In vivo inhibition of neuronal activity in the rat ventromedial prefrontal cortex by midbrain-raphe nuclei: role of 5-HT1A receptors.

abstract：:Chronic treatment with imipramine and reserpine increased fluoride-stimulated activity of adenylate cyclase in homogenates of cerebral cortex and "limbic" forebrain of the rat. Concomitant treatment with lithium counteracted this effect, while lithium alone had no effect on the activity of adenylate cyclase. ...

journal_title：Neuropharmacology

authors： Andersen PH,Klysner R,Geisler A

更新日期：1984-04-01 00:00:00

abstract：:Prenatal exposure to the CB1 receptor agonist (R)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinylmethyl)-pyrrolo[1,2,3-de]-1,4-benzoxazinyl]-(1-naphthalenyl)methanone) mesylate (WIN) at a daily dose of 0.5 mg/kg, and Delta9-tetrahydrocannabinol (Delta9-THC) at a daily dose of 5 mg/kg, reduced dialysate glutamate levels in ...

journal_title：Neuropharmacology

authors： Castaldo P,Magi S,Gaetani S,Cassano T,Ferraro L,Antonelli T,Amoroso S,Cuomo V

更新日期：2007-09-01 00:00:00

abstract：:A new mGluR antagonist, MAP4 (the alpha-methyl derivative of L-AP4), was found to antagonize the synaptic depressant actions of L-AP4 at the lateral perforant path synapse, in rat hippocampal slices. ...

journal_title：Neuropharmacology

authors： Bushell TJ,Jane DE,Tse HW,Watkins JC,Davies CH,Garthwaite J,Collingridge GL

更新日期：1995-02-01 00:00:00

abstract：:Radioligand binding studies were performed in membranes of human cerebellum using [125I][Tyr3]octreotide also known as [125I]204-090, [125I]LTT-SRIF-28 ([Leu8, D-Trp22, 125I-Tyr25]SRIF-28) and [125I]CGP 23996 ([125I]c[Asu-Lys-Asn-Phe-Trp-Lys-Thr-Tyr-Thr-Ser]) to characterize the nature of cerebellar somatostatin recep...

journal_title：Neuropharmacology

authors： Piwko C,Thoss VS,Probst A,Hoyer D

更新日期：1996-06-01 00:00:00

abstract：:Amphetamine (AMPH) acts as a substrate of the dopamine transporter (DAT) and causes a dramatic increase in extracellular dopamine (DA). Upon entering DA neurons, AMPH promotes DA efflux via DAT through a mechanism implicating depletion of DA from vesicular stores, activation of kinase pathways and transporter phosphor...

journal_title：Neuropharmacology

authors： Runegaard AH,Dencker D,Wörtwein G,Gether U

更新日期：2019-12-15 00:00:00

abstract：:Excitatory neurotransmission mediated by N-methyl-d-aspartate receptors (NMDARs) is fundamental to learning and memory and, when impaired, causes certain neurological disorders. NMDARs are heterotetrameric complexes composed of two GluN1 [NR1] and two GluN2(A-D) [NR2(A-D)] subunits. The GluN2 subunit is responsible fo...

journal_title：Neuropharmacology

authors： Punnakkal P,Jendritza P,Köhr G

更新日期：2012-04-01 00:00:00

abstract：:Methylphenidate (MPD), or Ritalin, is a psychostimulant that is prescribed for an extended period of time to children and adolescents with attention deficit hyperactivity disorder. Adolescence is a time of critical brain maturation and development, and the drug exposure during this time could lead to lasting changes i...

journal_title：Neuropharmacology

authors： Lee MJ,Yang PB,Wilcox VT,Burau KD,Swann AC,Dafny N

更新日期：2009-09-01 00:00:00

abstract：:Many studies in preclinical animal models have described fear-reducing effects of the neuropeptide oxytocin in the central nucleus of the amygdala. However, recent studies have refined the role of oxytocin in the central amygdala, which may extend to the selection of an active defensive coping style in the face of imm...

journal_title：Neuropharmacology

authors： van den Burg EH,Hegoburu C

更新日期：2020-08-15 00:00:00

abstract：:The present study used pharmacological and gene ablation techniques to examine the involvement of kappa opioid receptors (KOPr) in modulating the convulsant effects of two mechanistically different drugs: cocaine and pentylenetetrazol (PTZ; GABA-A receptor antagonist) in mice. Systemic administration of the selective ...

journal_title：Neuropharmacology

authors： Kaminski RM,Witkin JM,Shippenberg TS

更新日期：2007-03-01 00:00:00

abstract：:Intracerebroventricular administration of neurotensin (NT) suppresses locomotor activity. However, the brain regions that mediate the locomotor depressant effect of NT and receptor subtype-specific mechanisms involved are unclear. Using a brain-penetrating, selective NT receptor type 1 (NTS1) agonist PD149163, we inve...

journal_title：Neuropharmacology

authors： Vadnie CA,Hinton DJ,Choi S,Choi Y,Ruby CL,Oliveros A,Prieto ML,Park JH,Choi DS

