Molecular biology of inflammation and sepsis: a primer.

abstract：OBJECTIVE:Intensive care unit (ICU) length of stay (LOS) and hospital LOS are common indices used to compare performance of hospitals and are yardsticks used in efforts to contain costs, yet there is no standardized method of quantitating this outcome variable. Attempts have been made to correct LOS according to diseas...

journal_title：Critical care medicine

authors： Marik PE,Hedman L

更新日期：2000-06-01 00:00:00

abstract：OBJECTIVE:In the ICU, discussions between clinicians and surrogate decision makers are often accompanied by conflict about a patient's prognosis or care plan. Trust plays a role in limiting conflict, but little is known about the determinants of trust in the ICU. We sought to identify the dimensions of trust and clinic...

journal_title：Critical care medicine

authors： Hutchison PJ,McLaughlin K,Corbridge T,Michelson KN,Emanuel L,Sporn PH,Crowley-Matoka M

更新日期：2016-12-01 00:00:00

abstract：OBJECTIVES:Vascular beds vary in their responses to atrial natriuretic peptide and sodium nitroprusside. Both of these agents dilate blood vessels by increasing intracellular guanosine 3',5'-cyclic monophosphate (cyclic-GMP) but activate different enzymes in the vascular smooth muscle cell. We aimed to determine if the...

journal_title：Critical care medicine

authors： Zhang LM,Castresana M,Newman WH

更新日期：1994-09-01 00:00:00

abstract：OBJECTIVES:Radial artery applanation tonometry allows completely noninvasive continuous cardiac output estimation. The aim of the present study was to compare cardiac output measurements obtained with applanation tonometry (AT-CO) using the T-Line system (Tensys Medical, San Diego, CA) with cardiac output measured by i...

journal_title：Critical care medicine

authors： Wagner JY,Sarwari H,Schön G,Kubik M,Kluge S,Reichenspurner H,Reuter DA,Saugel B

更新日期：2015-07-01 00:00:00

abstract：:Capnography is a valuable tool in the management of cardiac arrest, since end-tidal CO2 (PetCO2) correlates well with cardiac output and there are no other suitable noninvasive ways to measure this important variable during resuscitation. Animal studies also suggest that PetCO2 correlates well with the likelihood of r...

journal_title：Critical care medicine

authors： Callaham M,Barton C

更新日期：1990-04-01 00:00:00

abstract：OBJECTIVE:To compare two forms of continuous renal replacement therapy, continuous venovenous hemofiltration (CVVH) vs. continuous venovenous hemodialysis (CVVHD), in terms of the removal of inflammatory mediators from the blood of patients with systemic inflammatory response syndrome and acute renal failure. DESIGN:R...

journal_title：Critical care medicine

authors： Kellum JA,Johnson JP,Kramer D,Palevsky P,Brady JJ,Pinsky MR

更新日期：1998-12-01 00:00:00

abstract：OBJECTIVE:To assess survival after cardiac arrest and to determine whether age is an independent determinant of late mortality or poor neurologic outcome. DESIGN:Analyses using results of Brain Resuscitation Clinical Trial I (1979 to 1984) and Brain Resuscitation Clinical Trial II (1984 to 1989), two randomized, doubl...

journal_title：Critical care medicine

authors： Rogove HJ,Safar P,Sutton-Tyrrell K,Abramson NS

更新日期：1995-01-01 00:00:00

abstract：:Three patients under observation in ICUs developed mechanical upper airway obstruction requiring surgical intervention for airway control. One patient was treated by tracheotomy placed through a vertical midline incision and 2 patients were treated by cricothyroidotomy followed by elective tracheostomy and closure of ...

journal_title：Critical care medicine

authors： Schecter WP,Wilson RS

更新日期：1981-08-01 00:00:00

abstract：OBJECTIVE:To comparatively evaluate cerebral metabolic rate of oxygen consumption and a modification of it, cerebral consumption of oxygen, in patients with acute brain injury with acute anemia. DESIGN:Prospective, observational study. SETTING:Neuroscience intensive care unit (ICU) of a university hospital. PATIENTS...

journal_title：Critical care medicine

authors： Cruz J,Jaggi JL,Hoffstad OJ

更新日期：1993-08-01 00:00:00

abstract：:A small, double-blind crossover study compared the efficacy of aminophylline and doxapram in ventilator weaning of eight premature infants recovering from respiratory distress syndrome (RDS). Although neither drug was significantly better than the other, four infants were weaned from mechanical ventilation after drug ...

journal_title：Critical care medicine

authors： Eyal FG,Sagi EF,Alpan G,Glick B,Arad I

更新日期：1985-02-01 00:00:00

abstract：OBJECTIVE:Liquid lung ventilation has been demonstrated to improve cardiorespiratory function after cardiopulmonary bypass. We hypothesized that liquid lung ventilation (LLV) would decrease the pulmonary inflammatory response after cardiopulmonary bypass (CPB). DESIGN:Prospective, randomized, experimental, controlled,...

