Hemodialysis of amikacin in critically ill patients.

Abstract:

:The clearance of amikacin during hemodialysis (HD) was determined in eight critically ill patients. The dialysis period averaged 3.4 h with a blood flow of 200 ml/min. The average amikacin clearance between dialysis was 7.30 +/- 4.78 (SD) ml/min which increased to 37.5 +/- 8.01 ml/min during dialysis. The average serum amikacin concentration before dialysis fell 27% after dialysis. The fraction of drug in the body removed only from dialysis averaged 21%. Although amikacin was cleared more effectively during HD compared to the interdialysis period, the small amount of drug removed suggests that routine supplemental dosing of amikacin after HD may not be necessary.

journal_name

Crit Care Med

journal_title

Critical care medicine

authors

Armstrong DK,Hodgman T,Visconti JA,Reilley TE,Garner WL,Dasta JF

doi

10.1097/00003246-198805000-00010

subject

Has Abstract

pub_date

1988-05-01 00:00:00

pages

517-20

issue

5

eissn

0090-3493

issn

1530-0293

journal_volume

16

pub_type

杂志文章
  • Hypophosphatemia induced by mechanical ventilation in patients with chronic obstructive pulmonary disease.

    abstract::The aim of this study was to assess prospectively the variations of serum phosphorus concentration (P) after onset of mechanical ventilation (MV) in patients with chronic obstructive pulmonary disease (COPD) and acute respiratory acidosis. In 14 COPD patients, we measured P, PaCO2, and pH, immediately before MV (H0), ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198911000-00005

    authors: Laaban JP,Grateau G,Psychoyos I,Laromiguière M,Vuong TK,Rochemaure J

    更新日期:1989-11-01 00:00:00

  • Critical care problems of the newborn: insensible water loss in small premature infants.

    abstract::During the control period in this study, small premature infants, 1500 g in birth weight, had insensible water loss (IWL) of 2.28 g/kg/hr (equivlaent to 54 ml/kg/day), which is considerably higher than in full term infants. Under phototherapy, there was a significant increase in IWL (3.14 g/kg/hr) associated with incr...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-197511000-00006

    authors: Yeh TF,Vidyasagar D,Pildes RS

    更新日期:1975-11-01 00:00:00

  • Mild hypothermia attenuates circulatory and pulmonary dysfunction during experimental endotoxemia.

    abstract:OBJECTIVE:We tested whether mild hypothermia impacts on circulatory and respiratory dysfunction during experimental endotoxemia. DESIGN:Randomized controlled prospective experimental study. SETTING:Large animal facility, Medical University of Graz, Austria. SUBJECTS:Thirteen anesthetized and mechanically ventilated ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0b013e31829791da

    authors: Schwarzl M,Seiler S,Wallner M,von Lewinski D,Huber S,Maechler H,Steendijk P,Zelzer S,Truschnig-Wilders M,Obermayer-Pietsch B,Lueger A,Pieske BM,Post H

    更新日期:2013-12-01 00:00:00

  • Multicenter study of oxygen-insensitive handheld glucose point-of-care testing in critical care/hospital/ambulatory patients in the United States and Canada.

    abstract:OBJECTIVES:Existing handheld glucose meters are glucose oxidase (GO)-based. Oxygen side reactions can introduce oxygen dependency, increase potential error, and limit clinical use. Our primary objectives were to: a) introduce a new glucose dehydrogenase (GD)-based electrochemical biosensor for point-of-care testing; b)...

    journal_title:Critical care medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1097/00003246-199803000-00036

    authors: Kost GJ,Vu HT,Lee JH,Bourgeois P,Kiechle FL,Martin C,Miller SS,Okorodudu AO,Podczasy JJ,Webster R,Whitlow KJ

    更新日期:1998-03-01 00:00:00

  • Prediction of Large Vessel Occlusions in Acute Stroke: National Institute of Health Stroke Scale Is Hard to Beat.

