Nosocomial Infection.

Abstract:

OBJECTIVE:The first 70 years of critical care can be considered a period of "industrial revolution-like" advancement in terms of progressing the understanding and care of critical illness. Unfortunately, like the industrial revolution's impact on the environment, advancing ICU care of increasingly elderly, immunosuppressed, and debilitated individuals has resulted in a greater overall burden and complexity of nosocomial infections within modern ICUs. Given the rapid evolution of nosocomial infections, the authors provide an updated review. DATA SOURCES AND STUDY SELECTION:We searched PubMed and OVID for peer-reviewed literature dealing with nosocomial infections in the critically ill, as well as the websites of government agencies involved with the reporting and prevention of nosocomial infections. Search terms included nosocomial infection, antibiotic resistance, microbiome, antibiotics, and intensive care. DATA EXTRACTION AND DATA SYNTHESIS:Nosocomial infections in the ICU setting are evolving in multiple domains including etiologic pathogens plus novel or emerging pathogens, prevalence, host risk factors, antimicrobial resistance, interactions of the host microbiome with nosocomial infection occurrence, and understanding of pathogenesis and prevention strategies. Increasing virulence and antimicrobial resistance of nosocomial infections mandate increasing efforts toward their prevention. CONCLUSIONS:Nosocomial infections are an important determinant of outcome for patients in the ICU setting. Systematic research aimed at improving the prevention and treatment of nosocomial infections is still needed.

journal_name

Crit Care Med

journal_title

Critical care medicine

authors

Kollef MH,Torres A,Shorr AF,Martin-Loeches I,Micek ST

doi

10.1097/CCM.0000000000004783

subject

Has Abstract

pub_date

2021-02-01 00:00:00

pages

169-187

issue

2

eissn

0090-3493

issn

1530-0293

pii

00003246-202102000-00002

journal_volume

49

pub_type

杂志文章
  • Effect of classic heatstroke on serum procalcitonin.

    abstract:OBJECTIVE:Procalcitonin, the precursor peptide of calcitonin, has been shown to be a serum marker of the severity and mortality of several systemic inflammatory response syndromes. This study addressed the correlation of serum procalcitonin with the course of classic (nonexertional) heatstroke. DESIGN:Serum samples we...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199708000-00024

    authors: Nylén ES,Al Arifi A,Becker KL,Snider RH Jr,Alzeer A

    更新日期:1997-08-01 00:00:00

  • Critical Care Bed Capacity in Asian Countries and Regions.

    abstract:OBJECTIVE:To assess the number of adult critical care beds in Asian countries and regions in relation to population size. DESIGN:Cross-sectional observational study. SETTING:Twenty-three Asian countries and regions, covering 92.1% of the continent's population. PARTICIPANTS:Ten low-income and lower-middle-income eco...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000004222

    authors: Phua J,Faruq MO,Kulkarni AP,Redjeki IS,Detleuxay K,Mendsaikhan N,Sann KK,Shrestha BR,Hashmi M,Palo JEM,Haniffa R,Wang C,Hashemian SMR,Konkayev A,Mat Nor MB,Patjanasoontorn B,Nafees KMK,Ling L,Nishimura M,Al Bahrani

    更新日期:2020-05-01 00:00:00

  • Short term abstinence from smoking: its place in preoperative preparation.

    abstract::Newer pulmonary function instruments make measurement of small airway function possible as a routine, inexpensive part of preoperative preparation of patients with obstructive lung disease. Patients with early stages of chronic obstructive lung disease have maldistribution of ventilation and perfusion producing an inc...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-197507000-00001

    authors: Chodoff P,Margand PM,Knowles CL

    更新日期:1975-07-01 00:00:00

  • Aerosolized antibiotics in mechanically ventilated patients: delivery and response.

