Abstract:
:The current study describes the effect of cypermethrin, fluoxetine, and thiabendazole, at environmentally relevant concentrations, on the expression of heat shock protein 70 (HSP70) and interleukin 1β (IL-1β), using Xenopus laevis larvae as animal model. Cytokines and interleukins are considered good predictors of the immunotoxic potential of xenobiotics. Tadpoles at stage 47 (normal tables of X. laevis) were exposed under static conditions to: 0.3 and 30 µg/L fluoxetine, 0.7 µg/L thiabendazole, and 0.24 µg/L cypermethrin. The effects were evaluated at 7, 24, and 72 h, and 6 and 9 d. Randomly chosen tadpoles were used as genetic material for detection of hsp70 and IL-1β mRNA induction through reverse transcription PCR. Tadpoles exposed to 30 µg/L fluoxetine showed mRNA expression of both genes at all exposure times, whereas at 0.3 µg/L a peak response for hsp70 was observed after 24 h, and the increase in IL-1β mRNA was statistically significant with respect to the control 72 h after exposure. Thiabendazole induced a high expression of mRNA for both hsp70 and IL-1β at all exposure times. Cypermethrin increased the hsp70 mRNA levels, with a peak at 24 h, and provoked high expression of IL-1β mRNA at all exposure times. Considering the relationship between HSP70 and IL-1β and their involvement (mainly of IL-1β) in immune responses, certain changes observed in their expression could be considered warning indicators of potential immunotoxic effects of these substances on Xenopus.
journal_name
Environ Toxicol Chemjournal_title
Environmental toxicology and chemistryauthors
Martini F,Fernández C,Segundo LS,Tarazona JV,Pablos MVdoi
10.1002/etc.313subject
Has Abstractpub_date
2010-11-01 00:00:00pages
2536-43issue
11eissn
0730-7268issn
1552-8618journal_volume
29pub_type
杂志文章abstract::Laboratory bioassays were conducted to evaluate the effects on honeybee behavior of sublethal doses of insecticides chronically administered orally or by contact. Emergent honeybees received a daily dose of insecticide ranging from one-fifth to one-five-hundredth of the median lethal dose (LD50) during 11 d. After exp...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/08-110.1
更新日期:2009-01-01 00:00:00
abstract::Fluorotelomer carboxylic acids (FTCAs) and the corresponding unsaturated acids (FTUCAs) are known intermediates in the biodegradation of industrially produced fluorotelomer alcohols (FTOHs) to environmentally persistent perfluorinated carboxylic acids (PFCAs). The FTCAs and FTUCAs are of concern for their toxicity, re...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.211
更新日期:2010-08-01 00:00:00
abstract::As contaminant exposures in aquatic ecosystems continue to increase, the need for streamlining research efforts in environmental toxicology using predictive frameworks also grows. One such framework is the adverse outcome pathway (AOP). An AOP framework organizes and utilizes toxicological information to connect measu...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.4757
更新日期:2020-08-01 00:00:00
abstract::Aluminum (Al) toxicity to aquatic organisms is strongly affected by water chemistry. Toxicity-modifying factors such as pH, dissolved organic carbon (DOC), hardness, and temperature have a large impact on the bioavailability and toxicity of Al to aquatic organisms. The importance of water chemistry on the bioavailabil...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.4020
更新日期:2018-01-01 00:00:00
abstract::Since the early 2000s, biotic ligand models and related constructs have been a dominant paradigm for risk assessment of aqueous metals in the environment. We critically review 1) the evidence for the mechanistic approach underlying metal bioavailability models; 2) considerations for the use and refinement of bioavaila...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章,评审
doi:10.1002/etc.4560
更新日期:2020-01-01 00:00:00
abstract::Acute and chronic toxicity of eight agricultural adjuvants (Bond, Kinetic, Plyac, R-11, Silwet L-77, Sylgard 309, X-77, and WaterMaxx) to Daphnia pulex were evaluated with 48-h acute lethal concentration estimates (LC50) and a 10-d population growth-rate measurement, the instantaneous rate of increase (r1). Based on L...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/02-504
更新日期:2003-12-01 00:00:00
abstract::An increased demand for chemical toxicity evaluations has resulted in the need for alternative testing strategies that address animal welfare concerns. The fish embryo toxicity (FET) test developed for zebrafish (Danio rerio) is one such alternative, and the application of the FET test to other species such as the fat...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.2718
更新日期:2014-11-01 00:00:00
