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Monoamine oxidase inhibitors in resistant major depression. A double-blind comparison of brofaromine and tranylcypromine in patients resistant to tricyclic antidepressants.

Abstract：

:In a double-blind study the selective monoamine oxidase-A inhibitor brofaromine was compared with the classical MAOI tranylcypromine in 39 patients with major depression resistant to treatment with tricyclic antidepressants. Concerning efficacy no significant differences were found. Ten out of 22 patients responded to brofaromine and 5 out of 17 patients to tranylcypromine. Adverse effects favoured brofaromine. Although orthostatic hypotension occurred in both groups, severe decrease in blood pressure and dizziness occurred significantly more with tranylcypromine. Both MAOIs caused a decrease in stage 4 and REM sleep and an increase in REM latency. In most patients receiving tranylcypromine REM sleep was completely abolished.

journal_name

J Affect Disord

journal_title

Journal of affective disorders

authors

Nolen WA,Haffmans PM,Bouvy PF,Duivenvoorden HJ

doi

10.1016/0165-0327(93)90104-r

subject

Has Abstract

pub_date

1993-07-01 00:00:00

pages

189-97

issue

3

eissn

0165-0327

issn

1573-2517

pii

0165-0327(93)90104-R

journal_volume

28

pub_type

临床试验,杂志文章,随机对照试验

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