Distinct roles of cellular Lck and p80 proteins in herpesvirus saimiri Tip function on lipid rafts.

abstract：:Borna disease virus infection of neonatal rats results in a characteristic behavioral syndrome and apoptosis of subsets of neurons in the hippocampus and cerebellum (neonatal Borna disease [NBD]). The cellular mechanisms leading to neurodevelopmental damage in NBD have not been fully elucidated. Insights into this mod...

journal_title：Journal of virology

authors： Williams BL,Lipkin WI

更新日期：2006-09-01 00:00:00

abstract：UNLABELLED:Baculovirus DNAs are synthesized and inserted into preformed capsids to form nucleocapsids at a site in the infected cell nucleus, termed the virogenic stroma. Nucleocapsid assembly ofAutographa californicamultiple nucleopolyhedrovirus (AcMNPV) requires the major capsid protein VP39 and nine minor capsid pro...

journal_title：Journal of virology

authors： Guan Z,Zhong L,Li C,Wu W,Yuan M,Yang K

更新日期：2016-03-28 00:00:00

abstract：:As an approach to identifying hepatocyte receptors for the avian hepadnavirus duck hepatitis B virus (DHBV), hybridomas were prepared from mice immunized with permissive duck hepatocytes. Monoclonal antibodies (MAbs) were screened for the ability to inhibit binding of DHBV particles to primary duck hepatocytes and to ...

journal_title：Journal of virology

authors： Guo JT,Pugh JC

更新日期：1997-06-01 00:00:00

abstract：:The origin and role of the endonuclease activity associated with purified virions of simian virus 40, previously described by this and other laboratories, have been further investigated. We found that the enzymatic activity from virions of temperature-sensitive (ts) mutants is not more heat labile than that from wild-...

journal_title：Journal of virology

authors： Dooley DC,Ryzlak MT,Ozer HL

更新日期：1976-02-01 00:00:00

abstract：:The contributions of the glycoproteins gI (ORF67) and gE (ORF68) to varicella-zoster virus (VZV) replication were investigated in deletion mutants made by using cosmids with VZV DNA derived from the Oka strain. Deletion of both gI and gE prevented virus replication. Complete deletion of gI or deletions of 60% of the N...

journal_title：Journal of virology

authors： Mallory S,Sommer M,Arvin AM

更新日期：1997-11-01 00:00:00

abstract：:During ϕX174 morphogenesis, 240 copies of the external scaffolding protein D organize 12 pentameric assembly intermediates into procapsids, a reaction reconstituted in vitro In previous studies, ϕX174 strains resistant to exogenously expressed dominant lethal D genes were experimentally evolved. Resistance was achieve...

journal_title：Journal of virology

authors： Cherwa JE Jr.,,Tyson J,Bedwell GJ,Brooke D,Edwards AG,Dokland T,Prevelige PE,Fane BA

更新日期：2016-12-16 00:00:00

abstract：:To localize the epitopes recognized by monoclonal antibodies (MAbs) specific for the S1 subunit of the murine coronavirus JHMV spike protein, we have expressed S1 proteins with different deletions from the C terminus of S1. S1utt is composed of the entire 769-amino-acid (aa) S1 protein; S1NM, S1N, S1n(330), and S1n(22...

journal_title：Journal of virology

authors： Kubo H,Yamada YK,Taguchi F

更新日期：1994-09-01 00:00:00

abstract：:Understanding the mechanism(s) of action of the hepatitis B virus (HBV)-encoded protein HBx is fundamental to elucidating the underlying mechanisms of chronic liver disease and hepatocellular carcinoma caused by HBV infection. In our continued attempts to identify cellular targets of HBx, we have previously reported t...

journal_title：Journal of virology

authors： Rahmani Z,Huh KW,Lasher R,Siddiqui A

更新日期：2000-03-01 00:00:00

abstract：:We previously demonstrated that human cytomegalovirus (HCMV) infection induced the activation of the cellular transcription factor NF-kappaB. Here, we investigate the mechanism for the HCMV-induced NF-kappaB activation and the role that the induced NF-kappaB plays in transactivation of the major immediate-early promot...

journal_title：Journal of virology

authors： DeMeritt IB,Milford LE,Yurochko AD

更新日期：2004-05-01 00:00:00

abstract：:Upon infection of Japanese encephalitis virus (JEV), baby hamster kidney (BHK-21) and Chinese hamster ovary (CHO) cells were killed by a mechanism involved in apoptosis. While readily established in a variety of cell lines, JEV persistence has never been successfully instituted in BHK-21 and CHO cells. Since stable ex...

journal_title：Journal of virology

authors： Liao CL,Lin YL,Shen SC,Shen JY,Su HL,Huang YL,Ma SH,Sun YC,Chen KP,Chen LK

