Nitroxide conjugate of a thermally responsive elastin-like polypeptide for noninvasive thermometry.

Abstract:

:Hyperthermia, as an adjuvant with radiation and chemotherapy, has shown promise in the treatment of cancer. The relevant biological effects of a hyperthermia treatment are both time and temperature-dependent, creating a need for accurate thermometry. We present a novel noninvasive thermometry modality that combines a temperature responsive biopolymer, the elastin-like polypeptide (ELP), and nitroxide to produce an ELP-nitroxide conjugate. When examined with electron paramagnetic resonance (EPR) spectroscopy, the ELP-nitroxide conjugate has temperature-dependent spectral line widths whose predictive accuracy is approximately 0.3 degrees C (80 microM). We believe that the temperature-dependent changes observed in the EPR spectrum are due to the combined effect of temperature, viscosity and effective radius on the rotational correlation time of the ELP-nitroxide conjugate.

journal_name

Med Phys

journal_title

Medical physics

authors

Dreher MR,Elas M,Ichikawa K,Barth ED,Chilkoti A,Rosen GM,Halpern HJ,Dewhirst M

doi

10.1118/1.1782677

subject

Has Abstract

pub_date

2004-10-01 00:00:00

pages

2755-62

issue

10

eissn

0094-2405

issn

2473-4209

journal_volume

31

pub_type

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