Effect of albumin dialysis on intracranial pressure increase in pigs with acute liver failure: a randomized study.

Abstract:

BACKGROUND:Increased intracranial pressure (ICP) worsens the outcome of acute liver failure (ALF). This study investigates the underlying pathophysiological mechanisms and evaluates the therapeutic effect of albumin dialysis in ALF with use of the Molecular Adsorbents Recirculating System without hemofiltration/dialysis (modified, M-MARS). METHODS:Pigs were randomized into three groups: sham, ALF, and ALF + M-MARS. ALF was induced by hepatic devascularization (time = 0). M-MARS began at time = 2 and ended with the experiment at time = 6. ICP, arterial ammonia, brain water, cerebral blood flow (CBF), and plasma inflammatory markers were measured. RESULTS:ICP and arterial ammonia increased significantly over 6 hrs in the ALF group, in comparison with the sham group. M-MARS attenuated (did not normalize) the increased ICP in the ALF group, whereas arterial ammonia was unaltered by M-MARS. Brain water in the frontal cortex (grey matter) and in the subcortical white matter at 6 hrs was significantly higher in the ALF group than in the sham group. M-MARS prevented a rise in water content, but only in white matter. CBF and inflammatory mediators remained unchanged in all groups. CONCLUSION:The initial development of cerebral edema and increased ICP occurs independently of CBF changes in this noninflammatory model of ALF. Factor(s) other than or in addition to hyperammonemia are important, however, and may be more amenable to alteration by albumin dialysis.

journal_name

Crit Care Med

journal_title

Critical care medicine

authors

Sen S,Rose C,Ytrebø LM,Davies NA,Nedredal GI,Drevland SS,Kjønnø M,Prinzen FW,Hodges SJ,Deutz NE,Williams R,Butterworth RF,Revhaug A,Jalan R

doi

10.1097/01.ccm.0000196203.39832.3c

subject

Has Abstract

pub_date

2006-01-01 00:00:00

pages

158-64

issue

1

eissn

0090-3493

issn

1530-0293

pii

00003246-200601000-00022

journal_volume

34

pub_type

杂志文章
  • Right ventricular end-diastolic volume index as a predictor of preload status in patients on positive end-expiratory pressure.

    abstract:OBJECTIVE:To evaluate the clinical utility of right ventricular end-diastolic volume index (RVEDVI) and pulmonary artery occlusion pressure (PAOP) as measures of preload status in patients with acute respiratory failure receiving treatment with positive end-expiratory pressure. DESIGN:Prospective, cohort study. SETTI...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199811000-00017

    authors: Cheatham ML,Nelson LD,Chang MC,Safcsak K

    更新日期:1998-11-01 00:00:00

  • Blood conservation in the intensive care unit.

    abstract:OBJECTIVE:To describe blood conservation strategies for critically ill patients. DATA SOURCES:By using a predefined strategy, we searched the electronic databases of Medline, EMBASE, CINAHL, the Cochrane database of systematic reviews, Cochrane central register of controlled trials, ACP Journal Club, Database of abstr...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1097/01.CCM.0000099350.50651.46

    authors: Fowler RA,Berenson M

    更新日期:2003-12-01 00:00:00

  • Sodium nitroprusside and positive end-expiratory pressure are not detrimental in canine asymmetric pulmonary edema.

    abstract::The effects of PEEP and subsequent augmentation of cardiac output by sodium nitroprusside (SNP) were examined in a canine model of asymmetric oleic acid injury to the right lung. PEEP (9.2 +/- 0.5 cm H2O) was added to six animals to decrease venous admixture (Qsp/Qt) from 50.6 +/- 4.4% to 16.0 +/- 1.3% (p less than .0...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198903000-00008

    authors: Johnston WE,Vinten-Johansen J,Tommasi E

    更新日期:1989-03-01 00:00:00

  • Critical Care Ultrasound: A Systematic Review of International Training Competencies and Program.

