[Sensitivity and specificity of the BCG scar reading].

Abstract:

OBJECTIVE:To validate the BCG scar as a marker of BCG vaccination status. METHODS:A cross-sectional survey was carried out among 53,348 schoolchildren aged 6-14 years who underwent BCG scar examination as part of a large BCG vaccine trial taking place in the city of Manaus, Brazil. Results of BCG scar reading were compared with information on vaccine status of their vaccination cards or provided by parents or guardians. Double-reading was performed in a sub-sample. Data analysis was conducted using Stata 7 and Kappa coefficient. RESULTS:Of 52,348 schoolchildren studied, vaccine status information from parents/guardian letters was available for 29,254 and from vaccination cards for 4,947. There was found a high agreement between the double-readings of the scars (Kappa=0.81). When the agreement between letter and card information was the gold standard, the sensitivity of BCG scar readings was 96.6% (95%CI 96.0-97.1) and the specificity was 71.1% (95%CI 55.7-83.7). The sensitivity was 96.1%, 97.3% and 95.3% for children vaccinated up to one month of age, four months and one year, respectively. CONCLUSIONS:Sensitivity and specificity did not show an association with the child's age at the scar reading. BCG scar was a good marker of BCG vaccination status regardless of age - from the first years of life up to 14 years old.

journal_name

Rev Saude Publica

journal_title

Revista de saude publica

authors

Pereira SM,Bierrenbach AL,Dourado I,Barreto ML,Ichihara MY,Hijjar MA,Rodrigues LC

doi

10.1590/s0034-89102003000200015

subject

Has Abstract

pub_date

2003-04-01 00:00:00

pages

254-9

issue

2

eissn

0034-8910

issn

1518-8787

pii

S0034-89102003000200015

journal_volume

37

pub_type

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