Mutation in enterovirus 71 capsid protein VP1 confers resistance to the inhibitory effects of pyridyl imidazolidinone.

abstract：:The repurposing of existing drugs is being pursued as a means by which to accelerate the development of novel regimens for the treatment of drug-susceptible and drug-resistant tuberculosis (TB). In the current study, we assessed the activity of the antipsychotic drug thioridazine (TRZ) in combination with the standard...

journal_title：Antimicrobial agents and chemotherapy

authors： Dutta NK,Pinn ML,Karakousis PC

更新日期：2014-07-01 00:00:00

abstract：:Ramoplanin is an actinomycetes-derived antibiotic with broad-spectrum activity against Gram-positive bacteria that has been evaluated in clinical trials for the treatment of gastrointestinal vancomycin-resistant enterococci (VRE) and Clostridium difficile infections. Recent studies have proposed that ramoplanin binds ...

journal_title：Antimicrobial agents and chemotherapy

authors： Cheng M,Huang JX,Ramu S,Butler MS,Cooper MA

更新日期：2014-11-01 00:00:00

abstract：:There are currently few or no published data on the amount of cerebrospinal fluid (CSF) penetration of daptomycin in patients with suspected or documented neurosurgical infections. We conducted a prospective study, assessing the pharmacokinetics and CSF penetration of a single intravenous daptomycin dose administered ...

journal_title：Antimicrobial agents and chemotherapy

authors： Kullar R,Chin JN,Edwards DJ,Parker D,Coplin WM,Rybak MJ

更新日期：2011-07-01 00:00:00

abstract：:Disinfectant-tolerant Listeria monocytogenes biofilms can colonize surfaces that come into contact with food, leading to contamination and, potentially, food-borne illnesses. To better understand the process of L. monocytogenes biofilm formation and dispersal, we screened 1,120 off-patent FDA-approved drugs and identi...

journal_title：Antimicrobial agents and chemotherapy

authors： Nguyen UT,Harvey H,Hogan AJ,Afonso AC,Wright GD,Burrows LL

更新日期：2014-11-01 00:00:00

abstract：:The distribution of subclasses mefA and mefE of the mefA gene among 116 M-phenotype streptococci was as follows: pneumococci (38 strains had mefE and 4 mefA), viridans streptococci (49 mefE and 1 mefA), and Streptococcus pyogenes (24 mefA). Spain(9V)-3-14 and England(14)-9 clones of serotype 14 were dominant among pne...

journal_title：Antimicrobial agents and chemotherapy

authors： Ardanuy C,Tubau F,Liñares J,Domínguez MA,Pallarés R,Martín R,Spanish Pneumococcal Infection Study Network (G03\/103).

更新日期：2005-02-01 00:00:00

abstract：:Conventional therapy for human cytomegalovirus (CMV) relies on inhibition of the viral DNA polymerase. Ganciclovir (GCV) is the first-line therapy, but when GCV-resistant strains emerge, alternative therapies are extremely limited and are associated with significant toxicities. Combination of anti-CMV agents that act ...

journal_title：Antimicrobial agents and chemotherapy

authors： Cai H,Kapoor A,He R,Venkatadri R,Forman M,Posner GH,Arav-Boger R

更新日期：2014-01-01 00:00:00

abstract：:A multi-center study of 1,838 clinical isolates established the accuracy of diffusion susceptibility tests with 30-mug cephalothin disks and 30-mug cefamandole disks. The same interpretive zone standards can be applied to tests with either disk but the two drugs cannot be tested interchangeably. ...

journal_title：Antimicrobial agents and chemotherapy

authors： Barry AL,Schoenknecht FD,Shadomy S,Sherris JC,Thornsberry C,Washington JA,Kammer RB

