Measuring the cone contribution to the ERG b-wave to assess function and predict anatomical rescue in RCS rats.

Abstract:

:Subretinal injections of human retinal pigment epithelial (RPE) cells early in the course of retinal degeneration in Royal College of Surgeons (RCS) rats can rescue photoreceptors. Fourteen injected animals were studied using a double flash electroretinogram (ERG): 10 were examined longitudinally and four terminally with immunohistochemistry. The proportion of cone contribution to the ERG b-wave rather than the absolute size of isolated cone response proved to be a reliable indicator of function over time and a predictor of the proportion of cones identified anatomically in the area of optimal photoreceptor rescue.

journal_name

Vision Res

journal_title

Vision research

authors

Pinilla I,Lund RD,Lu B,Sauvé Y

doi

10.1016/j.visres.2004.09.014

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

635-41

issue

5

eissn

0042-6989

issn

1878-5646

pii

S0042-6989(04)00457-2

journal_volume

45

pub_type

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