Abstract:
:Photosynthesis-inhibiting phenylurea derivatives, such as diuron, are widely used as herbicides. Diuron concentrations clearly exceeding the predicted-no-effect concentration have been regularly measured in European freshwater systems. The frequently observed exposure to mixtures of phenylureas additionally increases the hazard to aquatic primary producers. Fluctuating numbers and concentrations of individual toxicants make experimental testing of every potential mixture unfeasible. Thus, predictive approaches to the mixture hazard assessment are needed. For this purpose, two concepts are at hand, both of which make use of known toxicities of the individual components but are based on opposite mechanistic suppositions: Concentration addition is based on the idea of similar mechanisms of action, whereas independent action assumes dissimilarly acting mixture components. On the basis of pharmacological reasoning, it was therefore anticipated that the joint algal toxicity of phenylurea mixtures would be predictable by concentration addition. Indeed, we could demonstrate a high predictive power of concentration addition for these combinations. Surprisingly, however, the opposite concept of independent action proved to be equally valid, because both concepts predicted virtually identical mixture toxicities. This exceptional case has previously been derived from theoretical considerations. Now, the tested phenylurea mixtures serve as an example for the practical relevance of this situation for multicomponent mixtures.
journal_name
Environ Toxicol Chemjournal_title
Environmental toxicology and chemistryauthors
Backhaus T,Faust M,Scholze M,Gramatica P,Vighi M,Grimme LHdoi
10.1897/02-497subject
Has Abstractpub_date
2004-02-01 00:00:00pages
258-64issue
2eissn
0730-7268issn
1552-8618journal_volume
23pub_type
杂志文章abstract::As contaminant exposures in aquatic ecosystems continue to increase, the need for streamlining research efforts in environmental toxicology using predictive frameworks also grows. One such framework is the adverse outcome pathway (AOP). An AOP framework organizes and utilizes toxicological information to connect measu...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.4757
更新日期:2020-08-01 00:00:00
abstract::Methylmercury is the predominant chemical form of mercury reported in the eggs of wild birds, and the embryo is the most sensitive life stage to methylmercury toxicity. Protective guidelines have been based mainly on captive-breeding studies with chickens (Gallus gallus), mallards (Anas platyrhynchos), and ring-necked...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/08-316.1
更新日期:2009-03-01 00:00:00
abstract::Significant amounts of soil contaminated with polychlorinated biphenyls (PCBs) were discovered at a military radar station in Saglek Bay, Labrador, Canada, in 1996. Subsequent work showed elevated PCB concentrations in local marine sediments, in the benthic-associated food web, and in some ringed seals (Pusa hispida)....
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.2468
更新日期:2014-03-01 00:00:00
abstract::Linear alkylbenzene sulfonates (LAS) can be found in high concentrations in sewage sludge and, hence, may enter the soil compartment as a result of sludge application. Here, LAS may pose a risk for soil-dwelling organisms. In the present probabilistic risk assessment, statistical extrapolation has been used to assess ...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/1551-5028(2001)020<1690:earaol>2.0.co;2
更新日期:2001-08-01 00:00:00
abstract::Ten agronomic plant species were exposed to different concentrations of nano-titanium dioxide (nTiO2 ) or nano-cerium oxide (nCeO2 ) (0 μg/mL, 250 μg/mL, 500 μg/mL, and 1000 μg/mL) to examine potential effects on germination and early seedling development. The authors modified a standard test protocol developed for so...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.3374
更新日期:2016-09-01 00:00:00
abstract::The assessment of chemicals as bioaccumulative in the regulatory process makes use of the bioconcentration factor as a metric. However, this metric does not account for the dietary uptake route and therefore cannot be applied to terrestrial food chains. In recent years, the biomagnification factor (BMF) and the trophi...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.2229
更新日期:2013-07-01 00:00:00
abstract::The present study examined the relative importance of copper (aqueous Cu and CuO particles of different sizes) added to sediment to determine the bioaccumulation, toxicokinetics, and effects in the deposit feeder Potamopyrgus antipodarum. In experiment 1, the bioaccumulation of Cu (240 µg Cu/g dry wt of sediment) adde...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.2216
更新日期:2013-07-01 00:00:00
