Abstract:
:An endonuclease II preparation from Escherichia coli makes single strand breaks in DNA which has been treated with the carcinogen 7-bromomethyl-12-methylbenz[alpha]anthracene. In addition, the enzyme preparation excises N6-(12-methylbenz[alpha]anthracenyl-7-methyl)adenine and N2-(12-methylbenz[alpha]anthracenyl-7-methyl)guanine residues from the DNA. These are relased as the modified purine bases, not as purine nucleoside derivatives. The rate of release of the adenine derivative is three to four times that of the guanine derivative.
journal_name
Biochemistryjournal_title
Biochemistryauthors
Kirtikar DM,Dipple A,Goldthwait DAdoi
10.1021/bi00697a002subject
Has Abstractpub_date
1975-12-30 00:00:00pages
5548-53issue
26eissn
0006-2960issn
1520-4995journal_volume
14pub_type
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