The significance of hypoxemia with low inspired O2 fraction before extubation.

abstract：OBJECTIVE:To study the impact of diabetes mellitus on the relationship between glycemia and mortality in critically ill patients. DESIGN:Retrospective observational study. SETTING:Intensive care units of two university hospitals. PATIENTS:Cohort of 4946 critically ill patients including 728 patients with diabetes me...

journal_title：Critical care medicine

authors： Egi M,Bellomo R,Stachowski E,French CJ,Hart GK,Hegarty C,Bailey M

更新日期：2008-08-01 00:00:00

abstract：OBJECTIVE:In patients undergoing surgical repair of aortic dissection, false lumen perfusion during cardiopulmonary bypass may produce central nervous system damage, myocardial ischemia, aortic rupture, and death. We describe a method to detect false lumen perfusion at the beginning of retrograde aortic perfusion that ...

journal_title：Critical care medicine

authors： Voci P,Testa G,Tritapepe L,Menichetti A,Caretta Q

更新日期：2000-06-01 00:00:00

abstract：OBJECTIVE:To evaluate the use of the selective alpha 1-adrenergic receptor agonist phenylephrine in the hemodynamic support of patients with septic shock. DESIGN:Retrospective analysis of clinical use of phenylephrine. SETTING:Surgical ICU in a university hospital. PATIENTS:Thirteen patients with septic shock (diagn...

journal_title：Critical care medicine

authors： Gregory JS,Bonfiglio MF,Dasta JF,Reilley TE,Townsend MC,Flancbaum L

更新日期：1991-11-01 00:00:00

abstract：OBJECTIVES:In-hospital pediatric sepsis mortality has decreased substantially, but long-term mortality and morbidity among children initially surviving sepsis, is unknown. Accordingly, the Life After Pediatric Sepsis Evaluation investigation was conducted to describe the trajectory of mortality and health-related quali...

journal_title：Critical care medicine

authors： Zimmerman JJ,Banks R,Berg RA,Zuppa A,Newth CJ,Wessel D,Pollack MM,Meert KL,Hall MW,Quasney M,Sapru A,Carcillo JA,McQuillen PS,Mourani PM,Wong H,Chima RS,Holubkov R,Coleman W,Sorenson S,Varni JW,McGalliard J,Haal

更新日期：2020-03-01 00:00:00

abstract：OBJECTIVE:To assess the efficacy of bulk diffusion in maintaining oxygenation during apnea testing for brain death. DESIGN:Case series. SETTING:ICU in a primary care hospital. PATIENTS:Twenty-four consecutive patients with suspected brain death. Most patients suffered cerebral trauma from vehicular accidents. INTER...

journal_title：Critical care medicine

authors： al Jumah M,McLean DR,al Rajeh S,Crow N

更新日期：1992-11-01 00:00:00

abstract：OBJECTIVE:To present electron micrographs of lung tissue obtained from a patient exposed to high ventilatory pressures in the context of pulmonary dysfunction and pulmonary hypertension. DESIGN:Case report. SETTING:Adult intensive care unit of a university-affiliated teaching hospital. PATIENTS:A patient exposed to ...

journal_title：Critical care medicine

authors： Hotchkiss JR,Simonson DA,Marek DJ,Marini JJ,Dries DJ

更新日期：2002-10-01 00:00:00

abstract：OBJECTIVE:Inflammation and immobility are comorbid etiological factors inducing muscle weakness in critically ill patients. This study establishes a rat model to examine the effect of inflammation and immobilization alone and in combination on muscle contraction, histology, and acetylcholine receptor regulation. DESIG...

journal_title：Critical care medicine

authors： Fink H,Helming M,Unterbuchner C,Lenz A,Neff F,Martyn JA,Blobner M

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:The genetic background of hypertensive crisis is unknown. We examined the association of polymorphisms in genes involved in the renin-angiotensin-aldosterone-system with hypertensive crisis. DESIGN:Population-based case-control study. SETTING:Emergency department at a tertiary care university hospital. PAT...