    abstract:OBJECTIVES:Endovascular treatment for acute ischemic stroke with a large vessel occlusion was recently shown to be effective. We aimed to develop a score capable of predicting large vessel occlusion eligible for endovascular treatment in the early hospital management. DESIGN:Retrospective, cohort study. SETTING:Two t...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000001630

    authors: Vanacker P,Heldner MR,Amiguet M,Faouzi M,Cras P,Ntaios G,Arnold M,Mattle HP,Gralla J,Fischer U,Michel P

    更新日期:2016-06-01 00:00:00

  • Protective effect of a novel, potent inhibitor of poly(adenosine 5'-diphosphate-ribose) synthetase in a porcine model of severe bacterial sepsis.

    abstract:OBJECTIVE:To determine whether activation of the nuclear enzyme poly(adenosine 5'-diphosphate [ADP]-ribose) synthetase (PARS) contributes to mortality rate, myocardial dysfunction, and cardiovascular collapse in a porcine model of sepsis induced by implantation of an infected clot. DESIGN:Prospective, random animal st...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-200205000-00004

    authors: Goldfarb RD,Marton A,Szabó E,Virág L,Salzman AL,Glock D,Akhter I,McCarthy R,Parrillo JE,Szabó C

    更新日期:2002-05-01 00:00:00

  • New pharmacologic therapies for acute heart failure.

    abstract::Given the limitations of high-dose diuretics and vasodilators and the increasing literature showing that inotropes, regardless of the dose used, have a detrimental effect on mortality, a variety of new agents are under investigation for the treatment of pulmonary and systemic congestion and restoration of cardiac outp...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1097/01.CCM.0000296810.74724.8D

    authors: Tavares M,Rezlan E,Vostroknoutova I,Khouadja H,Mebazaa A

    更新日期:2008-01-01 00:00:00

  • Interleukin-6 treatment reverses apoptosis and blunts susceptibility to intraperitoneal bacterial challenge following hemorrhagic shock.

    abstract:BACKGROUND:Resuscitation from hemorrhagic shock (HS) predisposes to subsequent infections. Susceptibility to infection following sepsis has been attributed to apoptosis. Interleukin (IL)-6 has been shown to have antiapoptotic properties and to decrease postresuscitation inflammation in rodent and porcine models of HS. ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/01.ccm.0000201901.30292.c2

    authors: Arikan AA,Yu B,Mastrangelo MA,Tweardy DJ

    更新日期:2006-03-01 00:00:00

  • Acute renal failure after ruptured abdominal aortic aneurysm: an improved clinical prognosis.

    abstract::Eleven cases of renal failure associated with resection of ruptured abdominal aortic aneurysm and requiring hemodialysis are reported. Previously described series have emphasized the extremely high mortality rate in such patients. In our clinical experience, however, 8 of 11 consecutively treated patients with this cl...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-197902000-00006

    authors: Sapir DG,Dandy WE Jr,Whelton A,Cooke CR

    更新日期:1979-02-01 00:00:00

  • High-risk intrahospital transport of critically ill patients: safety and outcome of the necessary "road trip".

    abstract:OBJECTIVE:Intrahospital transport of critically ill patients is often necessary for optimal patient care. However, transport of intensive care unit (ICU) patients within the hospital has been associated with a high rate of potentially detrimental complications. This study was designed to determine the occurrence rate o...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199510000-00009

    authors: Szem JW,Hydo LJ,Fischer E,Kapur S,Klemperer J,Barie PS

    更新日期:1995-10-01 00:00:00

  • Increased morbidity with increased pulmonary albumin flux in sepsis-related adult respiratory distress syndrome.

    abstract:OBJECTIVE:To determine the feasibility of utilizing a scintigraphic technique to differentiate patients with adult respiratory distress syndrome due to sepsis syndrome from control volunteers and patients with congestive heart failure. Gamma scintigraphy was compared with chest roentgenograms to predict mortality rate ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-199201000-00012

    authors: Byrne K,Tatum JL,Henry DA,Hirsch JI,Crossland M,Barnes T,Thompson JA,Young J,Sugerman HJ

    更新日期:1992-01-01 00:00:00

  • Effect of a Perioperative Intra-Aortic Balloon Pump in High-Risk Cardiac Surgery Patients: A Randomized Clinical Trial.