    abstract:OBJECTIVES:Critical care ultrasonography has become established within ICUs as a diagnostic tool and to guide management strategies and practical procedures. Following an international consensus statement in 2011, various national professional societies and organizations have sought to develop and deliver training prog...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000003626

    authors: Wong A,Galarza L,Duska F

    更新日期:2019-03-01 00:00:00

  • Endothelial cell apoptosis in sepsis.

    abstract:OBJECTIVE:To discuss a potential role for endothelial cell apoptosis in the pathogenesis of sepsis. DATA SOURCES:Studies published in biomedical journals and studies from the authors' laboratory. STUDY SELECTION:In vitro and in vivo studies of endothelial cell apoptosis in endotoxin and sepsis models. DATA EXTRACTIO...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1097/00003246-200205001-00009

    authors: Hotchkiss RS,Tinsley KW,Swanson PE,Karl IE

    更新日期:2002-05-01 00:00:00

  • Perioperative diabetic and hyperglycemic management issues.

    abstract:OBJECTIVE AND DESIGN:To review and discuss selected literature, expert opinion, and conventional care of the hyperglycemic perioperative or critically ill patient. MAIN POINTS:Diabetes mellitus, the most commonly encountered perioperative endocrinopathy, continues to increase dramatically in prevalence. Diabetes is th...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1097/01.ccm.0000115623.52021.c0

    authors: Coursin DB,Connery LE,Ketzler JT

    更新日期:2004-04-01 00:00:00

  • Critical level of oxygen delivery after cardiopulmonary bypass.

    abstract::The relationship between oxygen uptake (Vo2) and delivery (Do2) was examined in 64 patients immediately after cardiopulmonary bypass. In 44 patients with lactate levels below 2.5 mmol/L, Vo2 decreased proportionally when Do2 decreased below 300 ml/min X m2. At a Do2 over this level, Vo2 plateaued at 105 +/- 13 (SD) ml...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198703000-00002

    authors: Komatsu T,Shibutani K,Okamoto K,Kumar V,Kubal K,Sanchala V,Lees DE

    更新日期:1987-03-01 00:00:00

  • Stem cells in sepsis and acute lung injury.

    abstract:OBJECTIVE:Sepsis and acute lung injury continue to be major causes of morbidity and mortality worldwide despite advances in our understanding of pathophysiology and the discovery of new management strategies. Recent investigations show that stem cells may be beneficial as prognostic biomarkers and novel therapeutic str...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1097/CCM.0b013e3181f96f5f

    authors: Cribbs SK,Matthay MA,Martin GS

    更新日期:2010-12-01 00:00:00

  • Selenium, systemic immune response syndrome, sepsis, and outcome in critically ill patients.

    abstract:OBJECTIVES:To confirm early, marked decrease in plasma selenium concentrations in patients admitted to a surgical and medical intensive care unit (ICU), and to study this decrease according to the presence or absence of systemic inflammatory response syndrome (SIRS), sepsis, or direct ischemia-reperfusion. DESIGN:Pros...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199809000-00021

    authors: Forceville X,Vitoux D,Gauzit R,Combes A,Lahilaire P,Chappuis P

    更新日期:1998-09-01 00:00:00

  • Measurement properties of the Clinical Risk Index for Babies--reliabilty, validity beyond the first 12 hours, and responsiveness over 7 days.

    abstract:OBJECTIVES:Clinical Risk Index for Babies (CRIB) is a simple instrument used to measure clinical risk and illness severity in very low birth-weight infants. We assessed its reliability, validity beyond the first 12 hrs after birth, and responsiveness to individual change in condition after 7 days. DESIGN:Cohort study....