journal_title：Critical care medicine

authors： Sunder-Plassmann G,Kittler H,Eberle C,Hirschl MM,Woisetschläger C,Derhaschnig U,Laggner AN,Hörl WH,Födinger M

更新日期：2002-10-01 00:00:00

abstract：OBJECTIVE:This study determined the time course for inhibition of lipopolysaccharide-induced acute lung injury following a single dose of genistein. In addition, the study investigated whether a multiple dosing schedule with genistein retained the inhibitory effects on acute lung injury, nuclear factor-kappaB activatio...

journal_title：Critical care medicine

authors： Kang JL,Lee HW,Lee HS,Pack IS,Castranova V,Koh Y

更新日期：2003-02-01 00:00:00

abstract：BACKGROUND:Hemoglobin (Hb) induces vasoconstriction by heme group binding nitric oxide in an irreversible fashion. Recent in vitro studies indicate that the thiol groups in Hb reversibly bind nitric oxide and participate in trans-nitrosylation reactions with other thiols. Sepsis is a pathophysiologic state characterize...

journal_title：Critical care medicine

authors： Tejedor C,Lorente JA,Delgado MA,Fernández-Segoviano P,De Paula M,Tobalina R,Alonso M,Moscoso A,Soto F,Blázquez J,Esteban A

更新日期：2002-11-01 00:00:00

abstract：OBJECTIVES:The aim of this study was to evaluate the efficacy of perioperative intra-aortic balloon pump use in high-risk cardiac surgery patients. DESIGN:A single-center randomized controlled trial and a meta-analysis of randomized controlled trials. SETTING:Heart Institute of São Paulo University. PATIENTS:High-ri...

journal_title：Critical care medicine

authors： Rocha Ferreira GS,de Almeida JP,Landoni G,Vincent JL,Fominskiy E,Gomes Galas FRB,Gaiotto FA,Dallan LO,Franco RA,Lisboa LA,Palma Dallan LR,Fukushima JT,Rizk SI,Park CL,Strabelli TM,Gelas Lage SH,Camara L,Zeferino S,Jar

更新日期：2018-08-01 00:00:00

abstract：BACKGROUND AND METHODS:The purpose of this study was twofold: the development of a chronic model of leukocyte-mediated pulmonary injury and the evaluation of the protective effects of methylprednisolone. Rabbits were inoculated ip with zymosan. Blood gases and circulating leukocytes were evaluated. Survivors were kille...

journal_title：Critical care medicine

authors： Chiara O,Giomarelli PP,Borrelli E,Casini A,Segala M,Grossi A

更新日期：1991-02-01 00:00:00

abstract：OBJECTIVES:Extracellular mitochondrial DNA and N-formyl peptides released following tissue damage may contribute to systemic inflammation through stimulation of the innate immune system. In this review, we evaluate existing in vivo human data regarding a role for mitochondrial DNA and N-formyl peptides in producing sys...

journal_title：Critical care medicine

authors： Lubkin DT,Bishawi M,Barbas AS,Brennan TV,Kirk AD

更新日期：2018-12-01 00:00:00

abstract：OBJECTIVE:Although contraindicated, there are situations when a patient who has recently taken a phosphodiesterase 5 inhibitor (e.g., sildenafil) might need intravenous nitroglycerin (NTG) treatment. This study determined if, and at what dose, intravenous NTG could be administered safely to men with coronary artery dis...

journal_title：Critical care medicine

authors： Parker JD,Bart BA,Webb DJ,Koren MJ,Siegel RL,Wang H,Malhotra B,Jen F,Glue P

更新日期：2007-08-01 00:00:00

abstract：:Utilizing a well-established porcine model of cardiac arrest, we found that end-tidal CO2 concentration (ETCO2) strikingly decreased to approximately 24% of control levels, immediately after cardiac arrest and before precordial compression. During precordial compression, ETCO2 progressively increased to 46% of control...

