当前位置： SCI文献检索 > JOURNAL OF THE NEUROLOGICAL SCIENCES期刊下所有文献 > Fate of neutralizing and binding antibodies to IFN beta in MS patients treated with IFN beta for 6 years.

Fate of neutralizing and binding antibodies to IFN beta in MS patients treated with IFN beta for 6 years.

Abstract：

:An increasing number of evidence is showing that during prolonged treatment of relapsing-remitting multiple sclerosis (RRMS) with interferon (IFN) beta 1a or IFN beta 1b, the patients may develop serum anti-IFN antibody. It has been argued that some of the RRMS patients receiving IFN beta, who developed antibodies to IFN, lose them over time even though the treatment continues. To gain further insights into this issue, we performed a study to establish what happened to binding antibodies (BAB) and neutralizing antibodies (NAB) in 42 RRMS patients treated for 6 years with IFN beta 1a and/or IFN beta 1b. While the data of BAB analysis did not allow to reach definite conclusions, the results on NAB development confirm that the presence of this type of antibodies is transitory; in fact, most of the positive patients reverted to seronegative, although the IFN treatment is still ongoing; the only patients who were positive for NAB at 6 years of treatment are those whose serum contains high concentration of them. The paper also shows that patients lose antibodies to IFN independently on the type of IFN used for the treatment. In conclusion, the data indicate that the disappearance of the anti-IFN antibodies from the serum while the patients are still undergoing IFN treatment depends on the titer of antibodies but not on the type of IFN administered.

journal_name

J Neurol Sci

journal_title

Journal of the neurological sciences

authors

Bellomi F,Scagnolari C,Tomassini V,Gasperini C,Paolillo A,Pozzilli C,Antonelli G

doi

10.1016/s0022-510x(03)00173-4

subject

Has Abstract

pub_date

2003-11-15 00:00:00

pages

3-8

issue

1-2

eissn

0022-510X

issn

1878-5883

pii

S0022510X03001734

journal_volume

215

pub_type

临床试验,杂志文章,随机对照试验

相关文献

JOURNAL OF THE NEUROLOGICAL SCIENCES文献大全
  • Vascular dementia among elderly Arabs in Wadi Ara.

    abstract：:Dementia of the Alzheimer type (DAT) and vascular dementia (VaD) are the two major subtypes of dementia. In our epidemiological study of DAT in an Arab community in Wadi Ara, Israel, we found a high prevalence of late onset DAT. Illiteracy, smoking, diabetes mellitus (DM) and hypertension are very frequent in Wadi Ara...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(02)00269-1

    authors： Bowirrat A,Friedland RP,Korczyn AD

    更新日期：2002-11-15 00:00:00

  • Updates on Somatoform Disorders (SFMD) in Parkinson's Disease and Dementia with Lewy Bodies and discussion of phenomenology.

    abstract：:Somatoform Disorders (SFMD) were recently described in Parkinson Disease (PD) and Dementia with Lewy Bodies (DLB). The present paper updates the observations in our cohort of patients and further details clinical phenomenology. Of 3178 patients consecutively referred to our Institutions from 1999, 1572 subjects had ne...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2011.07.010

    authors： Onofrj M,Thomas A,Tiraboschi P,Wenning G,Gambi F,Sepede G,Di Giannantonio M,Di Carmine C,Monaco D,Maruotti V,Ciccocioppo F,D'Amico MC,Bonanni L

    更新日期：2011-11-15 00:00:00

  • Susceptibility-weighted imaging reveals cerebral microvascular injury in severe COVID-19.

    abstract：:We evaluated the incidence, distribution, and histopathologic correlates of microvascular brain lesions in patients with severe COVID-19. Sixteen consecutive patients admitted to the intensive care unit with severe COVID-19 undergoing brain MRI for evaluation of coma or neurologic deficits were retrospectively identif...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2021.117308

    authors： Conklin J,Frosch MP,Mukerji SS,Rapalino O,Maher MD,Schaefer PW,Lev MH,Gonzalez RG,Das S,Champion SN,Magdamo C,Sen P,Harrold GK,Alabsi H,Normandin E,Shaw B,Lemieux JE,Sabeti PC,Branda JA,Brown EN,Westover MB,Huan