    abstract:OBJECTIVES:The aim of this study was to evaluate the efficacy of perioperative intra-aortic balloon pump use in high-risk cardiac surgery patients. DESIGN:A single-center randomized controlled trial and a meta-analysis of randomized controlled trials. SETTING:Heart Institute of São Paulo University. PATIENTS:High-ri...

    journal_title:Critical care medicine

    pub_type: 杂志文章,随机对照试验

    doi:10.1097/CCM.0000000000003185

    authors: Rocha Ferreira GS,de Almeida JP,Landoni G,Vincent JL,Fominskiy E,Gomes Galas FRB,Gaiotto FA,Dallan LO,Franco RA,Lisboa LA,Palma Dallan LR,Fukushima JT,Rizk SI,Park CL,Strabelli TM,Gelas Lage SH,Camara L,Zeferino S,Jar

    更新日期:2018-08-01 00:00:00

  • Intra-aortic balloon pump effects on macrocirculation and microcirculation in cardiogenic shock patients supported by venoarterial extracorporeal membrane oxygenation*.

    abstract:OBJECTIVES:This study was designed to assess the effects on macrocirculation and microcirculation of adding an intra-aortic balloon pump to peripheral venoarterial extracorporeal membrane oxygenation in patients with severe cardiogenic shock and little/no residual left ventricular ejection. DESIGN:A prospective, singl...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000000410

    authors: Petroni T,Harrois A,Amour J,Lebreton G,Brechot N,Tanaka S,Luyt CE,Trouillet JL,Chastre J,Leprince P,Duranteau J,Combes A

    更新日期:2014-09-01 00:00:00

  • Long-Term Mental Health Problems After Delirium in the ICU.

    abstract:OBJECTIVES:To determine whether delirium during ICU stay is associated with long-term mental health problems defined as symptoms of anxiety, depression, and posttraumatic stress disorder. DESIGN:Prospective cohort study. SETTING:Survey study, 1 year after discharge from a medical-surgical ICU in the Netherlands. PAT...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000001861

    authors: Wolters AE,Peelen LM,Welling MC,Kok L,de Lange DW,Cremer OL,van Dijk D,Slooter AJ,Veldhuijzen DS

    更新日期:2016-10-01 00:00:00

  • Opportunities to Improve Antibiotic Appropriateness in U.S. ICUs: A Multicenter Evaluation.

    abstract:OBJECTIVES:To use a standardized tool for a multicenter assessment of antibiotic appropriateness in ICUs and identify local antibiotic stewardship improvement opportunities. DESIGN:Pilot point prevalence conducted on October 5, 2016; point prevalence survey conducted on March 1, 2017. SETTING:ICUs in 12 U.S. acute ca...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000004344

    authors: Trivedi KK,Bartash R,Letourneau AR,Abbo L,Fleisher J,Gagliardo C,Kelley S,Nori P,Rieg GK,Silver P,Srinivasan A,Vargas J,Ostrowsky B,Partnership for Quality Care (PQC) Inpatient Antimicrobial Stewardship Working Group.

    更新日期:2020-07-01 00:00:00

  • Collapse of the Microbiome, Emergence of the Pathobiome, and the Immunopathology of Sepsis.

    abstract::The definition of sepsis has been recently modified to accommodate emerging knowledge in the field, while at the same time being recognized as challenging, if not impossible, to define. Here, we seek to clarify the current understanding of sepsis as one that has been typically framed as a disorder of inflammation to o...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000002172

    authors: Alverdy JC,Krezalek MA

    更新日期:2017-02-01 00:00:00

  • Therapeutic potential of intraluminal oxygenation.

    abstract:OBJECTIVE:To discuss the potential therapeutic value of intraluminal oxygenation of the gut in critical illness. DATA SOURCES:Relevant articles published in the English language literature. STUDY SELECTION:No special study has been carried out for the present presentation. DATA EXTRACTION:Information from the litera...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1097/00003246-199302001-00012

    authors: Haglund U

    更新日期:1993-02-01 00:00:00

  • Oliguria, volume overload, and loop diuretics.

