Nitroxide conjugate of a thermally responsive elastin-like polypeptide for noninvasive thermometry.

Abstract:

:Hyperthermia, as an adjuvant with radiation and chemotherapy, has shown promise in the treatment of cancer. The relevant biological effects of a hyperthermia treatment are both time and temperature-dependent, creating a need for accurate thermometry. We present a novel noninvasive thermometry modality that combines a temperature responsive biopolymer, the elastin-like polypeptide (ELP), and nitroxide to produce an ELP-nitroxide conjugate. When examined with electron paramagnetic resonance (EPR) spectroscopy, the ELP-nitroxide conjugate has temperature-dependent spectral line widths whose predictive accuracy is approximately 0.3 degrees C (80 microM). We believe that the temperature-dependent changes observed in the EPR spectrum are due to the combined effect of temperature, viscosity and effective radius on the rotational correlation time of the ELP-nitroxide conjugate.

journal_name

Med Phys

journal_title

Medical physics

authors

Dreher MR,Elas M,Ichikawa K,Barth ED,Chilkoti A,Rosen GM,Halpern HJ,Dewhirst M

doi

10.1118/1.1782677

subject

Has Abstract

pub_date

2004-10-01 00:00:00

pages

2755-62

issue

10

eissn

0094-2405

issn

2473-4209

journal_volume

31

pub_type

杂志文章
  • Efficient implementations of a pseudodynamical stochastic filtering strategy for static elastography.

    abstract::A computationally efficient pseudodynamical filtering setup is established for elasticity imaging (i.e., reconstruction of shear modulus distribution) in soft-tissue organs given statically recorded and partially measured displacement data. Unlike a regularized quasi-Newton method (QNM) that needs inversion of ill-con...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.3158808

    authors: Banerjee B,Roy D,Vasu RM

    更新日期:2009-08-01 00:00:00

  • SU-E-T-476: GPU-Based Monte Carlo Radiotherapy Dose Calculation Using Phase- Space Sources.

    abstract:PURPOSE:To design an efficient method for utilizing phase-space source models in the GPU-based Monte Carlo (MC) dose calculation engine gDPM. METHODS:In GPU-based MC algorithms, particles are transported in parallel on different threads. Particles of different types and energies can require significantly different exe...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4735565

    authors: Townson R,Jia X,Zavgorodni S,Jiang S

    更新日期:2012-06-01 00:00:00

  • A respiratory-gated treatment system for proton therapy.

    abstract::Proton therapy offers the potential for excellent dose conformity and reduction in integral dose. The superior dose distribution is, however, much more sensitive to changes in radiological depths along the beam path than for photon fields. Respiratory motion can cause such changes for treatments sites like lung, liver...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.2756602

    authors: Lu HM,Brett R,Sharp G,Safai S,Jiang S,Flanz J,Kooy H

    更新日期:2007-08-01 00:00:00

  • Accuracy, reproducibility, and uncertainty analysis of thyroid-probe-based activity measurements for determination of dose calibrator settings.

    abstract:PURPOSE:In the nuclear medicine department, the activity of radiopharmaceuticals is measured using dose calibrators (DCs) prior to patient injection. The DC consists of an ionization chamber that measures current generated by ionizing radiation (emitted from the radiotracer). In order to obtain an activity reading, the...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4966027

    authors: Esquinas PL,Tanguay J,Gonzalez M,Vuckovic M,Rodríguez-Rodríguez C,Häfeli UO,Celler A

    更新日期:2016-12-01 00:00:00

  • Noise, resolution, and sensitivity considerations in the design of a single-slice emission-transmission computed tomographic system.

    abstract::A prototype Emission-Transmission Computed Tomography (ETCT) system is being developed that will acquire single-slice x-ray transmission CT images simultaneously with single photon emission computed tomography (SPECT) images. This system will permit the correlation of anatomical information from x-ray CT with function...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.596643

    authors: Liew SC,Hasegawa BH

    更新日期:1991-09-01 00:00:00

  • SU-E-T-228: The Beauty and the Beast: Transition from Film/paper Charts to Paperless Environment with a New TrueBeam/ARIA System in a Small Community Hospital on a Tight Budget.

