Cross-talk between interleukin-6 and transforming growth factor-beta3 regulates extracellular matrix production by human fibroblasts from subjects with non-syndromic cleft lip and palate.

Abstract:

BACKGROUND:Transforming growth factor-beta (TGF-beta) interference with interleukin 6 (IL-6) activity and the role of the latter in early human embryonic development prompted us to examine the effects IL-6 on matrix synthesis and the effects of TGF-beta3 on IL-6 expression human cleft lip and palate (CLP) fibroblasts. METHODS:Collagen and glycosaminoglycan (GAG) synthesis were determined by radiolabeled precursors and biglycan expression by Northern blotting before and after adding IL-6. The effects of TGF-beta3 on IL-6 production were assayed by evaluating IL-6 transcript by Northern blotting and IL-6 protein secretion by enzyme-linked immunosorbent assay. RESULTS:The results showed that IL-6 elicited an inhibitory effect on collagen and GAG levels in CLP fibroblasts by lowering hyaluronan and dermatan sulfate secretion. IL-6 up-regulated biglycan expression, but less strongly than TGF-beta3. TGF-beta3 significantly down-regulated IL-6 transcript and secretion in CLP fibroblasts. CONCLUSIONS:These data suggest the increase in matrix components that characterize the CLP fibroblast phenotype might be due to a concerted TGF-beta3-IL-6 action. We hypothesize changes in cross-talk between TGF-beta3 and IL-6 signal transduction pathways are involved in the induction of cleft palate.

journal_name

J Periodontol

authors

Baroni T,Carinci P,Bellucci C,Lilli C,Becchetti E,Carinci F,Stabellini G,Pezzetti F,Caramelli E,Tognon M,Bodo M

doi

10.1902/jop.2003.74.10.1447

subject

Has Abstract

pub_date

2003-10-01 00:00:00

pages

1447-53

issue

10

eissn

0022-3492

issn

1943-3670

journal_volume

74

pub_type

杂志文章
  • Clinical evaluation of acellular allograft dermis for the treatment of human gingival recession.

    abstract:BACKGROUND:Periodontal root coverage procedures to treat recession areas are indicated for unesthetic, exposed, and/or painful root surfaces. Many methods, most using autogenous soft tissue grafts, have been utilized, but with associated morbidity at the donor sites. An alternative donor material would reduce the morbi...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章

    doi:10.1902/jop.2001.72.8.998

    authors: Aichelmann-Reidy ME,Yukna RA,Evans GH,Nasr HF,Mayer ET

    更新日期:2001-08-01 00:00:00

  • Effect of systemically administered naproxen sodium on clinical parameters and myeloperoxidase and elastase-like activity levels in gingival crevicular fluid.

    abstract:BACKGROUND:The present study was conducted to determine the possible effect of naproxen sodium on clinical status and the enzymatic profile of gingival crevicular fluid (GCF) when given as adjunct to periodontal treatment. METHODS:A total of 34 subjects with chronic periodontitis were selected and divided into two gro...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,随机对照试验

    doi:10.1902/jop.2007.060412

    authors: Aras H,Cağlayan F,Güncü GN,Berberoğlu A,Kilinç K

    更新日期:2007-05-01 00:00:00

  • The association between osteopenia and periodontal attachment loss in older women.

    abstract:BACKGROUND:Recent research suggests that osteopenia may be a predisposing factor for periodontal tissue destruction. If so, then a relationship should exist between measures of systemic bone mineral density and periodontal tissue destruction. The purpose of the present cross-sectional study was to evaluate the associat...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1902/jop.1999.70.9.982

    authors: Weyant RJ,Pearlstein ME,Churak AP,Forrest K,Famili P,Cauley JA

    更新日期:1999-09-01 00:00:00

  • Value of antibiotic prophylaxis in periodontal surgery.

    abstract::THE MORBIDITY and incidence of bacteremia in periodontal surgery with or without cephalexin prophylaxis were assessed in adults on the basis of clinical evaluations and blood cultures. Cephalexin reduced the incidence of polymicrobic bacteremias. There was no correlation between objective signs of tissue healing and a...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1982.53.5.319

    authors: Appleman MD,Sutter VL,Sims TN

    更新日期:1982-05-01 00:00:00

  • Application of periodontal tissue engineering using enamel matrix derivative and a human fibroblast-derived dermal substitute to stimulate periodontal wound healing in Class III furcation defects.

    abstract:BACKGROUND:Enamel matrix derivative (EMD) has been shown to promote several aspects of periodontal regeneration in vitro and in vivo. Recently, a bioengineered tissue (DG) was developed to promote wound healing of chronic skin ulcers. This pilot study sought to assess the effects of EMD and DG, alone or in combination,...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2006.030264

    authors: Hovey LR,Jones AA,McGuire M,Mellonig JT,Schoolfield J,Cochran DL

    更新日期:2006-05-01 00:00:00

  • Novel and known periodontal pathogens residing in gingival crevicular fluid are associated with rheumatoid arthritis.