更新日期：1998-12-01 00:00:00

abstract：:The Vpr protein, encoded by the human immunodeficiency virus type 1 (HIV-1) genome, is one of the nonstructural proteins packaged in large amounts into viral particles. We have previously reported that Vpr associates with the DNA repair enzyme uracil DNA glycosylase (UDG). In this study, we extended these observations...

journal_title：Journal of virology

authors： Willetts KE,Rey F,Agostini I,Navarro JM,Baudat Y,Vigne R,Sire J

更新日期：1999-02-01 00:00:00

abstract：:The global diversity of human immunodeficiency virus type 1 (HIV-1) genotypes, termed subtypes A to J, is considerable and growing. However, relatively few studies have provided evidence for an associated phenotypic divergence. Recently, we demonstrated subtype-specific functional differences within the long terminal ...

journal_title：Journal of virology

authors： Montano MA,Nixon CP,Essex M

更新日期：1998-10-01 00:00:00

abstract：:Since 2005, a large poliomyelitis outbreak associated with type 2 circulating vaccine-derived poliovirus (cVDPV2) has occurred in northern Nigeria, where immunization coverage with trivalent oral poliovirus vaccine (tOPV) has been low. Phylogenetic analysis of P1/capsid region sequences of isolates from each of the 40...

journal_title：Journal of virology

authors： Burns CC,Shaw J,Jorba J,Bukbuk D,Adu F,Gumede N,Pate MA,Abanida EA,Gasasira A,Iber J,Chen Q,Vincent A,Chenoweth P,Henderson E,Wannemuehler K,Naeem A,Umami RN,Nishimura Y,Shimizu H,Baba M,Adeniji A,Williams AJ,

更新日期：2013-05-01 00:00:00

abstract：:We report the use of a HeLa whole cell extract (WCE) runoff transcription system for the study of cis- and trans-acting elements, participating in the regulation of transcription initiation from the P38 promoter of the parvovirus minute virus of mice (MVM). Our initial studies with HeLa WCE indicated that transcriptio...

journal_title：Journal of virology

authors： Krauskopf A,Resnekov O,Aloni Y

更新日期：1990-01-01 00:00:00

abstract：:Infection of newborn Lewis rats with Borna disease virus (neonatal Borna disease [NBD]) results in cerebellar damage without the cellular inflammation associated with infections in later life. Purkinje cell (PC) damage has been reported for several models of early-life viral infection, including NBD; however, the time...

journal_title：Journal of virology

authors： Williams BL,Yaddanapudi K,Hornig M,Lipkin WI

更新日期：2007-03-01 00:00:00

abstract：:The DNA region encoding the complete herpes simplex virus type 1 (HSV-1) glycoprotein K (gK) was inserted into a baculovirus transfer vector, and recombinant viruses expressing gK were isolated. Four gK-related recombinant baculovirus-expressed peptides of 29, 35, 38, and 40 kDa were detected with polyclonal antibody ...

journal_title：Journal of virology

authors： Ghiasi H,Slanina S,Nesburn AB,Wechsler SL

更新日期：1994-04-01 00:00:00

abstract：:The E5 oncoprotein of bovine papillomavirus type 1 is a 44-amino-acid, hydrophobic polypeptide which localizes predominantly in Golgi membranes and appears to transform cells through the activation of tyrosine kinase growth factor receptors. In fibroblasts, E5 interacts with both the 16-kilodalton vacuolar ATPase subu...

journal_title：Journal of virology

authors： Sparkowski J,Mense M,Anders J,Schlegel R

更新日期：1996-04-01 00:00:00

abstract：:We established a novel experimental model for human T-cell leukemia virus type 1 (HTLV-1)-induced tumor using NOD-SCID/gammac(null) (NOG) mice. This model is very useful for investigating the mechanism of tumorigenesis and malignant cell growth of adult T-cell leukemia (ATL)/lymphoma, which still remains unclear. Nine...

journal_title：Journal of virology

authors： Dewan MZ,Terashima K,Taruishi M,Hasegawa H,Ito M,Tanaka Y,Mori N,Sata T,Koyanagi Y,Maeda M,Kubuki Y,Okayama A,Fujii M,Yamamoto N

更新日期：2003-05-01 00:00:00

abstract：:To assess the effect of the polyomavirus (Py) early proteins, the large T (LT), middle T (MT), and small T (ST) antigens, on gene expression from the Py late promoter, replication-defective plasmid constructs with the bacterial chloramphenicol acetyltransferase (cat) gene linked to this promoter were cotransfected int...

journal_title：Journal of virology

authors： Kern FG,Pellegrini S,Cowie A,Basilico C

更新日期：1986-10-01 00:00:00

abstract：UNLABELLED:In contrast to many viruses, human cytomegalovirus (HCMV) is unable to productively infect most cancer-derived cell lines. The mechanisms of this restriction are unclear. To explore this issue, we tested whether defined oncogenic alleles, including the simian virus 40 (SV40) T antigen (TAg) and oncogenic H-R...

