Magnesium-adenosine triphosphate in the treatment of shock, ischemia, and sepsis.

abstract：OBJECTIVE:The administration of endotoxin to healthy humans reduces cerebral blood flow but its influence on dynamic cerebral autoregulation remains unknown. We considered that a reduction in arterial carbon dioxide tension would attenuate cerebral perfusion and improve dynamic cerebral autoregulation in healthy subjec...

journal_title：Critical care medicine

authors： Brassard P,Kim YS,van Lieshout J,Secher NH,Rosenmeier JB

更新日期：2012-06-01 00:00:00

abstract：:Biological systems are innately complex, display nonlinear behavior, and respond to both disease and its treatment in similar complex ways. Complex systems display self-organization and predictive behavior along a range of possible states, often referred to as chaotic behavior, and can be both characterized and quanti...

journal_title：Critical care medicine

authors： Pinsky MR

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:To test the reliability and validity of a modified moral distress tool, originally developed for the nursing profession, on respiratory care practitioners. To describe the relationship between moral distress, career dissatisfaction, and job turnover in respiratory care. DESIGN:A 28-question survey was develo...

journal_title：Critical care medicine

authors： Schwenzer KJ,Wang L

更新日期：2006-12-01 00:00:00

abstract：OBJECTIVES:Survivors of critical illness in early life are at risk of long-term-memory and attention impairments. However, their neurobiologic substrates remain largely unknown. DESIGN:A prospective follow-up study. SETTING:Erasmus MC-Sophia Children's Hospital, Rotterdam, the Netherlands. PATIENTS:Thirty-eight scho...

journal_title：Critical care medicine

authors： Schiller RM,IJsselstijn H,Madderom MJ,Rietman AB,Smits M,van Heijst AFJ,Tibboel D,White T,Muetzel RL

更新日期：2017-10-01 00:00:00

abstract：OBJECTIVE:To compare three devices that measure core body temperature at the bedside in ICU patients. DESIGN:Prospective, consecutive sample. SETTING:Voluntary community teaching hospital. PATIENTS:Fifteen patients, 78 +/- 6 (SD) yrs of age, admitted to the medical ICU over a 5-month period who had pulmonary artery ...

journal_title：Critical care medicine

authors： Nierman DM

更新日期：1991-06-01 00:00:00

abstract：OBJECTIVE:To review the anti-inflammatory and anti-apoptotic properties of drotrecogin alfa (activated) (recombinant human activated protein C), emphasizing its modulatory effects on endothelial nuclear factor-kappaB. We propose a broad anti-inflammatory effect of drotrecogin alfa (activated), acting on both endotheliu...

journal_title：Critical care medicine

authors： Joyce DE,Grinnell BW

更新日期：2002-05-01 00:00:00

abstract：BACKGROUND:Remarkable progress has been made during the last decade in defining the molecular mechanisms that underlie septic shock. This rapidly expanding field is leading to new therapeutic opportunities in the management of severe sepsis. AIM:To provide the clinician with a timely summary of the molecular biology o...

journal_title：Critical care medicine

authors： Cinel I,Opal SM

更新日期：2009-01-01 00:00:00

abstract：OBJECTIVES:Although discussing a prognosis is a duty of physicians caring for critically ill patients, little is known about surrogate decision-makers' beliefs about physicians' ability to prognosticate. We sought to determine: 1) surrogates' beliefs about whether physicians can accurately prognosticate for critically ...

journal_title：Critical care medicine

authors： Zier LS,Burack JH,Micco G,Chipman AK,Frank JA,Luce JM,White DB

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVE:A 3-yr study funded by the U.S. Department of Health and Human Services was conducted to identify potential barriers to and opportunities for increasing the number hospitals with donation after cardiac death (DCD) protocols, the support of DCD by individuals involved in the donation request process, and the n...

journal_title：Critical care medicine

authors： D'Alessandro AM,Peltier JW,Phelps JE

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVE:Severe thermal injury causes immune dysfunctions involving both pro- and anti-inflammatory mechanisms. It subsequently leads to a state of immune deficiency that shares some similarities with sepsis-induced immunosuppression. A hallmark of the latter is established by decreased monocyte human leukocyte antige...

journal_title：Critical care medicine

authors： Venet F,Tissot S,Debard AL,Faudot C,Crampé C,Pachot A,Ayala A,Monneret G

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVES:This report examines the frequency, type, and prognostic factors of medical (nonneurologic) complications after subarachnoid hemorrhage in a large, prospective study. The influences of contemporary neurosurgical, neurological, and critical care practice on mortality and morbidity rates after aneurysmal subar...

journal_title：Critical care medicine

authors： Solenski NJ,Haley EC Jr,Kassell NF,Kongable G,Germanson T,Truskowski L,Torner JC