journal_title：Critical care medicine

authors： Trevino RP,Bisera J,Weil MH,Rackow EC,Grundler WG

更新日期：1985-11-01 00:00:00

abstract：OBJECTIVE:Very elderly persons admitted to ICUs are at high risk of death. To document life-sustaining interventions (mechanical ventilation, vasopressors, renal replacement therapy) provided in the ICU and outcomes of care. DESIGN:Multicenter, prospective cohort study. SETTING:ICUs of 24 Canadian hospitals. PARTICI...

journal_title：Critical care medicine

authors： Heyland D,Cook D,Bagshaw SM,Garland A,Stelfox HT,Mehta S,Dodek P,Kutsogiannis J,Burns K,Muscedere J,Turgeon AF,Fowler R,Jiang X,Day AG,Canadian Critical Care Trials Group.,Canadian Researchers at the End of Life Network.

更新日期：2015-07-01 00:00:00

abstract：OBJECTIVE:To define the impact of prehospital hypotension on the dynamic, systemic acute inflammatory response to blunt trauma. DESIGN:Retrospective study. SETTINGS:Tertiary care institution. PATIENTS:Twenty-two hypotensive blunt trauma patients matched with 28 normotensive blunt trauma patients. INTERVENTION:None....

journal_title：Critical care medicine

authors： Almahmoud K,Namas RA,Zaaqoq AM,Abdul-Malak O,Namas R,Zamora R,Sperry J,Billiar TR,Vodovotz Y

更新日期：2015-07-01 00:00:00

abstract：:High frequency positive pressure ventilation (HFPPV) was compared with normal frequency positive pressure ventilation (NFPPV) during diagnostic fiberoptic-bronchoscopy. HFPPV was achieved by a simple modification of the Minivent, and gave satisfactory alveolar ventilation and oxygenation. In all 11 patients and over p...

journal_title：Critical care medicine

authors： Flatau E,Lewinsohn G,Konichezky S,Lev A,Barzilay E

更新日期：1982-11-01 00:00:00

abstract：OBJECTIVES:To assess the amount of nutrients delivered, prescribed, and required for critically ill patients and to identify the reasons for discrepancies between prescriptions and requirements and between prescriptions and actual delivery of nutrition. DESIGN:Prospective cohort study. SETTING:Twelve-bed medical inte...

journal_title：Critical care medicine

authors： De Jonghe B,Appere-De-Vechi C,Fournier M,Tran B,Merrer J,Melchior JC,Outin H

更新日期：2001-01-01 00:00:00

abstract：BACKGROUND:Although thrombocytopenia in the intensive care unit (ICU) is associated with a poorer outcome, the precise relationship between the time course of platelet counts and the mortality rate has not been well defined. OBJECTIVE:To describe the time course of the platelet count in relation to the mortality rate ...

journal_title：Critical care medicine

authors： Akca S,Haji-Michael P,de Mendonça A,Suter P,Levi M,Vincent JL

更新日期：2002-04-01 00:00:00

abstract：OBJECTIVE:To review recent advances in the use of transforming growth factor (TGF)-beta in acute lung injury and to apply this knowledge to understanding the pathophysiology of this syndrome. DATA SOURCES AND STUDY SELECTION:Published research and review articles in the English language related to the role of TGF-beta...

journal_title：Critical care medicine

authors： Dhainaut JF,Charpentier J,Chiche JD

更新日期：2003-04-01 00:00:00

abstract：OBJECTIVE:To determine whether neutrophil depletion could eradicate intestinal bacterial translocation in bum-injured rats. DESIGN:Prospective, randomized, controlled study. SETTING:University research laboratory. SUBJECTS:Adult male Sprague-Dawley rats. INTERVENTIONS:The rats were intravenously administered a rabb...