    更新日期：2021-01-15 00:00:00

  • Human M1-, M2- and M3-muscarinic cholinergic receptors: binding characteristics of agonists and antagonists.

    abstract：:The muscarinic acetylcholine receptors were identified in membrane preparations from human tissues by the specific binding of 1-[benzilic-4,4'-3H] quinuclidinyl benzilate. Saturation binding isotherms of this radioligand yielded a total amount of receptors of 435 +/- 208, 159 +/- 65 and 913 +/- 89 fmol/mg protein, res...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(90)90099-9

    authors： Vanderheyden P,Gies JP,Ebinger G,De Keyser J,Landry Y,Vauquelin G

    更新日期：1990-06-01 00:00:00

  • EMG dynamics in polymyositis. A quantitative single motor unit potential study.

    abstract：:A multidimensional quantitative EMG analysis method with averaged motor unit potentials (MUPs) was applied to a study of different stages of polymyositis. The duration parameters had a general tendency to increase in polymyositis. The only exception was the total MUP duration, which decreased in the onset stage of acu...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(82)90029-6

    authors： Partanen J,Lang H

    更新日期：1982-12-01 00:00:00

  • Metallothionein in Menkes' disease: induction in cultured muscle cells.

    abstract：:Menkes' disease is an inherited disturbance of copper metabolism. Addition of copper to the medium of cultured fibroblasts and lymphoblasts from patients with Menkes' disease results in an increased induction of metallothionein. We investigated the metallothionein induction in response to copper and zinc in muscle cel...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(90)90012-c

    authors： Herzberg NH,Wolterman RA,van den Berg GJ,Barth PG,Bolhuis PA

    更新日期：1990-12-01 00:00:00

  • Diagnostic value of MR imaging in the Lewis-Sumner syndrome: a case series.

    abstract：:Lewis-Sumner syndrome (LSS) is considered a variant of chronic inflammatory demyelinating polyneuropathy (CIDP), which is more frequently described with exclusive upper limb involvement. The diagnosis of LSS is clinical and electrophysiological. However, these are not always obvious and in view of its rarity, the diag...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2014.04.033

    authors： Rajabally YA,Knopp MJ,Martin-Lamb D,Morlese J

    更新日期：2014-07-15 00:00:00

  • Autonomic dysfunction in different subtypes of post-acute ischemic stroke.

    abstract：OBJECTIVES:Central autonomic impairment is frequent in ischemic stroke at acute or chronic stages. The mechanism by which these symptoms occur in patients with ischemic stroke has not been elucidated. This study sought to investigate cardiovascular autonomic function in patients with different subtypes of post-acute is...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2013.11.036

    authors： Xiong L,Leung HW,Chen XY,Leung WH,Soo OY,Wong KS

    更新日期：2014-02-15 00:00:00

  • Effect of partial denervation on motor units in the ageing rat medial gastrocnemius.

    abstract：:The ageing neuromuscular system is thought to undergo a continual process of reorganization as motoneurones are lost and surviving motor nerves reinnervate neighbouring denervated muscle fibres. However, the extent to which collateral reinnervation is able to compensate for neural deficits in the ageing individual is ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(92)90148-e

    authors： Einsiedel LJ,Luff AR

    更新日期：1992-10-01 00:00:00

  • White matter lesions and depression in patients with Parkinson's disease.

    abstract：:Depression is frequently associated with Parkinson disease (PD) but neural basis is still unclear. In previous studies white matter changes present as signal hyperintesities on T2-wighted MRI studies (WMHs) commonly observed in older adults have been associated with depressive symptomatology. In this study we investig...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2012.07.021

    authors： Petrovic IN,Stefanova E,Kozic D,Semnic R,Markovic V,Daragasevic NT,Kostic VS