    abstract:OBJECTIVES:To determine whether aerosolized antibiotics can be delivered efficiently to the lower respiratory tract in mechanically ventilated patients and to define possible clinical responses to these agents. DESIGN:Prospective serial study with cases as their own control. SETTING:A 10-bed respiratory care unit for...

    journal_title:Critical care medicine

    pub_type: 临床试验,杂志文章

    doi:10.1097/00003246-199801000-00013

    authors: Palmer LB,Smaldone GC,Simon SR,O'Riordan TG,Cuccia A

    更新日期:1998-01-01 00:00:00

  • Correction factor for thermodilution determination of cardiac output in children.

    abstract::The authors determined the correction factor (Ct) for three sizes of commonly available central venous catheters. These catheters are used as the injectate catheter when a 2.5 Fr transthoracic thermistor is used to determine cardiac output by thermodilution. The valves for Ct were highly reproducible. These determinat...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198112000-00014

    authors: Baskoff JD,Maruschak GF

    更新日期:1981-12-01 00:00:00

  • Airway pressure measurement during high frequency oscillatory ventilation.

    abstract::We developed a method to measure accurately pressures at the airway opening (Pao) and in the trachea (Ptr) in neonates during high frequency oscillatory ventilation (HFOV) from 15-30 Hz. All component parts of the pressure-measuring system were tested as a unit against a reference transducer in a closed chamber in whi...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198401000-00011

    authors: Boynton BR,Mannino FL,Meathe EA,Kopotic RJ,Friederichsen G

    更新日期:1984-01-01 00:00:00

  • Modification of the Hemoccult slide test for occult blood in gastric juice.

    abstract::The Hemoccult slide test is used frequently to test for the presence of occult blood in samples of gastric juice obtained from critically ill patients. The purpose of this study was to investigate the accuracy of this test to determine the presence of blood in human gastric juice at various pH values. Gastric aspirate...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198210000-00016

    authors: Long PC,Wilentz KV,Sudlow G,Skillman JJ

    更新日期:1982-10-01 00:00:00

  • Early experience with continuous arteriovenous hemofiltration in critically ill pediatric patients.

    abstract::The applicability of continuous arteriovenous hemofiltration (CAVH) for renal replacement therapy was evaluated in three infants and two young children with catastrophic medical and surgical illnesses. In the first four patients, CAVH was used in conjunction with either peritoneal or hemodialysis. In the fifth patient...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198612000-00014

    authors: Leone MR,Jenkins RD,Golper TA,Alexander SR

    更新日期:1986-12-01 00:00:00

  • Urea removal during continuous hemodiafiltration.

    abstract:OBJECTIVE:To compare urea nitrogen removal by continuous hemodiafiltration vs. functional native kidneys in critically ill, septic patients receiving > 2 g of amino acids/kg body weight per day. DESIGN:Prospective, comparative, unblinded study. SETTING:Trauma critical care units of a Level I adult trauma hospital. P...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199403000-00009

    authors: Frankenfield DC,Reynolds HN,Wiles CE 3rd,Badellino MM,Siegel JH

    更新日期:1994-03-01 00:00:00

  • A National Emergency Airway Registry for children: landscape of tracheal intubation in 15 PICUs.

    abstract:OBJECTIVES:To characterize the landscape of process of care and safety outcomes for tracheal intubation across pediatric intensive care units BACKGROUND:Procedural process of care and safety outcomes of tracheal intubation across pediatric intensive care units has not been described. We hypothesize that the novel Nati...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0b013e3182746736

    authors: Nishisaki A,Turner DA,Brown CA 3rd,Walls RM,Nadkarni VM,National Emergency Airway Registry for Children (NEAR4KIDS).,Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network.