journal_title：Journal of virology

authors： Xu S,Schafer X,Munger J

更新日期：2016-04-14 00:00:00

abstract：:To facilitate the determination of the genomic location of the vaccinia virus gene(s) encoding alpha-amanitin resistance (alpha r) (Villarreal et al., J. Virol. 51:359-366, 1984), a collection of alpha r, temperature-sensitive (ts) mutants were isolated. The premise of these experiments was that mutants might be found...

journal_title：Journal of virology

authors： Villarreal EC,Hruby DE

更新日期：1986-01-01 00:00:00

abstract：:The gH/gL complex plays an essential role in virus entry and cell-cell spread of herpes simplex virus (HSV). Very few immunologic reagents were previously available to either identify important functional regions or gain information about structural features of this complex. Therefore, we generated and characterized a...

journal_title：Journal of virology

authors： Cairns TM,Shaner MS,Zuo Y,Ponce-de-Leon M,Baribaud I,Eisenberg RJ,Cohen GH,Whitbeck JC

更新日期：2006-03-01 00:00:00

abstract：:We analyzed control sequences of the human papovavirus JC virus (JCV) to define the cis-acting elements that regulate specific expression of the viral early region genes in glial cells. Nuclear run-on transcription, S1 analysis, and chloramphenicol acetyltransferase enzyme activity in a transient transfection assay es...

journal_title：Journal of virology

authors： Tada H,Lashgari M,Rappaport J,Khalili K

更新日期：1989-01-01 00:00:00

abstract：:BCX 2798 (4-azido-5-isobutyrylamino-2,3-didehydro-2,3,4,5-tetradeoxy-d-glycero-d-galacto-2-nonulopyranosic acid) effectively inhibited the activities of the hemagglutinin-neuraminidase (HN) of human parainfluenza viruses (hPIV) in vitro and protected mice from lethal infection with a recombinant Sendai virus whose HN ...

journal_title：Journal of virology

authors： Alymova IV,Taylor G,Mishin VP,Watanabe M,Murti KG,Boyd K,Chand P,Babu YS,Portner A

更新日期：2008-09-01 00:00:00

abstract：:Pseudorabies virus (PRV), a member of the Alphaherpesvirinae, has a complex multilayered extracellular virion that is structurally conserved among other herpesviruses. PRV virions contain a double-stranded DNA genome within a proteinaceous capsid surrounded by the tegument, a layer of viral and cellular proteins. The ...

journal_title：Journal of virology

authors： Kramer T,Greco TM,Enquist LW,Cristea IM

更新日期：2011-07-01 00:00:00

abstract：:Herpes simplex virus 1 (HSV-1) establishes lifelong latent infections in neurons. Reactivation from latency can lead to serious recurrent disease, including stromal keratitis, corneal scarring, blindness, and encephalitis. Although numerous studies link stress to an increase in the incidence of reactivation from laten...

journal_title：Journal of virology

authors： Harrison KS,Zhu L,Thunuguntla P,Jones C

更新日期：2019-06-14 00:00:00

abstract：:Thirty-six monoclonal antibodies from mice and three from rats were raised against a peptide corresponding to the immunodominant domain of the transmembrane gp41 protein of human immunodeficiency virus (HIV) type 1 (LGLWGCSGKLIC; amino acid residues 598 to 609). Of these, three monoclonal antibodies from the mice and ...

journal_title：Journal of virology

authors： Oldstone MB,Tishon A,Lewicki H,Dyson HJ,Feher VA,Assa-Munt N,Wright PE

更新日期：1991-04-01 00:00:00

abstract：:Embryonic stem cells are subjected to a dynamic genome regulation during development. Here we report that the ectopic lentiviral transgenes are quickly silenced in murine embryonic carcinoma P19 cells. The silencing was correlated with CpG hypermethylation in the transgene promoter. Using high-resolution sodium bisulf...

journal_title：Journal of virology

authors： He J,Yang Q,Chang LJ

更新日期：2005-11-01 00:00:00

abstract：:Reoviruses are a leading model for understanding cellular mechanisms of virus-induced apoptosis. Reoviruses induce apoptosis in multiple cell lines in vitro, and apoptosis plays a key role in virus-induced tissue injury of the heart and brain in vivo. The activation of transcription factors NF-kappaB and c-Jun are key...

journal_title：Journal of virology

authors： DeBiasi RL,Clarke P,Meintzer S,Jotte R,Kleinschmidt-Demasters BK,Johnson GL,Tyler KL

更新日期：2003-08-01 00:00:00

abstract：:Recombinant Epstein-Barr viruses (EBV) with a translation termination codon mutation inserted into the nuclear protein 3A (EBNA-3A) or 3C (EBNA-3C) open reading frame were generated by second-site homologous recombination. These mutant viruses were used to infect primary B lymphocytes to assess the requirement of EBNA...

journal_title：Journal of virology

authors： Tomkinson B,Robertson E,Kieff E

更新日期：1993-04-01 00:00:00