    更新日期：2012-11-15 00:00:00

  • A novel mutation in FHL1 in a family with X-linked scapuloperoneal myopathy: phenotypic spectrum and structural study of FHL1 mutations.

    abstract：:An X-linked myopathy was recently associated with mutations in the four-and-a-half-LIM domains 1 (FHL1) gene. We identified a family with late onset, slowly progressive weakness of scapuloperoneal muscles in three brothers and their mother. A novel missense mutation in the LIM2 domain of FHL1 (W122C) co-segregated wit...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2010.06.017

    authors： Chen DH,Raskind WH,Parson WW,Sonnen JA,Vu T,Zheng Y,Matsushita M,Wolff J,Lipe H,Bird TD

    更新日期：2010-09-15 00:00:00

  • Hemispheric differences in malignant middle cerebral artery stroke.

    abstract：BACKGROUND:We recently reported that left versus right hemisphere cerebral infarctions patients more frequently have worse outcomes. However our clinical experience led us to suspect that the incidence of malignant middle cerebral artery infarctions (MMCA) was higher in the right compared to the left hemispheric stroke...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.jns.2015.04.036

    authors： Rastogi V,Lamb DG,Williamson JB,Stead TS,Penumudi R,Bidari S,Ganti L,Heilman KM,Hedna VS

    更新日期：2015-01-01 00:00:00

  • Therapy adherence issues in Parkinson's disease.

    abstract：:The response to dopamine replacement therapy in patients with degenerative parkinsonism is variable. Reasons for a poor therapy response include the type of parkinsonism, comorbidities, and differential effects on clinical features. An additional explanation, which has received much less attention, is sub-optimal ther...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.jns.2009.08.053

    authors： Grosset D,European PD Therapy Compliance Study Group.

    更新日期：2010-02-15 00:00:00

  • Olfactory dysfunction in patients with multiple sclerosis.

    abstract：:Association of changes in olfactory-related structures with olfactory function in patients with multiple sclerosis (MS) is not well understood. We used a T&T olfactometer test kit to evaluate olfactory function in 26 patients with MS and 26 age- and sex-matched healthy controls (HC). Then, Brain MRI were performed and...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2016.03.045

    authors： Li LM,Yang LN,Zhang LJ,Fu Y,Li T,Qi Y,Wang J,Zhang DQ,Zhang N,Liu J,Yang L

    更新日期：2016-06-15 00:00:00

  • Is it clinically relevant to repair focal multiple sclerosis lesions?

    abstract：:Multiple sclerosis (MS) is an inflammatory disease of the central nervous system, predominantly, but not exclusively, involving the normal appearing white matter. Until very recently we believed that nervous dysfunction in MS was completely depending on the accumulation of lesions in the white matter of the CNS. As a ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.jns.2007.09.001

    authors： Comi G

    更新日期：2008-02-15 00:00:00

  • An epidemic of optic neuropathy in Tanzania: characterization of the visual disorder and associated peripheral neuropathy.

    abstract：:An epidemic of subacute bilateral visual failure has affected large numbers of teenagers and young adult Africans in coastal Tanzania since 1988. Previous work had indicated that many patients had sensory symptoms, but the nature of the neurological involvement was uncertain. The primary objective of this study was to...

    journal_title：Journal of the neurological sciences

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0022-510x(96)00162-1

    authors： Plant GT,Mtanda AT,Arden GB,Johnson GJ

    更新日期：1997-02-12 00:00:00

  • Distribution of scalp somatosensory potentials evoked by stimulation of the tibial nerve in man.

    abstract：:The scalp distribution of the response to stimulation of the tibial nerve at the medial malleolus was systematically analysed. The somatosensory evoked potential (SEP) was recorded with electrodes placed in a transversal line over the ipsilateral and contralateral postcentral gyri and in a sagittal line over the longi...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(83)90038-2

    authors： Berić A,Prevec TS

    更新日期：1983-05-01 00:00:00

  • Acute endothelial swelling is induced in endoneurial microvessels by ischemia.