    更新日期:2013-03-01 00:00:00

  • Quality of communication in the ICU and surrogate's understanding of prognosis.

    abstract:OBJECTIVE:Although misperceptions about prognosis by surrogates in ICUs are common and influence treatment decisions, there is no validated, practical way to measure the effectiveness of prognostic communication. Surrogates' subjective ratings of quality of communication have been used in other domains as markers of ef...

    journal_title:Critical care medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1097/CCM.0000000000000719

    authors: Chiarchiaro J,Buddadhumaruk P,Arnold RM,White DB

    更新日期:2015-03-01 00:00:00

  • Brief inhalation of low-dose carbon monoxide protects rodents and swine from postoperative ileus.

    abstract:OBJECTIVE:Carbon monoxide (CO), an endogenous byproduct of heme metabolism, is produced at high levels in injured tissue via induction of heme-oxygenase-1 activity, where it contributes to the modulation of proinflammatory processes. Alone, CO has potent anti-inflammatory effects in models of acute and chronic inflamma...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/01.ccm.0000166349.76514.40

    authors: Moore BA,Overhaus M,Whitcomb J,Ifedigbo E,Choi AM,Otterbein LE,Bauer AJ

    更新日期:2005-06-01 00:00:00

  • Early Differentiation of Shiga Toxin-Associated Hemolytic Uremic Syndrome in Critically Ill Adults With Thrombotic Microangiopathy Syndromes.

    abstract:OBJECTIVES:Thrombotic microangiopathy syndromes are a heterogeneous group of severe diseases that often require ICU admission. Prompt initiation of targeted therapies is required for atypical hemolytic uremic syndrome and thrombotic thrombocytopenic purpura, whereas there is no specific consensus therapy for Shiga toxi...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000003292

    authors: Joseph A,Rafat C,Zafrani L,Mariani-Kurkdjian P,Veyradier A,Hertig A,Rondeau E,Mariotte E,Azoulay E

    更新日期:2018-09-01 00:00:00

  • Multicenter, double-blind study of intravenous milrinone for patients with acute heart failure in Japan. Japan Intravenous Milrinone Investigators.

    abstract:OBJECTIVES:Milrinone is a phosphodiesterase F-III inhibitor with positive inotropic and vasodilating activities. We investigated the hemodynamic response and pharmacokinetics of intravenous milrinone in patients with acute heart failure. DESIGN:Double-blind studies: a prospective, multicenter, double-blind, dose-findi...

    journal_title:Critical care medicine

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1097/00003246-199609000-00010

    authors: Seino Y,Momomura S,Takano T,Hayakawa H,Katoh K

    更新日期:1996-09-01 00:00:00

  • Influence of positive end-expiratory pressure on cardiac performance in premature infants: a Doppler-echocardiographic study.

    abstract::Because determining cardiac output is difficult in premature infants, little is known about the hemodynamic effects of PEEP in this age group. We used pulsed-wave Doppler echocardiography to assess the hemodynamic effects of PEEP increments in ten premature infants with respiratory distress syndrome. At a PEEP of 4 cm...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198707000-00007

    authors: Hausdorf G,Hellwege HH

    更新日期:1987-07-01 00:00:00

  • Initial pH, base deficit, lactate, anion gap, strong ion difference, and strong ion gap predict outcome from major vascular injury.

    abstract:OBJECTIVE:This study determines whether acid-base data obtained in the emergency department correlate with outcome from major vascular injury. DESIGN:Observational, retrospective record review of trauma patients requiring vascular repair (torso or extremity, January 1988 to December 1997). Data included age, Injury Se...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/01.ccm.0000125517.28517.74

    authors: Kaplan LJ,Kellum JA

    更新日期:2004-05-01 00:00:00

  • Recombinant human erythropoietin pretreatment attenuates acute renal tubular injury against ischemia-reperfusion by restoring transient receptor potential channel-6 expression and function in collecting ducts.

