A double-blind placebo-controlled study to evaluate the safety and efficacy of L-2-oxothiazolidine-4-carboxylic acid in the treatment of patients with acute respiratory distress syndrome.

abstract：:Because of the neonate's susceptibility to pulmonary hypertension (PHN) and his inefficiency in invoking the compensatory mechanisms often used by adults to maintain stable levels of O2 consumption (VO2) in the face of changes in O2 delivery (DO2) and metabolic demand, we have attempted to define the O2 handling capab...

journal_title：Critical care medicine

authors： Hammerman C,Komar K,Abu-Khudair H,Olsen T

更新日期：1988-08-01 00:00:00

abstract：OBJECTIVE:The mortality of critically ill patients associated with intestinal ischemia/reperfusion remains very high, which results from multiorgan dysfunction or failure due to intestinal injury induced by intestinal ischemia/reperfusion. This study was carried out to investigate whether intestinal ischemia/reperfusio...

journal_title：Critical care medicine

authors： Zhou J,Huang WQ,Li C,Wu GY,Li YS,Wen SH,Lei WL,Liu KX

更新日期：2012-08-01 00:00:00

abstract：OBJECTIVES:To develop a predictive equation to estimate the frequency of blood drawing for intensive care unit (ICU) laboratory tests and to evaluate variations in ICU blood sampling practices after adjusting for patient and institutional factors. DESIGN:Prospective, inception, cohort study. SETTING:Forty-two ICUs in...

journal_title：Critical care medicine

authors： Zimmerman JE,Seneff MG,Sun X,Wagner DP,Knaus WA

更新日期：1997-05-01 00:00:00

abstract：OBJECTIVE:Delayed surfactant treatment (>2 hrs after birth) is less effective than early treatment in conventionally ventilated preterm infants with respiratory distress syndrome. The objective of this study was to evaluate if this time-dependent efficacy of surfactant treatment is also present during open lung ventila...

journal_title：Critical care medicine

authors： van Veenendaal MB,van Kaam AH,Haitsma JJ,Lutter R,Lachmann B

更新日期：2006-11-01 00:00:00

abstract：OBJECTIVES:To evaluate the internal consistency, validity, responsiveness, and minimal important difference of the Functional Status Score for the ICU, a physical function measure designed for the ICU. DESIGN:Clinimetric analysis. SETTINGS:Five international datasets from the United States, Australia, and Brazil. PA...

journal_title：Critical care medicine

authors： Huang M,Chan KS,Zanni JM,Parry SM,Neto SG,Neto JA,da Silva VZ,Kho ME,Needham DM

更新日期：2016-12-01 00:00:00

abstract：BACKGROUND:Overdoses of calcium channel blocker agents result in hyperglycemia, primarily due to the blockade of pancreatic L-type calcium channels and insulin resistance on the cellular level. The clinical significance of the hyperglycemia in this setting has not previously been described. METHODS:This study is a ret...

journal_title：Critical care medicine

authors： Levine M,Boyer EW,Pozner CN,Geib AJ,Thomsen T,Mick N,Thomas SH

更新日期：2007-09-01 00:00:00

abstract：:The heart rate variability (HRV) of 82 patients exhibiting sinus rhythm and admitted for possible myocardial infarction (MI) was evaluated. Using a simple information entropy measure to quantify the HRV, patients subsequently diagnosed with MI or experiencing significant dysrhythmia (n = 35) exhibited less entropy (0....

journal_title：Critical care medicine

authors： Zbilut JP,Lawson L

更新日期：1988-01-01 00:00:00

abstract：OBJECTIVE:Unplanned readmission of hospitalized patients to an intensive care unit (ICU) is associated with a worse outcome, but our ability to identify who is likely to deteriorate after ICU dismissal is limited. The objective of this study is to develop and validate a numerical index, named the Stability and Workload...

journal_title：Critical care medicine

authors： Gajic O,Malinchoc M,Comfere TB,Harris MR,Achouiti A,Yilmaz M,Schultz MJ,Hubmayr RD,Afessa B,Farmer JC

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:To evaluate the cardiopulmonary effects of the novel endothelin receptor antagonist tezosentan in endotoxin-induced lung injury in sheep and to assess the dose response to tezosentan and endothelin-1 in healthy sheep. DESIGN:Prospective, randomized, controlled experimental study. SETTING:University animal l...

journal_title：Critical care medicine

authors： Kuklin VN,Kirov MY,Evgenov OV,Sovershaev MA,Sjöberg J,Kirova SS,Bjertnaes LJ

更新日期：2004-03-01 00:00:00

abstract：OBJECTIVES:Hospitals use a variety of strategies to maximize the availability of limited ICU beds. Boarding, which involves assigning patients to an open bed in a different subspecialty ICU, is one such practice employed when ICU occupancy levels are high, and beds in a particular unit are unavailable. Boarding disrupt...

