Abstract:
:A flow injection spectrophotometric procedure was developed for determination of acetylcysteine in sachets and liquid formulations. The determination of this drug was carried out by reacting it with bromine chemically generated in flow injection system monitored continuously at 400 nm. Acetylcysteine reacts with bromine causing a decrease in the absorbance that is proportional to the analyte concentration. The bromine in excess was destroyed on-line by an ascorbic acid solution before the discard. The calibration curve for acetylcysteine determination was linear in the concentration range from 1.6 x 10(-4) to 1.6 x 10(-3) mol/l with a detection limit of 8.0 x 10(-5) mol/l. The relative standard deviation (R.S.D.) was lesser than 1.2% for a solution containing 5.3 x 10(-4) mol/l acetylcysteine (n=10), and 60 determinations per hour were obtained.
journal_name
J Pharm Biomed Analjournal_title
Journal of pharmaceutical and biomedical analysisauthors
Suarez WT,Vieira HJ,Fatibello-Filho Odoi
10.1016/j.jpba.2004.11.032subject
Has Abstractpub_date
2005-04-01 00:00:00pages
771-5issue
4eissn
0731-7085issn
1873-264Xpii
S0731-7085(04)00612-0journal_volume
37pub_type
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