更新日期：2014-10-01 00:00:00

abstract：:The involvement of metabotropic glutamate receptor group II (mGluRII) in the induction of long-term depression (LTD) was investigated in the medial perforant path of the rat dentate gyrus, a region with a very high density of mGluRII. Perfusion of either of two potent mGluRII agonists, (2S,1R,2R,3R)-2-(2S, 1'R, 2'R, 3...

journal_title：Neuropharmacology

authors： Huang L,Killbride J,Rowan MJ,Anwyl R

更新日期：1999-01-01 00:00:00

abstract：:The effects of a variety of 5-hydroxytryptamine (5-HT) receptor agonists and antagonists on behaviour in 5- and 20-day old rat pups have been investigated. Increased locomotion and head-weaving responses were induced in both age groups by 8-OH-DPAT (8-hydroxy-2-(di-n-propylamino)tetralin; 5-HT1A agonist); 5-MeODMT (5-...

journal_title：Neuropharmacology

authors： Jackson HC,Kitchen I

更新日期：1989-06-01 00:00:00

abstract：:Glioblastoma (GBM), the most aggressive brain tumor, has a poor prognosis due to the ease of migration to surrounding healthy brain tissue. Recent studies have shown that bradykinin receptors are involved in the progression of various cancers. However, the molecular mechanism and pathological role of bradykinin recept...

journal_title：Neuropharmacology

authors： Liu YS,Hsu JW,Lin HY,Lai SW,Huang BR,Tsai CF,Lu DY

更新日期：2019-01-01 00:00:00

abstract：:Trace Amine-Associated Receptor 1 (TAAR1) is a G protein-coupled receptor (GPCR) expressed in several mammalian brain areas and activated by "trace amines" (TAs). TAs role is unknown; however, discovery of their receptors provided an opportunity to investigate their functions. In vivo evidence has indicated an inhibit...

journal_title：Neuropharmacology

authors： Leo D,Mus L,Espinoza S,Hoener MC,Sotnikova TD,Gainetdinov RR

更新日期：2014-06-01 00:00:00

abstract：:Nicotine stimulates the secretion of catecholamines from sympathetic nerve endings and adrenal medulla by acting on peripheral nicotinic cholinergic receptors. Nicotine is also a potent stimulant in the central nervous system but the significance of nicotinic receptors in brain in mediating cardiovascular and sympatho...

journal_title：Neuropharmacology

authors： Kiritsy-Roy JA,Mousa SA,Appel NM,Van Loon GR

更新日期：1990-06-01 00:00:00

abstract：:Most current pharmacologic antidepressant treatments target monoaminergic systems confronts some problems such as low rate of remission and high risk for relapse indicating new therapeutic strategy is urgently need. Evidences showed that impairments in mitochondrial function were associated with the pathogenesis of mo...

journal_title：Neuropharmacology

authors： Yang N,Ren Z,Zheng J,Feng L,Li D,Gao K,Zhang L,Liu Y,Zuo P

更新日期：2016-06-01 00:00:00

abstract：:Receptor-mediated signal transduction is thought to play an important role in neuronal differentiation and the modification of synaptic connections during brain development. The intracellular signalling molecule phospholipase C-beta1 (PLC-beta1), which is activated via specific neurotransmitter receptors, has recently...

journal_title：Neuropharmacology

authors： Hannan AJ,Kind PC,Blakemore C

更新日期：1998-04-01 00:00:00

abstract：:Granule cell axon terminals of rat cerebellum possess benzodiazepine-insensitive GABA(A) receptors mediating glutamate release. We have investigated the ability of benzodiazepines, ethanol and furosemide to modulate the function of these receptors in the cerebellum of alcohol-tolerant (AT) and alcohol-nontolerant (ANT...

journal_title：Neuropharmacology

authors： Schmid G,Bonanno G,Raiteri L,Sarviharju M,Korpi ER,Raiteri M

更新日期：1999-09-01 00:00:00

abstract：:Using the isoquinoline carboxamide derivative, PK 11195 as selective ligand, the binding properties of peripheral benzodiazepine binding sites were compared on platelets of alcoholics and non-alcoholic, healthy controls. When compared to controls, alcoholics during prolonged ethanol consumption show a significant redu...

journal_title：Neuropharmacology

authors： Suranyi-Cadotte B,Lafaille F,Dongier M,Dumas M,Quirion R

更新日期：1988-04-01 00:00:00

abstract：:The aim of the present study was to determine the influence of thyroid hormone, T3, on the regulation of hippocampal BDNF expression by 5-HT receptor agonists. Chronic T3 administration prior to treatment with the 5-HT(1A) agonist, 8-OH-DPAT, significantly decreased BDNF mRNA in the dentate gyrus region of the hippoca...