    abstract：:Structural alterations of endoneurial microvessels occur in diabetic neuropathy and are statistically associated with severity of nerve fiber loss and teased fiber abnormality. It is therefore hypothesized that the microvessel alterations may cause or contribute to pathologic alterations of nerve fibers in diabetic ne...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(90)90197-u

    authors： Benstead TJ,Sangalang VE,Dyck PJ

    更新日期：1990-10-01 00:00:00

  • Immunoglobulin gene rearrangement analysis in cerebrospinal fluid of patients with lymphoproliferative processes.

    abstract：OBJECTIVE:To determine the sensitivity and specificity of clonal immunoglobulin heavy chain gene rearrangement (IGHR) analysis in the distinction of benign and malignant lymphoproliferative diseases. METHODS:A retrospective analysis was conducted of patients in whom a malignant lymphoproliferative process was suspecte...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2006.05.044

    authors： Baehring JM,Hochberg FH,Betensky RA,Longtine J,Sklar J

    更新日期：2006-09-25 00:00:00

  • A baseline study for detection of Parkinson's disease with 3D-transcranial sonography and uni-lateral reconstruction.

    abstract：INTRODUCTION:TCS is a well-established technique for diagnosis of Parkinson's disease (PD). Volumetric 3D-TCS is a promising complementary approach for objective acquisition and analysis, in particular for less experienced sonographers. This study provides baselines for Parkinson detection (sensitivity and specificity)...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2018.12.001

    authors： Plate A,Maiostre J,Levin J,Bötzel K,Ahmadi SA

    更新日期：2019-02-15 00:00:00

  • Kidney function changes and their relation with the progression of cerebral small vessel disease and cognitive decline.

    abstract：AIMS:We aimed to study whether worsening in markers of kidney function parallels the progression in cerebral small vessel disease (cSVD) and cognitive decline. METHODS:Data from the ISSYS (Investigating Silent Strokes in Hypertensives Study), a longitudinal population-based study in hypertensives aged 50-70 and dement...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2019.116635

    authors： Jiménez-Balado J,Riba-Llena I,Pizarro J,Palasí A,Penalba A,Ramírez C,Maisterra O,Espinel E,Ramos N,Pujadas F,Serón D,Delgado P

    更新日期：2020-02-15 00:00:00

  • Frontal lobe dysfunction in amyotrophic lateral sclerosis.

    abstract：:The aim of the present study was to investigate the involvement of frontal lobe dysfunction in amyotrophic lateral sclerosis (ALS) using ocular motor paradigms and neuropsychological testing. Fifty-one patients with ALS participated in the following ocular motor tasks: (1) a three-choice task and (2) a remembered sacc...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(01)00683-9

    authors： Evdokimidis I,Constantinidis TS,Gourtzelidis P,Smyrnis N,Zalonis I,Zis PV,Andreadou E,Papageorgiou C

    更新日期：2002-03-15 00:00:00

  • Reduced cerebrospinal fluid concentrations of oxysterols in response to natalizumab treatment of relapsing remitting multiple sclerosis.

    abstract：BACKGROUND:Natalizumab therapy reduces inflammation and degeneration of the CNS in relapsing-remitting multiple sclerosis (RRMS). In cerebrospinal fluid (CSF) the concentration of 24S-hydroxycholesterol (24OHC) reflect neurodegeneration, whereas 27-hydroxycholesterol (27OHC) is dependent on the integrity of the blood-b...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2015.08.1537

    authors： Novakova L,Axelsson M,Malmeström C,Zetterberg H,Björkhem I,Karrenbauer VD,Lycke J

    更新日期：2015-11-15 00:00:00

  • Chronic progressive spinobulbar spasticity with disturbance of voluntary eyelid closure. Report of a case with special reference to MRI and electrophysiological findings.