更新日期：1979-01-01 00:00:00

abstract：:Rezafungin is a new long-acting echinocandin currently in phase 3 development. Epidemiological cutoff values are necessary for breakpoint setting but have not been established due to unexplained interlaboratory MIC variations observed in a prior multicenter study. Here we investigated if the choice of microtiter plate...

journal_title：Antimicrobial agents and chemotherapy

authors： Arendrup MC,Jørgensen KM,Hare RK,Cuenca-Estrella M,Zaragoza O

更新日期：2019-08-23 00:00:00

abstract：:A total of 295 ceftiofur-resistant Escherichia coli isolates were obtained from 489 cloacal samples collected at five different Belgian broiler farms with the aim to evaluate the diversity of this resistance at the farm level. Strains were examined for resistance against beta-lactam antibiotics and other antimicrobial...

journal_title：Antimicrobial agents and chemotherapy

authors： Smet A,Martel A,Persoons D,Dewulf J,Heyndrickx M,Catry B,Herman L,Haesebrouck F,Butaye P

更新日期：2008-04-01 00:00:00

abstract：:Pseudomonas aeruginosa is inherently resistant to most conventional antibiotics. The mechanism of resistance of this bacterium is mainly associated with the low permeability of its outer membrane to these agents. We sought to assess the bactericidal efficacy of liposome-entrapped aminoglycosides against resistant clin...

journal_title：Antimicrobial agents and chemotherapy

authors： Mugabe C,Halwani M,Azghani AO,Lafrenie RM,Omri A

更新日期：2006-06-01 00:00:00

abstract：:The therapeutic activity of ciprofloxacin, enoxacin, and ofloxacin was evaluated in guinea pigs with acute and chronic experimental Pseudomonas aeruginosa pneumonia. Intratracheal instillations of P. aeruginosa resulted in fatal pneumonia in all untreated animals within 36 h. Among treatment groups (80 mg/kg [body wei...

journal_title：Antimicrobial agents and chemotherapy

authors： Kemmerich B,Small GJ,Pennington JE

更新日期：1986-03-01 00:00:00

abstract：:Infections due to methicillin-resistant Staphylococcus aureus (MRSA) are an important cause of morbidity and mortality in hospital patients. Moreover, increased incidences of outpatient MRSA have been recently reported. This study investigated the bactericidal activity of dalbavancin, a novel, semisynthetic glycopepti...

journal_title：Antimicrobial agents and chemotherapy

authors： Jabés D,Candiani G,Romanó G,Brunati C,Riva S,Cavaleri M

更新日期：2004-04-01 00:00:00

abstract：:The 4,6-disubstituted 2-deoxystreptamines interfere with protein biosynthesis by specifically targeting the ribosomal A site. These drugs show subtle variations in the chemical groups of rings I, II, and III. In the present study we used site-directed mutagenesis to generate mutant strains of Mycobacterium smegmatis m...

journal_title：Antimicrobial agents and chemotherapy

authors： Hobbie SN,Pfister P,Brüll C,Westhof E,Böttger EC

更新日期：2005-12-01 00:00:00

abstract：:In this study, susceptibilities were determined for AZD0914, a spiropyrimidinetrione DNA gyrase inhibitor, azithromycin, doxycycline, and levofloxacin against Mycoplasma and Ureaplasma species. The activity of AZD0914 was comparable to that of levofloxacin and doxycycline against Mycoplasma genitalium and Mycoplasma p...

journal_title：Antimicrobial agents and chemotherapy

authors： Waites KB,Crabb DM,Duffy LB,Huband MD

更新日期：2015-01-01 00:00:00

abstract：:Ribavirin 5'-triphosphate (RTP), derived from the broad-spectrum antiviral compound ribavirin (Virazole), can selectively inhibit influenza virus ribonucleic acid polymerase in a cell-free assay. Ribavirin and its 5'-monophosphate have no effect on the polymerase. The inhibition is competitive with respect to adenosin...