    abstract:BACKGROUND:Periodontitis is a suspected environmental risk factor for the development of rheumatoid arthritis (RA). However, correlation mechanisms between the two pathologies remain elusive. This study examined potential correlations between detached subgingival bacteria collected in gingival crevicular fluid (GCF) an...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1002/JPER.20-0295

    authors: Manoil D,Bostanci N,Mumcu G,Inanc N,Can M,Direskeneli H,Belibasakis GN

    更新日期:2020-07-31 00:00:00

  • Collinin reduces Porphyromonas gingivalis growth and collagenase activity and inhibits the lipopolysaccharide-induced macrophage inflammatory response and osteoclast differentiation and function.

    abstract:BACKGROUND:Collinin is a secondary plant metabolite belonging to the class of geranyloxycoumarins. We explored the potential beneficial impact of collinin on periodontal health by investigating its effect on Porphyromonas gingivalis (P. gingivalis), lipopolysaccharide (LPS)-induced inflammatory response of macrophages,...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2012.120118

    authors: Santos J,Marquis A,Epifano F,Genovese S,Curini M,Grenier D

    更新日期:2013-05-01 00:00:00

  • Implants in regenerated bone in a primate model.

    abstract:BACKGROUND:Earlier publications from our laboratory described the use of guided bone regeneration to fill large bone voids in the mandible created through en bloc resection in primates. The present report describes placement of implants into the regenerated bone with subsequent prostheses construction and loading. MET...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2001.72.6.703

    authors: Fritz ME,Jeffcoat MK,Reddy M,Koth D,Braswell LD,Malmquist J,Lemons J

    更新日期:2001-06-01 00:00:00

  • Langerhans-cell histiocytosis: a clinical case without bone involvement.

    abstract:BACKGROUND:Langerhans-cell histiocytosis (LCH) is a group of rare disorders histologically characterized by the proliferation of Langerhans cells. Multiple organs and systems may be involved by the disease. Typically, there is bone involvement and, less frequently, lesions may be found in the lungs, liver, lymph nodes,...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2005.76.1.143

    authors: Manfredi M,Corradi D,Vescovi P

    更新日期:2005-01-01 00:00:00

  • Inflammatory and immune mediators in crevicular fluid from HIV-infected injecting drug users.

    abstract::Gingival crevicular fluid (GCF) levels of the polymorphonuclear leukocyte (PMN) lysosomal enzyme beta-glucuronidase (beta G), the pro-inflammatory cytokine interleukin 1 beta (IL-1 beta), and immunoglobulins (IgA, IgG, and IgM) were examined in 16 HIV seropositive (HIV+) and 10 HIV seronegative (HIV-) injecting drug u...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1997.68.3.249

    authors: Grbic JT,Lamster IB,Mitchell-Lewis D

    更新日期:1997-03-01 00:00:00

  • Smoker's melanosis. A case report.

    abstract::Smoker's melanosis is a benign pigmentation of the oral mucosa, predominantly observed on the attached anterior mandibular gingiva and interdental papillae. These macular lesions are independent of genetic factors, therapeutic medication usage, and various systemic disorders. As a group they are often seen after the t...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,评审

    doi:10.1902/jop.1991.62.8.524

    authors: Brown FH,Houston GD

    更新日期:1991-08-01 00:00:00

  • Using a Delphi panel to survey criteria for successful periodontal therapy in anterior teeth.

    abstract:BACKGROUND:Valuable decision making for periodontal treatment success in situations where there is ambiguous or conflicting information was previously reported using a consensus building method, the Delphi survey, for posterior teeth with chronic periodontitis. This study focuses on outcome measures relevant in assessi...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2005.76.9.1508

    authors: Lightfoot WS,Hefti A,Mariotti A

    更新日期:2005-09-01 00:00:00

  • Guided bone regeneration for dehiscence and fenestration defects on implants using an absorbable polymer barrier.

    abstract:BACKGROUND:Guided bone regeneration (GBR) using a non-absorbable barrier has provided clinicians the ability to place implants in sites compromised by insufficient bone, including immediate extraction sites. Recent evidence suggests that successful GBR outcomes may be possible using bioabsorbable polymer barriers. MET...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2001.72.2.250

    authors: Rosen PS,Reynolds MA

    更新日期:2001-02-01 00:00:00

  • Periodontal Conditions of Sites Treated With Gingival Augmentation Surgery Compared With Untreated Contralateral Homologous Sites: An 18- to 35-Year Long-Term Study.