abstract::Fluvalinate has been extensively used in the United States to combat honey bee colony loss due to Varroa destructor mites. Our objectives were to investigate the extent of fluvalinate contamination in commercially available wax and to define exposure pathways to larval and adult honey bees. All the commercial wax test...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.4427
更新日期:2019-06-01 00:00:00
abstract::Urban stormwater is an important but incompletely characterized contributor to surface-water toxicity. The present study used 5 bioassays of 2 model organisms (Daphnia magna and fathead minnow, Pimephales promelas) to investigate stormwater toxicity and mitigation by full-scale iron-enhanced sand filters (IESFs). Stor...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.4227
更新日期:2018-10-01 00:00:00
abstract::Mining of the world's second-largest nickel deposits in the area of Sudbury, Ontario, Canada, has caused acidification and metal saturation of some catchments. We conducted artificial stream studies in the years 2001 and 2002 to assess the effects of treated metal mine effluents (MMEs) from three different mining oper...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/04-116r.1
更新日期:2006-01-01 00:00:00
abstract::Acute and chronic bioassays were used to evaluate the lethal and sublethal effects of copper chloride and tributyltin chloride on mahi mahi (Coryphaena hippurus) embryos, a pelagic life stage often found in the surface microlayer where anthropogenic contaminants can accumulate. Acute bioassay testing determined the me...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/07-369.1
更新日期:2008-10-01 00:00:00
abstract::Many chemicals have recently been demonstrated to possess estrogenic activity and may potentially interfere with normal sexual development. In the present study, we quantified the effects of waterborne exposure to 17beta-estradiol on the gonopodial development and sexual activity of male eastern mosquitofish (Gambusia...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:
更新日期:2002-12-01 00:00:00
abstract::Polychlorinated biphenyls (PCBs), including coplanar congeners, hexachlorocyclohexane isomers, chlordane-related compounds, and hexachlorobenzene, were found in the breast muscle of Steller's sea eagles (SSE) and white-tailed sea eagles (WSE) threatened species, collected in Hokkaido, Japan, during the two years from ...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/1551-5028(2002)021<0842:apopbc>2.0.co;2
更新日期:2002-04-01 00:00:00
abstract::A new short life-cycle test methodology is presented to evaluate sublethal effects of contaminated sediments to the harpacticoid copepod species Nitocra spinipes. The method combines a 4-d survival-gravidity test with a 7-d development test. For water-only Cu exposures, the sensitivity of the development test endpoint...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.513
更新日期:2011-06-01 00:00:00
abstract::A study of the ecotoxicity of different short aliphatic protic ionic liquids (PILs) on terrestrial organisms was conducted. Tests performed within the present study include those assessing the effects of PILs on soil microbial functions (carbon and nitrogen mineralization) and terrestrial plants. The results show that...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.683
更新日期:2011-12-01 00:00:00
abstract::Photosynthesis-inhibiting phenylurea derivatives, such as diuron, are widely used as herbicides. Diuron concentrations clearly exceeding the predicted-no-effect concentration have been regularly measured in European freshwater systems. The frequently observed exposure to mixtures of phenylureas additionally increases ...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/02-497
更新日期:2004-02-01 00:00:00
abstract::The environmental prevalence of engineered nanomaterials, particularly nanoparticulate silver (AgNP), is expected to increase substantially. The ubiquitous use of commercial products containing AgNP may result in their release to the environment, and the potential for ecological effects is unknown. Detecting engineere...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.719
更新日期:2012-01-01 00:00:00
abstract::Herbicide drift may cause adverse effects on natural and semi-natural plant communities, and it has been debated whether the current ecological risk assessments are adequate to protect non-target terrestrial plant species (NTTP). In this study, nine NTTPs with different lifespans (three annual/ six perennial) belongin...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.4992
更新日期:2021-01-25 00:00:00
abstract::Metal cation toxicity to basidiomycete fungi is poorly understood, despite its well-known importance in terrestrial ecosystems. Moreover, there is no reported methodology for the routine evaluation of metal toxicity to basidiomycetes. In the present study, we describe the development of a procedure to assess the acute...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.42