    abstract::Acute kidney injury (AKI) is commonly and increasingly encountered in patients with critical illness. In the past, epidemiologic studies have consistently found that oliguria further increases the risk of death from AKI. Compared with patients outside the intensive care unit (ICU), critically ill patients are more lik...

    journal_title:Critical care medicine

    pub_type: 杂志文章,评审

    doi:10.1097/CCM.0b013e318168c92f

    authors: Bagshaw SM,Bellomo R,Kellum JA

    更新日期:2008-04-01 00:00:00

  • Effect of increased radiant warmer power output on state of hydration in the critically ill neonate.

    abstract::To correlate radiant warmer bed power output with state of hydration in the critically ill infant, warmer power input was measured by a wattmeter and recorded by an on-line computer every 5 sec for 2 periods of 8-24 h each in 11 newborns with respiratory distress syndrome (mean birth weight 1.42 kg, mean gestational a...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198210000-00012

    authors: Engle WD,Baumgart S,Fox WW,Polin RA

    更新日期:1982-10-01 00:00:00

  • The Very Elderly Admitted to ICU: A Quality Finish?

    abstract:OBJECTIVE:Very elderly persons admitted to ICUs are at high risk of death. To document life-sustaining interventions (mechanical ventilation, vasopressors, renal replacement therapy) provided in the ICU and outcomes of care. DESIGN:Multicenter, prospective cohort study. SETTING:ICUs of 24 Canadian hospitals. PARTICI...

    journal_title:Critical care medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1097/CCM.0000000000001024

    authors: Heyland D,Cook D,Bagshaw SM,Garland A,Stelfox HT,Mehta S,Dodek P,Kutsogiannis J,Burns K,Muscedere J,Turgeon AF,Fowler R,Jiang X,Day AG,Canadian Critical Care Trials Group.,Canadian Researchers at the End of Life Network.

    更新日期:2015-07-01 00:00:00

  • Sodium bicarbonate infusion to reduce cardiac surgery-associated acute kidney injury: a phase II multicenter double-blind randomized controlled trial.

    abstract:OBJECTIVES:Cardiac surgery-associated acute kidney injury occurs in up to 50% of patients and is associated with increased mortality and morbidity. This study aimed to discover if perioperative urinary alkalinization with sodium bicarbonate infusion reduces the prevalence of cardiac surgery-associated acute kidney inju...

    journal_title:Critical care medicine

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1097/CCM.0b013e31828a3f99

    authors: McGuinness SP,Parke RL,Bellomo R,Van Haren FM,Bailey M

    更新日期:2013-07-01 00:00:00

  • Comparison of arterial and venous blood samples for the diagnosis of bacteremia in critically ill patients.

    abstract::We compared the blood culture results obtained either by venipuncture or through an arterial catheter in 51 critically ill patients with 217 clinically suspected episodes of bacteremia. During each episode, three blood culture samples, two arterial and one venous, were drawn within 1 h. One or more cultures were posit...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:

    authors: Väisänen IT,Michelsen T,Valtonen V,Mäkeläinen A

    更新日期:1985-08-01 00:00:00

  • Clinical and economic outcomes of involving pharmacists in the direct care of critically ill patients with infections.

    abstract:OBJECTIVE:To determine whether the absence or presence of clinical pharmacists in intensive care units (ICUs) results in differences in mortality rates, length of ICU stay, and ICU charges for Medicare patients with nosocomial-acquired infections, community-acquired infections, and sepsis. DESIGN, SETTING, AND PATIENT...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0b013e31818f2269

    authors: MacLaren R,Bond CA,Martin SJ,Fike D

    更新日期:2008-12-01 00:00:00

  • Guidelines for critical care medicine training and continuing medical education.

    abstract:OBJECTIVE:Critical care medicine trainees and faculty must acquire and maintain the skills necessary to provide state-of-the art clinical care to critically ill patients, to improve patient outcomes, optimize intensive care unit utilization, and continue to advance the theory and practice of critical care medicine. Thi...

    journal_title:Critical care medicine

    pub_type: 指南,杂志文章,实务指引

    doi:10.1097/01.CCM.0000104916.33769.9A

    authors: Dorman T,Angood PB,Angus DC,Clemmer TP,Cohen NH,Durbin CG Jr,Falk JL,Helfaer MA,Haupt MT,Horst HM,Ivy ME,Ognibene FP,Sladen RN,Grenvik AN,Napolitano LM,American College of Critical Care Medicine.

