Molecular biology of inflammation and sepsis: a primer.

abstract：OBJECTIVE:To evaluate a novel combination of preoperative, intraoperative, and postoperative variables (including the Parsonnet, and the Acute Physiology and Chronic Health Evaluation II and III [APACHE II and III] scores) in cardiac surgery patients in order to predict hospital outcome, complications, and length of st...

journal_title：Critical care medicine

authors： Turner JS,Morgan CJ,Thakrar B,Pepper JR

更新日期：1995-11-01 00:00:00

abstract：OBJECTIVE:This study was done to assess the effects of temperature on bleeding time and clotting time in normal male and female volunteers. DESIGN:Open study utilizing normal volunteers. SETTING:University research laboratory. SUBJECTS:Fifty-four healthy male and female volunteers, ranging in age from 19 to 35 yrs, ...

journal_title：Critical care medicine

authors： Valeri CR,MacGregor H,Cassidy G,Tinney R,Pompei F

更新日期：1995-04-01 00:00:00

abstract：:Last year, >28,000 people received organ transplants from >14,000 donors in the United States. Unfortunately, the wait list now tops 91,000, with the gap between recipient needs and available donor organs at around 60,000. This has motivated a host of efforts to increase organ supply, including driver's license and do...

journal_title：Critical care medicine

authors： Aulisio MP,Devita M,Luebke D

更新日期：2007-02-01 00:00:00

abstract：OBJECTIVES:Severe coronavirus disease 2019 is associated with an extensive pneumonitis and frequent coagulopathy. We sought the true prevalence of thrombotic complications in critically ill patients with severe coronavirus disease 2019 on the ICU, with or without extracorporeal membrane oxygenation. DESIGN:We undertoo...

journal_title：Critical care medicine

authors： Mirsadraee S,Gorog DA,Mahon CF,Rawal B,Semple TR,Nicol ED,Arachchillage DRJ,Devaraj A,Price S,Desai SR,Ridge CA,Singh S,Padley SPG

更新日期：2021-01-06 00:00:00

abstract：OBJECTIVES:The primary objective of this study was to identify which patient demographic, patient health, and hospital characteristics were associated with in-hospital mortality. A secondary objective was to determine the relative influence of these characteristics on mortality. DESIGN AND SETTING:Public-use data for ...

journal_title：Critical care medicine

authors： Banta JE,Joshi KP,Beeson L,Nguyen HB

更新日期：2012-11-01 00:00:00

abstract：OBJECTIVES:ICU admission delays can negatively affect patient outcomes, but emergency department volume and boarding times may also affect these decisions and associated patient outcomes. We sought to investigate the effect of emergency department and ICU capacity strain on ICU admission decisions and to examine the ef...

journal_title：Critical care medicine

authors： Mathews KS,Durst MS,Vargas-Torres C,Olson AD,Mazumdar M,Richardson LD

更新日期：2018-05-01 00:00:00

abstract：:Measuring gas exchange in critically ill patients can provide valuable information on their nutritional status and energy expenditure. Several semiautomated machines are available for measuring oxygen consumption (VO2) and carbon dioxide production (VCO2). This study evaluated, under controlled laboratory conditions, ...

journal_title：Critical care medicine

authors： Eccles RC,Swinamer DL,Jones RL,King EG

更新日期：1986-09-01 00:00:00

abstract：OBJECTIVE:To test whether intensive care unit (ICU) nasal screening for methicillin-resistant Staphylococcus aureus (MRSA) predicts the presence or absence of MRSA infections requiring antimicrobial treatment. DESIGN:A prospective cohort study. SETTING:Medical ICU at Barnes-Jewish Hospital, a 1252-bed urban teaching ...

journal_title：Critical care medicine

authors： Sarikonda KV,Micek ST,Doherty JA,Reichley RM,Warren D,Kollef MH

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVE:Levosimendan is a novel inodilator that improves cardiac contractility by sensitizing troponin C to calcium. This drug has proved to be effective in treating advanced congestive heart failure but has not been evaluated in septic settings. The purpose of the present study was to study the effects of this drug ...

journal_title：Critical care medicine

authors： Oldner A,Konrad D,Weitzberg E,Rudehill A,Rossi P,Wanecek M

更新日期：2001-11-01 00:00:00

abstract：BACKGROUND:We have previously described a method for the precise delivery of inhaled nitric oxide (iNO) via a conventional, continuous-flow, pressure-limited, time-cycled ventilator. Because of the augmented effect of iNO decreasing pulmonary vascular resistance with high-frequency oscillatory ventilation (HFOV), we de...

journal_title：Critical care medicine

authors： Espinosa RM,Marks KH

更新日期：1999-11-01 00:00:00

abstract：OBJECTIVE:Trauma induces a complex immune response that requires a systems biology research approach. Here, we used a novel technology, mass cytometry by time-of-flight, to comprehensively characterize the multicellular response to trauma. DESIGN:Peripheral blood mononuclear cells samples were stained with a 38-marker...

