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[Reproductive variables and risk of benign breast diseases. A case-control study].

Abstract：

:The purpose of the study was the identification of risk factors for benign breast diseases (BBD); 257 women with BBD diagnosed through pathological anatomy or cytology and a matched control for each were studied. Subjects were selected at The State University of Campinas Hospital and at a private clinic. To enter the study cases had to have a first diagnosis of BBD between October 1979 and August 1984. The following BBD were considered: dysplasia, fibroadenoma, cystic disease, papilloma and ductal ectasia. Reproductive variables were studied as risk factors, including menstrual ovulatory cycles. The date on which the BBD was diagnosed was defined as the index date. For controls, data were considered up to when they had reached the same age as the matched case on the occasion of her diagnosis. Nulliparity was a risk factor for BBD. First birth at or above age 30 was a protective factor. Women who had used contraceptive pills for two or more years had a significantly lower risk than those who had never used them. The number of menstrual ovulatory cycles was not found to be associated with the risk of BBD. The results obtained from the study of Brazilian women confirm some of the conclusions found in the literature, mainly those that associate some reproductive variables with the risk of BBD. A few of these variables are also confirmed as risk factors for breast cancer. :This study identified risk factors for benign breast diseases (BBD) and 257 women with BBD diagnosed through pathological anatomy or cytology and a matched control for each were studied. Subjects were selected at the State University of Campinas Hospital, Brazil, and at a private clinic. To enter the study, cases were first diagnosed with BBD between October 1979-August 1984. The BBDs which were considered were: dysplasia, fibroadenoma, cystic disease, papilloma, and ductal ectasia. Reproductive variables were studied as risk factors and included menstrual ovulatory cycles. The date on which BBD was diagnosed was defined as the index date. For controls, data were considered up to when they had reached the same age as the matched case on the occasion of diagnosis. Nulliparity was a risk factor for BBD. First birth or age above 30 was a protective factor. Women who had used oral contraceptives for 2 or more years had a significantly lower risk than those who had never used them. The number of menstrual ovulatory cycles was not found to be associated with BBD risk. Results obtained from this study Brazilian women confirm some of the conclusions found in the literature, mainly those that associate some reproductive variables with the risk of BBD. A few of these variables are also confirmed as risk factors for breast cancer. (author's modified)

journal_name

Rev Saude Publica

journal_title

Revista de saude publica

authors

Hardy EE,Pinotti JA,Osis MJ,Faúndes A

doi

10.1590/s0034-89101990000500006

subject

Has Abstract

pub_date

1990-10-01 00:00:00

pages

387-93

issue

eissn

0034-8910

issn

1518-8787

journal_volume

pub_type

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[Reproductive variables and risk of benign breast diseases. A case-control study].