    abstract:OBJECTIVE:Acute renal tubular injury is a serious complication in the postoperative period, which is associated with high mortality and increased ICU stay. We aimed to demonstrate the protective effect of rhEPO against acute tubular injury induced by ischemia-reperfusion and to explore the mechanism of canonical transi...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000000542

    authors: Shen S,Jin Y,Li W,Liu X,Zhang T,Xia W,Wang Y,Ma K

    更新日期:2014-10-01 00:00:00

  • Improving Survival of Critical Care Patients With Coronavirus Disease 2019 in England: A National Cohort Study, March to June 2020.

    abstract:OBJECTIVES:To measure temporal trends in survival over time in people with severe coronavirus disease 2019 requiring critical care (high dependency unit or ICU) management, and to assess whether temporal variation in mortality was explained by changes in patient demographics and comorbidity burden over time. DESIGN:Re...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000004747

    authors: Dennis JM,McGovern AP,Vollmer SJ,Mateen BA

    更新日期:2021-02-01 00:00:00

  • Energy expenditure in critically ill children.

    abstract:OBJECTIVES:To measure energy expenditure in critically ill children and compare it with the energy expenditure predicted by recommended formulas, and relate the measured energy expenditure to nutritional and clinical indices. DESIGN:A prospective, clinical study. SETTING:Tertiary care pediatric intensive care unit in...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-200004000-00042

    authors: Briassoulis G,Venkataraman S,Thompson AE

    更新日期:2000-04-01 00:00:00

  • Ventricular function in myocardial contusion: a preliminary study.

    abstract::During a consecutive 17 month period, 15 trauma patients were diagnosed as having a myocardial contusion on the basis of abnormal ECG in 14 patients, elevated creatinine phosphokinase (CPK) in 13 patients, and elevated CPK-Muscle Brain (CPK-MB) isoenzyme determination in 11 patients. Using these screening modalities, ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198201000-00005

    authors: Torres-Mirabal P,Gruenberg JC,Talbert JG,Brown RS

    更新日期:1982-01-01 00:00:00

  • Variability of cardiac output over time in medical intensive care unit patients.

    abstract:OBJECTIVES:To determine the amount of spontaneous variability of cardiac output over time in critically ill patients, and to determine the effect of mechanical ventilation on cardiac output variability over time. DESIGN:Case series. SETTING:Medical intensive care unit in a Veterans Affairs Medical Center. PATIENTS:T...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199402000-00012

    authors: Sasse SA,Chen PA,Berry RB,Sassoon CS,Mahutte CK

    更新日期:1994-02-01 00:00:00

  • Acute-phase proteins and mortality in status epilepticus: a 5-year observational cohort study.

    abstract:OBJECTIVE:Acute-phase proteins, such as C-reactive protein and albumin, may be related with course and outcome in status epilepticus, as changes of cytokine levels and blood-brain barrier breakdown during status epilepticus have been demonstrated. The aim of this study was to elucidate the association of C-reactive pro...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0b013e318287f2ac

    authors: Sutter R,Grize L,Fuhr P,Rüegg S,Marsch S

    更新日期:2013-06-01 00:00:00

  • Systemic human orbital fat-derived stem/stromal cell transplantation ameliorates acute inflammation in lipopolysaccharide-induced acute lung injury.

    abstract:OBJECTIVE:Acute lung injury results in acute respiratory distress syndrome. There is no standard therapy for acute respiratory distress syndrome but supportive care. Stem cells offer a new therapeutic potential for tissue regeneration as a result of their self-renewal, multipotency, and paracrine capabilities. The obje...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0b013e31823bc89a

    authors: Chien MH,Bien MY,Ku CC,Chang YC,Pao HY,Yang YL,Hsiao M,Chen CL,Ho JH

    更新日期:2012-04-01 00:00:00

  • Serum Protein Changes in Pediatric Sepsis Patients Identified With an Aptamer-Based Multiplexed Proteomic Approach.

