Lessons learned: critical care management of patients with Ebola in the United States.

Abstract:

OBJECTIVE:This report will describe the preparations for and the provision of care of two patients with Ebola virus disease in the biocontainment unit at the University of Nebraska Medical Center. DATA SOURCES:Patient medical records. STUDY SELECTION:Not applicable. DATA EXTRACTION:Not applicable. DATA SYNTHESIS:Not applicable. CONCLUSIONS:Safe and effective care of patients with Ebola virus disease requires significant communication and planning. Adherence to a predetermined isolation protocol is essential, including proper donning and doffing of personal protective equipment. Location of the patient care area and the logistics of laboratory testing, diagnostic imaging, and the removal of waste must be considered. Patients with Ebola virus disease are often dehydrated and need adequate vascular access for fluid resuscitation, nutrition, and phlebotomy for laboratory sampling. Advanced planning for acute life-threatening events and code status must be considered. Intensivist scheduling should account for the significant amount of time required for the care of patients with Ebola virus disease. With appropriate precautions and resources, designated hospitals in the United States can safely provide care for patients with Ebola virus disease.

journal_name

Crit Care Med

journal_title

Critical care medicine

authors

Johnson DW,Sullivan JN,Piquette CA,Hewlett AL,Bailey KL,Smith PW,Kalil AC,Lisco SJ

doi

10.1097/CCM.0000000000000935

subject

Has Abstract

pub_date

2015-06-01 00:00:00

pages

1157-64

issue

6

eissn

0090-3493

issn

1530-0293

journal_volume

43

pub_type

杂志文章
  • A double-blind placebo-controlled study to evaluate the safety and efficacy of L-2-oxothiazolidine-4-carboxylic acid in the treatment of patients with acute respiratory distress syndrome.

    abstract:OBJECTIVE:Acute respiratory distress syndrome is an abrupt inflammatory illness that involves damage from reactive oxygen species. We examined the efficacy and safety of oxothiazolidine-4-carboxylic acid (OTZ), a free radical scavenger, in treating acute respiratory distress syndrome. DESIGN:Double-blind, placebo-cont...

    journal_title:Critical care medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/CCM.0B013E318164E7E4

    authors: Morris PE,Papadakos P,Russell JA,Wunderink R,Schuster DP,Truwit JD,Vincent JL,Bernard GR

    更新日期:2008-03-01 00:00:00

  • Resolution of mucus plugging and atelectasis after intratracheal rhDNase therapy in a mechanically ventilated child with refractory status asthmaticus.

    abstract:OBJECTIVE:To report the dramatic resolution of unilateral mucus plugging and atelectasis in a mechanically ventilated child with refractory status asthmaticus after intratracheal recombinant human DNase (rhDNase) therapy. DESIGN:Case report. SETTING:Critical care unit. PATIENT:A 7-yr-old boy with status asthmaticus,...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-200002000-00045

    authors: Durward A,Forte V,Shemie SD

    更新日期:2000-02-01 00:00:00

  • The impact of adding 1 month of intensive care unit training in a categorical internal medicine residency program.

    abstract:OBJECTIVE:To determine the impact of adding a month of critical care training in the postgraduate year (PGY)-2 on the critical care skills of PGY-3 residents. DESIGN:Prospective, nonrandomized. SETTING:The internal medicine (IM) residency program of a tertiary care medical center. STUDY SUBJECTS:The study subjects i...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0b013e31819cc170

    authors: Mullon JJ,Gajic O,Gali B,Ficalora RD,Kolars JC,Afessa B

    更新日期:2009-04-01 00:00:00

  • Allergic and hypersensitivity reactions in the intensive care unit.

    abstract::Hypersensitivity reactions are defined as immunologically based adverse reactions to chemicals or medicinal agents. These reactions are common in the intensive care unit and can present as a simple, mildly symptomatic rash or as life-threatening anaphylactic reactions. Hypersensitivity reactions have traditionally bee...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1097/CCM.0b013e3181de0c99

    authors: Kanji S,Chant C

    更新日期:2010-06-01 00:00:00

  • Cognitive, Psychiatric, and Quality of Life Outcomes in Adult Survivors of Extracorporeal Membrane Oxygenation Therapy: A Scoping Review of the Literature.

    abstract:OBJECTIVES:To perform a scoping literature review of cognitive, psychiatric, and quality of life outcomes in adults undergoing extracorporeal membrane oxygenation for any indication. DATA SOURCES:We searched PubMed, EMBASE, Cochrane Library, Web of Science, CINAHL, and PsycINFO from inception to June 2019. STUDY SELE...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000004488

    authors: Khan IR,Saulle M,Oldham MA,Weber MT,Schifitto G,Lee HB

    更新日期:2020-10-01 00:00:00

  • Effects of naloxone and morphine on acute hypoxic survival in mice.