journal_title：Critical care medicine

authors： Stretch R,Della Penna N,Celi LA,Landon BE

更新日期：2018-04-01 00:00:00

abstract：BACKGROUND:Prevalence and causes of sex-based differences in morbidity and mortality secondary to cardiovascular disease remain controversial. Cardiac troponin I (cTnI) is a sensitive and specific marker for myocardial injury. Serial cTnI measurements have been used to identify perioperative myocardial cell injury. OB...

journal_title：Critical care medicine

authors： Schwarzenberger JC,Sun LS,Pesce MA,Heyer EJ,Delphin E,Almeida GM,Wood M

更新日期：2003-03-01 00:00:00

abstract：OBJECTIVE:To evaluate the role of continuous lateral rotational therapy on the development of ventilator-associated pneumonia in patients requiring long-term mechanical ventilation. DESIGN:Prospective control study. SETTING:Chronic ventilator unit in tertiary care hospital. METHODS:Thirty-seven patients requiring lo...

journal_title：Critical care medicine

authors： Kirschenbaum L,Azzi E,Sfeir T,Tietjen P,Astiz M

更新日期：2002-09-01 00:00:00

abstract：OBJECTIVES:Radiographic criteria for acute respiratory distress syndrome have been criticized for poor reliability. Our objective was to test an educational intervention to improve the radiographic identification of acute respiratory distress syndrome by participants in the Large Observational Study to Understand the G...

journal_title：Critical care medicine

authors： Goddard SL,Rubenfeld GD,Manoharan V,Dev SP,Laffey J,Bellani G,Pham T,Fan E

更新日期：2018-05-01 00:00:00

abstract：OBJECTIVES:To perform a scoping literature review of cognitive, psychiatric, and quality of life outcomes in adults undergoing extracorporeal membrane oxygenation for any indication. DATA SOURCES:We searched PubMed, EMBASE, Cochrane Library, Web of Science, CINAHL, and PsycINFO from inception to June 2019. STUDY SELE...

journal_title：Critical care medicine

authors： Khan IR,Saulle M,Oldham MA,Weber MT,Schifitto G,Lee HB

更新日期：2020-10-01 00:00:00

abstract：OBJECTIVE:The objectives of this study were to evaluate safety (primary) and clinical efficacy (secondary) of the humanized monoclonal anti-L-selectin antibody aselizumab in severely injured patients. DESIGN:Prospective phase II, parallel group, double-blind, randomized, placebo-controlled clinical trial. SETTING:Fou...

journal_title：Critical care medicine

authors： Seekamp A,van Griensven M,Dhondt E,Diefenbeck M,Demeyer I,Vundelinckx G,Haas N,Schaechinger U,Wolowicka L,Rammelt S,Stroobants J,Marzi I,Brambrink AM,Dziurdzik P,Gasiorowski J,Redl H,Beckert M,Khan-Boluki J

更新日期：2004-10-01 00:00:00

abstract：:Comparative hemodynamic measurements recorded in 19 cases of septic shock associated with Neisseria meningitidis bacteremia and in 20 shock cases associated with bacteremia due to other Gram-negative bacilli showed a significantly higher incidence of early myocardial depression in the cases with meningococcal infectio...

journal_title：Critical care medicine

authors： Monsalve F,Rucabado L,Salvador A,Bonastre J,Cuñat J,Ruano M

更新日期：1984-12-01 00:00:00

abstract：:Oxygen availability during cardiopulmonary bypass was assessed in 22 patients under hypothermic and relatively normothermic conditions. The patients were divided into two groups, 17 of whom received ACD blood and 5, CPD blood. The mean P50 for all patients fell from a preoperative value of 25.9 +/- 2.4 (SD) to 15.6 +/...

journal_title：Critical care medicine

authors： Fisher A,Foëx P,Emerson PM,Darley JH,Rauscher LA

更新日期：1977-05-01 00:00:00

abstract：OBJECTIVE:To determine whether peptic activity in bronchoalveolar fluid, due to the presence of the gastric proteolytic enzyme pepsin, could serve as a biochemical marker for pulmonary aspiration of gastric contents. DESIGN:Prospective, experimental trial. SETTING:A university animal research laboratory. SUBJECTS:Th...

journal_title：Critical care medicine

authors： Badellino MM,Buckman RF Jr,Malaspina PJ,Eynon CA,O'Brien GM,Kueppers F

更新日期：1996-11-01 00:00:00

abstract：:The authors have examined cardiopulmonary resuscitation (CPR) skills retention in a police force initially trained to instructor level performance skills as defined by the 1977 American Heart Association Instructor Manual. In 1977, the entire Winnipeg Police Force received a basic 8-h course of CPR training with recor...

journal_title：Critical care medicine

authors： Tweed WA,Wilson E,Isfeld B

更新日期：1980-11-01 00:00:00

abstract：OBJECTIVE:This study tested the hypothesis that intra-coronary transfusion of circulation-derived autologous CD34+ cells can improve ischemia-related left ventricular dysfunction in patients with severe diffuse coronary artery disease refractory to medication and unsuitable for coronary intervention. DESIGN:A prospect...

journal_title：Critical care medicine

authors： Lee FY,Chen YL,Sung PH,Ma MC,Pei SN,Wu CJ,Yang CH,Fu M,Ko SF,Leu S,Yip HK

