当前位置： SCI文献检索 > JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS期刊下所有文献 > Quality control of pharmaceutical formulations containing cisplatin, carboplatin, and oxaliplatin by micellar and microemulsion electrokinetic chromatography (MEKC, MEEKC).

Quality control of pharmaceutical formulations containing cisplatin, carboplatin, and oxaliplatin by micellar and microemulsion electrokinetic chromatography (MEKC, MEEKC).

Abstract：

:A micellar electrokinetic chromatography (MEKC) method was developed for the determination of cisplatin, carboplatin, and oxaliplatin in pharmaceutical formulations. The background electrolyte consisted of a phosphate buffer (pH 7.0; 25 mM) with sodium dodecyl sulfate (80 mM). The applied voltage was 30 kV and the sample injection was performed in the hydrodynamic mode. All analyses were carried out in a fused silica capillary with an internal diameter of 50 μm and a total length of 64.5 cm. The detection of target compounds was performed at 200 nm. Under these conditions, a complete separation of cisplatin, carboplatin and oxaliplatin was achieved in less than 10 min. The MEKC-UV method was validated and trueness values between 99.7% and 100.8% were obtained with repeatability and intermediate precision values of 0.7-1.4% and 1.1-1.7%, respectively for the three drugs. This method was found appropriate for controlling pharmaceutical formulations containing platinum complexes and successfully applied in quality control at the Geneva University Hospitals.

journal_name

J Pharm Biomed Anal

journal_title

Journal of pharmaceutical and biomedical analysis

authors

Nussbaumer S,Fleury-Souverain S,Schappler J,Rudaz S,Veuthey JL,Bonnabry P

doi

10.1016/j.jpba.2011.01.029

subject

Has Abstract

pub_date

2011-05-15 00:00:00

pages

253-8

issue

2

eissn

0731-7085

issn

1873-264X

pii

S0731-7085(11)00054-9

journal_volume

55

pub_type

杂志文章

相关文献

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS文献大全
  • Acute lung injury therapeutic mechanism exploration for Chinese classic prescription Qingzao Jiufei Decoction by UFLC-MS/MS quantification of bile acids, fatty acids and eicosanoids in rats.

    abstract：:Acute lung injury (ALI) is a common and complex inflammatory disease, which has been reasonably associated with carboxyl-containing metabolites in our preliminary non-targeted metabolomic strategy. Qingzao Jiufei Decoction (QZJFD), a classic prescription, is widely used in the treatment of pulmonary inflammatory injuri...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/j.jpba.2020.113463

    authors： Wang T,Lin S,Liu R,Li H,Liu Z,Xu H,Li Q,Bi K

    更新日期：2020-09-10 00:00:00

  • Direct separation and quantitative determination of clenbuterol enantiomers by high performance liquid chromatography using an amide type chiral stationary phase.

    abstract：:Enantiomers of clenbuterol were directly separated by a new high performance chromatographic method on Chirex 3005 column. Several parameters such as mobile phase composition, column temperature and flow rate were studied. Baseline enantioseparation was achieved, using the optimized mobile phase of n-hexane-1,2-dichol...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/s0731-7085(02)00671-4

    authors： Song Y,Wang D,Hu Y,Chen X,Jiao Y,Hou D

    更新日期：2003-02-26 00:00:00

  • A simple method for assaying colistimethate sodium in pharmaceutical aerosol samples using high performance liquid chromatography.

    abstract：:A rapid and simple reversed-phase high performance liquid chromatography (HPLC) method for the quantitation of colistimethate sodium in pharmaceutical formulations has been developed. The chromatographic separation was performed using a Phenomenex Kinetex XB-C18 column with gradient elution using a mobile phase contai...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/j.jpba.2017.04.021

    authors： Metcalf AP,Hardaker LEA,Hatley RHM

    更新日期：2017-08-05 00:00:00

  • Metabolic profiles of neotuberostemonine and tuberostemonine in rats by high performance liquid chromatography/quadrupole time-of-flight mass spectrometry.