    abstract:OBJECTIVE:To investigate a role of the opiate system during acute hypoxic hypoxia, the effects of naloxone and morphine on hypoxic survival rate were investigated in awake adult mice. DESIGN:Prospective, randomized, animal trial. SETTING:University research laboratory. SUBJECTS:Male dd-Y mice (n = 864 in experiment ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199909000-00035

    authors: Endoh H,Taga K,Yamakura T,Sato K,Watanabe I,Fukuda S,Shimoji K

    更新日期:1999-09-01 00:00:00

  • Withholding and withdrawing of life support from patients with severe head injury.

    abstract:OBJECTIVE:To characterize the withholding or withdrawing of life support from patients with severe head injury. SETTING:San Francisco General Hospital, a city and county hospital with a Level I trauma center. DESIGN:A standardized questionnaire was used to collect data on demographics and functional outcome of severe...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199509000-00018

    authors: O'Callahan JG,Fink C,Pitts LH,Luce JM

    更新日期:1995-09-01 00:00:00

  • Mild hypothermic cardiopulmonary resuscitation improves outcome after prolonged cardiac arrest in dogs.

    abstract:BACKGROUND AND METHODS:This study was designed to explore the effect of mild cerebral and systemic hypothermia (34 degrees C) on outcome after prolonged cardiac arrest in dogs. After ventricular fibrillation with no flow of 10 min, and standard external CPR with epinephrine (low flow) from ventricular fibrillation time...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199103000-00017

    authors: Sterz F,Safar P,Tisherman S,Radovsky A,Kuboyama K,Oku K

    更新日期:1991-03-01 00:00:00

  • Carbamezapine for pain management in Guillain-Barré syndrome patients in the intensive care unit.

    abstract:OBJECTIVE:To evaluate carbamezapine (CBZ) for neuritic pain relief in Guillain-Barré syndrome (GBS) patients in the intensive care unit (ICU). DESIGN:Prospective, double-blind, randomly allocated cross-over study days. SETTING:ICU in a tertiary care university hospital. PARTICIPANTS:Twelve consecutive, conscious adu...

    journal_title:Critical care medicine

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1097/00003246-200003000-00009

    authors: Tripathi M,Kaushik S

    更新日期:2000-03-01 00:00:00

  • Migration of human monocytes in response to procalcitonin.

    abstract:OBJECTIVE:Circulating serum levels of procalcitonin rise significantly during bacterial infection. Because calcitonin is known to be a monocyte chemoattractant, we investigated whether procalcitonin, a prohormone of calcitonin, also affects leukocyte migration. DESIGN:Prospective, controlled in vitro study. SETTING:U...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-200205000-00025

    authors: Wiedermann FJ,Kaneider N,Egger P,Tiefenthaler W,Wiedermann CJ,Lindner KH,Schobersberger W

    更新日期:2002-05-01 00:00:00

  • Hypercapnic acidosis induced by nutrition in mechanically ventilated patients: glucose versus fat.

    abstract::Total parenteral nutrition (TPN) increases CO2 production (VCO2) in patients on intermittent positive-pressure ventilation who cannot match their CO2 excretion to the CO2 load, leading to an increase in PaCO2. We studied gas exchange and blood gas values in six patients with chronic respiratory failure, who were venti...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198507000-00005

    authors: Herve P,Simonneau G,Girard P,Cerrina J,Mathieu M,Duroux P

    更新日期:1985-07-01 00:00:00

  • National estimates of intensive care utilization and costs: Canada and the United States.

    abstract::Although ICUs generate attention as consumers of resources, no national data on utilization and costs were available in Canada. U.S. estimates are too old for current comparison. Based on national hospital survey data from Statistics Canada, we calculated the utilization of ICUs in all Canadian general hospitals from ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199011000-00020

    authors: Jacobs P,Noseworthy TW

    更新日期:1990-11-01 00:00:00

  • Continuous Versus Intermittent Infusion of Vancomycin and the Risk of Acute Kidney Injury in Critically Ill Adults: A Systematic Review and Meta-Analysis.

    abstract:OBJECTIVES:Critically ill patients routinely receive vancomycin as empiric antibiotic therapy. A continuous infusion administration strategy may be superior to intermittent infusion by minimizing peak concentrations and variability thereby optimizing safety. We performed a systematic review and meta-analysis to investi...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000004326

    authors: Flannery AH,Bissell BD,Bastin MT,Morris PE,Neyra JA

    更新日期:2020-06-01 00:00:00

  • Comparison of right atrial and pulmonary capillary wedge pressures.

