Abstract:
:Amyloid beta protein (beta A4), the major component of the core of amyloid plaques in Alzheimer disease, is derived from the transmembrane amyloid precursor proteins (APPs). Our recent studies showed that a murine member of the evolutionarily conserved APP family, amyloid precursor-like protein 1 (APLP1), is specifically localized to the cerebral cortex postsynaptic density and may thus participate in brain synaptic function. To investigate regulatory mechanisms of APLP1 synthesis at the genomic level, we isolated and characterized genomic clones containing the mouse APLP1 gene. Sequence analysis revealed a genomic structure consisting of 17 exons and a promoter region that is devoid of apparent TATA and CCAAT boxes. The 5' region contains putative binding sites for AP-1, heat-shock protein, and Sp1, suggesting that multiple elements are potentially involved in regulating transcription of the APLP1 gene.
journal_name
Genomicsjournal_title
Genomicsauthors
Zhong S,Wu K,Black IB,Schaar DGdoi
10.1006/geno.1996.0096subject
Has Abstractpub_date
1996-02-15 00:00:00pages
159-62issue
1eissn
0888-7543issn
1089-8646pii
S0888-7543(96)90096-8journal_volume
32pub_type
杂志文章相关文献
GENOMICS文献大全abstract::Sperm motility is one of the most important indicators to evaluate poultry fertility. In order to explore key molecular regulation roles related to sperm motility, we employed testicular RNA sequencing of pigeon. A total of 705 known and 385 novel microRNAs were identified. Compared with the low sperm motility group, ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.12.024
更新日期:2021-01-01 00:00:00
abstract::Human/rodent somatic cell hybrids have been exceedingly useful in assigning human genes and DNA sequences to specific human chromosomes. As new technologies for analyzing the human chromosome complement of such human/rodent hybrid cells become available, it is of critical importance that these be applied to enhance ch...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1993.1026
更新日期:1993-01-01 00:00:00
abstract::We used targeted exon trapping to clone portions of genes from human chromosome 21q22.3. One trapped sequence showed complete homology with the cDNA of human U2AF35 (M96982; HGM-approved nomenclature U2AF1), which encodes for the small 35-kDa subunit of the U2 snRNP auxiliary factor. Using the U2AF1 cDNA as a probe, w...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1996.0196
更新日期:1996-04-15 00:00:00
abstract::A comparison study of short SAGE versus GeneChip and long SAGE was conducted to determine if data were interchangeable between the techniques. Although SAGE and Affymetrix chip expression levels showed a significant correlation using the set of genes for which there was reliable and unambiguous mapping from tag-to-gen...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2004.06.014
更新日期:2004-10-01 00:00:00
abstract::A linkage analysis with 12 DNA markers from proximal 19q was performed in eight families with central core disease (CCO). Two-point analysis gave a peak lod score of Z = 4.95 at theta = 0.00 for the anonymous marker D19S190 and of Z = 2.53 at theta = 0.00 for the ryanodine receptor (RYR1) candidate gene. Multipoint li...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1993.1302
更新日期:1993-07-01 00:00:00
abstract::Fibulin-2 is a new extracellular matrix protein that we recently identified by characterizing mouse cDNA clones. Fibulin-2 mRNA is prominently expressed in mouse heart tissue and is present in low amounts in other tissues. In this study, we isolated and sequenced a 4.1-kb human fibulin-2 cDNA, which encoded a mature p...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1994.1404
更新日期:1994-07-15 00:00:00
abstract::To facilitate the practical application of highly efficient semiautomated methods for general application in genomic analyses, we have developed a fluorescence-based microsatellite marker resource. Ninety highly polymorphic microsatellite markers were combined to provide a rapid, accurate, and highly efficient initial...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1994.1628
更新日期:1994-11-15 00:00:00
