Abstract:
:Subretinal injections of human retinal pigment epithelial (RPE) cells early in the course of retinal degeneration in Royal College of Surgeons (RCS) rats can rescue photoreceptors. Fourteen injected animals were studied using a double flash electroretinogram (ERG): 10 were examined longitudinally and four terminally with immunohistochemistry. The proportion of cone contribution to the ERG b-wave rather than the absolute size of isolated cone response proved to be a reliable indicator of function over time and a predictor of the proportion of cones identified anatomically in the area of optimal photoreceptor rescue.
journal_name
Vision Resjournal_title
Vision researchauthors
Pinilla I,Lund RD,Lu B,Sauvé Ydoi
10.1016/j.visres.2004.09.014subject
Has Abstractpub_date
2005-03-01 00:00:00pages
635-41issue
5eissn
0042-6989issn
1878-5646pii
S0042-6989(04)00457-2journal_volume
45pub_type
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