    abstract::The right atrial pressure (Pra) was compared to the pulmonary capillary wedge pressure (Pcw) in 54 patients. In patients with heart disease, the correlation of Pra with Pcw was poor. However, in patients without clinical heart disease, Pra approximated Pcw, in both absolute number and change. This finding was independ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-197805000-00010

    authors: Risk C,Rudo N,Falltrick R,Feeley T,Don HF

    更新日期:1978-05-01 00:00:00

  • Salutary effects of ATP-MgCl2 on the depressed endothelium-dependent relaxation during hyperdynamic sepsis.

    abstract:OBJECTIVES:Studies have shown that endothelium-dependent relaxation (mediated by endothelium-derived nitric oxide) is depressed during the early, hyperdynamic stage of sepsis. Although it is known that ATP-MgCl2 produces beneficial effects following various adverse circulatory conditions, it remains unknown whether thi...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199905000-00035

    authors: Wang P,Ba ZF,Cioffi WG,Bland KI,Chaudry IH

    更新日期:1999-05-01 00:00:00

  • The significance of hypoxemia with low inspired O2 fraction before extubation.

    abstract::Arterial and transcutaneous O2 (PtcO2) and CO2 (PtcCO2) tensions, arterial O2 saturations (SaO2) and P50 values were measured in 47 patients before extubation. In order to unmask ventilation to perfusion (VA/Q) inequality, all variables were obtained without CPAP and with FIO2 of 0.40 as well as with CPAP of 5 cm H2O ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198309000-00007

    authors: Tahvanainen J,Nikki P

    更新日期:1983-09-01 00:00:00

  • Cocaine and the critical care challenge.

    abstract:OBJECTIVE:Cocaine, which first made its appearance >1,000 yrs ago, is now widely used throughout the world. The physiologic responses to cocaine may cause severe pathologic effects. This review highlights the many critical care challenges resulting from these effects. DESIGN:Historical vignettes, epidemiologic factors...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1097/01.CCM.0000063258.68159.71

    authors: Shanti CM,Lucas CE

    更新日期:2003-06-01 00:00:00

  • High dose epinephrine in refractory pediatric cardiac arrest.

    abstract::Cardiac arrest has a poor prognosis, regardless of age group. Children who fail to respond to two standard doses of epinephrine (0.01 mg/kg) rarely survive to hospital discharge, and most die without the return of spontaneous circulation (ROSC). We treated seven consecutive children in cardiac arrest with high dose ep...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198912000-00004

    authors: Goetting MG,Paradis NA

    更新日期:1989-12-01 00:00:00

  • Early Differentiation of Shiga Toxin-Associated Hemolytic Uremic Syndrome in Critically Ill Adults With Thrombotic Microangiopathy Syndromes.

    abstract:OBJECTIVES:Thrombotic microangiopathy syndromes are a heterogeneous group of severe diseases that often require ICU admission. Prompt initiation of targeted therapies is required for atypical hemolytic uremic syndrome and thrombotic thrombocytopenic purpura, whereas there is no specific consensus therapy for Shiga toxi...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000003292

    authors: Joseph A,Rafat C,Zafrani L,Mariani-Kurkdjian P,Veyradier A,Hertig A,Rondeau E,Mariotte E,Azoulay E

    更新日期:2018-09-01 00:00:00

  • Iced temperature injectate for thermodilution cardiac output determination causes minimal effects on cardiodynamics.

    abstract:OBJECTIVES:Controversy exists regarding the ideal injectate temperature for measuring cardiac output. Iced temperature injectate gives a higher signal/noise ratio and less variability in the measured cardiac output. Thus, less volume and fewer measurements are required. Advocates of room temperature injectate have sugg...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199603000-00021

    authors: Fang HK,Krahmer RL,Rypins EB,Law WR

    更新日期:1996-03-01 00:00:00

  • Long-term health-related quality of life in survivors of sepsis. Short Form 36: a valid and reliable measure of health-related quality of life.

    abstract:OBJECTIVE:To describe the long-term health-related quality of life (HRQL) of survivors of sepsis and to evaluate the reliability and validity of the medical outcomes study Short Form-36 (SF-36) in this population. STUDY DESIGN:Cross-sectional survey. SETTING:University intensive care unit. PATIENTS:Surviving patient...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-200011000-00006

    authors: Heyland DK,Hopman W,Coo H,Tranmer J,McColl MA

    更新日期:2000-11-01 00:00:00

  • Endogenous protein C activation in patients with severe sepsis.

    abstract:OBJECTIVE:To review how endogenous protein C activation might change in disease states and to discuss the implications of these findings in the context of severe sepsis. DATA SOURCE:A review of the published literature in PubMed together with data from abstracts from 2001 to present. DATA EXTRACTION AND SYNTHESIS:Act...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1097/01.ccm.0000126125.79861.d3

    authors: Liaw PC

    更新日期:2004-05-01 00:00:00

  • Adverse effects of high-dose epinephrine on cerebral blood flow during experimental cardiopulmonary resuscitation.