    abstract:BACKGROUND:The aim of this split-mouth study is to compare long-term (18 to 35 years) periodontal conditions of sites treated with gingival augmentation procedures (GAPs) and untreated homologous contralateral sites. METHODS:Forty-seven patients with 64 sites (test group), with lack of attached gingiva associated with...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2016.160284

    authors: Agudio G,Cortellini P,Buti J,Pini Prato G

    更新日期:2016-12-01 00:00:00

  • The use of blade implants in a selected population of partially edentulous adults. A 15-year report.

    abstract::In order to provide longitudinal data for endosteal bladevent implants, a continuing study is being conducted from an original group of 49 implants in 32 patients placed 15 years ago. The present work evaluated 26 of these bladevent implants in 18 patients. Three basic patterns were observed 15 years postoperatively: ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1987.58.9.589

    authors: Smithloff M,Fritz ME

    更新日期:1987-09-01 00:00:00

  • Effects of two cetylpyridinium chloride-containing mouthwashes on bacterial plaque.

    abstract::The purpose of this single blind clinical study was to determine the effects of two commerical mouthwashes (one containing cetylpyridinium chloride and domiphen bromide and the other containing only cetlypridinium chloride) on existing plaque accumulations. A second purpose was to determine if a residual effect could ...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章

    doi:10.1902/jop.1976.47.7.419

    authors: Barnes GP,Roberts DW,Katz RV,Woolridge ED Jr

    更新日期:1976-07-01 00:00:00

  • Clinical recommendations for avoiding and managing surgical complications associated with implant dentistry: a review.

    abstract::Proposing to place endosseous implants is an integral facet of dental treatment plans. Their insertion is usually associated with a low incidence of untoward events. However, despite careful planning, surgical complications can arise: infection, intraoral hemorrhage, wound dehiscence, postoperative pain, lack of prima...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,评审

    doi:10.1902/jop.2008.070067

    authors: Greenstein G,Cavallaro J,Romanos G,Tarnow D

    更新日期:2008-08-01 00:00:00

  • Vertical ridge augmentation using an equine bone and collagen block infused with recombinant human platelet-derived growth factor-BB: a randomized single-masked histologic study in non-human primates.

    abstract:BACKGROUND:This study tests the effectiveness of hydroxyapatite and collagen bone blocks of equine origin (eHAC), infused with recombinant human platelet-derived growth factor-BB (rhPDGF-BB), to augment localized posterior mandibular defects in non-human primates (Papio hamadryas). METHODS:Bilateral critical-sized def...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2012.110478

    authors: Nevins M,Al Hezaimi K,Schupbach P,Karimbux N,Kim DM

    更新日期:2012-07-01 00:00:00

  • Sinus floor augmentation with simultaneous implant placement in the severely atrophic maxilla.

    abstract::Dental implant placement associated with augmentation of the sinus floor in the severely atrophic maxilla can be performed in 1- or 2-surgical stages, depending on the height of the residual alveolar bone. A minimum of 4 to 5 mm of residual alveolar bone height is recommended for a 1-stage surgical procedure. The pres...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1998.69.12.1397

    authors: Peleg M,Mazor Z,Chaushu G,Garg AK

    更新日期:1998-12-01 00:00:00

  • Traumatic bone cyst resembling apical periodontitis.

    abstract::Among the pseudocysts of the jaws, the traumatic bone cyst is known as an asymptomatic lesion often noted unintentionally during routine radiographic examinations. The lesion neither devitalizes the teeth within its borders, nor does it cause resorption of their roots. The well-demarcated traumatic bone cyst often pro...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1997.68.10.1019

    authors: Rosen DJ,Ardekian L,Machtei EE,Peled M,Manor R,Laufer D

    更新日期:1997-10-01 00:00:00

  • Blood cell gene expression profiling in subjects with aggressive periodontitis and chronic arthritis.

    abstract:BACKGROUND:Microarray analysis of local and peripheral cells in subjects with immune-inflammatory diseases may identify candidate genes associated with these diseases. The present study identified differentially expressed genes in peripheral blood mononuclear cells (PBMCs) from subjects with untreated localized aggress...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2008.070309

    authors: Sørensen LK,Havemose-Poulsen A,Sønder SU,Bendtzen K,Holmstrup P

    更新日期:2008-03-01 00:00:00

  • Exophytic mass of the gingiva as the first manifestation of metastatic pulmonary adenocarcinoma.

    abstract:BACKGROUND:Metastasis of a malignant tumor to the oral cavity is rare, but it can be the first manifestation of a primary tumor. METHODS:The clinicopathologic features of a gingival metastasis originating from lung adenocarcinoma in a female patient are described. A 57-year-old woman showed a rapidly growing, painless...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2008.070246

    authors: Pozzi EC,Altermatt HJ,Rees TD,Bornstein MM

    更新日期:2008-01-01 00:00:00

  • Sarcoidosis affecting the periodontium: a long-term follow-up case.