    更新日期:2004-01-01 00:00:00

  • Development and Validation of an Empiric Tool to Predict Favorable Neurologic Outcomes Among PICU Patients.

    abstract:OBJECTIVES:To create a novel tool to predict favorable neurologic outcomes during ICU stay among children with critical illness. DESIGN:Logistic regression models using adaptive lasso methodology were used to identify independent factors associated with favorable neurologic outcomes. A mixed effects logistic regressio...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000002753

    authors: Gupta P,Rettiganti M,Gossett JM,Daufeldt J,Rice TB,Wetzel RC

    更新日期:2018-01-01 00:00:00

  • Nalbuphine reversal of respiratory depression after epidural sufentanil.

    abstract::The use of epidural opioids for postoperative analgesia has been associated with respiratory depression. This report demonstrates the ability of nalbuphine to rapidly reverse the respiratory depression caused by epidural sufentanil while maintaining postoperative pain relief. ...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/00003246-198904000-00017

    authors: Cheng EY,May J

    更新日期:1989-04-01 00:00:00

  • Emergency preservation and delayed resuscitation allows normal recovery after exsanguination cardiac arrest in rats: a feasibility trial.

    abstract:OBJECTIVE:Emergency preservation and resuscitation (EPR) comprise a novel approach for resuscitation of exsanguination cardiac arrest victims. EPR uses a cold aortic flush to induce deep hypothermic preservation, followed by resuscitation with cardiopulmonary bypass. Development of a rat EPR model would enable study of...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/01.CCM.0000253398.61666.0D

    authors: Drabek T,Stezoski J,Garman RH,Wu X,Tisherman SA,Stezoski SW,Fisk JA,Jenkins L,Kochanek PM

    更新日期:2007-02-01 00:00:00

  • Characteristics and Outcomes of HIV-Infected Patients With Severe Sepsis: Continued Risk in the Post-Highly Active Antiretroviral Therapy Era.

    abstract:OBJECTIVES:Although highly active antiretroviral therapy has led to improved survival in HIV-infected individuals, outcomes for HIV-infected patients with sepsis in the post-highly active antiretroviral therapy era are conflicting. Access to highly active antiretroviral therapy and healthcare disparities continue to af...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/CCM.0000000000001003

    authors: Cribbs SK,Tse C,Andrews J,Shenvi N,Martin GS

    更新日期:2015-08-01 00:00:00

  • Association of low serum 25-hydroxyvitamin D levels and mortality in the critically ill.

    abstract:OBJECTIVE:We hypothesized that deficiency in 25-hydroxyvitamin D before hospital admission would be associated with all-cause mortality in the critically ill. DESIGN:Multicenter observational study of patients treated in medical and surgical intensive care units. SETTING:A total of 209 medical and surgical intensive ...

    journal_title:Critical care medicine

    pub_type: 杂志文章,多中心研究

    doi:10.1097/CCM.0b013e318206ccdf

    authors: Braun A,Chang D,Mahadevappa K,Gibbons FK,Liu Y,Giovannucci E,Christopher KB

    更新日期:2011-04-01 00:00:00

  • Proactive palliative care in the medical intensive care unit: effects on length of stay for selected high-risk patients.

    abstract:OBJECTIVE:The purpose of this study was to examine the effect of proactive palliative care consultation on length of stay for high-risk patients in the medical intensive care unit (MICU). DESIGN:A prospective pre/post nonequivalent control group design was used for this performance improvement study. SETTING:Seventee...

    journal_title:Critical care medicine

    pub_type: 杂志文章

    doi:10.1097/01.CCM.0000266533.06543.0C

    authors: Norton SA,Hogan LA,Holloway RG,Temkin-Greener H,Buckley MJ,Quill TE

    更新日期:2007-06-01 00:00:00