Complexity modeling: identify instability early.

abstract：OBJECTIVES:To describe the effectiveness of a comprehensive, interdisciplinary sepsis treatment protocol with regard to both implementation and outcomes and to compare the mortality rates and therapies of patients with septic shock with similar historical controls. DESIGN:Prospective, interventional cohort study with ...

journal_title：Critical care medicine

authors： Shapiro NI,Howell MD,Talmor D,Lahey D,Ngo L,Buras J,Wolfe RE,Weiss JW,Lisbon A

更新日期：2006-04-01 00:00:00

abstract：OBJECTIVES:Preclinical studies reveal the neuroprotective properties of xenon, especially when combined with hypothermia. The purpose of this study was to investigate the feasibility and cardiac safety of inhaled xenon treatment combined with therapeutic hypothermia in out-of-hospital cardiac arrest patients. DESIGN:A...

journal_title：Critical care medicine

authors： Arola OJ,Laitio RM,Roine RO,Grönlund J,Saraste A,Pietilä M,Airaksinen J,Perttilä J,Scheinin H,Olkkola KT,Maze M,Laitio TT

更新日期：2013-09-01 00:00:00

abstract：OBJECTIVES:To examine a hygroscopic condenser after clinical use and to describe the interaction of a hygroscopic condenser and a closed circuit suction system used simultaneously. DESIGN:Prospective evaluation of hygroscopic condensers used clinically, and laboratory investigation of a hygroscopic condenser used with...

journal_title：Critical care medicine

authors： Martinez FJ,Pietchel S,Wise C,Walek J,Beamis JF

更新日期：1994-10-01 00:00:00

abstract：OBJECTIVE:Information booklets have not been assessed by the families of intensive care unit (ICU) patients. This study explored the information that the relatives of adult ICU patients wanted to find in the information booklets. DESIGN:Multicenter survey. SETTING:Twenty-three French ICUs. SUBJECTS:One close relativ...

journal_title：Critical care medicine

authors： Soltner C,Lassalle V,Galienne-Bouygues S,Pottecher J,Floccard B,Delapierre L,Jungfer F,Sargentini C,Alberti C,Beydon L,Lifrea Group.

更新日期：2009-07-01 00:00:00

abstract：OBJECTIVE:To examine the role of platelets, fibrin, and adhesion molecules in mediating neutrophil-endothelial cell interactions in septic shock. DESIGN:Controlled experiments using phase contrast microscopy to examine neutrophil, platelet, and endothelial cell interactions in flowing cell suspensions under simulated ...

journal_title：Critical care medicine

authors： Kirschenbaum LA,McKevitt D,Rullan M,Reisbeck B,Fujii T,Astiz ME

更新日期：2004-09-01 00:00:00

abstract：OBJECTIVE:In 1991, the American College of Chest Physicians (ACCP) and the Society of Critical Care Medicine (SCCM) convened a "Consensus Conference," the goals of which were "to provide a conceptual and a practical framework to define the systemic inflammatory response to infection, which is a progressive injurious pr...

journal_title：Critical care medicine

authors： Levy MM,Fink MP,Marshall JC,Abraham E,Angus D,Cook D,Cohen J,Opal SM,Vincent JL,Ramsay G,SCCM\/ESICM\/ACCP\/ATS\/SIS.

更新日期：2003-04-01 00:00:00

abstract：:Doppler ultrasound has been used extensively in assessing adequacy of circulation. We have found it to be convenient in the identification of blood flow, particularly in hypotensive states where percutaneous radial artery cannulation of the vessel is tedious and difficult to perform. The technique is simple, atraumati...

journal_title：Critical care medicine

authors： Nagabhushan S,Colella JJ Jr,Wagner R

更新日期：1976-11-01 00:00:00

abstract：:To correlate radiant warmer bed power output with state of hydration in the critically ill infant, warmer power input was measured by a wattmeter and recorded by an on-line computer every 5 sec for 2 periods of 8-24 h each in 11 newborns with respiratory distress syndrome (mean birth weight 1.42 kg, mean gestational a...

journal_title：Critical care medicine

authors： Engle WD,Baumgart S,Fox WW,Polin RA

更新日期：1982-10-01 00:00:00

abstract：OBJECTIVES:The electronic health record is a primary source of information for all professional groups participating in ICU rounds. We previously demonstrated that, individually, all professional groups involved in rounds have significant blind spots in recognition of patient safety issues in the electronic health reco...

journal_title：Critical care medicine

authors： Bordley J,Sakata KK,Bierman J,McGrath K,Mulanax A,Nguyen L,Mohan V,Gold JA