journal_title：Antimicrobial agents and chemotherapy

authors： Eriksson B,Helgstrand E,Johansson NG,Larsson A,Misiorny A,Norén JO,Philipson L,Stenberg K,Stening G,Stridh S,Oberg B

更新日期：1977-06-01 00:00:00

abstract：:Pyrosequencing was used to detect rapidly and estimate the number of 23S rRNA genes with a G2576T mutation in 43 linezolid-resistant and -susceptible clinical isolates of enterococci. The method showed 100% concordance with PCR-restriction fragment length polymorphism for detecting isolates homozygous for either G2576...

journal_title：Antimicrobial agents and chemotherapy

authors： Sinclair A,Arnold C,Woodford N

更新日期：2003-11-01 00:00:00

abstract：:When strains harboring R factor and showing ampicillin (APC) resistance were inoculated on plates containing various concentrations of APC, mutants carrying various levels of APC resistance occurred at high frequencies. Increases in the level of APC resistance were due to a quantitative increase in the formation of pe...

journal_title：Antimicrobial agents and chemotherapy

authors： Odakura Y,Tanaka T,Hashimoto H,Mitsuhashi S

更新日期：1973-03-01 00:00:00

abstract：:This study was undertaken to investigate biochemical, genetic, and epidemiological aspects of resistance to aminoglycoside antibiotics among 650 consecutive isolates of Pseudomonas aeruginosa from Parkland Memorial Hospital, Dallas, Tex. In 364 strains, minimal inhibitory concentrations were 25 mug/ml or greater for g...

journal_title：Antimicrobial agents and chemotherapy

authors： Holmes RK,Minshew BH,Gould IK,Sanford JP

更新日期：1974-09-01 00:00:00

abstract：:In a randomized crossover trial, six volunteers received 200- and 400-mg doses of loracarbef (LY 163892), a new oral cephalosporin. Mean +/- standard error of the mean concentrations in serum obtained after 1.5 and 3 h were 13.2 +/- 2.8 and 4.3 +/- 0.7 mg/liter, respectively, after the 400-mg dose and 6.9 +/- 1.0 and ...

journal_title：Antimicrobial agents and chemotherapy

authors： Van der Auwera P

更新日期：1992-03-01 00:00:00

abstract：:Laboratory-based in vitro antimicrobial susceptibility testing is the foundation for guiding anti-infective therapy and monitoring antimicrobial resistance trends. We used whole-genome sequencing (WGS) technology to identify known antimicrobial resistance determinants among strains of nontyphoidal Salmonella and corre...

journal_title：Antimicrobial agents and chemotherapy

authors： McDermott PF,Tyson GH,Kabera C,Chen Y,Li C,Folster JP,Ayers SL,Lam C,Tate HP,Zhao S

更新日期：2016-08-22 00:00:00

abstract：:The role of Ser-235 in the catalytic mechanism of the TEM-1 beta-lactamase has been explored by the study of a mutant enzyme in which Ser-235 has been substituted by alanine (Ala-235 mutant enzyme). A comparative kinetic analysis of both the wild-type and the Ala-235 TEM-1 enzymes revealed little effect of this substi...

journal_title：Antimicrobial agents and chemotherapy

authors： Imtiaz U,Manavathu EK,Lerner SA,Mobashery S

更新日期：1993-11-01 00:00:00

abstract：:We have developed a chromatographic assay with high sensitivity and specificity to quantify G418 sulfate (Geneticin), an antibiotic used routinely in molecular genetics experiments for selecting eukaryotic transformants. With this method, G418 in tissues and plasma samples can be quantitated without the confounding fa...

journal_title：Antimicrobial agents and chemotherapy

authors： Bethune C,Bui T,Liu ML,Kay MA,Ho RJ

更新日期：1997-03-01 00:00:00

abstract：:To compare the effect of ritonavir on plasma amprenavir pharmacokinetics, healthy adults received either fosamprenavir (700 mg twice a day [BID]) or amprenavir (600 mg BID) alone and in combination with ritonavir (100 mg BID). Ritonavir increased plasma amprenavir pharmacokinetic parameters to a similar extent when co...