journal_title：Neuropharmacology

authors： Vaidya VA,Castro ME,Pei Q,Sprakes ME,Grahame-Smith DG

更新日期：2001-01-01 00:00:00

abstract：:Behavioral and electrophysiological comparative analyses of the effects of 2-o-chlorobenzoyl-4-chloro-N-methyl-N alpha-glycylglycinanilide hydrate (45-0088-S) and diazepam on the CNS were performed with cats and monkeys. No essential difference between 45-0088-S and diazepam on the effects in the CNS was observed, alt...

journal_title：Neuropharmacology

authors： Yamamoto K,Sawada T,Utsumi S,Naito Y,Koshida H

更新日期：1982-05-01 00:00:00

abstract：:The techniques of co-immunoprecipitation and immunocytochemical co-labelling are classically used to identify protein-protein interactions. We have used an antibody to the rat small conductance calcium-activated potassium channel subtype 1 (rSK1) to immunoprecipitate proteins from rat brain. A 35 kDa protein was recog...

journal_title：Neuropharmacology

authors： Fletcher S,Bowden SE,Marrion NV

更新日期：2003-05-01 00:00:00

abstract：:This study was performed to investigate the effects of exercise on the synthesis of dopamine (DA) and 5-hydroxytryptamine (5-HT) in the brain of the trained rat. The consequences on the relationships between these two systems were also examined. The sum of the levels of free 3,4-dihydroxyphenyl acetic acid (DOPAC) plu...

journal_title：Neuropharmacology

authors： Chaouloff F,Laude D,Merino D,Serrurrier B,Guezennec Y,Elghozi JL

更新日期：1987-08-01 00:00:00

abstract：:Amphetamine has been shown to either potentiate or protect against MPTP neurotoxicity. The time course of changes in dopamine and its metabolites was examined after MPTP, amphetamine, or MPTP plus amphetamine administration. Results suggest that under conditions of granular depletion and release of dopamine by 10 mg/k...

journal_title：Neuropharmacology

authors： Sershen H,Mason MF,Reith ME,Hashim A,Lajtha A

更新日期：1986-08-01 00:00:00

abstract：:The heart rate of the anaesthetized rabbit was slowed by electrical stimulation of the hypothalamus with 7-9 sec trains of 250-330 microA pulses, duration 1 msec, frequency 60 Hz. This vagally-mediated cardio-decelerator response was attenuated in a dose-dependent manner after intravenous administration of phenoxybenz...

journal_title：Neuropharmacology

authors： Evans MH,Sutton MR,Williamson NM

更新日期：1983-01-01 00:00:00

abstract：:Antipsychotic drug treatment increases neurotensin (NT) neurotransmission, and the exogenous administration of NT produces antipsychotic-like effects in rodents. In order to investigate whether "endogenous" NT may act as a natural occurring antipsychotic or may mediate antipsychotic drug activity, the effects of the s...

journal_title：Neuropharmacology

authors： Casti P,Marchese G,Casu G,Ruiu S,Pani L

更新日期：2004-07-01 00:00:00

abstract：:The in vivo striatal binding of [3H]SCH 23390, an antagonist of the D1 dopamine receptors, was investigated in mice submitted to pretreatment to either decrease (gammabutyrolactone 750 mg/kg, i.p.) or, increase (3,4-dihydroxyphenylalanine (L-DOPA) 200 mg/kg i.p. plus dexamphetamine 4 mg/kg, s.c.) dopaminergic transmis...

journal_title：Neuropharmacology

authors： Thibaut F,Vaugeois JM,Bonnet JJ,Costentin J

更新日期：1996-03-01 00:00:00

abstract：:The roles of recognition sites for central neurotransmitters in the mediation of the behavioural effects of the putative 5-hydroxytryptamine (5-HT1) receptor agonist, RU 24969 [5-methoxy-3(1,2,3,6-tetrahydropyridin-4-yl)1H indole] in the rat have been examined. The drug RU 24969 was found to have high affinity for 5-H...

journal_title：Neuropharmacology

authors： Tricklebank MD,Middlemiss DN,Neill J

更新日期：1986-08-01 00:00:00

abstract：:The role of neurally born acetylcholine in the central modulation of cardiovascular short-term variability was assessed using a pharmacological probe physostigmine, a cholinesterase inhibitor that can act centrally also. Experiments were performed in instrumented conscious rats. Equidistant sampling at 20 Hz of systol...

journal_title：Neuropharmacology

authors： Milutinović S,Murphy D,Japundzić-Zigon N

更新日期：2006-06-01 00:00:00

abstract：:Neurogenesis requires the balance between the proliferation of newly formed progenitor cells and subsequent death of surplus cells. RT-PCR and immunocytochemistry demonstrated the presence of P2X7 receptor mRNA and immunoreactivity in cultured neural progenitor cells (NPCs) prepared from the adult mouse subventricular...

journal_title：Neuropharmacology

authors： Messemer N,Kunert C,Grohmann M,Sobottka H,Nieber K,Zimmermann H,Franke H,Nörenberg W,Straub I,Schaefer M,Riedel T,Illes P,Rubini P

更新日期：2013-10-01 00:00:00