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:To assess the possible benefits of sympatholytics on uncontrolled hemorrhage in unanesthetized rats. DESIGN:A randomized laboratory study using rats to test the effects of sympatholytics on uncontrolled hemorrhage. SETTING:Research laboratory. SUBJECTS:Forty female Sprague-Dawley rats, randomly assigned in...

journal_title：Critical care medicine

authors： Rudé MJ,Soucy DM,Hagedorn F,Illner H,Shires GT

更新日期：1999-09-01 00:00:00

abstract：BACKGROUND AND METHODS:The development of a multifactorial coagulopathy after massive transfusion is a well-recognized clinical problem that is almost always accompanied by hypothermia. The purpose of this study was to investigate the isolated effect of alterations of temperature on the integrity of the coagulation cas...

journal_title：Critical care medicine

authors： Rohrer MJ,Natale AM

更新日期：1992-10-01 00:00:00

abstract：OBJECTIVE:Our knowledge of the molecular mechanisms of sepsis has attained exponential growth. Yet, the pillars of its care remain antibiotics, fluid resuscitation, and physiologic support of failing organ systems. The inability to bring biologic breakthroughs to the bedside is not for lack of effort. Over 60 clinical ...

journal_title：Critical care medicine

authors： Lewis AJ,Lee JS,Rosengart MR

更新日期：2018-09-01 00:00:00

abstract：:Assessment of creatinine clearance (CC) in ICU patients was compared using three methods. The reference method (CC 24 h) used measurements of serum creatinine and urinary creatinine after collection of urine over a 24-h period. The other two methods were predictive methods: the Kampmann nomogram and the formula develo...

journal_title：Critical care medicine

authors： Martin C,Alaya M,Bras J,Saux P,Gouin F

更新日期：1990-11-01 00:00:00

abstract：:Although ICUs generate attention as consumers of resources, no national data on utilization and costs were available in Canada. U.S. estimates are too old for current comparison. Based on national hospital survey data from Statistics Canada, we calculated the utilization of ICUs in all Canadian general hospitals from ...

journal_title：Critical care medicine

authors： Jacobs P,Noseworthy TW

更新日期：1990-11-01 00:00:00

abstract：:The Pediatric Risk of Mortality (PRISM) score was developed from the Physiologic Stability Index (PSI) to reduce the number of physiologic variables required for pediatric ICU (PICU) mortality risk assessment and to obtain an objective weighting of the remaining variables. Univariate and multivariate statistical techn...

journal_title：Critical care medicine

authors： Pollack MM,Ruttimann UE,Getson PR

更新日期：1988-11-01 00:00:00

abstract：OBJECTIVE:This study determines whether acid-base data obtained in the emergency department correlate with outcome from major vascular injury. DESIGN:Observational, retrospective record review of trauma patients requiring vascular repair (torso or extremity, January 1988 to December 1997). Data included age, Injury Se...

journal_title：Critical care medicine

authors： Kaplan LJ,Kellum JA

更新日期：2004-05-01 00:00:00

abstract：OBJECTIVE:To determine the relative distribution of fluid within the extracellular fluid volume (ECFV) and the effect on oxygen delivery after infusing either normal saline or 5% albumin in cardiac surgical patients. DESIGN:Prospective, randomized, unblinded, interventional study. SETTING:Cardiac surgical intensive c...

journal_title：Critical care medicine

authors： Ernest D,Belzberg AS,Dodek PM

更新日期：2001-12-01 00:00:00

abstract：:Bed rest is frequently prescribed for critically ill patients because it is assumed to be beneficial for preventing complications, for conserving scarce metabolic resources, and for providing patient comfort. Furthermore, higher levels of physical activity in critically ill patients have been assumed to be impractical...

journal_title：Critical care medicine

authors： Brower RG

更新日期：2009-10-01 00:00:00

abstract：OBJECTIVES:Studies have shown contradicting results on the association of nursing workload and mortality. Most of these studies expressed workload as patients per nurse ratios; however, this does not take into account that some patients require more nursing time than others. Nursing time can be quantified by tools like...

journal_title：Critical care medicine

authors： Margadant C,Wortel S,Hoogendoorn M,Bosman R,Spijkstra JJ,Brinkman S,de Keizer N

更新日期：2020-01-01 00:00:00

abstract：OBJECTIVE:Therapeutic hypothermia in the ICU requires mechanical ventilation and sedation. Hypothermia reduces the metabolism of commonly used IV sedatives. The use of long-acting sedative agents may confound neurologic assessment. Volatile anesthetics have been reported to provide protection against ischemia-reperfusi...

journal_title：Critical care medicine

authors： Hellström J,Öwall A,Martling CR,Sackey PV

更新日期：2014-02-01 00:00:00

abstract：OBJECTIVE:To determine the specific effect of peak volume history pressure on the inflation limb of the pressure-volume curve and peak pressure-volume curve pressure on the deflation limb of the pressure-volume curve. DESIGN:Prospective assessment of pressure-volume curves in saline, lung lavage injured sheep. SETTIN...