    abstract：:Neotuberostemonine (NS) and tuberostemonine (TS), a pair of stereoisomers, are the active components contained in Stemona tuberosa, an antitussive herbal medicine in China. Two isomers have different pharmacological efficacies, which will be related with their in vivo disposition. However, the metabolic fates of NS an...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/j.jpba.2017.04.018

    authors： Tong Y,Xu W,Wu Y,Ou L,Zhang M,Xu X,Zhang C

    更新日期：2017-07-15 00:00:00

  • The validation of column-switching LC/MS as a high-throughput approach for direct analysis of di(2-ethylhexyl) phthalate released from PVC medical devices in intravenous solution.

    abstract：:Health Canada reported recently that medical devices containing di(2-ethylhexyl) phthalate (DEHP) should not be used in the clinical treatment of infants, young boys, pregnant women, and nursing mothers. The risk assessment of DEHP released from PVC medical devices is an important issue for hospitalized patients. In t...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/s0731-7085(03)00019-0

    authors： Inoue K,Higuchi T,Okada F,Iguchi H,Yoshimura Y,Sato A,Nakazawa H

    更新日期：2003-04-10 00:00:00

  • Simultaneous determination of alpha-fetoprotein, human chorionic gonadotropin and estriol in serum of pregnant women by time-resolved fluoroimmunoassay.

    abstract：:We have developed a simple and rapid time-resolved fluoroimmunoassay (TR-FIA) for simultaneous determination of alpha-fetoprotein (AFP), human chorionic gonadotropin (hCG) and estriol (E3) using europium and samarium ion chelate. In the proposed method, we used a combination of a 96-well microtiter plate for the AFP a...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/s0731-7085(99)00010-2

    authors： Ito K,Oda M,Tsuji A,Maeda M

    更新日期：1999-06-01 00:00:00

  • Combining biochemical with (1)H NMR-based metabolomics approach unravels the antidiabetic activity of genipin and its possible mechanism.

    abstract：:Diabetes mellitus is a typical heterogeneous metabolic disorder characterized by abnormal metabolism of carbohydrates, lipids and proteins. Genipin possesses a wide spectrum of biological activities including ameliorating effects on diabetes, but the definite mechanism of this effect remains unknown. To investigate th...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/j.jpba.2016.06.041

    authors： Shen XL,Liu H,Xiang H,Qin XM,Du GH,Tian JS

    更新日期：2016-09-10 00:00:00

  • Analysis of 44 pharmaceuticals consumed by elderly using liquid chromatography coupled to tandem mass spectrometry.

    abstract：:Elderly people represent about the 15% of the total world population and often include a polymedicated age group with an average consumption of 5-10 pills per day. The main pharmaceuticals consumed are antianalgesics, antidiabetics, anti-parkinson compounds, anti-convulsants, drugs to treat constipation and drugs to t...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/j.jpba.2019.02.016

    authors： Gómez-Canela C,Sala-Comorera T,Pueyo V,Barata C,Lacorte S

    更新日期：2019-05-10 00:00:00

  • Novel immunoaffinity extraction for liquid chromatographic determination of major metabolites of 4-acetoxy-2-(4-methylphenyl)benzothiazole in plasma.

    abstract：:Group extraction of the metabolites of 4-acetoxy-2-(4-methylphenyl)benzothiazole has been achieved through the use of an immunoaffinity adsorbent. The antisera elicited from an immunogen, 4-hydroxy-2-(4-formylphenyl)benzothiazole O-carboxymethyloxime-bovine serum albumin conjugate, were characterized to have a broad a...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/0731-7085(94)90016-7

    authors： Miyairi S,Shimada H,Awata N,Goto J,Nambara T

    更新日期：1994-03-01 00:00:00

  • Simulation of fractograms of fat emulsions in power-programmed sedimentation field-flow fractionation (SdFFF).

