Right motor neglect associated with dynamic aphasia, loss of drive and amnesia: case report and cerebral blood flow study.

Abstract:

:A 30-year-old right-handed man had right motor neglect, amnesia, aphasia and loss of drive following bilateral thalamic and subthalamic infarctions. Serial resting cerebral blood flow (CBF) measurements with either Xenon 133 inhalation or positron emission tomography at 1, 8 and 10 months post-onset showed a widespread and long-lasting low CBF in the cortex. An additional CBF measurement, during motor tasks, showed a marked interhemispheric asymmetry in the pattern of activation: whereas left hand movement resulted in a CBF increase in contralateral superior rolandic and prerolandic areas, no significant regional CBF changes were seen during right hand movement, despite recovery from motor neglect. This loss of CBF increase in cortical motor and premotor areas during voluntary movement of the previously neglected side points to a disruption of cortico-subcortical pathways subserving motor activation. The pathophysiology of aphasia, loss of drive and amnesia as well as their relationships to motor neglect, may also be discussed on the basis of thalamo-cortical disconnections.

journal_name

Neuropsychologia

journal_title

Neuropsychologia

authors

de la Sayette V,Le Doze F,Bouvard G,Morin I,Eustache F,Fiorelli M,Viader F,Morin P

doi

10.1016/0028-3932(92)90021-d

subject

Has Abstract

pub_date

1992-02-01 00:00:00

pages

109-21

issue

2

eissn

0028-3932

issn

1873-3514

journal_volume

30

pub_type

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