    abstract:OBJECTIVES:Sepsis, a life-threatening organ dysfunction caused by a dysregulated host response to infection, is a leading cause of death and disability among children worldwide. Identifying sepsis in pediatric patients is difficult and can lead to treatment delay. Our objective was to assess the host proteomic response...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000004083

    authors: Shubin NJ,Navalkar K,Sampson D,Yager TD,Cermelli S,Seldon T,Sullivan E,Zimmerman JJ,Permut LC,Piliponsky AM

    更新日期:2020-01-01 00:00:00

  • Lung Purinoceptor Activation Triggers Ventilator-Induced Brain Injury.

    abstract:OBJECTIVES:Mechanical ventilation can cause ventilator-induced brain injury via afferent vagal signaling and hippocampal neurotransmitter imbalances. The triggering mechanisms for vagal signaling during mechanical ventilation are unknown. The objective of this study was to assess whether pulmonary transient receptor po...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000003977

    authors: González-López A,López-Alonso I,Pickerodt PA,von Haefen C,Amado-Rodríguez L,Reimann H,Niendorf T,Kuebler W,Albaiceta GM,Francis RCE,Spies CD

    更新日期:2019-11-01 00:00:00

  • Carriage of methicillin-resistant Staphylococcus aureus, ceftazidime-resistant Gram-negative bacilli, and vancomycin-resistant enterococci before and after intensive care unit admission.

    abstract:OBJECTIVE:To measure patients' risk for acquiring antibiotic-resistant microorganisms associated with intensive care unit admission. DESIGN:Prospective, observational study. SETTING:Ten public hospitals including one university medical center. PATIENTS:Consecutive patients admitted to ten intensive care units. INTE...

    journal_title:Critical care medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1097/01.CCM.0000059437.01924.97

    authors: Ho PL,Hong Kong intensive care unit antimicrobial resistance study (HK-ICARE) Group.

    更新日期:2003-04-01 00:00:00

  • Endotracheal intubation and mechanical ventilation in severe asthma.

    abstract:OBJECTIVE:To determine the occurrence rate of complications and mortality in patients with severe asthma requiring endotracheal intubation and mechanical ventilation. DESIGN:Retrospective review of medical records from September 1982 to July 1988. SETTING:Urban, teaching hospital serving primarily indigent patients. ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199311000-00023

    authors: Zimmerman JL,Dellinger RP,Shah AN,Taylor RW

    更新日期:1993-11-01 00:00:00

  • Early treatment with ACTH-(1-24) in a rat model of hemorrhagic shock prolongs survival and extends the time-limit for blood reinfusion to be effective.

    abstract::The ability of ACTH-(1-24) to prolong survival and to extend the deadline for effective blood reinfusion has been studied in a model of lethal hypovolemic shock in the rat. Anesthetized rats were bled to a mean arterial pressure of 18 to 25 mm Hg and then subjected to one of the following iv treatments: a) saline; b) ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199008000-00014

    authors: Guarini S,Tagliavini S,Bazzani C,Ferrari W,Bertolini A

    更新日期:1990-08-01 00:00:00

  • Total liquid ventilation with perfluorocarbons increases pulmonary end-expiratory volume and compliance in the setting of lung atelectasis.

    abstract:OBJECTIVE:To compare compliance and end-expiratory lung volume during reexpansion of normal and surfactant-deficient ex vivo atelectatic lungs with either gas or total liquid ventilation. DESIGN:Controlled, animal study using an ex vivo lung preparation. SETTING:A research laboratory at a university medical center. ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199602000-00015

    authors: Tooley R,Hirschl RB,Parent A,Bartlett RH

    更新日期:1996-02-01 00:00:00

  • Rethinking brain death.

    abstract:OBJECTIVE:To evaluate whether current criteria for the diagnosis of brain death fulfill the requirement for the "irreversible cessation of all functions of the entire brain, including the brainstem." DATA SOURCES:Clinical, philosophical, legal, and public policy literature on the subject of brain death. DATA EXTRACTI...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1097/00003246-199212000-00018

    authors: Truog RD,Fackler JC

    更新日期:1992-12-01 00:00:00