    abstract:PURPOSE:To review the issues a physicist may encounter in a community hospital during the transition from film/paper charts to a paperless environment with ARIA and a TrueBeam LINAC. With a lean budget, it was necessary for the physics group to take on the project management responsibilities in order save costs. This w...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4735291

    authors: Chu K,Rasmussen B

    更新日期:2012-06-01 00:00:00

  • Comparison of p-type commercial electron diodes for in vivo dosimetry.

    abstract::This paper compares the characteristics of three types of commercial p-type electron diodes specially designed for in vivo dosimetry (Scanditronix EDD2, Sun Nuclear QED 111200-0 and PTW T60010E diodes coupled with a Therados DPD510 dosimeter) in electron fields with energies from 4.5 to 21 MeV, and in conditions simil...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.1630492

    authors: Marre D,Marinello G

    更新日期:2004-01-01 00:00:00

  • Dosimetric properties of neutrons from 21-MeV deuteron bombardment of a deuterium gas target.

    abstract::Spectra, yields, average energies, and kerma rates in tissue of neutrons from 21-MeV deuteron bombardment of deuterium gas targets have been calculated for target thicknesses of 1, 3.5, and 5 MeV. A high pressure gas cell was constructed and was filled with 33 atm of D2 gas (equivalent to an energy loss of 3.5 MeV for...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.594561

    authors: Weaver KA,Eenmaa J,Bichsel H,Wootton P

    更新日期:1979-05-01 00:00:00

  • SU-E-I-41: Characterization of a Linear Fiber-Optic Coupled Dosimeter.

    abstract:PURPOSE:This study investigated the dosimetry performance of a linear fiber-optic coupled dosimeter with a sensitive element varying from 3 to 15 cm in length. The dosimeter is comprised of a tissue equivalent plastic scintillating fiber coupled to a photomultiplier tube (PMT). The sensitive element has a length repres...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4734756

    authors: Hoerner M,Hintenlang D

    更新日期:2012-06-01 00:00:00

  • Automatic tumor segmentation in breast ultrasound images using a dilated fully convolutional network combined with an active contour model.

    abstract:PURPOSE:Due to the low contrast, blurry boundaries, and large amount of shadows in breast ultrasound (BUS) images, automatic tumor segmentation remains a challenging task. Deep learning provides a solution to this problem, since it can effectively extract representative features from lesions and the background in BUS i...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.13268

    authors: Hu Y,Guo Y,Wang Y,Yu J,Li J,Zhou S,Chang C

    更新日期:2019-01-01 00:00:00

  • Effect of surrounding vasculature on intravoxel BOLD signal.

    abstract:PURPOSE:The nonlocal influence from distant magnetization will affect the magnetic field at a voxel in question. Existing reports on BOLD simulation only consider vasculature inside a single voxel, thus omitting the contribution from the surrounding regions. In this article, the authors study the effect of the surround...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.3366251

    authors: Chen Z,Caprihan A,Calhoun V

    更新日期:2010-04-01 00:00:00

  • Air core detectors for Cerenkov-free scintillation dosimetry of brachytherapy β-sources.

    abstract:PURPOSE:Plastic scintillation detectors are used for dosimetry in small radiation fields with high dose gradients, e.g., provided by β-emitting sources like 106 Ru/106 Rh eye plaques. A drawback is a background signal caused by Cerenkov radiation generated by electrons passing the optical fibers (light guides) of this ...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.12374

    authors: Eichmann M,Thomann B

    更新日期:2017-09-01 00:00:00

  • SU-E-T-635: Effect of Planning Parameters on Tomotherapy Dosimetric Quality and Treatment Efficiency.

    abstract:PURPOSE:To investigate how the setting of optimization parameters, fractional dose and tuning structure in tomotherapy treatment planning affects plan dosimetric quality and treatment efficiency. METHODS:A digital phantom to simulate head and neck radiotherapy was constructed for this study. Tumor was 10cm long C-shap...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4735724

    authors: Lian J,Burkhardt K,Chera B,Chang S

    更新日期:2012-06-01 00:00:00

  • Experimental characterization of the miniannular phased array as a hyperthermia applicator.

    abstract::A series of experiments has been carried out in order to characterize a miniannular phased array applicator prior to possible clinical implementation. The energy deposition patterns over the frequency range of 100 to 200 MHz were determined in several human limb models of different complexities by measuring the electr...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.596037

    authors: Guerquin-Kern JL,Hagmann MJ,Levin RL

    更新日期:1987-07-01 00:00:00

  • Recognition of healthy and cancerous breast cells: Sensing the differences by dielectric spectroscopy.