更新日期：1995-06-01 00:00:00

abstract：OBJECTIVE:The first 70 years of critical care can be considered a period of "industrial revolution-like" advancement in terms of progressing the understanding and care of critical illness. Unfortunately, like the industrial revolution's impact on the environment, advancing ICU care of increasingly elderly, immunosuppre...

journal_title：Critical care medicine

authors： Kollef MH,Torres A,Shorr AF,Martin-Loeches I,Micek ST

更新日期：2021-02-01 00:00:00

abstract：:Thromboembolic disease ranks among the most dangerous and common complication in the postoperative or post-traumatic patient. As previously mentioned, the incidence is increasing and fatalities from this complication have also risen substantially. The pathogenesis of thromboembolic disease and the predictability of it...

journal_title：Critical care medicine

authors： Evarts CM

更新日期：1976-03-01 00:00:00

abstract：OBJECTIVE:The association between cigarette smoke exposure and the acute respiratory distress syndrome in patients with the most common acute respiratory distress syndrome risk factors of sepsis, pneumonia, and aspiration has not been well studied. The goal of this study was to test the association between biomarker-co...

journal_title：Critical care medicine

authors： Calfee CS,Matthay MA,Kangelaris KN,Siew ED,Janz DR,Bernard GR,May AK,Jacob P,Havel C,Benowitz NL,Ware LB

更新日期：2015-09-01 00:00:00

abstract：:A commercially available gas-chromatograph (Sentorr Gas Analyzer, Ohio Medical Products, Madison, WI) was tested, featuring continuous measurement of in vivo PaO2 and PaCO2 by means of a thin, heparin-coated catheter, inserted through an indwelling arterial line. Gas tensions are displayed every 4 min. The probes had ...

journal_title：Critical care medicine

authors： Carlon GC,Kahn RC,Ray C Jr,Howland WS

更新日期：1980-07-01 00:00:00

abstract：OBJECTIVES:In patients with acute hypoxemic respiratory failure, noninvasive ventilation and high-flow nasal cannula oxygen are alternative strategies to conventional oxygen therapy. Endotracheal intubation is frequently needed in these patients with a risk of delay, and early predictors of failure may help clinicians ...

journal_title：Critical care medicine

authors： Frat JP,Ragot S,Coudroy R,Constantin JM,Girault C,Prat G,Boulain T,Demoule A,Ricard JD,Razazi K,Lascarrou JB,Devaquet J,Mira JP,Argaud L,Chakarian JC,Fartoukh M,Nseir S,Mercat A,Brochard L,Robert R,Thille AW,REV

更新日期：2018-02-01 00:00:00

abstract：:The tradition of clinical ultrasound in the hands of physicians who provide critical care to the most acutely ill patients stretches back into the 1980s and is rich with experiences from surgical, emergency medicine, and other practices. Now, as critical care ultrasound explodes around the world, it is important to re...

journal_title：Critical care medicine

authors： Kendall JL,Hoffenberg SR,Smith RS

更新日期：2007-05-01 00:00:00

abstract：OBJECTIVES:To determine the point prevalence of medication errors at the time of transition of care from an ICU to non-ICU location and assess error types and risk factors for medication errors during transition of care. DESIGN:This was a multicenter, retrospective, 7-day point prevalence study. SETTING:Fifty-eight I...

journal_title：Critical care medicine

authors： Tully AP,Hammond DA,Li C,Jarrell AS,Kruer RM

更新日期：2019-04-01 00:00:00

abstract：BACKGROUND:Resuscitation from hemorrhagic shock (HS) predisposes to subsequent infections. Susceptibility to infection following sepsis has been attributed to apoptosis. Interleukin (IL)-6 has been shown to have antiapoptotic properties and to decrease postresuscitation inflammation in rodent and porcine models of HS. ...

journal_title：Critical care medicine

authors： Arikan AA,Yu B,Mastrangelo MA,Tweardy DJ

更新日期：2006-03-01 00:00:00

abstract：OBJECTIVE:Adrenal failure is common in critically ill patients, particularly those with sepsis. As liver failure and sepsis are both associated with increased circulating levels of endotoxin and proinflammatory mediators and reduced levels of apoprotein-1/high-density lipoprotein, we postulated that adrenal failure may...

journal_title：Critical care medicine

authors： Marik PE,Gayowski T,Starzl TE,Hepatic Cortisol Research and Adrenal Pathophysiology Study Group.

