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Transplantation of pediatric cadaveric kidneys into adult or pediatric recipients.

Abstract：

:In Japan, nationwide cadaveric organ sharing for kidney transplantation by the Japan Organ Transplant Network (JOTN) has operated since April 1995. This study retrospectively analyzed the long-term results of single pediatric donor kidneys transplanted into adult or pediatric recipients at a single center. From March 1983 to December 2002, 281 cadaveric renal allografts were transplanted at our center, including, 17 recipients of cadaveric kidneys from donors aged less than 16 years. We divided these 17 recipients into two groups: 10 adult recipients (group 1; G1) and seven pediatric recipients (group 2; G2). HLA-AB, -DR mismatches were 1.3 +/- 1.3, 0.7 +/- 0.5 in G1 and 2.6 +/- 1.3, 1.4 +/- 0.8 in G2, respectively (P < .05 for both). The end of the observation of this study was March 2003. Among G1, two recipients died with functioning grafts and one died after graft loss. Among G2, no recipients died. Patient survival rates at 1 and 5 years were 90% and 80% in G1 and 100% and 100% in G2, respectively. At the end of the observation in this study, five recipients among G1 and six recipients among G2 had functioning grafts. Graft survival rates at 1 and 5 years were 90% and 80% in G1 and 85.7% and 85.7% in G2, respectively. Our results demonstrate that transplantation of pediatric cadaveric kidneys into pediatric recipients was excellent compared to adult recipients in terms of survival. Priority to pediatric patients should be given especially in cases of pediatric donors.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Ishikawa N,Tanabe K,Tokumoto T,Ishida H,Miyamoto N,Shinmura H,Hattori M,Shiraga H,Ito K,Toma H

doi

10.1016/j.transproceed.2004.06.025

subject

Has Abstract

pub_date

2004-09-01 00:00:00

pages

2018-9

issue

7

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(04)00704-3

journal_volume

36

pub_type

杂志文章

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