A new function for a phosphotyrosine phosphatase: linking GRB2-Sos to a receptor tyrosine kinase.

abstract：:Moloney murine sarcoma virus carries an oncogenic sequence (v-mos) which is homologous to a single copy gene (c-mos) present in the normal cells of several vertebrate species. Because of the possible significance of c-mos sequences in normal development and malignant transformation induced by physical or chemical agen...

journal_title：Molecular and cellular biology

authors： Gattoni S,Kirschmeier P,Weinstein IB,Escobedo J,Dina D

更新日期：1982-01-01 00:00:00

abstract：:COUP-TF, an orphan member of the nuclear receptor superfamily, has been proposed to play a key role in regulating organogenesis, neurogenesis, and cellular differentiation during embryonic development. Since heterodimierization is a common theme within the nuclear receptor superfamily and has been demonstrated to modu...

journal_title：Molecular and cellular biology

authors： Leng X,Cooney AJ,Tsai SY,Tsai MJ

更新日期：1996-05-01 00:00:00

abstract：:Physiological cell deaths occur ubiquitously throughout biology and have common attributes, including apoptotic morphology with mitosis-like chromatin condensation and prelytic genome digestion. The fundamental question is whether a common mechanism of dying underlies these common hallmarks of death. Here we describe ...

journal_title：Molecular and cellular biology

authors： Harvey KJ,Blomquist JF,Ucker DS

更新日期：1998-05-01 00:00:00

abstract：:Growth factors and cyclic AMP (cAMP) are known to activate distinct intracellular signaling pathways. Fibroblast growth factor (FGF) activates ras-dependent kinase cascades, resulting in the activation of MAP kinases, whereas cAMP activates protein kinase A. In this study, we report that growth factors and cAMP act sy...

journal_title：Molecular and cellular biology

authors： Tan Y,Low KG,Boccia C,Grossman J,Comb MJ

更新日期：1994-11-01 00:00:00

abstract：:The J domain of simian virus 40 (SV40) large T antigen is required for efficient DNA replication and transformation. Despite previous reports demonstrating the promiscuity of J domains in heterologous systems, results presented here show the requirement for specific J-domain sequences in SV40 large-T-antigen-mediated ...

journal_title：Molecular and cellular biology

authors： Sullivan CS,Tremblay JD,Fewell SW,Lewis JA,Brodsky JL,Pipas JM

更新日期：2000-08-01 00:00:00

abstract：:The regulation of telomerase reverse transcriptase (TERT) plays an important role in the proliferative capacity and survival of cells. Here, we report that exogenously as well as endogenously induced oxidative stress leads to translocation of endogenous as well as overexpressed human TERT from the nucleus into the cyt...

journal_title：Molecular and cellular biology

authors： Haendeler J,Hoffmann J,Brandes RP,Zeiher AM,Dimmeler S

更新日期：2003-07-01 00:00:00

abstract：:We previously identified an RNA binding protein, CUGBP1, which binds to GCN repeats located within the 5' region of C/EBPbeta mRNAs and regulates translation of C/EBPbeta isoforms. To further investigate the role of RNA binding proteins in the posttranscriptional control of C/EBP proteins, we purified additional RNA b...

journal_title：Molecular and cellular biology

authors： Timchenko LT,Iakova P,Welm AL,Cai ZJ,Timchenko NA

更新日期：2002-10-01 00:00:00

abstract：:Signal transduction by antigen receptors and some Fc receptors requires the activation of a family of receptor-associated transmembrane accessory proteins. One common feature of the cytoplasmic domains of these accessory molecules is the presence is at least two YXXA repeats that are potential sites for interaction wi...

journal_title：Molecular and cellular biology

authors： Burkhardt AL,Costa T,Misulovin Z,Stealy B,Bolen JB,Nussenzweig MC

更新日期：1994-02-01 00:00:00

abstract：:Irradiation of simian virus 40 (SV40)-infected cells with low fluences of UV light (20 to 60 J/m2, inducing one to three pyrimidine dimers per SV40 genome) causes a dramatic inhibition of viral DNA replication. However, treatment of cells with UV radiation (20 J/m2) before infection with SV40 virus enhances the replic...

journal_title：Molecular and cellular biology

authors： Treger JM,Hauser J,Dixon K

更新日期：1988-06-01 00:00:00

abstract：:The carboxyl-terminal domain (CTD) of RNA polymerase II (Pol II) can be phosphorylated at serine 2 (Ser-2) and serine 5 (Ser-5) of the CTD heptad repeat YSPTSPS, and this phosphorylation is important in coupling transcription to RNA processing, including 5' capping, splicing, and polyadenylation. The mammalian endogen...

journal_title：Molecular and cellular biology

authors： Cheng C,Sharp PA

更新日期：2003-03-01 00:00:00

abstract：:Budding yeast polo kinase Cdc5p localizes to the spindle pole body (SPB) and to the bud-neck and plays multiple roles during M-phase progression. To dissect localization-specific mitotic functions of Cdc5p, we tethered a localization-defective N-terminal kinase domain of Cdc5p (Cdc5pDeltaC) to the SPB or to the bud-ne...