abstract::The present study examined how subcellular partitioning of Cd in plants with different strategies to store and detoxify Cd may affect trophic transfer of Cd to the isopod Porcellio dilatatus. The plant species used were Lactuca sativa, a horticultural metal accumulator species; Thlaspi caerulescens, a herbaceous hyper...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/08-154.1
更新日期:2008-12-01 00:00:00
abstract::A market for bisphenol A (BPA) replacement compounds has emerged due to restrictions on the use of BPA. Some of these compounds were detected in the environment, yet little is known about their toxicological properties. In the present study, an avian in vitro toxicogenomic approach was used to compare the effects of f...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.4985
更新日期:2021-01-19 00:00:00
abstract::Exposures to either zinc or lead in contaminated sediments have been shown to induce characteristic deformities in larval chironomids. This study examined the effects of exposure to lead and zinc in combination on Chironomus tentans larvae. Proportions of mouthpart deformities in populations of larvae reared in sedime...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/02-512
更新日期:2004-03-01 00:00:00
abstract::Biodegradation of trichloroethylene (TCE) by toluene-degrading bacteria was measured under aerobic conditions in aqueous and soil-slurry batch microcosms. For soil-phase experiments, a freshly contaminated soil and a soil containing only the desorption-resistant fraction of TCE were tested. In both cases, presence of ...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:
更新日期:2002-08-01 00:00:00
abstract::The toxicities of chemical mixtures containing 10 compounds, detected in wastewater treatment plant (WWTP) effluents, were investigated using Daphnia magna in a two-step prediction (TSP) model. The 10 chemicals determined by gas chromatography/ mass spectrometry in WWTP effluents included three groups: Three acetylcho...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/05-484r.1
更新日期:2006-08-01 00:00:00
abstract::The toxic effects of cadmium (Cd) on the green alga Chlorella vulgaris were investigated by following the response to Cd of various toxicity endpoints (cell growth, cell size, photochemical efficiency of PSII in the light or Φ(PSII), maximal photochemical efficiency or Fv/Fm, chlorophyll a fluorescence, esterase activ...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.2362
更新日期:2013-12-01 00:00:00
abstract::Acute and chronic toxicity of high-grade chlordane (98%) and bioaccumulation were investigated in Daphnia magna at water soluble concentrations obtained without cosolvent. The measured effective concentrations immobilizing 50% of the microcrustacea (95% confidence interval) were 22.6 (19.7-26.1) microg/L at 24 h and 1...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/08-564.1
更新日期:2009-10-01 00:00:00
abstract::Non-anadromous forms of Arctic char (Salvelinus alpinus), those that are restricted to lakes and rivers, typically have higher mercury (Hg) concentrations than anadromous forms, which migrate to and from the sea. Using tissue burden data from the literature and our own analyses, we performed a screening-level risk ass...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.4341
更新日期:2019-03-01 00:00:00
abstract::In the present study, microbial community responses to exposure to unweathered Macondo Well crude oil and conventional diesel in a sandy beach environment were determined. Biodegradation was assessed in mesocosm experiments with differing fuel amounts (2,000 and 4,000 mg/kg) and with or without inorganic nutrient amen...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.1770
更新日期:2012-05-01 00:00:00
abstract::The trophic transfer of monoaromatic hydrocarbons to predatory organisms feeding upon contaminated marine animals is not well reported within the scientific literature. Branched alkylbenzenes (BABs) unresolved by gas chromatography have been reported to be principal toxic components of bioaccumulated hydrocarbons in t...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/08-298.1
更新日期:2009-02-01 00:00:00
abstract::Six-month-old lesser scaup (Aythya affinis) and nestling tree swallows (Tachycineta bicolor) were injected intraperitoneally with beta-naphthoflavone (BNF) in corn oil or in vehicle alone. Liver samples were taken and stored at -80 degrees C until microsome preparation and monooxygenase assay. Skin samples were placed...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/2605021.1
更新日期:2006-10-01 00:00:00
abstract::The recently reported quantification of the atmospheric sampling artifact for perfluorooctanoic acid (PFOA) was applied to existing gas and particle concentration measurements. Specifically, gas phase concentrations were increased by a factor of 3.5 and particle-bound concentrations by a factor of 0.1. The correlation...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.1932