    abstract：:We describe a 56-year-old man who had a progressive pseudobulbar palsy, spastic tetraparesis, forced laughing and disturbance of voluntary eyelid closure, and was clinically compatible with chronic progressive spinobulbar spasticity. Magnetic resonance images (MRI) revealed atrophy of the bilateral motor cortices and ...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(90)90131-6

    authors： Nishimura M,Tojima M,Suga M,Hirose K,Tanabe H

    更新日期：1990-05-01 00:00:00

  • Cerebrovascular disease incidence in central Spain (NEDICES): a population-based prospective study.

    abstract：BACKGROUND:Stroke is one of the most disabling and burdensome health conditions worldwide, but no prospective population-based study has been conducted in Spain. Our aim was to assess age- and gender incidence rates of cerebrovascular disease, including stroke and transient ischemic attack, in three populations in cent...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2010.08.003

    authors： Martínez-Salio A,Benito-León J,Díaz-Guzmán J,Bermejo-Pareja F

    更新日期：2010-11-15 00:00:00

  • Lysophosphatidyl choline-induced focal demyelination in the rabbit corpus callosum. Electron-microscopic observations.

    abstract：:Under electrophysiological control, a focal demyelinating lesion can be produced in the corpus callosum of the rabbit by slow pressure injection of a 1% solution of lysophosphatidyl choline (LPC). Light- and electron-microscopic examination of the LPC demyelinated corpus callosum indicates that many axons remain struc...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/0022-510x(80)90202-6

    authors： Foster RE,Kocsis JD,Malenka RC,Waxman SG

    更新日期：1980-11-01 00:00:00

  • Primary central nervous system leukemia with a novel chromosomal translocation.

    abstract：:A case of central nervous system (CNS) leukemia with normal bone marrow, associated with a novel chromosomal abnormality, is described. A 58 year-old woman complained of hearing disturbance, severe headache and vomiting, and showed signs of meningeal irritation, as well as papilledema and bilateral dysacusis. Immature...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/s0022-510x(97)00099-3

    authors： Hayashi T,Onodera J,Mochizuki H,Onodera H,Abe K,Itoyama Y

    更新日期：1997-10-03 00:00:00

  • Cerebral disease in a nationwide Dutch pseudoxanthoma elasticum cohort with a systematic review of the literature.

    abstract：BACKGROUND:Pseudoxanthoma elasticum (PXE) is a monogenetic disease with progressive calcification of arteries and potential risk of stroke. To gain insights in the cerebral involvement in PXE, we evaluated prevalence and determinants of cerebral disease in our PXE cohort and performed a systematic review of literature....

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章,评审

    doi：10.1016/j.jns.2016.12.053

    authors： Kauw F,Kranenburg G,Kappelle LJ,Hendrikse J,Koek HL,Visseren FLJ,Mali WPT,de Jong PA,Spiering W

    更新日期：2017-02-15 00:00:00

  • Leigh-like syndrome with the T8993G mutation in the mitochondrial ATPase 6 gene: long-term follow-up discloses a slowly progressive course.

    abstract：:We describe the long-term clinical outcome of a patient with Leigh-like syndrome presenting as an early onset encephalopathy and peripheral neuropathy caused by the T8993G mutation in the mitochondrial DNA (mtDNA). Clinical follow-up for 20 years revealed a peculiar pattern of slow disease progression, characterized b...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2008.11.023

    authors： Sobreira C,Marques W Jr,Pontes Neto OM,Santos AC,Pina Neto JM,Barreira AA

    更新日期：2009-03-15 00:00:00

  • Mirror movements in Parkinson's disease: An under-appreciated clinical sign.

    abstract：INTRODUCTION:Mirror movements (MM) have been previously reported in patients with Parkinson's disease (PD). Despite being potentially relevant in PD, MM as a neurological sign have remained less recognized. In this study we critically evaluated the characteristic features of MM and their attributes among a cohort of PD...

    journal_title：Journal of the neurological sciences

    pub_type： 杂志文章

    doi：10.1016/j.jns.2016.05.026

    authors： Chatterjee P,Banerjee R,Choudhury S,Mondal B,Kulsum MU,Chatterjee K,Kumar H

    更新日期：2016-07-15 00:00:00