Abstract:
BACKGROUND:Neurocognitive functioning may be impaired in the luteal phase of the menstrual cycle due to associated changes in hypothalamic-pituitary adrenal (HPA) axis function. This study examines the relationship between changes in neurocognition and HPA axis function in different phases of the menstrual cycle. METHOD:Fifteen female volunteers, free from psychiatric history and hormonal medication were tested twice, during mid-follicular and late-luteal phases in a randomized, crossover design. Mood, neurocognitive function, and basal cortisol and dehydroepiandrosterone (DHEA) were profiled. RESULTS:Relative to the follicular phase, verbal fluency was impaired in the luteal phase and reaction times speeded on a continuous performance task, without affecting overall accuracy. 'Hedonic' scores on the UWIST-MACL scale were decreased in the luteal phase. There was also evidence of changes in the function of the HPA axis, with 24 h urinary cortisol concentrations and salivary DHEA levels being significantly lower during the luteal phase. CONCLUSIONS:These data suggest that luteal phase HPA axis function is lower than in the follicular phase in premenopausal healthy women. This putative biological difference may be important for our understanding of the aetiopathogenesis of menstrually related mood change and neurocognitive disturbance.
journal_name
Psychol Medjournal_title
Psychological medicineauthors
Symonds CS,Gallagher P,Thompson JM,Young AHdoi
10.1017/s0033291703008535subject
Has Abstractpub_date
2004-01-01 00:00:00pages
93-102issue
1eissn
0033-2917issn
1469-8978journal_volume
34pub_type
临床试验,杂志文章,随机对照试验abstract:BACKGROUND:Pharmaceutical industry funding of psychiatric research has increased significantly in recent decades, raising the question of a relationship between pharmaceutical company funding of clinical psychiatric studies and the outcomes of those studies. This study examines this relationship. METHOD:Abstracts of a...
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更新日期:2015-06-01 00:00:00
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pub_type: 社论,评审
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更新日期:2009-06-01 00:00:00
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更新日期:1995-11-01 00:00:00
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更新日期:1998-01-01 00:00:00
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