journal_title：Molecular and cellular biology

authors： Park JE,Park CJ,Sakchaisri K,Karpova T,Asano S,McNally J,Sunwoo Y,Leem SH,Lee KS

更新日期：2004-11-01 00:00:00

abstract：:The retrotransposon LINE-1 (L1) is a significant source of endogenous mutagenesis in humans. In each individual genome, a few retrotransposition-competent L1s (RC-L1s) can generate new heritable L1 insertions in the early embryo, primordial germ line, and germ cells. L1 retrotransposition can also occur in the neurona...

journal_title：Molecular and cellular biology

authors： Salvador-Palomeque C,Sanchez-Luque FJ,Fortuna PRJ,Ewing AD,Wolvetang EJ,Richardson SR,Faulkner GJ

更新日期：2019-03-19 00:00:00

abstract：:Mitogen activation of mRNA decay pathways likely involves specific endoribonucleases, such as G3BP, a phosphorylation-dependent endoribonuclease that associates with RasGAP in dividing but not quiescent cells. G3BP exclusively cleaves between cytosine and adenine (CA) after a specific interaction with RNA through the ...

journal_title：Molecular and cellular biology

authors： Tourrière H,Gallouzi IE,Chebli K,Capony JP,Mouaikel J,van der Geer P,Tazi J

更新日期：2001-11-01 00:00:00

abstract：:The human ERCC3 gene, which corrects specifically the nucleotide excision repair defect in human xeroderma pigmentosum group B and cross-complements the repair deficiency in rodent UV-sensitive mutants of group 3, encodes a presumed DNA helicase that is identical to the p89 subunit of the general transcription factor ...

journal_title：Molecular and cellular biology

authors： Ma L,Westbroek A,Jochemsen AG,Weeda G,Bosch A,Bootsma D,Hoeijmakers JH,van der Eb AJ

更新日期：1994-06-01 00:00:00

abstract：:Protein kinase GCN2 is a multidomain protein that contains a region homologous to histidyl-tRNA synthetases juxtaposed to the kinase catalytic moiety. Previous studies have shown that in response to histidine starvation, GCN2 phosphorylates eukaryotic initiation factor 2 (eIF-2), to induce the translational expression...

journal_title：Molecular and cellular biology

authors： Wek SA,Zhu S,Wek RC

更新日期：1995-08-01 00:00:00

abstract：:Mouse mammary epithelial cells can be transformed in primary cultures to preneoplastic and neoplastic states when treated with N-methyl-N-nitrosourea (MNU). Mammary carcinomas arising from MNU-induced hyperplastic alveolar nodules (a type of mouse mammary preneoplastic lesion) contained transforming c-Ki-ras genes whe...

journal_title：Molecular and cellular biology

authors： Miyamoto S,Sukumar S,Guzman RC,Osborn RC,Nandi S

更新日期：1990-04-01 00:00:00

abstract：:Pancreatic beta-cell-type-specific transcription of the insulin gene is principally regulated by a single cis-acting DNA sequence element, termed the insulin control element (ICE), which is found within the 5'-flanking region of the gene. The ICE activator is a heteromeric complex composed of an islet alpha/beta-cell-...

journal_title：Molecular and cellular biology

authors： Robinson GL,Cordle SR,Henderson E,Weil PA,Teitelman G,Stein R

更新日期：1994-10-01 00:00:00

abstract：:Adiponectin is a secretory protein abundantly secreted from adipocytes. It assembles into a number of different higher-order complexes. Adipocytes maintain tight control over circulating plasma levels, suggesting the existence of a complex, highly regulated biosynthetic pathway. However, the critical mediators of adip...

journal_title：Molecular and cellular biology

authors： Wang ZV,Schraw TD,Kim JY,Khan T,Rajala MW,Follenzi A,Scherer PE

更新日期：2007-05-01 00:00:00

abstract：:In Saccharomyces cerevisiae (budding yeast), commitment to cell division in late G(1) is promoted by the G(1) cyclin Cln3 and its associated cyclin-dependent kinase, Cdc28. We show here that all known aspects of the function of Cln3 in G(1) phase, including control of cell size, pheromone sensitivity, cell cycle progr...

journal_title：Molecular and cellular biology

authors： Wijnen H,Landman A,Futcher B

更新日期：2002-06-01 00:00:00

abstract：:We have used extrachromosomal substrates carrying immunoglobulin heavy-chain S mu and S gamma 3 switch region sequences to study activation and targeting of recombination by a transcriptional enhancer element. Substrates are transiently introduced into activated primary murine B cells, in which recombination involving...