journal_title：Critical care medicine

authors： Fazal N,Shamim M,Khan SS,Gamelli RL,Sayeed MM

更新日期：2000-05-01 00:00:00

abstract：OBJECTIVE:To determine whether plasma lipid hydroperoxides may be a useful marker for sepsis. DESIGN:Exploratory, open-label study. SETTING:Critical care unit at a university medical center. PATIENTS:Twelve patients with sepsis syndrome requiring hemodynamic monitoring with pulmonary artery catheters. Seven patients...

journal_title：Critical care medicine

authors： Keen RR,Stella L,Flanigan DP,Lands WE

更新日期：1991-09-01 00:00:00

abstract：OBJECTIVES:To develop a predictive equation to estimate the frequency of blood drawing for intensive care unit (ICU) laboratory tests and to evaluate variations in ICU blood sampling practices after adjusting for patient and institutional factors. DESIGN:Prospective, inception, cohort study. SETTING:Forty-two ICUs in...

journal_title：Critical care medicine

authors： Zimmerman JE,Seneff MG,Sun X,Wagner DP,Knaus WA

更新日期：1997-05-01 00:00:00

abstract：OBJECTIVE:The physicochemical approach, described by Stewart to investigate the acid-base balance, includes the strong ion gap (SIG), a quantitative measure of "unmeasured" anions, which strongly correlates to the corrected anion gap. The chemical nature of these anions is for the most part unknown. We hypothesized tha...

journal_title：Critical care medicine

authors： Moviat M,Terpstra AM,Ruitenbeek W,Kluijtmans LA,Pickkers P,van der Hoeven JG

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:To analyze plasma interferon-gamma and interleukin-10 concentrations in patients with systemic meningococcal disease and patients with severe Gram-positive septic shock caused by Streptococcus pneumoniae or Staphylococcus aureus. To study the in vitro cytokine (interferon-gamma and interleukin-10) responses i...

journal_title：Critical care medicine

authors： Bjerre A,Brusletto B,Høiby EA,Kierulf P,Brandtzaeg P

更新日期：2004-02-01 00:00:00

abstract：OBJECTIVE:To examine the association between the performance of a tracheostomy and intensive care unit and postintensive care unit mortality, controlling for treatment selection bias and confounding variables. DESIGN:Prospective, observational, cohort study. SETTING:Twelve French medical or surgical intensive care un...

journal_title：Critical care medicine

authors： Clec'h C,Alberti C,Vincent F,Garrouste-Orgeas M,de Lassence A,Toledano D,Azoulay E,Adrie C,Jamali S,Zaccaria I,Cohen Y,Timsit JF

更新日期：2007-01-01 00:00:00

abstract：OBJECTIVE:To report a case of fatal hyperkalemia owing to succinylcholine administration in a patient with mucositis secondary to chemotherapy. DESIGN:Case report. SETTING:Adult intensive care unit (ICU) at Dartmouth-Hitchcock Medical Center. PATIENTS:One patient with mucositis secondary to chemotherapy. MEASUREMEN...

journal_title：Critical care medicine

authors： Al-Khafaji AH,Dewhirst WE,Cornell CJ Jr,Quill TJ

更新日期：2001-06-01 00:00:00

abstract：OBJECTIVE:To evaluate the efficacy of the technique of selective decontamination of the digestive tract in preventing the development of secondary infection and its influence on morbidity and mortality rates in multiple trauma patients with chest injuries requiring intermittent positive-pressure ventilation. DESIGN:Pr...

journal_title：Critical care medicine

authors： Hammond JM,Potgieter PD,Saunders GL

更新日期：1994-01-01 00:00:00

abstract：OBJECTIVE:Acute aneurysmal subarachnoid hemorrhage (SAH) is a complex multifaceted disorder that plays out over days to weeks. Many patients with SAH are seriously ill and require a prolonged intensive care unit stay. Cardiopulmonary complications are common. The management of patients with SAH focuses on the anticipat...

journal_title：Critical care medicine

authors： Diringer MN

更新日期：2009-02-01 00:00:00