    abstract：:A quasi-empirical approach to the simulation of fractograms was examined to verify that the elution behavior of emulsions in power-based field programmed sedimentation field-flow fractionation (SdFFF) is consistent and predictable. The approach was applied to Intralipid, a commercial soybean emulsion and to an investi...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/0731-7085(95)01313-a

    authors： Levin S,Nudelman R,Reschiglian P,Pasti L

    更新日期：1995-06-01 00:00:00

  • Determination of metoprolol tartrate in tablets and human urine using flow-injection chemiluminescence method.

    abstract：:In this paper, a simple, rapid and sensitive flow-injection chemiluminescence method has been developed for the determination of metoprolol tartrate, which acts as a kind of sensitizer in the chemiluminescence emission from the redox of SO(3)(2-) with Ce(IV) in acidic medium. Under the optimized conditions, the propos...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/j.jpba.2006.04.008

    authors： Liu H,Ren J,Hao Y,Ding H,He P,Fang Y

    更新日期：2006-09-26 00:00:00

  • Application of Mosher's method for absolute configuration assignment to bioactive plants and fungi metabolites.

    abstract：:The review deals with the application of the NMR advanced Mosher's method for the assignment of the absolute configuration to plant and fungal metabolites belonging to different classes of natural compounds. The structural and stereochemical characterization of these naturally occurring metabolites, as well as their b...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/j.jpba.2017.02.037

    authors： Cimmino A,Masi M,Evidente M,Superchi S,Evidente A

    更新日期：2017-09-10 00:00:00

  • Acid and base degraded products of ketorolac.

    abstract：:The stability of ketorolac tromethamine was investigated in acid (0.5M HCl) and alkaline conditions (0.5M NaOH), using the same procedure reported by Devarajan et al. [2]. The acid and base degradation products were identified by liquid chromatography-mass spectrometry (LC-MS). ...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/j.jpba.2010.01.031

    authors： Salaris M,Nieddu M,Rubattu N,Testa C,Luongo E,Rimoli MG,Boatto G

    更新日期：2010-06-05 00:00:00

  • Quantitation of acetazolamide in rat plasma, brain tissue and cerebrospinal fluid by high-performance liquid chromatography.

    abstract：:A simple and sensitive high-performance liquid chromatographic method for the analysis of acetazolamide (AZ) in rat blood (plasma/serum, whole blood and serum ultrafiltrate), brain tissue and cerebrospinal fluid (CSF) was described. Quantitative extraction of AZ with ethyl acetate from both buffered plasma and brain t...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/s0731-7085(98)00024-7

    authors： Ichikawa N,Naora K,Hirano H,Iwamoto K

    更新日期：1998-09-01 00:00:00

  • Tocainide analogues binding to human serum albumin: a HPLAC and circular dichroism study.

    abstract：:A series of synthesised tocainide analogues were characterized for their human serum albumin (HSA) binding, using high-performance liquid affinity chromatography (HPLAC) and circular dichroism (CD). The synthesis and physico-chemical characterization of compounds 7a-7d is reported here. For the HPLAC investigation HSA...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/j.jpba.2010.03.005

    authors： Pistolozzi M,Franchini C,Corbo F,Muraglia M,De Giorgi M,Felix G,Bertucci C

    更新日期：2010-10-10 00:00:00

  • Simultaneous interaction of steroidal drugs with gamma- and hydroxypropyl-beta-cyclodextrin studied by charge-transfer chromatography.

    abstract：:The simultaneous interaction of 15 steroidal drugs with tau-cyclodextrin (tauCD) and hydroxypropyl-beta-CD (HPbetaCD) was determined by charge transfer chromatography and the relative strength of interaction was calculated for each drug-tauCD-HPbetaCD ternary complex. The mixture of CDs interacted with each steroidal ...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/s0731-7085(99)00234-4

    authors： Cserháti T,Forgács E

    更新日期：2000-02-01 00:00:00

  • Polymeric matrix membrane sensors for sensitive potentiometric determination of some beta-blockers in pharmaceutical preparations.