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199801000-00033

    authors: Fowlie PW,Gould CR,Tarnow-Mordi WO,Strang D

    更新日期:1998-01-01 00:00:00

  • Severe hypoglycemia in critically ill patients: risk factors and outcomes.

    abstract:OBJECTIVE:To determine the risk factors for development of severe hypoglycemia (defined as glucose <40 mg/dL) in critically ill patients and define the outcomes of this complication. DESIGN:Retrospective database review, including a case-control analysis that matched each patient with severe hypoglycemia with three co...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/01.CCM.0000282073.98414.4B

    authors: Krinsley JS,Grover A

    更新日期:2007-10-01 00:00:00

  • Guidelines for critical care medicine training and continuing medical education.

    abstract:OBJECTIVE:Critical care medicine trainees and faculty must acquire and maintain the skills necessary to provide state-of-the art clinical care to critically ill patients, to improve patient outcomes, optimize intensive care unit utilization, and continue to advance the theory and practice of critical care medicine. Thi...

    journal_title:Critical care medicine

    pub_type: 指南,杂志文章,实务指引

    doi:10.1097/01.CCM.0000104916.33769.9A

    authors: Dorman T,Angood PB,Angus DC,Clemmer TP,Cohen NH,Durbin CG Jr,Falk JL,Helfaer MA,Haupt MT,Horst HM,Ivy ME,Ognibene FP,Sladen RN,Grenvik AN,Napolitano LM,American College of Critical Care Medicine.

    更新日期:2004-01-01 00:00:00

  • Delayed Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Inhibition by Trametinib Attenuates Systemic Inflammatory Responses and Multiple Organ Injury in Murine Sepsis.

    abstract:OBJECTIVE:The mitogen-activated protein kinase/extracellular signal-regulated kinase signaling pathway is an essential component of innate immunity necessary for mediating proinflammatory responses in the setting of sepsis. We previously demonstrated that the mitogen-activated protein kinase 1/2 inhibitor trametinib pr...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000001672

    authors: Smith JA,Mayeux PR,Schnellmann RG

    更新日期:2016-08-01 00:00:00

  • Hypercortisolism in septic shock is not suppressible by dexamethasone infusion.

    abstract:OBJECTIVE:To explore the feedback regulation of glucocorticoids on corticotropin secretion in patients with septic and nonseptic circulatory shock. DESIGN:Prospective study. SETTING:An intensive care unit of a general hospital. PATIENTS:Two groups of patients with septic shock (n = 11) or nonseptic shock (n = 7). A ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199303000-00018

    authors: Perrot D,Bonneton A,Dechaud H,Motin J,Pugeat M

    更新日期:1993-03-01 00:00:00

  • Impaired adenosine-5'-triphosphate release from red blood cells promotes their adhesion to endothelial cells: a mechanism of hypoxemia after transfusion.

    abstract:OBJECTIVE:Transfusion of red blood cells has been linked to disappointing clinical outcomes in the critically ill, but specific mechanisms of organ dysfunction after transfusion remain poorly understood. We tested the hypothesis that red blood cell storage impairs the ability of red blood cells to release adenosine-5'-...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0b013e318225754f

    authors: Zhu H,Zennadi R,Xu BX,Eu JP,Torok JA,Telen MJ,McMahon TJ

    更新日期:2011-11-01 00:00:00

  • Perceptions of Ethical Decision-Making Climate Among Clinicians Working in European and U.S. ICUs: Differences Between Nurses and Physicians.

    abstract:OBJECTIVES:To examine perceptions of nurses and physicians in regard to ethical decision-making climate in the ICU and to test the hypothesis that the worse the ethical decision-making climate, the greater the discordance between nurses' and physicians' rating of ethical decision-making climate with physicians hypothes...

    journal_title:Critical care medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1097/CCM.0000000000004017

    authors: Jensen HI,Hebsgaard S,Hansen TCB,Johnsen RFA,Hartog CS,Soultati I,Szucs O,Wilson ME,van den Bulcke B,Benoit DD,Piers R

    更新日期:2019-12-01 00:00:00

  • Randomized comparison of nasojejunal and nasogastric feeding in critically ill patients.

    abstract:OBJECTIVE:Critically ill patients often develop large gastric residual volumes during nasogastric feeding as a result of poor gastroduodenal motility. Nasojejunal feeding may decrease the severity of this complication. The aim of this study was to determine whether nasojejunal feeding improved tolerance of enteral nutr...

    journal_title:Critical care medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00003246-200203000-00016

    authors: Davies AR,Froomes PR,French CJ,Bellomo R,Gutteridge GA,Nyulasi I,Walker R,Sewell RB