更新日期:2010-02-01 00:00:00
abstract::Vitellogenin (VTG) induction has proved to be a valuable biomarker for assessing exposure to environmental estrogens in fish. The widespread use of VTG in this regard has lead to the need for standardized assays to quantify VTG, and monoclonal antibodies have the potential to help accomplish this. A VTG enzyme-linked ...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:
更新日期:2002-01-01 00:00:00
abstract::The U.S. National Institute of Standards and Technology (NIST) petroleum crude oil was used to generate NIST water-accommodated hydrocarbon fractions (WAFs) for standardized assessment of crude oil effects on the copepod Amphiascus tenuiremis. Effects were assessed using a 96-well microplate, full life-cycle test. Bri...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/05-365r.1
更新日期:2006-07-01 00:00:00
abstract::The use of aqueous film-forming foam (AFFF) has resulted in the widespread occurrence of per- and polyfluoroalkyl substances (PFAS) in groundwater, drinking water, soils, sediments, and receiving waters throughout the United States and other countries. We present the research and development efforts to date by the Str...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.4894
更新日期:2021-01-01 00:00:00
abstract::Marine sediments accumulate a variety of contaminants and, in some cases, demonstrate toxicity because of this contamination. Toxicity identification evaluation (TIE) methods provide tools for identifying the toxic chemicals causing sediment toxicity. Currently, whole-sediment TIE methods are not available for anionic...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/06-014r.1
更新日期:2007-01-01 00:00:00
abstract::Soot, soot-amended sediment, and unamended sediment spiked with hydrophobic organic contaminants (HOC) were subjected to laboratory desorption and assimilation efficiency experiments in an effort to assess and compare the importance of soot in controlling HOC desorption and deposit-feeder assimilation efficiency. Thre...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/03-351a
更新日期:2004-11-01 00:00:00
abstract::Multispecies stream microcosms were used to test the toxicity of the pyrethroid fenvalerate (FV) associated with suspended particles in order to simulate a typical runoff exposure scenario. Stream microcosms were exposed for 1 h in triplicate to 0.0, 13.6, 136, or 1,365 microg/kg FV and effects were monitored for 93 d...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/1551-5028(2001)020<0757:rswpbf>2.0.co;2
更新日期:2001-04-01 00:00:00
abstract::Most of the public literature and available guidance documents on the conduct of freshwater whole-sediment toxicity identification and evaluations (TIEs) detail the use of test organisms and amending agents that are readily available in North America. These commonly used test organisms and the supported amending agent...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.3787
更新日期:2017-09-01 00:00:00
abstract::Radiotracer experiments were conducted to examine the influence of the concentration of Cd, Se, and Zn in ingested phytoplankton (dinoflagellate Prorocentrum minimum and diatom Thalassiosira weissflogii) and in ambient seawater on metal assimilation and elimination efficiencies of three marine copepods, Acartia spinic...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:
更新日期:2001-05-01 00:00:00
abstract::In tissues of freshwater fish-feeding mammals, 3,4-didehydroretinol (A2) is a major form of vitamin A. In mink liver, with organochlorine exposure, this analog has been found to decrease more than retinol (A1) and thus has potential as a sensitive freshwater biomarker. The presence of the analogs A1 and A2 as alcohol ...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:
更新日期:2002-02-01 00:00:00
abstract::Juvenile chinook salmon (Oncorhynchus tschawytscha) were fed a mixture of 14 polycyclic aromatic hydrocarbon (PAH) compounds that reflected the PAH composition of salmon stomach contents in an urban estuary of Puget Sound, Washington (USA). Following a 28-d dietary exposure, a standardized Listonella anguillarum chall...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1897/02-561
更新日期:2003-12-01 00:00:00
abstract::Treatment of municipal wastewater reduces the concentrations of some pharmaceuticals and personal care products (PPCPs), hormones, and drugs of abuse. However, reduced concentrations of these micropollutants in wastewater may not correlate with reduced toxicity because transformations of micropollutants and/or the for...
journal_title:Environmental toxicology and chemistry
pub_type: 杂志文章
doi:10.1002/etc.3939
更新日期:2018-01-01 00:00:00