journal_title：Critical care medicine

authors： Williams EA,Welty SE,Geske RS,Hubble CL,Craig DM,Quick G,Meliones JN,Cheifetz IM

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVE:To evaluate the safety and physiologic actions of ibuprofen in patients with severe sepsis. DESIGN:Randomized, double-blind, placebo-controlled trial. SETTING:Three university hospital medical ICUs. PATIENTS:Twenty-nine patients with clinical evidence of sepsis and the need for hemodynamic monitoring with ...

journal_title：Critical care medicine

authors： Haupt MT,Jastremski MS,Clemmer TP,Metz CA,Goris GB

更新日期：1991-11-01 00:00:00

abstract：BACKGROUND AND METHODS:Previous studies documented activation of protease enzymes such as the plasma kallikrein-kinin system in endotoxemia and sepsis, both in experimental animals and in patients. We investigated the actions of aprotinin (a protease inhibitor that binds to plasma kallikrein) on systemic hemodynamics a...

journal_title：Critical care medicine

authors： Cumming AD,Nimmo GR

更新日期：1992-08-01 00:00:00

abstract：OBJECTIVE:Antimicrobial effects of nitric oxide (NO) have been demonstrated in vitro against a variety of infectious pathogens, yet in vivo evidence of a potential therapeutic role for exogenous NO as an antimicrobial agent is limited. Thus, we assessed the effects of inhaled NO on pulmonary infection, leukocyte infilt...

journal_title：Critical care medicine

authors： Webert KE,Vanderzwan J,Duggan M,Scott JA,McCormack DG,Lewis JF,Mehta S

更新日期：2000-07-01 00:00:00

abstract：OBJECTIVE:To evaluate the effects of sympathetic and parasympathetic nervous system activity on the heart rate and other hemodynamic variables in acute emergency patients with mild to moderately severe trauma. DESIGN:Clinical study. SETTING:Level 1 university-run trauma service. PATIENTS:Fourteen trauma patients stu...

journal_title：Critical care medicine

authors： Fathizadeh P,Shoemaker WC,Wo CC,Colombo J

更新日期：2004-06-01 00:00:00

abstract：:Given the limitations of high-dose diuretics and vasodilators and the increasing literature showing that inotropes, regardless of the dose used, have a detrimental effect on mortality, a variety of new agents are under investigation for the treatment of pulmonary and systemic congestion and restoration of cardiac outp...

journal_title：Critical care medicine

authors： Tavares M,Rezlan E,Vostroknoutova I,Khouadja H,Mebazaa A

更新日期：2008-01-01 00:00:00

abstract：OBJECTIVES:The association between tobacco smoke exposure and critical illness is not well studied, largely because obtaining an accurate smoking history from critically ill patients is difficult. Biomarkers can provide quantitative data on active and secondhand cigarette smoke exposure. We sought to compare cigarette ...

journal_title：Critical care medicine

authors： Hsieh SJ,Ware LB,Eisner MD,Yu L,Jacob P 3rd,Havel C,Goniewicz ML,Matthay MA,Benowitz NL,Calfee CS

更新日期：2011-01-01 00:00:00

abstract：OBJECTIVES:To determine plasma aluminum concentrations and 24-hr urine aluminum excretion rate in long-term mechanically ventilated patients treated with 6 g of sucralfate daily for stress ulcer prophylaxis. DESIGN:Prospective study in long-term mechanically ventilated critically ill patients. SETTING:A surgical inte...

journal_title：Critical care medicine

authors： Tryba M,Kurz-Müller K,Donner B

更新日期：1994-11-01 00:00:00

abstract：OBJECTIVE:To determine the activation of nuclear factor-[kappa]B in peripheral blood CD14+ monocyte/macrophages and CD3+, CD4+, and CD8+ T cells in children with sepsis. DESIGN:Observational study. SETTING:University hospital. PATIENTS:Twenty-six children with sepsis (nine females and 17 males, aged between 10 days ...

journal_title：Critical care medicine

authors： Hotta N,Ichiyama T,Shiraishi M,Takekawa T,Matsubara T,Furukawa S

更新日期：2007-10-01 00:00:00

abstract：OBJECTIVES:To determine the effects of sustained, 3-day endotoxin infusion on early steps of the insulin-signaling pathway in rat liver and skeletal muscle in vivo; to examine insulin signaling in well-established acute endotoxin models of insulin resistance. DESIGN:Prospective, controlled animal study. SETTING:Unive...