    abstract:PURPOSE:The response of human cells to applied electrical signals depends on the cellular health status, because it is influenced by the composition and structure of the main cellular components. Therefore, electrical impedance-based techniques can be considered as sensitive tools to investigate healthy or disease stat...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.14425

    authors: Ambrico M,Lasalvia M,Ligonzo T,Ambrico PF,Perna G,Capozzi V

    更新日期:2020-10-01 00:00:00

  • Single shot MR tagging to quantify local tissue deformation during MRI-guided needle interventions: a feasibility study.

    abstract:PURPOSE:In MRI-guided needle interventions, such as biopsies and brachytherapy, tissue deformation caused by needle movement may result in localization errors and thus hamper the outcome of the procedure. Monitoring the local tissue deformation provides the ability to compensate for it, e.g., by increasing the needle i...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.3633906

    authors: van den Bosch MR,de Leeuw H,Zwanenburg JJ,Lagendijk JJ,Moerland MA

    更新日期:2011-10-01 00:00:00

  • Novel methods of measuring single scan dose profiles and cumulative dose in CT.

    abstract::Computed tomography dose index (CTDI) is a conventional indicator of the patient dose in CT studies. It is measured as the integration of the longitudinal single scan dose profile (SSDP) by using a 100-mm-long pencil ionization chamber and a single axial scan. However, the assumption that most of the SSDP is contained...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.1835571

    authors: Nakonechny KD,Fallone BG,Rathee S

    更新日期:2005-01-01 00:00:00

  • A comparison of reconstruction algorithms for C-arm mammography tomosynthesis.

    abstract::Digital tomosynthesis is an imaging technique to produce a tomographic image from a series of angular digital images in a manner similar to conventional focal plane tomography. Unlike film focal plane tomography, the acquisition of the data in a C-arm geometry causes the image receptor to be positioned at various angl...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.2219090

    authors: Rakowski JT,Dennis MJ

    更新日期:2006-08-01 00:00:00

  • Structure and adaptation of arteries to pulsatile flow: the case of the ascending aorta.

    abstract:PURPOSE:The objectives are: (i) assess the development of the impedance of some arteries during the first decades of life; (ii) determine the influence of pulse rate in arterial impedance; (iii) compare the structure of some arterial segments with optimized structures with respect to blood flow; and (iv) explain the el...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4876379

    authors: Silva C,Reis AH

    更新日期:2014-06-01 00:00:00

  • Reconstruction of diagnostic x-ray spectra by numerical analysis of transmission data.

    abstract::Numerical reconstruction of x-ray spectra from narrow-beam transmission data was tested with published spectra in the range from 45 to 100 kVp. Transmission curves were calculated from the spectra to simulate measured data. Spectra were reconstructed from these transmission curves with use of an iterative numerical an...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.595834

    authors: Huang PH,Chen TS,Kase KR

    更新日期:1986-09-01 00:00:00

  • The use of a priori information in the detection of mammographic microcalcifications to improve their classification.

    abstract::In this work, we present a calcification-detection scheme that automatically localizes calcifications in a previously detected cluster in order to generate the input for a cluster-classification scheme developed in the past. The calcification-detection scheme makes use of three pieces of a priori information: the loca...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.1559884

    authors: Salfity MF,Nishikawa RM,Jiang Y,Papaioannou J

    更新日期:2003-05-01 00:00:00

  • Tracking the dynamic seroma cavity using fiducial markers in patients treated with accelerated partial breast irradiation using 3D conformal radiotherapy.

    abstract:PURPOSE:The purpose of the present study was to perform an analysis of the changes in the dynamic seroma cavity based on fiducial markers in early stage breast cancer patients treated with accelerated partial breast irradiation (APBI) using three-dimensional conformal external beam radiotherapy (3D-CRT). METHODS:A pro...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4788644

    authors: Yue NJ,Haffty BG,Kearney T,Kirstein L,Chen S,Goyal S

    更新日期:2013-02-01 00:00:00

  • Semiautomated registration of pre- and intraoperative CT for image-guided percutaneous liver tumor ablation interventions.