abstract::A genetic basis for neural tube defects (NTD) is rarely doubted, but the genes involved have not yet been identified. This is partly due to a lack of suitable families on which to perform linkage analysis. An alternative approach is to use the many mouse genes that cause NTD as a means of isolating their human homolog...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(95)80165-i
更新日期:1995-04-10 00:00:00
abstract::Aldose reductase (alditol:NAD(P)+ 1-oxidoreductase; EC 1.1.1.21) (AR) catalyzes the reduction of several aldehydes, including that of glucose, to the corresponding sugar alcohol. Using a complementary DNA clone encoding human AR, we mapped the gene sequences to human chromosomes 1, 3, 7, 9, 11, 13, 14, and 18 by somat...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1993.1372
更新日期:1993-09-01 00:00:00
abstract::The use of round spermatids that are fully active at the transcriptional level to create zygotes (i.e. round spermatid injection; ROSI) raises the question regarding the downregulation of all specific genes that are transcribed from the paternal genome at fertilization. In this study, we show that protamine 1 and 2 mR...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2007.12.004
更新日期:2008-05-01 00:00:00
abstract::Fibrillin-1 is a large cysteine-rich glycoprotein of the 10-nm microfibrils in the extracellular matrix. A spectrum of mutations in the fibrillin-1 gene (FBN1) have been identified in patients with Marfan syndrome (MFS), and the majority of mutations resulting in the neonatal and often lethal form of MFS have been ide...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1996.0492
更新日期:1996-09-15 00:00:00
abstract::Interspersed repetitive sequence (IRS) PCR and repetitive element-to-bubble (IRS-bubble) PCR have been utilized to rapidly generate large numbers of mouse-specific, chromosome 1-enriched STSs from mouse-hamster somatic cell hybrids. Single-strand conformational polymorphism (SSCP) has been used to localize 39 new repe...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/s0888-7543(11)80007-8
更新日期:1993-12-01 00:00:00
abstract::Microcell hybrids containing various regions of human chromosome 8 were formed by microcell-mediated transfer of neo-tagged chromosome 8 into the cells derived from severe combined immunodeficiency (SCID) mouse. Thus, 110 cosmid markers were isolated from SV40-transformed SCID fibroblast cell line (SCVA) containing a ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1995.1125
更新日期:1995-07-20 00:00:00
abstract::Paulownia tomentosa is an important foundation forest tree species in semiarid areas. The lack of genetic information hinders research into the mechanisms involved in its response to abiotic stresses. Here, short-read sequencing technology (Illumina) was used to de novo assemble the transcriptome on P. tomentosa. A to...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2014.08.008
更新日期:2014-10-01 00:00:00
abstract::The desmogleins, together with the desmocollins, both members of the cadherin superfamily, are the adhesive proteins of the desmosome type of cell junction, characteristically found in epithelial cells. Three different human desmoglein isoforms are encoded by separate genes (DSG1, DSG2, and DSG3) located on chromosome...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(95)80067-v
更新日期:1995-01-20 00:00:00
abstract::The cerebral cortex is a tissue with a high degree of neuronal diversity. It consists of six cell layers with a unique set of neuronal subtypes. A crucial step in the process of cortical differentiation is the transition from a mitotically active neuroblast to a postmitotic young neuron. To identify genes involved in ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2002.6796
更新日期:2002-07-01 00:00:00
abstract::To resolve a candidate chromosome region on the middle part of bovine chromosome 6 (BTA6) containing several different quantitative trait locus (QTL) intervals, we constructed a high-resolution, integrated, comprehensive, and comparative map using a 12,000-rad, whole-genome, cattle-hamster radiation hybrid (RH) panel....