    abstract:OBJECTIVE:To study the effects of high-dose epinephrine, compared with standard-dose epinephrine, on the dynamics of superficial cortical cerebral blood flow as well as global cerebral oxygenation during experimental cardiopulmonary resuscitation. We hypothesized that high-dose epinephrine might be unable to improve ce...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-200005000-00028

    authors: Gedeborg R,Silander HC,Ronne-Engström E,Rubertsson S,Wiklund L

    更新日期:2000-05-01 00:00:00

  • At-risk drinkers are at higher risk to acquire a bacterial infection during an intensive care unit stay than abstinent or moderate drinkers.

    abstract:OBJECTIVES:To determine whether excessive alcohol consumption increases the risk for intensive care unit (ICU)-acquired bacterial infection, especially ventilator-associated pneumonia (VAP), in nontrauma patients. DESIGN:Prospective observational cohort study. SETTING:A 21-bed polyvalent ICU in a university hospital....

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0b013e318174dd75

    authors: Gacouin A,Legay F,Camus C,Volatron AC,Barbarot N,Donnio PY,Thomas R,Le Tulzo Y

    更新日期:2008-06-01 00:00:00

  • Death in the ICU: does the patient predict his own demise?

    abstract::Critically ill patients who fear impending death may die suddenly. We studied prospectively the incidence of death in critically ill surgical patients who articulated the fear that they were about to die. Physiologic, environmental, and behavioral correlates which might influence perceptions of impending death were ex...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198607000-00005

    authors: Poulton TJ,Butdorf MB

    更新日期:1986-07-01 00:00:00

  • Patients' recollection of intensive care unit experience.

    abstract::This study evaluates the recall of 100 patients after ICU admission. There was a wide spectrum of race, religion, occupation, and educational levels. The more common diagnoses included asthma, pneumonia, trauma, and adult respiratory distress syndrome. The average Acute Physiology and Chronic Health Evaluation (APACHE...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199009000-00012

    authors: Turner JS,Briggs SJ,Springhorn HE,Potgieter PD

    更新日期:1990-09-01 00:00:00

  • Sleep and Work in ICU Physicians During a Randomized Trial of Nighttime Intensivist Staffing.

    abstract:OBJECTIVES:To compare sleep, work hours, and behavioral alertness in faculty and fellows during a randomized trial of nighttime in-hospital intensivist staffing compared with a standard daytime intensivist model. DESIGN:Prospective observational study. SETTING:Medical ICU of a tertiary care academic medical center du...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000003773

    authors: Bakhru RN,Basner M,Kerlin MP,Halpern SD,Hansen-Flaschen J,Rosen IM,Dinges DF,Schweickert WD

    更新日期:2019-07-01 00:00:00

  • Practices in Triage and Transfer of Critically Ill Patients: A Qualitative Systematic Review of Selection Criteria.

    abstract:OBJECTIVES:To identify and appraise articles describing criteria used to prioritize or withhold a critical care admission. DATA SOURCES:PubMed, Embase, Medline, EBM Reviews, and CINAHL Complete databases. Gray literature searches and a manual review of references were also performed. Preferred Reporting Items for Syst...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000004624

    authors: Dahine J,Hébert PC,Ziegler D,Chenail N,Ferrari N,Hébert R

    更新日期:2020-11-01 00:00:00

  • Mortality among patients admitted to intensive care units during weekday day shifts compared with "off" hours.

    abstract:OBJECTIVE:To determine whether mortality rates among intensive care unit (ICU) patients differ according to the time of ICU admission, we compared the death rates for patients admitted during weekday day shifts and off hours (from 6:30 pm to 8:29 am the next day for night shifts, from Saturday 1:00 pm to Monday 8:29 am...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/01.CCM.0000249832.36518.11

    authors: Luyt CE,Combes A,Aegerter P,Guidet B,Trouillet JL,Gibert C,Chastre J

    更新日期:2007-01-01 00:00:00

  • Colonization with broad-spectrum cephalosporin-resistant gram-negative bacilli in intensive care units during a nonoutbreak period: prevalence, risk factors, and rate of infection.

    abstract:OBJECTIVE:To define the epidemiology of broad-spectrum cephalosporin-resistant gram-negative bacilli in intensive care units (ICUs) during a nonoutbreak period, including the prevalence, the risk factors for colonization, the frequency of acquisition, and the rate of infection. DESIGN:Prospective cohort study. SETTIN...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199906000-00026

    authors: D'Agata EM,Venkataraman L,DeGirolami P,Burke P,Eliopoulos GM,Karchmer AW,Samore MH

    更新日期:1999-06-01 00:00:00