    abstract：:Five poly(vinyl chloride) matrix membrane sensors responsive to some beta-blockers (atenolol, bisoprolol, metoprolol, propranolol and timolol) are described and characterized. The sensors are based on the use of the ion-association complexes of the beta-blocker cations with tungstophosphate anion as electroactive mate...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/s0731-7085(03)00015-3

    authors： Hassan SS,Abou-Sekkina MM,El-Ries MA,Wassel A

    更新日期：2003-04-24 00:00:00

  • European survey on the content of lead in lip products.

    abstract：:223 lip articles (representing 55 brands) were purchased in 15 European Union Member States and analysed for lead content. Various lip products (lipsticks and lip glosses), shades (red, brown, purple and pink) and price ranges (3 categories) were investigated. The analytical method employed a microwave-assisted acid d...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/j.jpba.2012.11.047

    authors： Piccinini P,Piecha M,Torrent SF

    更新日期：2013-03-25 00:00:00

  • The S-oxidative degradation of a novel corticosteroid tipredane (INN) Part III. Detailed investigations into the disulphoxidation of tipredane.

    abstract：:The methyl- and ethylsulphoxide diastereoisomers (V and VI) of the corticosteroid tipredane (INN, I) have been shown to undergo further stereoselective S-oxidation to yield diastereoisomeric disulphoxides (II). Interactive computer optimisation software was employed to develop semi-preparative chromatography condition...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/s0731-7085(96)01860-2

    authors： Euerby MR,Graham JA,Johnson CM,Lewis RJ,Wallace DB

    更新日期：1996-12-01 00:00:00

  • Quantification of endostar in rat plasma by LC-MS/MS and its application in a pharmacokinetic study.

    abstract：:LC-MS/MS is a promising analytical platform for the quantification of recombinant therapeutic proteins in biological fluids for pharmacokinetic (PK) studies. Herein, an absolute quantification method based on LC-MS/MS technique was developed to quantify endostar, which is modified from the recombinant human endostatin...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/j.jpba.2012.07.017

    authors： Li YC,Liang Y,Tang ZY,Xiao YN,Hao HP,Wang GJ

    更新日期：2012-11-01 00:00:00

  • Determination of sulphathiazole and sulphanilamide by photochemically induced fluorescence and first-derivative fluorescence.

    abstract：:This manuscript reports the usefulness of the determination of sulphathiazole (ST) using photochemically induced fluorescence (RTPF) and RTPF coupling with first derivative (D1-RTPF), and the determination of sulphanilamide (SAN) by meaning first derivative of the emission spectrum. By irradiating 5 min, with intense ...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/j.jpba.2004.12.024

    authors： García MC,Diez NM,Gil DB,López FS

    更新日期：2005-06-15 00:00:00

  • Mixture design applied in compatibility studies of catechin and lipid compounds.

    abstract：:The aim of this work was to evaluate the compatibility of (+)-catechin (CA) and excipients commonly used to prepare micro and nanoemulsions using thermal analysis along with complementary assays. Lipid compounds labrasol, plurol and ethyl oleate were combined with CA according to a simplex centroid mixture design and ...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/j.jpba.2017.11.069

    authors： Ferreira-Nunes R,Gratieri T,Gelfuso GM,Cunha-Filho M

    更新日期：2018-02-05 00:00:00

  • The use of atomic spectroscopy in the pharmaceutical industry for the determination of trace elements in pharmaceuticals.

    abstract：:The subject of the analysis of various elements, including metals and metalloids, in the pharmaceutical industry has seen increasing importance in the last 10-15 years, as modern analytical instrumentation has afforded analysts with the opportunity to provide element-specific, accurate and meaningful information relat...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章,评审

    doi：10.1016/j.jpba.2010.11.030

    authors： Lewen N

    更新日期：2011-06-25 00:00:00

  • Chiral separation of terbutaline and non-steroidal anti-inflammatory drugs by using a new lysine-bridged hemispherodextrin in capillary electrophoresis.