journal_title：Critical care medicine

authors： Nishida T,Suchodolski K,Schettino GP,Sedeek K,Takeuch M,Kacmarek RM

更新日期：2004-06-01 00:00:00

abstract：OBJECTIVE:After a stay in the intensive care unit, patients risk experiencing delusional memories, memory loss, and symptoms of posttraumatic stress. Since the 1990s, diaries have been kept for intensive care unit patients to help fill in memory gaps, aid psychosocial recovery, and improve health-related quality of lif...

journal_title：Critical care medicine

authors： Egerod I,Christensen D,Schwartz-Nielsen KH,Agård AS

更新日期：2011-08-01 00:00:00

abstract：OBJECTIVE:The benefit of continuous on-site presence by a staff academic critical care specialist in the intensive care unit of a teaching hospital is not known. We compared the quality of care and patient/family and provider satisfaction before and after changing the staffing model from on-demand to continuous 24-hr c...

journal_title：Critical care medicine

authors： Gajic O,Afessa B,Hanson AC,Krpata T,Yilmaz M,Mohamed SF,Rabatin JT,Evenson LK,Aksamit TR,Peters SG,Hubmayr RD,Wylam ME

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVE:To investigate whether inhibition of cyclooxygenase-2, a critical component of the inflammatory pathway, is neuroprotective in a neonatal rat model of cerebral hypoxia-ischemia. The development of brain inflammation largely contributes to neonatal brain injury that may lead to a lifetime of neurologic deficit...

journal_title：Critical care medicine

authors： Fathali N,Ostrowski RP,Lekic T,Jadhav V,Tong W,Tang J,Zhang JH

更新日期：2010-02-01 00:00:00

abstract：OBJECTIVE:To test the effects of three hemoglobin solutions on liver function and hepatic morphology after resuscitation from severe hemorrhagic shock. DESIGN:Prospective study. SETTING:Laboratory. SUBJECTS:Thirty-three beagle dogs. INTERVENTION:Hemorrhagic shock was induced in anesthetized dogs by removal of blood...

journal_title：Critical care medicine

authors： Eldridge J,Russell R,Christenson R,Sakamoto R,Williams J,Parr M,Trump B,Delaney P,Mackenzie CF

更新日期：1996-04-01 00:00:00

abstract：:The conjunctival oxygen monitor reflects oxygen tension of the internal carotid artery without introducing the heating artifact characteristic of transcutaneous monitors. It is now being used in the ICU and the operating room to measure accurately and continuously Po2 and temperature of conjunctival tissue. We examine...

journal_title：Critical care medicine

authors： Isenberg SJ,Green BF

更新日期：1985-08-01 00:00:00

abstract：:Sequential assessment of renal function in 50 critically ill postoperative patients was done by simultaneous determinants of osmolar, free water, creatinine and sodium clearances, and fractional excretion of sodium. The traumatic and nontraumatic critically ill surgical patients had a characteristic pattern of creatin...

journal_title：Critical care medicine

authors： Brown R,Babcock R,Talbert J,Gruenberg J,Czurak C,Campbell M

更新日期：1980-02-01 00:00:00

abstract：OBJECTIVES:To characterize the rates of accidental removal of endotracheal tubes, nasogastric tubes, central venous catheters, and arterial catheters. To assess the efficacy of corrective measures aimed at reducing the accidental removal of these devices. DESIGN:Prospective, observational, and interventional study. S...

journal_title：Critical care medicine

authors： Carrión MI,Ayuso D,Marcos M,Paz Robles M,de la Cal MA,Alía I,Esteban A

更新日期：2000-01-01 00:00:00

abstract：:Oxygen availability during cardiopulmonary bypass was assessed in 22 patients under hypothermic and relatively normothermic conditions. The patients were divided into two groups, 17 of whom received ACD blood and 5, CPD blood. The mean P50 for all patients fell from a preoperative value of 25.9 +/- 2.4 (SD) to 15.6 +/...

journal_title：Critical care medicine

authors： Fisher A,Foëx P,Emerson PM,Darley JH,Rauscher LA

更新日期：1977-05-01 00:00:00

abstract：OBJECTIVE:Acute lung injury results in acute respiratory distress syndrome. There is no standard therapy for acute respiratory distress syndrome but supportive care. Stem cells offer a new therapeutic potential for tissue regeneration as a result of their self-renewal, multipotency, and paracrine capabilities. The obje...

journal_title：Critical care medicine

authors： Chien MH,Bien MY,Ku CC,Chang YC,Pao HY,Yang YL,Hsiao M,Chen CL,Ho JH

更新日期：2012-04-01 00:00:00