    更新日期:2002-03-01 00:00:00

  • New pharmacologic therapies for acute heart failure.

    abstract::Given the limitations of high-dose diuretics and vasodilators and the increasing literature showing that inotropes, regardless of the dose used, have a detrimental effect on mortality, a variety of new agents are under investigation for the treatment of pulmonary and systemic congestion and restoration of cardiac outp...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1097/01.CCM.0000296810.74724.8D

    authors: Tavares M,Rezlan E,Vostroknoutova I,Khouadja H,Mebazaa A

    更新日期:2008-01-01 00:00:00

  • Neutrophil depletion in rats reduces burn-injury induced intestinal bacterial translocation.

    abstract:OBJECTIVE:To determine whether neutrophil depletion could eradicate intestinal bacterial translocation in bum-injured rats. DESIGN:Prospective, randomized, controlled study. SETTING:University research laboratory. SUBJECTS:Adult male Sprague-Dawley rats. INTERVENTIONS:The rats were intravenously administered a rabb...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-200005000-00048

    authors: Fazal N,Shamim M,Khan SS,Gamelli RL,Sayeed MM

    更新日期:2000-05-01 00:00:00

  • Occurrence of nosocomial pneumonia in mechanically ventilated trauma patients: a comparison of sucralfate and ranitidine.

    abstract:OBJECTIVE:To determine if there is a difference in nosocomial pneumonia frequency rate in mechanically ventilated trauma patients treated with sucralfate vs. ranitidine for stress ulcer prophylaxis. DESIGN:Prospective, randomized trial. SETTING:A 640-bed urban teaching hospital and trauma center. PATIENTS:Ninety-two...

    journal_title:Critical care medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00003246-199312000-00012

    authors: Pickworth KK,Falcone RE,Hoogeboom JE,Santanello SA

    更新日期:1993-12-01 00:00:00

  • Intensive care unit morbidity and mortality from eclampsia: an evaluation of the Acute Physiology and Chronic Health Evaluation II score and the Glasgow Coma Scale score.

    abstract:OBJECTIVE:To determine the maternal morbidity and mortality in patients with eclampsia admitted to an intensive care unit (ICU), and to establish the efficacy of the Acute Physiology and Chronic Health Evaluation (APACHE) II score, the organ system failure score as defined by Knaus, and the Glasgow Coma Scale (GCS) sco...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-200001000-00020

    authors: Bhagwanjee S,Paruk F,Moodley J,Muckart DJ

    更新日期:2000-01-01 00:00:00

  • Hemodynamic and colloid osmotic pressure alterations in the surgical patient.

    abstract::Colloid osmotic pressure (COP) was measured simultaneously with cardiorespiratory measurements in 103 surgical patients suspected of having circulatory problems. In a small subset of 28 patients, measurements were taken before, during, and after surgical operations. Similarly, data sets were taken before, during, and ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198303000-00010

    authors: Shippy CR,Shoemaker WC

    更新日期:1983-03-01 00:00:00

  • Systemic human orbital fat-derived stem/stromal cell transplantation ameliorates acute inflammation in lipopolysaccharide-induced acute lung injury.

    abstract:OBJECTIVE:Acute lung injury results in acute respiratory distress syndrome. There is no standard therapy for acute respiratory distress syndrome but supportive care. Stem cells offer a new therapeutic potential for tissue regeneration as a result of their self-renewal, multipotency, and paracrine capabilities. The obje...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0b013e31823bc89a

    authors: Chien MH,Bien MY,Ku CC,Chang YC,Pao HY,Yang YL,Hsiao M,Chen CL,Ho JH

    更新日期:2012-04-01 00:00:00

  • Rehabilitation interventions for postintensive care syndrome: a systematic review.

    abstract:OBJECTIVE:An increasing number of ICU patients survive and develop mental, cognitive, or physical impairments. Various interventions support recovery from this postintensive care syndrome. Physicians in charge of post-ICU patients need to know which interventions are effective. DATA SOURCES:Systematic literature searc...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1097/CCM.0000000000000148

    authors: Mehlhorn J,Freytag A,Schmidt K,Brunkhorst FM,Graf J,Troitzsch U,Schlattmann P,Wensing M,Gensichen J