    abstract：:A method for the separation of a mixture of terbutaline and non-steroidal anti-inflammatory drugs was developed using capillary electrophoresis with a new hemispherodextrin, ad hoc designed, the lysine - bridged hemispherodextrin (THLYSH). The use of lysine residues to bridge the trehalose capping unit moiety to the c...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/j.jpba.2017.07.041

    authors： Cucinotta V,Messina M,Contino A,Maccarrone G,Orlandini S,Giuffrida A

    更新日期：2017-10-25 00:00:00

  • Real-time in vitro dissolution of 5-aminosalicylic acid from single ethyl cellulose coated extrudates studied by UV imaging.

    abstract：:The purpose of this study was to investigate the in vitro release of 5-aminosalicylic acid from single extrudates by UV imaging and to explore the technique as a visualization tool for detecting film coating defects on extrudates coated with a thin ethyl cellulose layer. 5-Aminosalicylic acid extrudates were film coat...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/j.jpba.2013.04.028

    authors： Gaunø MH,Vilhelmsen T,Larsen CC,Boetker JP,Wittendorff J,Rantanen J,Østergaard J

    更新日期：2013-09-01 00:00:00

  • Standardization of marketed Kumariasava--an Ayurvedic Aloe vera product.

    abstract：:Kumariasava is a marketed ayurvedic formulation containing Aloe vera as one of the main ingredients. Present study aims to standardize Kumariasava based upon chromatographic and spectral studies. Various extracts of Kumariasava have been prepared and evaluated. Chloroform extract indicated presence of three well-resol...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/j.jpba.2004.11.044

    authors： Elamthuruthy AT,Shah CR,Khan TA,Tatke PA,Gabhe SY

    更新日期：2005-04-29 00:00:00

  • Clinical analysis of sampatrilat, a combined renal endopeptidase and angiotensin-converting enzyme inhibitor II: assay in the plasma and urine of human volunteers by dissociation enhanced lanthanide fluorescence immunoassay (DELFIA).

    abstract：:Sampatrilat is a dual inhibitor of angiotensin converting enzyme (ACE) and neutral endopeptidase (NEP) under development for the treatment of hypertension and congestive heart failure. In order to support the early clinical development (with oral administration and an expected low bioavailability), a sensitive and sel...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/s0731-7085(97)00127-1

    authors： Venn RF,Barnard G,Kaye B,Macrae PV,Saunders KC

    更新日期：1998-01-01 00:00:00

  • A sandwich immunoassay for brucellosis diagnosis based on immune magnetic beads and quantum dots.

    abstract：:Brucellosis is a serious zoonosis with a rapid increase in incidence across epidemic regions. Currently, there are numerous methods for diagnosing brucellosis. However, these studies often have a few defects, such as low sensitivity, poor specificity, time consuming, laborious, and even potential biological risk. To o...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/j.jpba.2017.03.002

    authors： Li L,Yin D,Xu K,Liu Y,Song D,Wang J,Zhao C,Song X,Li J

    更新日期：2017-07-15 00:00:00

  • Direct injection of aqueous samples in packed column supercritical fluid chromatography of isosorbide-5-mononitrate from drug release testing.

    abstract：:A method for the analysis of aqueous samples of isosorbide-5-mononitrate (5-ISMN) is presented. It is based on packed column supercritical fluid chromatography (SFC) using 20% of 2-propanol in carbon dioxide as the mobile phase and a diol silica column as the stationary phase. Using the described conditions it is poss...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/s0731-7085(02)00072-9

    authors： Gyllenhaal O,Hulthe J

    更新日期：2002-06-20 00:00:00

  • Determination of lovastatin in human plasma by ultra-performance liquid chromatography-electrospray ionization tandem mass spectrometry and its application in a pharmacokinetic study.

    abstract：:A selective, rapid and sensitive ultra performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) method was developed for the quantitative determination of lovastatin in human plasma and its application in a pharmacokinetic study. With mycophenolate mofetil as internal standard, sample pretreatment invol...

    journal_title：Journal of pharmaceutical and biomedical analysis

    pub_type： 杂志文章

    doi：10.1016/j.jpba.2007.12.005

    authors： Yuan H,Wang F,Tu J,Peng W,Li H

    更新日期：2008-03-13 00:00:00