the outcome of acute liver failure (ALF). This study investigates the underlying pathophysiological mechanisms and evaluates the therapeutic effect of albumin dialysis in ALF with use of the Molecular Adsorbents Recirculating System without hemofiltration/dialysi...

journal_title：Critical care medicine

authors： Sen S,Rose C,Ytrebø LM,Davies NA,Nedredal GI,Drevland SS,Kjønnø M,Prinzen FW,Hodges SJ,Deutz NE,Williams R,Butterworth RF,Revhaug A,Jalan R

更新日期：2006-01-01 00:00:00

abstract：OBJECTIVE:To determine the effects of a hydroxyethyl starch-deferoxamine conjugate on hepatic microcirculation in an isobaric, anesthetized rat model of hemorrhagic shock and asanguineous resuscitation. DESIGN:Prospective, randomized, controlled study. SETTING:Laboratory at a university hospital. SUBJECTS:Twenty-thr...

journal_title：Critical care medicine

authors： Bauer M,Feucht K,Ziegenfuss T,Marzi I

更新日期：1995-02-01 00:00:00

abstract：OBJECTIVES:A recent post hoc analysis suggested that driving pressure may be more important than traditional ventilatory variables in determining outcome in mechanically ventilated patients with acute respiratory distress syndrome. We conducted a systematic review and meta-analysis to summarize the risk of mortality fo...

journal_title：Critical care medicine

authors： Aoyama H,Pettenuzzo T,Aoyama K,Pinto R,Englesakis M,Fan E

更新日期：2018-02-01 00:00:00

abstract：OBJECTIVES:Less than half of the thousands of children who suffer in-hospital cardiac arrests annually survive, and neurologic injury is common among survivors. Hemodynamic-directed cardiopulmonary resuscitation improves short-term survival, but its impact on longer term survival and mitochondrial respiration-a potenti...

journal_title：Critical care medicine

authors： Lautz AJ,Morgan RW,Karlsson M,Mavroudis CD,Ko TS,Licht DJ,Nadkarni VM,Berg RA,Sutton RM,Kilbaugh TJ

更新日期：2019-03-01 00:00:00

abstract：:Ischemia of the intestines damages the permeability of the intestinal wall, allowing lipopolysaccharide (LPS) (endotoxin) to leak from the gut lumen into the blood circulation, causing shock and death. We measured LPS levels associated with corticosteroid treatment vs. no treatment in cats whose superior mesenteric ar...

journal_title：Critical care medicine

authors： Gaffin SL,Gathiram P,Wells MT,Brock-Utne JG

更新日期：1986-10-01 00:00:00

abstract：OBJECTIVE:Significant mortality in patients with sepsis results from the development of multiple organ dysfunction syndrome. Small-volume resuscitation with 7.5% NaCl hypertonic saline has been proposed to restore physiologic hemodynamics in hemorrhagic shock. Therefore, we hypothesized that hypertonic saline resuscita...

journal_title：Critical care medicine

authors： Shih CC,Chen SJ,Chen A,Wu JY,Liaw WJ,Wu CC

更新日期：2008-06-01 00:00:00

abstract：PURPOSE:To review the rationale for adenosine triphosphate-magnesium chloride (ATP-MgCl2) administration in shock, ischemia, and sepsis; the beneficial effects on cellular and organ functions and survival; and possible mechanisms of these effects. DATA SOURCES:Current literature review. STUDY SELECTION:Articles deeme...

journal_title：Critical care medicine

authors： Harkema JM,Chaudry IH

更新日期：1992-02-01 00:00:00

abstract：OBJECTIVES:The objectives of this article are to introduce and explore a novel paradigm based on complex nonlinear systems, and to evaluate its application to critical care research regarding the systemic host response and multiple organ dysfunction syndrome (MODS). DATA SOURCES:Published original work, review article...

journal_title：Critical care medicine

authors： Seely AJ,Christou NV

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVES:Over 2,500 children undergo hematopoietic stem cell transplantation in the United States each year, and up to 35% require PICU support for life-threatening complications. PICU mortality has dropped from 85% to 44%, but interpretation is confounded by significant cohort heterogeneity. Reports conflict regardi...

journal_title：Critical care medicine

authors： Zinter MS,Dvorak CC,Spicer A,Cowan MJ,Sapru A

更新日期：2015-09-01 00:00:00

abstract：OBJECTIVE:To estimate the prevalence of, the risk factors associated with, and the outcome of tracheostomy in a heterogeneous population of mechanically ventilated patients. DESIGN:Prospective, observational cohort study. SETTING:A total of 361 intensive care units from 12 countries. PATIENTS:A cohort of 5,081 patie...

journal_title：Critical care medicine

authors： Frutos-Vivar F,Esteban A,Apezteguía C,Anzueto A,Nightingale P,González M,Soto L,Rodrigo C,Raad J,David CM,Matamis D,D' Empaire G,International Mechanical Ventilation Study Group.