更新日期:2012-09-01 00:00:00
abstract::As a persistent bioaccumulative compound, perfluorooctanoic acid (PFOA) is found in various ecosystems and receives growing attention. The acute toxicity of PFOA was tested on 2 freshwater microalgae, Chlamydomonas reinhardtii and Scenedesmus obliquus. The 96-h concentration for 50% of maximal effect (EC50) values wer...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.2532
更新日期:2014-05-01 00:00:00
abstract::Urban stormwater is an important but incompletely characterized contributor to surface-water toxicity. The present study used 5 bioassays of 2 model organisms (Daphnia magna and fathead minnow, Pimephales promelas) to investigate stormwater toxicity and mitigation by full-scale iron-enhanced sand filters (IESFs). Stor...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.4227
更新日期:2018-10-01 00:00:00
abstract::Demographic methods can translate toxicant effects on individuals into consequences for populations. To date few such studies have been conducted with longer-lived invertebrates. This is because full life-cycle experiments are difficult with such species. Here we report the effects of copper and cadmium on the key dem...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:
更新日期:2003-07-01 00:00:00
abstract::The current study describes the effect of cypermethrin, fluoxetine, and thiabendazole, at environmentally relevant concentrations, on the expression of heat shock protein 70 (HSP70) and interleukin 1β (IL-1β), using Xenopus laevis larvae as animal model. Cytokines and interleukins are considered good predictors of the...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.313
更新日期:2010-11-01 00:00:00
abstract::Microplastics are emerging threat contaminants that have been shown to provide toxic pollutants, either from the environment or from their inherent toxic monomers and additives, a pathway into the aquatic food web. In the present study, the occurrence, abundance, and composition of microplastic load in the surface wat...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.4677
更新日期:2020-04-01 00:00:00
abstract::Field populations of aquatic organisms, particularly those inhabiting flowing waters, likely are exposed to short pulses of pesticides following periods of spray drift, surface runoff, or drain flow. In the present study, we investigated the effect of pulse exposures of a pyrethroid insecticide, esfenvalerate, on surv...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/03-547.1
更新日期:2005-01-01 00:00:00
abstract::Multispecies stream microcosms were used to test the toxicity of the pyrethroid fenvalerate (FV) associated with suspended particles in order to simulate a typical runoff exposure scenario. Stream microcosms were exposed for 1 h in triplicate to 0.0, 13.6, 136, or 1,365 microg/kg FV and effects were monitored for 93 d...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/1551-5028(2001)020<0757:rswpbf>2.0.co;2
更新日期:2001-04-01 00:00:00
abstract::The octanol-water partioning of inorganic mercury decreased with increasing sulfide, supporting a model that predicts decreased fractions of neutral Hg-S species with increasing sulfide. These results help explain the decreased availability of Hg to methylating bacteria under sulfidic conditions, and the inverse relat...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.5620181004
更新日期:1999-10-01 00:00:00
abstract::Mercury (Hg) stable isotope analysis is an emerging technique that has contributed to a better understanding of many aspects of the biogeochemical cycling of Hg in the environment. However, no study has yet evaluated its usefulness in elucidating the sources of methylmercury (MeHg) in songbird species, a common organi...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.3941
更新日期:2018-01-01 00:00:00
abstract::Nitrogen, sulfur, or oxygen heterocyclic aromatic hydrocarbons (NSO-HETs) and short-chained alkyl phenols (SCAPs) are commonly detected in groundwater at contaminated sites and in the surrounding environment. It is now scientific consensus that these chemicals pose a risk to human and ecosystem health. However, toxici...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.4423
更新日期:2019-06-01 00:00:00
abstract::This study evaluated the effects of dietary methylmercury (MeHg) on immune system development in captive-reared nestling American kestrels (Falco sparverius) to determine whether T cell-mediated and antibody-mediated adaptive immunity are targets for MeHg toxicity at environmentally relevant concentrations. Nestlings ...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.519
更新日期:2011-06-01 00:00:00