Origin of the vertebrate visual cycle: II. Visual cycle proteins are localized in whole brain including photoreceptor cells of a primitive chordate.

Abstract:

:The visual cycle system in a primitive chordate, ascidian Ciona intestinalis, was studied by whole-mount in situ hybridization and by whole-mount immunohistochemistry. Three visual cycle proteins, Ciona homologue of RGR (Ci-opsin3), CRALBP (Ci-CRALBP), and BCO/RPE65 (Ci-BCO/RPE65) were widely distributed in the brain vesicle and visceral ganglion. To identify the visual cycle system in a primitive chordate, we compared the localization of photoreceptor-specific proteins (visual pigment and arrestin) and visual cycle proteins (Ci-opsin3 and Ci-CRALBP). The ascidian visual cycle is composed of two cellular compartments, the photoreceptors and the brain vesicle, but some photoreceptor cells also contain visual cycle proteins.

journal_name

Vision Res

journal_title

Vision research

authors

Tsuda M,Kusakabe T,Iwamoto H,Horie T,Nakashima Y,Nakagawa M,Okunou K

doi

10.1016/j.visres.2003.09.012

subject

Has Abstract

pub_date

2003-12-01 00:00:00

pages

3045-53

issue

28

eissn

0042-6989

issn

1878-5646

pii

S0042698903005546

journal_volume

43

pub_type

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