journal_title：Antimicrobial agents and chemotherapy

authors： Wire MB,Baker KL,Jones LS,Shelton MJ,Lou Y,Thomas GJ,Berrey MM

更新日期：2006-04-01 00:00:00

abstract：:The only human cathelicidin, the 37-residue peptide LL-37, exhibits antimicrobial activity against both gram-positive and gram-negative bacteria. We studied the ability of several fragments of LL-37, exhibiting different antimicrobial activities, to interact with membranes whose compositions mimic the cytoplasmic memb...

journal_title：Antimicrobial agents and chemotherapy

authors： Epand RF,Wang G,Berno B,Epand RM

更新日期：2009-09-01 00:00:00

abstract：:A patient with AIDS and chronic diarrhea caused by Enterocytozoon bieneusi was successfully treated with nitazoxanide, producing a complete clinical and parasitological response, while off of antiviral therapy. This suggests that nitazoxanide may be effective in treating microsporidiosis caused by E. bieneusi, a disea...

journal_title：Antimicrobial agents and chemotherapy

authors： Bicart-Sée A,Massip P,Linas MD,Datry A

更新日期：2000-01-01 00:00:00

abstract：:We report the identification of a carbapenem-resistant, hypervirulent Klebsiella pneumoniae (hvKp) strain which produced the carbapenemase VIM-1. Genomic analysis showed that the strain belonged to sequence type ST23 and serotype K1, a major hvKp clone, and harbored three resistance-encoding plasmids. Among them, a bl...

journal_title：Antimicrobial agents and chemotherapy

authors： Dong N,Sun Q,Huang Y,Shu L,Ye L,Zhang R,Chen S

更新日期：2019-08-23 00:00:00

abstract：:The hyl(Efm) gene (encoding a putative hyaluronidase) has been found almost exclusively in Enterococcus faecium clinical isolates, and recently, it was shown to be on a plasmid which increased the ability of E. faecium strains to colonize the gastrointestinal tract. In this work, the results of mating experiments betw...

journal_title：Antimicrobial agents and chemotherapy

authors： Arias CA,Panesso D,Singh KV,Rice LB,Murray BE

更新日期：2009-10-01 00:00:00

abstract：:We present a new strategy for predicting novel antibiotic mechanisms of action based on the analysis of whole-genome microarray data. We first built up a reference compendium of Bacillus subtilis expression profiles induced by 14 different antibiotics. This data set was expanded by adding expression profiles from muta...

journal_title：Antimicrobial agents and chemotherapy

authors： Freiberg C,Fischer HP,Brunner NA

更新日期：2005-02-01 00:00:00

abstract：:In a single quantitative study, we measured acrA, acrB, tolC, mdfA, and norE expression in Escherichia coli clinical isolates by using real-time PCR. acrA and acrB overexpression strongly correlated with fluoroquinolone and multidrug resistance; tolC, mdfA, and norE expression did not. The order of abundance of efflux...

journal_title：Antimicrobial agents and chemotherapy

authors： Swick MC,Morgan-Linnell SK,Carlson KM,Zechiedrich L

更新日期：2011-02-01 00:00:00

abstract：:(S)-9-(3-Hydroxy-2-phosphonylmethoxypropyl)adenine [(S)-HPMPA], (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)-2,6-diaminopurine [(S)-HPMPDAP], cyclic (S)-HPMPA [(S)-cHPMPA], 9-(2-phosphonylmethoxyethoxyethyl)-2,6-diaminopurine (PMEDAP), and (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine [(S)-HPMPC] were examined fo...

journal_title：Antimicrobial agents and chemotherapy

authors： Lin JC,De Clercq E,Pagano JS

更新日期：1991-11-01 00:00:00