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2002.6778
更新日期:2002-06-01 00:00:00
abstract::Ciliary neurotrophic factor (CNTF) has recently been found to be important for the survival of motor neurons and has shown activity in animal models of amyotrophic lateral sclerosis (ALS). CNTF therefore holds promise as a treatment for ALS, and it and its receptor (CNTFR) are candidates for a gene involved in familia...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1993.1409
更新日期:1993-09-01 00:00:00
abstract::The human lymphoid cell activation antigen CD39 is a known E-type apyrase that hydrolyzes extracellular ATP and ADP, a function important in homotypic adhesion, platelet aggregation, and removal by activated lymphocytes of the lytic effect of ATP. The recently identified putative rat homologue of CD39L1 has been shown...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1998.5317
更新日期:1998-06-15 00:00:00
abstract::In an attempt to identify the genetic basis for susceptibility to non-insulin-dependent diabetes mellitus within the context of obesity, we generated 401 genetically obese Leprfa/Leprfa F2 WKY13M intercross rats that demonstrated wide variation in multiple phenotypic measures related to diabetes, including plasma gluc...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1997.4672
更新日期:1997-05-01 00:00:00
abstract::A somatic cell hybrid panel, consisting of 25 cell lines, has been developed to localize loci subregionally on chromosome 22. Over 300 markers in the form of STSs or hybridization probes have been assigned to one of 24 unique regions or "bins" using this panel. This ordered collection of markers will aid in the assemb...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1996.0358
更新日期:1996-07-15 00:00:00
abstract::In the past decades, the rapid growth of computer and database technologies has led to the rapid growth of large-scale medical datasets. On the other, medical applications with high dimensional datasets that require high speed and accuracy are rapidly increasing. One of the dimensionality reduction approaches is featu...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.07.027
更新日期:2020-11-01 00:00:00
abstract::The human XPF protein, an endonuclease subunit essential for DNA excision repair, may also function in homologous recombination. To investigate a possible link between mammalian XPF and recombination that occurs during meiosis, we isolated, characterized, and determined an expression profile for the mouse Xpf gene. Th...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1999.6016
更新日期:1999-12-15 00:00:00
abstract::Despite the broad variety of available microRNA (miRNA) prediction tools, their application to the discovery and annotation of novel miRNA genes in domestic species is still limited. In this study we designed a comprehensive pipeline (eMIRNA) for miRNA identification in the yet poorly annotated porcine genome and demo...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2019.12.005
更新日期:2020-05-01 00:00:00
abstract::The genes for type XIII collagen (COL13A1) and prolyl 4-hydroxylase (P4HA) were previously assigned to human chromosome 10q by radioactive in situ hybridization. Here we have applied fluorescence in situ hybridization combined with targets representing different levels of resolution to determine, first, the order of t...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1997.5015
更新日期:1997-12-01 00:00:00
abstract::Through its three operating programs, the Howard Hughes Medical Institute has supported a substantial amount of basic and clinical molecular research, has acted as a facilitator in initiating and funding a number of meetings, nationally and internationally, including work groups dealing with databases, and has support...
journal_title:Genomics
pub_type: 历史文章,杂志文章
doi:10.1016/0888-7543(89)90141-9
更新日期:1989-11-01 00:00:00
abstract::Pulsed-field gel electrophoresis and flow dot-blot analysis have been used to construct a physical map of the q32-q34 region of chromosome 9, where one of the loci responsible for tuberous sclerosis (TSC1) has been mapped by genetic linkage. Five linked groups of markers have been defined by pulsed-field gel electroph...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1993.1056
更新日期:1993-02-01 00:00:00
abstract::We have mapped the mouse protein tyrosine phosphatase epsilon (PTP epsilon, gene symbol Ptpre) gene to the distal region of chromosome 7 by linkage analysis using two sets of multilocus genetic crosses. The human PTP epsilon gene (gene symbol PTPRE) was mapped to chromosome 10q26 by fluorescence in situ hybridization....
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1996.0061
更新日期:1996-02-01 00:00:00
abstract::Pulmonary surfactant consists of a complex mixture of phospholipids and several proteins essential to normal respiratory function. Two of the surfactant proteins, SP-A and SP-D, appear to have lectin-like activity relevant to the local phagocytic defense. Using polymerase chain reaction (PCR)-based somatic cell hybrid...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1993.1324
更新日期:1993-08-01 00:00:00
abstract::PCR primers specific to the human liver fructose-1,6-bisphosphatase (FBP) gene were designed and used to isolate a cosmid clone. Physical mapping of the FBP cosmid by FISH, and genetic mapping of an associated GA repeat polymorphism (PIC = 0.35), located the liver FBP gene to chromosome 9q22.3 with no recombination be...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1995.1230
更新日期:1995-09-01 00:00:00