    abstract:PURPOSE:In CT-guided liver tumor ablation interventions, registration of a preoperative contrast-enhanced CT image to the intraoperative CT image is hypothesized to improve guidance. This is a highly challenging registration task due to differences in patient poses and large deformations, and therefore high registratio...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1002/mp.12332

    authors: Gunay G,Luu MH,Moelker A,van Walsum T,Klein S

    更新日期:2017-07-01 00:00:00

  • Automatic quantitative low contrast analysis of digital chest phantom radiographs.

    abstract::Up to the present, the majority of low contrast object evaluations performed on phantom images have been accomplished in a subjective fashion. This is mainly due to the time and effort required to manually measure each radiograph with a densitometer to obtain quantitative results. However, with the development of digi...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.1543153

    authors: Kwan AL,Filipow LJ,Le LH

    更新日期:2003-03-01 00:00:00

  • Deadtime correction for two multihead Anger cameras in 131I dual-energy-window-acquisition mode.

    abstract::Two side-by-side energy windows, one at the photopeak and one at lower energy, are sometimes employed in quantitative SPECT studies. We measured the count-rate losses at moderately high activities of 131I for two multihead Anger cameras in such a dual-window-acquisition mode by imaging a decaying source composed of tw...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.598162

    authors: Koral KF,Zasadny KR,Ackermann RJ,Ficaro EP

    更新日期:1998-01-01 00:00:00

  • Neutron and gamma spectroscopy for clinical dosimetry.

    abstract::Neutron and photon energy spectra were measured in different depths and lateral positions in tissue-equivalent phantoms exposed to a therapeutical 14.1 MeV neutron beam. Intensity weighted mass energy absorption coefficients were derived for application in ionization chamber dosimetry in mixed neutron-gamma fields. Th...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.594744

    authors: Schmidt R,Magiera E,Scobel W

    更新日期:1980-09-01 00:00:00

  • Characteristic performance evaluation of a photon counting Si strip detector for low dose spectral breast CT imaging.

    abstract:PURPOSE:The possible clinical applications which can be performed using a newly developed detector depend on the detector's characteristic performance in a number of metrics including the dynamic range, resolution, uniformity, and stability. The authors have evaluated a prototype energy resolved fast photon counting x-...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.4892174

    authors: Cho HM,Barber WC,Ding H,Iwanczyk JS,Molloi S

    更新日期:2014-09-01 00:00:00

  • A feasible method for clinical delivery verification and dose reconstruction in tomotherapy.

    abstract::Delivery verification is the process in which the energy fluence delivered during a treatment is verified. This verified energy fluence can be used in conjunction with an image in the treatment position to reconstruct the full three-dimensional dose deposited. A method for delivery verification that utilizes a measure...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.1352579

    authors: Kapatoes JM,Olivera GH,Ruchala KJ,Smilowitz JB,Reckwerdt PJ,Mackie TR

    更新日期:2001-04-01 00:00:00

  • Dose and dose averaged LET comparison of ¹H, ⁴He, ⁶Li, ⁸Be, ¹⁰B, ¹²C, ¹⁴N, and ¹⁶O ion beams forming a spread-out Bragg peak.

    abstract:PURPOSE:Modern clinical accelerators are capable of producing ion beams from protons up to neon. This work compares the depth dose distribution and corresponding dose averaged linear energy transfer (LET) distribution, which is related to the biological effectiveness, for different ion beams (¹H, ⁴He, ⁶Li, ⁸Be, ¹⁰B, ¹²...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.3662911

    authors: Kantemiris I,Karaiskos P,Papagiannis P,Angelopoulos A

    更新日期:2011-12-01 00:00:00

  • Thermoluminescent dosimetry of the SourceTech Medical model STM1251 125I seed.

    abstract::Many new models of 125I seeds are being introduced, mainly due to the increase in prostate seed implants. We have evaluated the SourceTech Medical (STM), model STM1251, 125I seed using thermoluminescent dosimeters (TLDs) in a solid water phantom. TLD cubes, LiF TLD-100, with dimension 1 mm on each edge, were irradiate...

    journal_title:Medical physics

    pub_type: 杂志文章

    doi:10.1118/1.1577251

    authors: Chiu-Tsao ST,Duckworth TL,Hsiung CY,Li Z,Williamson J,Patel NS,Harrison LB

    更新日期:2003-07-01 00:00:00