更新日期：2005-02-01 00:00:00

abstract：OBJECTIVES:To assess the specific host responses to systemic endotoxemia and tumor necrosis factor (TNF) activation after abdominal aortic aneurysm surgery by measuring antiendotoxin core antibodies (EndoCab) immunoglobulin (Ig)G and IgM, and soluble p55TNF receptor concentrations. The role of the gut in initiating the...

journal_title：Critical care medicine

authors： Soong CV,Halliday MI,Barclay GR,Hood JM,Rowlands BJ,Barros D'Sa AA

更新日期：1997-09-01 00:00:00

abstract：:Critical decreases in oxygen delivery (DO2) and mixed venous oxygen saturation (SvO2) are associated with anaerobic metabolism and, therefore, lactic acidosis. We studied 50 consecutive patients with sepsis and 50 consecutive patients with acute myocardial infarction (AMI) in whom the arterial blood lactate was greate...

journal_title：Critical care medicine

authors： Astiz ME,Rackow EC,Kaufman B,Falk JL,Weil MH

更新日期：1988-07-01 00:00:00

abstract：OBJECTIVE:To review published studies of the influence of platelet factor 4 (PF4) and other cationic proteins on the generation of activated protein C (APC) by the thrombomodulin-protein C system. DATA SOURCE:Using the PubMed citation index, literature published from 1973 to 2003 regarding cationic proteins, PF4, and ...

journal_title：Critical care medicine

authors： Slungaard A

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVES:To characterize the landscape of process of care and safety outcomes for tracheal intubation across pediatric intensive care units BACKGROUND:Procedural process of care and safety outcomes of tracheal intubation across pediatric intensive care units has not been described. We hypothesize that the novel Nati...

journal_title：Critical care medicine

authors： Nishisaki A,Turner DA,Brown CA 3rd,Walls RM,Nadkarni VM,National Emergency Airway Registry for Children (NEAR4KIDS).,Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND AND METHODS:Calcium-channel blockers may attenuate vasospasm after transient ischemia and improve organ blood flow after resuscitation. Our aim was to assess the effect of diltiazem on systemic oxygen delivery and consumption, hemodynamics, electroencephalogram (EEG), and organ blood flow after restoration o...

journal_title：Critical care medicine

authors： Lindner KH,Prengel AW,Ahnefeld FW,Ensinger H,Schürmann W

更新日期：1992-05-01 00:00:00

abstract：OBJECTIVE:To study the impact of a clinical pharmacist in a pediatric intensive care unit. The goals of the study were to determine the type and quantity of patient care interventions recommended by a clinical pharmacist and to specifically examine cost savings (or loss) that resulted from clinical pharmacist recommend...

journal_title：Critical care medicine

authors： Krupicka MI,Bratton SL,Sonnenthal K,Goldstein B

更新日期：2002-04-01 00:00:00

abstract：OBJECTIVE:To develop practice parameters for the evaluation of adult patients who develop a new fever in the intensive care unit (ICU) for the purpose of guiding clinical practice. PARTICIPANTS:A task force of 13 experts in disciplines related to critical care medicine, infectious diseases, and surgery was convened fr...

journal_title：Critical care medicine

authors： O'Grady NP,Barie PS,Bartlett J,Bleck T,Garvey G,Jacobi J,Linden P,Maki DG,Nam M,Pasculle W,Pasquale MD,Tribett DL,Masur H

更新日期：1998-02-01 00:00:00

abstract：OBJECTIVE:This pilot study was designed to identify which contextual factors facilitate/hinder the implementation of the awakening, breathing, coordination, delirium, and early mobility (ABCDE) bundle for guidance in future studies. DESIGN:The sources of data for this study included document review, planned site visit...

journal_title：Critical care medicine

authors： Carrothers KM,Barr J,Spurlock B,Ridgely MS,Damberg CL,Ely EW

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVES:To assess whether, in patients under mechanical ventilation, fluid responsiveness is predicted by the effects of short respiratory holds on cardiac index estimated by esophageal Doppler. DESIGN:Prospective, monocentric study. SETTING:Medical ICU. PATIENTS:Twenty-eight adult patients with acute circulatory...

journal_title：Critical care medicine

authors： Dépret F,Jozwiak M,Teboul JL,Alphonsine JE,Richard C,Monnet X

更新日期：2019-02-01 00:00:00

abstract：OBJECTIVE:To characterize the withholding or withdrawing of life support from patients with severe head injury. SETTING:San Francisco General Hospital, a city and county hospital with a Level I trauma center. DESIGN:A standardized questionnaire was used to collect data on demographics and functional outcome of severe...

