Abstract:
:Clostridium hathewayi is a newly described Clostridium species isolated from the feces of healthy human individuals, but its clinical significance is not known. We describe a case of human infection associated with C. hathewayi. The bacterium (strain HKU18) was isolated from the blood culture of a 39-year-old patient with acute gangrenous appendicitis complicated by septic shock. The cells were strictly anaerobic, nonmotile rods that stained gram negative. Conventional phenotypic tests and commercial identification systems failed to identify HKU18 to the species level. 16S rRNA gene analysis showed 1.4% nucleotide difference between the sequence of HKU18 and that of C. hathewayi, indicating that HKU18 was a strain of C. hathewayi. The patient responded to appendectomy and antibiotic treatment. 16S rRNA gene sequencing would be useful in further characterizing the clinical disease spectrum of C. hathewayi.
journal_name
J Clin Microbioljournal_title
Journal of clinical microbiologyauthors
Woo PC,Lau SK,Woo GK,Fung AM,Yiu VP,Yuen KYdoi
10.1128/JCM.42.12.5947-5949.2004subject
Has Abstractpub_date
2004-12-01 00:00:00pages
5947-9issue
12eissn
0095-1137issn
1098-660Xpii
42/12/5947journal_volume
42pub_type
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