journal_title：Critical care medicine

authors： Seshadri A,Brat GA,Yorkgitis BK,Keegan J,Dolan J,Salim A,Askari R,Lederer JA

更新日期：2017-09-01 00:00:00

abstract：OBJECTIVE:To evaluate the safety of human albumin administered for therapeutic purposes. DESIGN:Retrospective compilation of spontaneously reported serious adverse events. SETTING:Records of serious adverse event reports received from 1990 through 1997 by nine major suppliers of therapeutic human albumin worldwide. ...

journal_title：Critical care medicine

authors： von Hoegen I,Waller C

更新日期：2001-05-01 00:00:00

abstract：OBJECTIVE:Pressure inflating the lung during mechanical ventilation is the difference between pressure applied at the airway opening (Pao) and pleural pressure (Ppl). Depending on the chest wall's contribution to respiratory mechanics, a given positive end-expiratory and/or end-inspiratory plateau pressure may be appro...

journal_title：Critical care medicine

authors： Talmor D,Sarge T,O'Donnell CR,Ritz R,Malhotra A,Lisbon A,Loring SH

更新日期：2006-05-01 00:00:00

abstract：OBJECTIVES:To assess trends in the use of extracorporeal membrane oxygenation for poisoning in the United States. DESIGN:Retrospective cohort study. SETTING:The National Poison Data System, the databased owned and managed by the American Association of Poison Control Centers, the organization that supports and accred...

journal_title：Critical care medicine

authors： Cole JB,Olives TD,Ulici A,Litell JM,Bangh SA,Arens AM,Puskarich MA,Prekker ME

更新日期：2020-08-01 00:00:00

abstract：OBJECTIVES:Approximately one in every four patients who present to the emergency department with sepsis progresses to septic shock within 72 hours of arrival. In this study, we describe key patient characteristics present within 4 hours of emergency department arrival that are associated with developing septic shock be...

journal_title：Critical care medicine

authors： Capp R,Horton CL,Takhar SS,Ginde AA,Peak DA,Zane R,Marill KA

更新日期：2015-05-01 00:00:00

abstract：OBJECTIVE:Pulmonary air embolism, causing vessel obstruction and primary or secondary reactions of blood, can lead to acute lung injury. In addition, nitric oxide has been known to play a key role in various causes of lung injury. In this study we employed the isolated rat lung model to investigate the effects of l-arg...

journal_title：Critical care medicine

authors： Chu SJ,Lee TY,Yan HC,Lin SH,Li MH

更新日期：2005-09-01 00:00:00

abstract：:High frequency positive pressure ventilation (HFPPV) was compared with normal frequency positive pressure ventilation (NFPPV) during diagnostic fiberoptic-bronchoscopy. HFPPV was achieved by a simple modification of the Minivent, and gave satisfactory alveolar ventilation and oxygenation. In all 11 patients and over p...

journal_title：Critical care medicine

authors： Flatau E,Lewinsohn G,Konichezky S,Lev A,Barzilay E

更新日期：1982-11-01 00:00:00

abstract：:By definition, the acute respiratory distress syndrome is associated with diffuse cellular infiltration and proteinaceous edema. It is generally believed that the widespread injury that characterizes acute respiratory distress syndrome is a process that is launched almost synchronously throughout the lung, caused by b...

journal_title：Critical care medicine

authors： Marini JJ

更新日期：2010-10-01 00:00:00

abstract：OBJECTIVES:To determine if vecuronium doses individualized by peripheral nerve stimulation are lower than those doses chosen by standard clinical techniques; and to determine whether patients monitored by peripheral nerve stimulation exhibit shorter recovery times and less prolonged neuromuscular blockade after discont...

journal_title：Critical care medicine

authors： Rudis MI,Sikora CA,Angus E,Peterson E,Popovich J Jr,Hyzy R,Zarowitz BJ

更新日期：1997-04-01 00:00:00

abstract：OBJECTIVE:To determine the limits of agreement between the cardiac output and volumetric data estimated by impedance cardiography with the cardiac output determined by thermodilution and the left ventricular ejection fraction and end-diastolic volume estimated from left ventriculography. DESIGN:A prospective study. S...

journal_title：Critical care medicine

authors： Marik PE,Pendelton JE,Smith R

更新日期：1997-09-01 00:00:00

abstract：OBJECTIVE:To determine whether the difference between oxygen consumption (VO2) measured by metabolic gas monitoring systems and by the Fick principle is related to venous admixture, deadspace/tidal volume ratio, or alveolar-arterial oxygen tension gradient in critically ill patients. DESIGN:A prospective study. SETTI...