journal_title：Critical care medicine

authors： McCowen KC,Ling PR,Ciccarone A,Mao Y,Chow JC,Bistrian BR,Smith RJ

更新日期：2001-04-01 00:00:00

abstract：OBJECTIVES:The electronic health record is a primary source of information for all professional groups participating in ICU rounds. We previously demonstrated that, individually, all professional groups involved in rounds have significant blind spots in recognition of patient safety issues in the electronic health reco...

journal_title：Critical care medicine

authors： Bordley J,Sakata KK,Bierman J,McGrath K,Mulanax A,Nguyen L,Mohan V,Gold JA

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVE:Traumatic brain injury contributes to morbidity and mortality in children and boys are disproportionately represented. Hypotension is common and worsens outcome after traumatic brain injury. Extracellular signal-related kinase mitogen-activated protein kinase is upregulated and reduces cerebral blood flow aft...

journal_title：Critical care medicine

authors： Armstead WM,Kiessling JW,Kofke WA,Vavilala MS

更新日期：2010-09-01 00:00:00

abstract：OBJECTIVES:To synthesize the literature describing interventions to improve hand hygiene in ICUs, to evaluate the quality of the extant research, and to outline the type, and efficacy, of interventions described. DATA SOURCES:Systematic searches were conducted in November 2016 using five electronic databases: Medline,...

journal_title：Critical care medicine

authors： Lydon S,Power M,McSharry J,Byrne M,Madden C,Squires JE,O'Connor P

更新日期：2017-11-01 00:00:00

abstract：OBJECTIVE:To determine factors influencing rationing decisions in a surgical ICU during a temporary nursing shortage when two to six of the unit's 16 beds were closed. DESIGN:Blinded, concurrent data collection, retrospective chart review. SETTING:Surgical ICU. PATIENTS:All patients (n = 308) for whom a surgical ICU...

journal_title：Critical care medicine

authors： Marshall MF,Schwenzer KJ,Orsina M,Fletcher JC,Durbin CG Jr

更新日期：1992-03-01 00:00:00

abstract：OBJECTIVE:To validate performance characteristics of the intensive care unit (ICU) admission mortality probability model, version III (MPM0-III) on Project IMPACT data submitted in 2004 and 2005. This data set was external from the MPM0-III developmental and internal validation data collected between 2001 and 2004. DE...

journal_title：Critical care medicine

authors： Higgins TL,Kramer AA,Nathanson BH,Copes W,Stark M,Teres D

更新日期：2009-05-01 00:00:00

abstract：:Ventricular fibrillation (VF) can masquerade as asystole. We report a 54-yr-old male in cardiac arrest who, on surface ECG, appeared to be in VF or asystole. A bedside intracardiac recording using a transmyocardial pacing wire showed the true rhythm to be atrial fibrillation (AF) with high grade atrioventricular block...

journal_title：Critical care medicine

authors： Ornato JP,Gonzales ER,Garnett R

更新日期：1987-04-01 00:00:00

abstract：OBJECTIVES:The Accreditation Council for Graduate Medical Education recently released new standards for supervision and duty hours for residency programs. These new standards, which will affect over 100,000 residents, take effect in July 2011. In response to these new guidelines, the Society of Critical Care Medicine c...

journal_title：Critical care medicine

authors： Pastores SM,O'Connor MF,Kleinpell RM,Napolitano L,Ward N,Bailey H,Mollenkopf FP Jr,Coopersmith CM

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVE:Acute respiratory distress syndrome is an abrupt inflammatory illness that involves damage from reactive oxygen species. We examined the efficacy and safety of oxothiazolidine-4-carboxylic acid (OTZ), a free radical scavenger, in treating acute respiratory distress syndrome. DESIGN:Double-blind, placebo-cont...

journal_title：Critical care medicine

authors： Morris PE,Papadakos P,Russell JA,Wunderink R,Schuster DP,Truwit JD,Vincent JL,Bernard GR

更新日期：2008-03-01 00:00:00

abstract：OBJECTIVE:To provide a meta-analysis of current literature concerning the validation of thoracic impedance cardiography (TIC) and to explain the variations in the reported results from the differences in the studies. DATA SOURCES:A computer-assisted search of English-language, German, and Dutch literature was performe...

journal_title：Critical care medicine

authors： Raaijmakers E,Faes TJ,Scholten RJ,Goovaerts HG,Heethaar RM

更新日期：1999-06-01 00:00:00

abstract：:Last year, >28,000 people received organ transplants from >14,000 donors in the United States. Unfortunately, the wait list now tops 91,000, with the gap between recipient needs and available donor organs at around 60,000. This has motivated a host of efforts to increase organ supply, including driver's license and do...

journal_title：Critical care medicine

authors： Aulisio MP,Devita M,Luebke D

更新日期：2007-02-01 00:00:00