journal_title：Molecular and cellular biology

authors： Leung H,Maizels N

更新日期：1994-02-01 00:00:00

abstract：:We have constructed an ALDH3a1 null mouse to investigate the role of this enzyme that comprises nearly one-half of the total water-soluble protein in the mouse corneal epithelium. ALDH3a1-deficient mice are viable and fertile, have a corneal epithelium with a water-soluble protein content approximately half that of wi...

journal_title：Molecular and cellular biology

authors： Nees DW,Wawrousek EF,Robison WG Jr,Piatigorsky J

更新日期：2002-02-01 00:00:00

abstract：:A series of deletion mutants spanning the promoter of the adenovirus early-region IV (EIV) gene were tested for transcriptional activity, using both in vitro and in vivo assays. Four distinct domains had additive effects on efficient transcription from the EIV promoter in HeLa whole-cell extracts. The first resided 20...

journal_title：Molecular and cellular biology

authors： Hanaka S,Nishigaki T,Sharp PA,Handa H

更新日期：1987-07-01 00:00:00

abstract：:E3 ubiquitin ligases, which target specific molecules for proteolytic destruction, have emerged as key regulators of immune functions. Several E3 ubiquitin ligases, including c-Cbl, Cbl-b, GRAIL, Itch, and Nedd4, have been shown to negatively regulate T-cell activation. Here, we report that the HECT-type E3 ligase AIP...

journal_title：Molecular and cellular biology

authors： Chen A,Gao B,Zhang J,McEwen T,Ye SQ,Zhang D,Fang D

更新日期：2009-10-01 00:00:00

abstract：:PGC-1α is a key transcription coactivator regulating energy metabolism in a tissue-specific manner. PGC-1α expression is tightly regulated, it is a highly labile protein, and it interacts with various proteins--the known attributes of intrinsically disordered proteins (IDPs). In this study, we characterize PGC-1α as a...

journal_title：Molecular and cellular biology

authors： Adamovich Y,Shlomai A,Tsvetkov P,Umansky KB,Reuven N,Estall JL,Spiegelman BM,Shaul Y

更新日期：2013-07-01 00:00:00

abstract：:Circadian clock genes are regulated through a transcriptional-translational feedback loop. Alterations of the chromatin structure by histone acetyltransferases and histone deacetylases (HDACs) are commonly implicated in the regulation of gene transcription. However, little is known about the transcriptional regulation...

journal_title：Molecular and cellular biology

authors： Naruse Y,Oh-hashi K,Iijima N,Naruse M,Yoshioka H,Tanaka M

更新日期：2004-07-01 00:00:00

abstract：:The polycomb protein Bmi-1 represses the INK4a locus, which encodes the tumor suppressors p16 and p14(ARF). Here we report that Bmi-1 is downregulated when WI-38 human fibroblasts undergo replicative senescence, but not quiescence, and extends replicative life span when overexpressed. Life span extension by Bmi-1 requ...

journal_title：Molecular and cellular biology

authors： Itahana K,Zou Y,Itahana Y,Martinez JL,Beausejour C,Jacobs JJ,Van Lohuizen M,Band V,Campisi J,Dimri GP

更新日期：2003-01-01 00:00:00

abstract：:The Ki-67 protein is widely used as a tumor proliferation marker. However, whether Ki-67 affects cell cycle progression has been controversial. Here we demonstrate that depletion of Ki-67 in human hTERT-RPE1, WI-38, IMR90, and hTERT-BJ cell lines and primary fibroblast cells slowed entry into S phase and coordinately ...

journal_title：Molecular and cellular biology

authors： Sun X,Bizhanova A,Matheson TD,Yu J,Zhu LJ,Kaufman PD

更新日期：2017-08-11 00:00:00

abstract：:The amplified CAD genes in N-(phosphonacetyl)-L-aspartate (PALA)-resistant Syrian hamster cells are located in an expanded chromosomal region emanating from the site of the wild-type gene at the tip of the short arm of chromosome B-9. The terminus of B-9 in PALA-sensitive cells contains a cluster of rRNA genes (i.e., ...

journal_title：Molecular and cellular biology

authors： Wahl GM,Vitto L,Rubnitz J

更新日期：1983-11-01 00:00:00

abstract：:SWI-SNF alters DNA-histone interactions within a nucleosome in an ATP-dependent manner. These alterations cause changes in the topology of a closed circular nucleosomal array that persist after removal of ATP from the reaction. We demonstrate here that a remodeled closed circular array will revert toward its original ...

journal_title：Molecular and cellular biology

authors： Guyon JR,Narlikar GJ,Sullivan EK,Kingston RE

更新日期：2001-02-01 00:00:00

abstract：:We have screened an adult rat cerebellar cDNA library in search of novel protein tyrosine-kinase (PTK) cDNAs. A cDNA for a putative PTK, trkB, was cloned, and its sequence indicates that it is likely to be derived from a gene for a ligand-regulated receptor closely related to the human trk oncogene. Northern (RNA) ana...

journal_title：Molecular and cellular biology

authors： Middlemas DS,Lindberg RA,Hunter T

更新日期：1991-01-01 00:00:00