Abstract:
:To determine the rate at which IS6110 restriction fragment length polymorphism (RFLP) patterns in Mycobacterium tuberculosis change over time, we applied a smooth nonparametric survival model to several data sets, including data from previous publications on the rate of change. The results strongly suggest a simple parametric model, with an instantaneous change at time zero and essentially a zero rate of change thereafter. Our interpretation of the results is that at the time of collection of the first isolate, more than one strain is present. We speculate that the selection of mutant strains is most likely during rapid growth, revival of the dormant bacteria, and/or adaptation to a new host. The parameter most accurately describing changing RFLP patterns is the proportion of isolates with band changes, rather than the half-life or the rate of change.
journal_name
J Clin Microbioljournal_title
Journal of clinical microbiologyauthors
Eilers PH,Van Soolingen D,Thi Ngoc Lan N,Warren RM,Borgdorff MWdoi
10.1128/JCM.42.6.2461-2464.2004subject
Has Abstractpub_date
2004-06-01 00:00:00pages
2461-4issue
6eissn
0095-1137issn
1098-660Xpii
42/6/2461journal_volume
42pub_type
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