更新日期：2005-06-01 00:00:00

abstract：OBJECTIVE:A hallmark of amniotic fluid embolism is the induction of coagulation defects. Little is known about the nature of these defects or the causative agent or agents. The purpose of this study was to assess the effects of meconium containing (native) meconium-amniotic-fluid infusion (MAFI) and meconium-free (cent...

journal_title：Critical care medicine

authors： Petroianu GA,Altmannsberger SH,Maleck WH,Assmus HP,Friedberg C,Bergler WF,Rüfer R

更新日期：1999-02-01 00:00:00

abstract：OBJECTIVE:Use of antibiotics in critically ill patients may increase the risk of invasive Candida infection. The objective of this study was to determine whether increased exposure to antibiotics is associated with increased prevalence of invasive Candida infection. DESIGN:Substudy using data from a randomized control...

journal_title：Critical care medicine

authors： Jensen JU,Hein L,Lundgren B,Bestle MH,Mohr T,Andersen MH,Løken J,Tousi H,Søe-Jensen P,Lauritsen AØ,Strange D,Petersen JA,Thormar K,Larsen KM,Drenck NE,Helweg-Larsen J,Johansen ME,Reinholdt K,Møller JK,Olesen B,Are

更新日期：2015-03-01 00:00:00

abstract：OBJECTIVE:This report will describe the preparations for and the provision of care of two patients with Ebola virus disease in the biocontainment unit at the University of Nebraska Medical Center. DATA SOURCES:Patient medical records. STUDY SELECTION:Not applicable. DATA EXTRACTION:Not applicable. DATA SYNTHESIS:No...

journal_title：Critical care medicine

authors： Johnson DW,Sullivan JN,Piquette CA,Hewlett AL,Bailey KL,Smith PW,Kalil AC,Lisco SJ

更新日期：2015-06-01 00:00:00

abstract：:Pentoxifylline has been shown to increase red blood cell malleability, thus increasing capillary blood flow in a number of disease states. The present study was undertaken to determine whether pentoxifylline might improve tissue oxygenation after anesthesia and during an operation in rats. Rats were anesthetized and d...

journal_title：Critical care medicine

authors： Soliman MH,O'Neal K,Waxman K

更新日期：1987-02-01 00:00:00

abstract：OBJECTIVES:To test whether hospital-based physicians made different intensive care unit and life-sustaining treatment decisions for otherwise identical black and white patients with end-stage cancer and life-threatening hypoxia. DESIGN:We conducted a randomized trial of the relationship between patient race and physic...

journal_title：Critical care medicine

authors： Barnato AE,Mohan D,Downs J,Bryce CL,Angus DC,Arnold RM

更新日期：2011-07-01 00:00:00

abstract：OBJECTIVES:Severe coronavirus disease 2019 is associated with an extensive pneumonitis and frequent coagulopathy. We sought the true prevalence of thrombotic complications in critically ill patients with severe coronavirus disease 2019 on the ICU, with or without extracorporeal membrane oxygenation. DESIGN:We undertoo...

journal_title：Critical care medicine

authors： Mirsadraee S,Gorog DA,Mahon CF,Rawal B,Semple TR,Nicol ED,Arachchillage DRJ,Devaraj A,Price S,Desai SR,Ridge CA,Singh S,Padley SPG

更新日期：2021-01-06 00:00:00

abstract：:A new quantitative method for measuring the prognosis and severity of illness in terms of probability of survival was developed from 224 studies in an index population of 220 critically ill surgical patients. Patients were selected preoperatively to eliminate pre-existing cardiac disease, cirrhosis, nutritional debili...

journal_title：Critical care medicine

authors： Bland RD,Shoemaker WC

更新日期：1985-02-01 00:00:00

abstract：OBJECTIVE:To test the hypotheses that, for uncontrolled hemorrhagic shock (UHS) in rats, mild hypothermia, compared with normothermia, would increase long-term survival as well as moderate hypothermia, oxygen breathing would increase survival further, and hypothermia and oxygen would mitigate visceral ischemia (dysoxia...

journal_title：Critical care medicine

authors： Takasu A,Stezoski SW,Stezoski J,Safar P,Tisherman SA

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVE:Effective therapies are needed to reverse the increased vascular permeability that characterizes acute inflammatory diseases such as acute lung injury. FTY720 is a pharmaceutical analog of the potent barrier-enhancing phospholipid, sphingosine 1-phosphate. Because both FTY720 and sphingosine 1-phosphate have ...

journal_title：Critical care medicine

authors： Wang L,Sammani S,Moreno-Vinasco L,Letsiou E,Wang T,Camp SM,Bittman R,Garcia JG,Dudek SM

更新日期：2014-03-01 00:00:00

abstract：OBJECTIVES:Extracorporeal membrane oxygenation is used to stabilize severe cardiocirculatory and/or respiratory failure. However, extracorporeal membrane oxygenation is associated with a coagulopathy characterized by thromboembolic and hemorrhagic complications. This study aimed to characterize the pathomechanism of th...

journal_title：Critical care medicine

authors： Granja T,Hohenstein K,Schüssel P,Fischer C,Prüfer T,Schibilsky D,Wendel HP,Jaschonek K,Serna-Higuita L,Schlensak C,Häberle H,Rosenberger P,Straub A

更新日期：2020-05-01 00:00:00