    更新日期:2014-05-01 00:00:00

  • A prospective study of the impact of patient preferences on life-sustaining treatment and hospital cost.

    abstract:OBJECTIVES:Ethicists advise that life-sustaining treatment decisions should be made in keeping with patient preferences. Until recently, there has been little systematic study of the impact of patient preferences on the use of various life-sustaining treatments or the consequent cost of hospital care. This prospective ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199611000-00009

    authors: Danis M,Mutran E,Garrett JM,Stearns SC,Slifkin RT,Hanson L,Williams JF,Churchill LR

    更新日期:1996-11-01 00:00:00

  • System for umbilical artery monitoring.

    abstract::A simple, safe, and effective system for umbilical artery monitoring controls continuous fluid infusion to prevent fluid overinfusion and keep the catheter from clotting. Accurate and continuous pressure measurements can be recorded simultaneously with fluid infusion. A convenient method for checking dynamic response ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198207000-00009

    authors: Gardner RM,Parker J,Feinauer LR

    更新日期:1982-07-01 00:00:00

  • The Very Elderly Admitted to ICU: A Quality Finish?

    abstract:OBJECTIVE:Very elderly persons admitted to ICUs are at high risk of death. To document life-sustaining interventions (mechanical ventilation, vasopressors, renal replacement therapy) provided in the ICU and outcomes of care. DESIGN:Multicenter, prospective cohort study. SETTING:ICUs of 24 Canadian hospitals. PARTICI...

    journal_title:Critical care medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1097/CCM.0000000000001024

    authors: Heyland D,Cook D,Bagshaw SM,Garland A,Stelfox HT,Mehta S,Dodek P,Kutsogiannis J,Burns K,Muscedere J,Turgeon AF,Fowler R,Jiang X,Day AG,Canadian Critical Care Trials Group.,Canadian Researchers at the End of Life Network.

    更新日期:2015-07-01 00:00:00

  • Platelet hyperfunction is decreased by additional aspirin loading in patients presenting with myocardial infarction on daily aspirin therapy.

    abstract:OBJECTIVE:Currently 162-325 mg aspirin is recommended for the treatment of acute coronary syndrome. We tested the effect of an additional loading dose of 250 mg aspirin at the onset of acute coronary syndrome in patients who were already on chronic therapy with 100 mg aspirin. DESIGN:This was a prospective trial in pa...

    journal_title:Critical care medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/CCM.0b013e3181de8b1e

    authors: Fuchs I,Spiel AO,Frossard M,Derhaschnig U,Riedmüller E,Jilma B

    更新日期:2010-06-01 00:00:00

  • Exhaled nitric oxide level decreases after cardiopulmonary bypass in adult patients.

    abstract:OBJECTIVE:To measure exhaled nitric oxide (NO) and compare it with lung function after cardiopulmonary bypass (CPB) in adult patients. Pulmonary dysfunction is sometimes observed after CPB. Impaired production of NO may account for this dysfunction. DESIGN:Prospective, single-center, observational study. SETTING:Univ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-200012000-00012

    authors: Ishibe Y,Liu R,Hirosawa J,Kawamura K,Yamasaki K,Saito N

    更新日期:2000-12-01 00:00:00

  • Does noninvasive positive pressure ventilation improve outcome in acute hypoxemic respiratory failure? A systematic review.

    abstract:CONTEXT:The results of studies on noninvasive positive pressure ventilation (NPPV) for acute hypoxemic respiratory failure unrelated to cardiogenic pulmonary edema have been inconsistent. OBJECTIVE:To assess the effect of NPPV on the rate of endotracheal intubation, intensive care unit and hospital length of stay, and...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1097/01.ccm.0000148011.51681.e2

    authors: Keenan SP,Sinuff T,Cook DJ,Hill NS

    更新日期:2004-12-01 00:00:00