Abstract:
:Recent studies on the molecular mechanisms controlling the mammalian cell cycle have disclosed a large family of cdc2-related serine/threonine kinases. Among this gene family, the PCTAIRE protein kinases comprise a distinct subfamily of unknown cellular function. To analyze the genomic structure and chromosomal location of the PCTAIRE-1 and -3 genes, we isolated human cosmid clones for each gene by screening a human genomic library with murine PCTAIRE cDNA probes. Overlapping clones encompassing approximately 60 kb of genomic DNA were obtained for both PCTAIRE-1 and -3. These clones were confirmed to encode authentic PCTAIRE genes by the detection of exon-intron structures and the coincidence of the nucleotide sequence of exons to that of the published human cDNAs. Using these cosmid clones as probes for FISH analyses, the chromosomal loci for PCTAIRE-1 and PCTAIRE-3 were assigned to bands Xp11 and 1q31-q32, respectively.
journal_name
Genomicsjournal_title
Genomicsauthors
Okuda T,Valentine VA,Shapiro DN,Downing JRdoi
10.1006/geno.1994.1245subject
Has Abstractpub_date
1994-05-01 00:00:00pages
217-21issue
1eissn
0888-7543issn
1089-8646pii
S0888-7543(84)71245-6journal_volume
21pub_type
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