Abstract:
:The ageing neuromuscular system is thought to undergo a continual process of reorganization as motoneurones are lost and surviving motor nerves reinnervate neighbouring denervated muscle fibres. However, the extent to which collateral reinnervation is able to compensate for neural deficits in the ageing individual is unknown. The ability of the senescent motoneurone to increase the size of its peripheral field was therefore investigated following transection of the right L5 ventral root in male Sprague Dawley rats aged 775 +/- 50 days. This procedure resulted in an extensive partial denervation of the right medial gastrocnemius muscle. After a recovery period of between 28 and 31 days the isometric contractile properties of surviving motor units were compared to control motor units from both the contralateral muscle and a group of unoperated control animals aged 791 +/- 39 days. Motor unit force was found to be unchanged after partial denervation and the absence of any alteration in motor unit size was confirmed by histological analysis. However, the time course of the isometric twitch was significantly longer for both fast and slow motor unit types and the conduction velocity of motoneurones innervating fast units was decreased following partial denervation. These results demonstrate that senescent motor nerves are unable to substantially increase the size of their peripheral fields by extensive collateral reinnervation.
journal_name
J Neurol Scijournal_title
Journal of the neurological sciencesauthors
Einsiedel LJ,Luff ARdoi
10.1016/0022-510x(92)90148-esubject
Has Abstractpub_date
1992-10-01 00:00:00pages
178-84issue
1-2eissn
0022-510Xissn
1878-5883pii
0022-510X(92)90148-Ejournal_volume
112pub_type
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journal_title:Journal of the neurological sciences
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更新日期:1997-07-01 00:00:00
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journal_title:Journal of the neurological sciences
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doi:10.1016/0022-510x(92)90270-u
更新日期:1992-11-01 00:00:00
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doi:10.1016/j.jns.2011.02.016
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/0022-510x(83)90147-8
更新日期:1983-08-01 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/0022-510x(92)90049-q
更新日期:1992-04-01 00:00:00
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pub_type: 杂志文章
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更新日期:1994-01-01 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/j.jns.2011.04.007
更新日期:2011-07-15 00:00:00
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pub_type: 杂志文章
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更新日期:2011-04-15 00:00:00
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journal_title:Journal of the neurological sciences
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更新日期:2012-07-15 00:00:00
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pub_type: 临床试验,杂志文章
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更新日期:2008-08-15 00:00:00
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pub_type: 杂志文章
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更新日期:1991-12-01 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/0022-510x(87)90210-3
更新日期:1987-01-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2007-06-15 00:00:00
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pub_type: 杂志文章
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更新日期:1984-11-01 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
doi:10.1016/0022-510x(85)90022-x
更新日期:1985-01-01 00:00:00
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journal_title:Journal of the neurological sciences
pub_type: 杂志文章
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更新日期:2013-10-15 00:00:00