journal_title：Critical care medicine

authors： Myburgh JA,Webb RK,Worthley LI

更新日期：1992-04-01 00:00:00

abstract：:To evaluate the effect of meconium on pulmonary surface tension properties, the mechanics of 30 excised, separated canine pulmonary lobes were studied. Meconia were blended in normal saline to produce solutions of 10% and 20%. Solutions were filtered to remove large particles and instilled endobronchially into the can...

journal_title：Critical care medicine

authors： Chen CT,Toung TJ,Rogers MC

更新日期：1985-04-01 00:00:00

abstract：OBJECTIVE:To compare carbon dioxide-induced changes in cerebral oxy- and deoxyhemoglobin, measured by near-infrared spectroscopy, with those changes in jugular venous oxygen saturation in adult patients with acute brain disease. DESIGN:A prospective study. SETTING:The medical and surgical intensive care unit of a uni...

journal_title：Critical care medicine

authors： Tateishi A,Maekawa T,Soejima Y,Sadamitsu D,Yamamoto M,Matsushita M,Nakashima K

更新日期：1995-10-01 00:00:00

abstract：:Recorded values (SpO2) of oxygen saturation from six noninvasive pulse oximeters were compared to each other and to the value from a cooximeter. Simultaneous measurements were obtained from each instrument in eight healthy nonsmoking volunteers rendered hypoxic greater than 70% SpO2. Functional arterial oxygen saturat...

journal_title：Critical care medicine

authors： Choe H,Tashiro C,Fukumitsu K,Yagi M,Yoshiya I

更新日期：1989-07-01 00:00:00

abstract：OBJECTIVE:Sepsis is a frequent cause of admission, but incidence rates based on administrative data have previously produced large differences in estimates. The aim of the study was to estimate the incidence of community-acquired sepsis based on patients' symptoms and clinical findings at arrival to the hospital. DESI...

journal_title：Critical care medicine

authors： Henriksen DP,Laursen CB,Jensen TG,Hallas J,Pedersen C,Lassen AT

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVE:To assess the prevalence of acute kidney injury in patients with subarachnoid hemorrhage patients. DESIGN:Retrospective analysis of all subarachnoid hemorrhage admissions. SETTINGS:Neurocritical care unit. PATIENTS:All patients with a diagnosis of subarachnoid hemorrhage between 2009 and 2014. INTERVENTIO...

journal_title：Critical care medicine

authors： Sadan O,Singbartl K,Kandiah PA,Martin KS,Samuels OB

更新日期：2017-08-01 00:00:00

abstract：OBJECTIVES:Prone-position ventilation (PPV) induces acute improvement in oxygenation in many patients with acute respiratory distress syndrome (ARDS), with some maintaining their oxygenation even after they were returned to the supine position, but it is unclear what clinical factors determine the sustained oxygenation...

journal_title：Critical care medicine

authors： Lee DL,Chiang HT,Lin SL,Ger LP,Kun MH,Huang YC

更新日期：2002-07-01 00:00:00

abstract：OBJECTIVE:To estimate the prevalence of, the risk factors associated with, and the outcome of tracheostomy in a heterogeneous population of mechanically ventilated patients. DESIGN:Prospective, observational cohort study. SETTING:A total of 361 intensive care units from 12 countries. PATIENTS:A cohort of 5,081 patie...

journal_title：Critical care medicine

authors： Frutos-Vivar F,Esteban A,Apezteguía C,Anzueto A,Nightingale P,González M,Soto L,Rodrigo C,Raad J,David CM,Matamis D,D' Empaire G,International Mechanical Ventilation Study Group.

更新日期：2005-02-01 00:00:00

abstract：OBJECTIVES:Microcirculatory alterations are associated with adverse outcome in subsets of critically ill patients. The prevalence and significance of microcirculatory alterations in the general ICU population are unknown. We studied the prevalence of microcirculatory alterations in a heterogeneous ICU population and it...

journal_title：Critical care medicine

authors： Vellinga NA,Boerma EC,Koopmans M,Donati A,Dubin A,Shapiro NI,Pearse RM,Machado FR,Fries M,Akarsu-Ayazoglu T,Pranskunas A,Hollenberg S,Balestra G,van Iterson M,van der Voort PH,Sadaka F,Minto G,Aypar U,Hurtado FJ,Mar

更新日期：2015-01-01 00:00:00

abstract：BACKGROUND:The early detection of bacterial meningitis is crucial for successful outcome. Heparin-binding protein, a potent inducer of increased vascular permeability, is released from activated neutrophils in severe sepsis. OBJECTIVE:In this study we investigated whether heparin-binding protein levels in cerebrospina...

journal_title：Critical care medicine

authors： Linder A,Akesson P,Brink M,Studahl M,Björck L,Christensson B

更新日期：2011-04-01 00:00:00