更新日期：2015-10-01 00:00:00

abstract：OBJECTIVE:Resuscitation of hemorrhagic hypotension after traumatic brain injury is challenging. A hemoglobin-based oxygen carrier may offer advantages. The novel therapeutic hemoglobin-based oxygen carrier, polynitroxylated pegylated hemoglobin (PNPH), may represent a neuroprotective hemoglobin-based oxygen carrier for...

journal_title：Critical care medicine

authors： Shellington DK,Du L,Wu X,Exo J,Vagni V,Ma L,Janesko-Feldman K,Clark RS,Bayir H,Dixon CE,Jenkins LW,Hsia CJ,Kochanek PM

更新日期：2011-03-01 00:00:00

abstract：OBJECTIVES:Sepsis, a life-threatening organ dysfunction caused by a dysregulated host response to infection, is a leading cause of death and disability among children worldwide. Identifying sepsis in pediatric patients is difficult and can lead to treatment delay. Our objective was to assess the host proteomic response...

journal_title：Critical care medicine

authors： Shubin NJ,Navalkar K,Sampson D,Yager TD,Cermelli S,Seldon T,Sullivan E,Zimmerman JJ,Permut LC,Piliponsky AM

更新日期：2020-01-01 00:00:00

abstract：BACKGROUND:Early excision with autograft-allograft closure is standard in severe burn management. Cadaver skin is associated with risks such as antigenicity, infection, and limited availability and shelf life. Previous studies have shown that Integra is safe to use in burns of <20% total body surface area. However, the...

journal_title：Critical care medicine

authors： Branski LK,Herndon DN,Pereira C,Mlcak RP,Celis MM,Lee JO,Sanford AP,Norbury WB,Zhang XJ,Jeschke MG

更新日期：2007-11-01 00:00:00

abstract：:Chest physiotherapy (CPT) is used frequently in the ICU, but there is little available information that quantitates its effect on cardiac or respiratory function. Nineteen mechanically ventilated patients with post-traumatic respiratory failure were studied before, immediately after, and 2 h after CPT was used to mana...

journal_title：Critical care medicine

authors： Mackenzie CF,Shin B

更新日期：1985-06-01 00:00:00

abstract：OBJECTIVE:In 1991, the American College of Chest Physicians (ACCP) and the Society of Critical Care Medicine (SCCM) convened a "Consensus Conference," the goals of which were "to provide a conceptual and a practical framework to define the systemic inflammatory response to infection, which is a progressive injurious pr...

journal_title：Critical care medicine

authors： Levy MM,Fink MP,Marshall JC,Abraham E,Angus D,Cook D,Cohen J,Opal SM,Vincent JL,Ramsay G,SCCM\/ESICM\/ACCP\/ATS\/SIS.

更新日期：2003-04-01 00:00:00

abstract：OBJECTIVE:To determine the occurrence rate of complications and mortality in patients with severe asthma requiring endotracheal intubation and mechanical ventilation. DESIGN:Retrospective review of medical records from September 1982 to July 1988. SETTING:Urban, teaching hospital serving primarily indigent patients. ...

journal_title：Critical care medicine

authors： Zimmerman JL,Dellinger RP,Shah AN,Taylor RW

更新日期：1993-11-01 00:00:00

abstract：:The right atrial pressure (Pra) was compared to the pulmonary capillary wedge pressure (Pcw) in 54 patients. In patients with heart disease, the correlation of Pra with Pcw was poor. However, in patients without clinical heart disease, Pra approximated Pcw, in both absolute number and change. This finding was independ...

journal_title：Critical care medicine

authors： Risk C,Rudo N,Falltrick R,Feeley T,Don HF

更新日期：1978-05-01 00:00:00

abstract：OBJECTIVE:To determine xanthine oxidase activity, free radical concentrations, and lipid peroxidation in patients with sepsis syndrome compared with noninfected critically ill patients. DESIGN:A prospective observational study. SETTING:A nine-bed intensive care unit in a university teaching hospital trust. PATIENTS:...

journal_title：Critical care medicine

authors： Galley HF,Davies MJ,Webster NR

更新日期：1996-10-01 00:00:00

abstract：OBJECTIVE:To review the history and development of critical care nurses, the supply and demand issues related to critical care nursing, critical care nursing's contribution to patient outcomes, and recommendations to ensure a steady and strong workforce. DATA SOURCE AND SELECTION:Information presented in this article ...

journal_title：Critical care medicine

authors： Robnett MK

更新日期：2006-03-01 00:00:00

abstract：OBJECTIVES:Monocytes and macrophages produce interleukin-1β by inflammasome activation which involves adenosine triphosphate release, pannexin-1 channels, and P2X7 receptors. However, interleukin-1β can also be produced in an inflammasome-independent fashion. Here we studied if this mechanism also involves adenosine tr...

journal_title：Critical care medicine

authors： Lee AH,Ledderose C,Li X,Slubowski CJ,Sueyoshi K,Staudenmaier L,Bao Y,Zhang J,Junger WG

更新日期：2018-12-01 00:00:00