journal_title：Critical care medicine

authors： O'Callahan JG,Fink C,Pitts LH,Luce JM

更新日期：1995-09-01 00:00:00

abstract：OBJECTIVES:Acinetobacter baumannii complex bacteremia has been identified increasingly in critical patients admitted in ICUs. Notably, A. baumannii complex bacteremia has a high mortality rate, yet the risk factors associated with mortality remain unclear and controversial. DESIGN:Retrospective study. SETTING:All adu...

journal_title：Critical care medicine

authors： Lee HY,Chen CL,Wu SR,Huang CW,Chiu CH

更新日期：2014-05-01 00:00:00

abstract：:Arterial oxygen saturation, determined noninvasively by pulse oximetry in 32 pediatric patients with cyanotic congenital heart disease (CHD), was compared with oxygen saturation measured by a cooximeter in simultaneously obtained arterial blood samples. The patients were studied in the cardiac catheterization laborato...

journal_title：Critical care medicine

authors： Boxer RA,Gottesfeld I,Singh S,LaCorte MA,Parnell VA Jr,Walker P

更新日期：1987-11-01 00:00:00

abstract：OBJECTIVES:The purpose of this study was to examine whether anandamide, an endogenous cannabinoid receptor ligand, is involved in the pathogenesis of septic encephalopathy. DESIGN:Prospective, controlled study. SUBJECTS:Male Wistar rats (7 wks old) were randomly divided into four groups as follows: group 1, control (...

journal_title：Critical care medicine

authors： Kadoi Y,Hinohara H,Kunimoto F,Saito S,Goto F

更新日期：2005-11-01 00:00:00

abstract：OBJECTIVE:An increasing number of ICU patients survive and develop mental, cognitive, or physical impairments. Various interventions support recovery from this postintensive care syndrome. Physicians in charge of post-ICU patients need to know which interventions are effective. DATA SOURCES:Systematic literature searc...

journal_title：Critical care medicine

authors： Mehlhorn J,Freytag A,Schmidt K,Brunkhorst FM,Graf J,Troitzsch U,Schlattmann P,Wensing M,Gensichen J

更新日期：2014-05-01 00:00:00

abstract：OBJECTIVE:Sepsis is life-threatening organ dysfunction due to dysregulated host responses to infection. Current knowledge of human B-cell alterations in sepsis is sparse. We tested the hypothesis that B-cell loss in sepsis involves distinct subpopulations of B cells and investigated mechanisms of B-cell depletion. DES...

journal_title：Critical care medicine

authors： Shankar-Hari M,Fear D,Lavender P,Mare T,Beale R,Swanson C,Singer M,Spencer J

更新日期：2017-05-01 00:00:00

abstract：:To determine whether end-tidal carbon dioxide tension (PETCO2) accurately reflects PaCO2 during high-frequency jet ventilation (HFJV), 43 studies were performed on eight mongrel dogs with normal lungs. During HFJV, minute volume was modified to obtain a range of PaCO2 values from 15.5 to 74.5 torr. When PETCO2 was mea...

journal_title：Critical care medicine

authors： Algora-Weber A,Rubio JJ,Dominguez de Villota E,Cortes JL,Gomez D,Mosquera JM

更新日期：1986-10-01 00:00:00

abstract：OBJECTIVES:The association between tobacco smoke exposure and critical illness is not well studied, largely because obtaining an accurate smoking history from critically ill patients is difficult. Biomarkers can provide quantitative data on active and secondhand cigarette smoke exposure. We sought to compare cigarette ...

journal_title：Critical care medicine

authors： Hsieh SJ,Ware LB,Eisner MD,Yu L,Jacob P 3rd,Havel C,Goniewicz ML,Matthay MA,Benowitz NL,Calfee CS

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVES:To perform a complete immunological characterization of compensatory anti-inflammatory response syndrome in patients with sepsis and to explore the relationship between these changes and clinical outcomes of 28-day mortality and secondary infections. DESIGN:Prospective single-center study conducted between ...

journal_title：Critical care medicine

authors： Gomez HG,Gonzalez SM,Londoño JM,Hoyos NA,Niño CD,Leon AL,Velilla PA,Rugeles MT,Jaimes FA

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVE:To develop clinical practice guidelines for the use of restraining therapies to maintain physical and psychological safety of adult and pediatric patients in the intensive care unit. PARTICIPANTS:A multidisciplinary, multispecialty task force of experts in critical care practice was convened from the members...

journal_title：Critical care medicine

authors： Maccioli GA,Dorman T,Brown BR,Mazuski JE,McLean BA,Kuszaj JM,Rosenbaum SH,Frankel LR,Devlin JW,Govert JA,Smith B,Peruzzi WT,American College of Critical Care Medicine, Society of Critical Care Medicine.

更新日期：2003-11-01 00:00:00