    abstract:BACKGROUND:Clinical manifestations of sarcoidosis affecting the periodontium could mimic aggressive periodontitis. This case report documents the occurrence of sarcoidosis affecting the periodontium, including its clinical features, diagnosis, treatment, and 6-year follow-up. METHODS:An individual with a history of pu...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2007.070117

    authors: Moretti AJ,Fiocchi MF,Flaitz CM

    更新日期:2007-11-01 00:00:00

  • Combining host modulation and topical antimicrobial therapy in the management of moderate to severe periodontitis: a randomized multicenter trial.

    abstract:BACKGROUND:Previous studies showed that host modulation therapy (HMT) or topical antimicrobial therapy (TAT) provided significant adjunctive benefits to scaling and root planing (SRP) in the treatment of chronic periodontitis (CP). The purpose of this study was to evaluate a combination therapy involving SRP, HMT, and ...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1902/jop.2008.070237

    authors: Novak MJ,Dawson DR 3rd,Magnusson I,Karpinia K,Polson A,Polson A,Ryan ME,Ciancio S,Drisko CH,Kinane D,Powala C,Bradshaw M

    更新日期:2008-01-01 00:00:00

  • Fibrin linkage: a precursor for new attachment.

    abstract::Previous studies indicated that connective tissue attachment to the root surface appeared to be dependent upon a chronologic healing sequence related to fibrin and collagen interactions. It was the purpose of the present study to try and substantiate this hypothesis by using histologic techniques designed to different...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.1983.54.3.141

    authors: Polson AM,Proye MP

    更新日期:1983-03-01 00:00:00

  • Cyclooxygenase-2-Dependent Prostaglandin (PG) E2 Downregulates Matrix Metalloproteinase-3 Production via EP2 /EP4 Subtypes of PGE2 Receptors in Human Periodontal Ligament Cells Stimulated With Interleukin-1α.

    abstract:BACKGROUND:Prostaglandin E2 (PGE2 ), which exerts its actions via EP receptors (EP1 , EP2 , EP3 , and EP4 ), is a bioactive metabolite produced by cyclooxygenase (COX)-1 and/or COX-2 from arachidonic acid. In the present study, we investigated whether COX-2-derived PGE2 regulated matrix metalloproteinase (MMP)-3 produc...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2005.76.6.929

    authors: Yan M,Noguchi K,Ruwanpura SMPM,Ishikawa I

    更新日期:2005-06-01 00:00:00

  • Surgical or non-surgical periodontal treatment: factors affecting patient decision making.

    abstract:BACKGROUND:This study explored which factors affected patients' decisions to pursue either surgical or non-surgical periodontal treatment. METHODS:Data were collected from 74 patients at a regularly scheduled periodontal appointment, at which each patient was told that periodontal treatment was needed, and 2 weeks fol...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2006.050206

    authors: Patel AM,Richards PS,Wang HL,Inglehart MR

    更新日期:2006-04-01 00:00:00

  • Full-mouth therapy versus individual quadrant root planning: a critical commentary.

    abstract:BACKGROUND:This commentary compares the abilities of full-mouth disinfection (FDIS), full-mouth root planing (FRP), and partial-mouth disinfection (PDIS) to improve periodontal health. FDIS consists of 4 quadrants of root planing completed within 24 hours with adjunctive chlorhexidine therapies (e.g., rinsing, subgingi...

    journal_title:Journal of periodontology

    pub_type: 杂志文章,评审

    doi:10.1902/jop.2002.73.7.797

    authors: Greenstein G

    更新日期:2002-07-01 00:00:00

  • Citric acid demineralization and subepithelial connective tissue grafts.

    abstract:BACKGROUND:The present study was designed to evaluate the effect, if any, of citric acid root demineralization in the outcome of subepithelial connective tissue grafts performed to cover localized gingival recessions. METHODS:Thirty-six patients participated, each providing one gingival recession; 19 received citric a...

    journal_title:Journal of periodontology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1902/jop.2000.71.4.568

    authors: Caffesse RG,De LaRosa M,Garza M,Munne-Travers A,Mondragon JC,Weltman R

    更新日期:2000-04-01 00:00:00

  • Are gingival phenotype, residual ridge height, and membrane thickness critical for the perforation of maxillary sinus?

    abstract:BACKGROUND:Sinus membrane perforation is the most common complication of the sinus-augmentation procedure. Anatomic factors have been implicated in the risk of sinus membrane perforation (SMP) during sinus-lift surgery. However, there are no reports on the relationships among gingival phenotype (GP), residual ridge hei...

    journal_title:Journal of periodontology

    pub_type: 杂志文章

    doi:10.1902/jop.2011.110110

    authors: Yilmaz HG,Tözüm TF

    更新日期:2012-04-01 00:00:00