Can disulfiram potentiate the dexamethasone suppression test in depressive patients?

Abstract:

:Transient DST non-suppression during disulfiram-treatment was fortuitously observed in a depressed patient. A disulfiram-potentiated DST (DSTd) was constructed by giving 800 mg disulfiram on the dexamethasone and postdexamethasone days. DST and DSTd were compared intraindividually in 21 patients and 14 controls. Disulfiram-potentiation was significant in constantly depressed patients, and in questionable controls due to possible subclinical depression or somatic factors which may cause 'false-positive' results. It did not occur in depressed patients during marked improvement or long-term recovery, and not in accurately screened controls. DSTd was significantly correlated with depression ratings, whereas DST was not.

journal_name

J Affect Disord

authors

Bergsholm P,Oulie D,Holsten F,Myking O

doi

10.1016/0165-0327(93)90059-s

subject

Has Abstract

pub_date

1993-08-01 00:00:00

pages

241-7

issue

4

eissn

0165-0327

issn

1573-2517

pii

0165-0327(93)90059-S

journal_volume

28

pub_type

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