Abstract:
:Neurofibromatosis 2 is an autosomal-dominant disease, which is characterized by vestibular schwannomas, cataract, retinal hamartomas as well as tumors of the peripheral and central nerve system, demonstrating a variety of expression. The ophthalmologist plays an important role in making the diagnosis, as several ocular manifestations may be shown during childhood, before tumors of the central nerve system become symptomatic. An early diagnosis of NF 2 may prevent deafness by early surgical intervention. Due to primary and secondary reasons such as age-related processes, different sensations like hearing or vision may be compromised. Neuropathy may lead to vestibular disturbances and loss of muscle control. Therapeutic options include cataract surgery, implantation of cochlear or brainstem implants as well as conservative therapy of the ocular surface in paresis of the VIIth cranial nerve or learning to read from the lips. The human NF2 gene was cloned from chromosome 22 in 1993. The major part of the genetic alterations described so far are point mutations as well as deletions or insertions in or around the exons. Geno-phenotype correlations allow some predictions of the course of the disease to be made.
journal_name
Klin Monbl Augenheilkdjournal_title
Klinische Monatsblatter fur Augenheilkundeauthors
Feucht M,Mautner VF,Richard Gdoi
10.1055/s-2005-857956subject
Has Abstractpub_date
2005-04-01 00:00:00pages
312-6issue
4eissn
0023-2165issn
1439-3999journal_volume
222pub_type
杂志文章,评审abstract:BACKGROUND:Presented is a patient whose history showed that during a hammer-blow on a piece of iron something had flown into his left eye. Clinical investigation revealed a 9-mm long, horizontal, paracentrally located, penetrating corneal wound. Temporally in the same region the iris was torn in its entire width. The l...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2005-857910
更新日期:2005-02-01 00:00:00
abstract::A cases of Pyoderma vegetans attacking only the outer skin of the eyelid and leaving free the conjunctiva is reported. The diagnosis of this rare condition, belonging to the pemphigus diseases, depends on clinical course and especially on histological investigation. The aetiology of Pyoderma vegetans still remains unk...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1978-08-01 00:00:00
abstract:BACKGROUND:Transmitted in an autosomal dominant fashion, the pattern dystrophies involve the retinal pigment epithelium and the external macular retina and are usually divided into four different entities. However, a progression from one form to another is possible, various forms may coexist in the same patient and a c...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1035218
更新日期:1996-05-01 00:00:00
abstract:BACKGROUND:The short-term impact of eye muscle surgery on the blood-aqueous barrier has been described by iris fluoresceinangiography and laser tyndallometry. The aim of this study was to investigate the long-term effects of eye muscle surgery on the oxygen supply of the anterior segment of the eye by determination of ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2007-962981
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND:First described in 1957, anterior segment ischemia (ASI) following extraocular muscle surgery for non paralytic or paralytic strabismus is a rare but serious complication. Systemic and anatomical risk factors can be identified and vesselsparing surgical techniques used. The aim of this study is to evaluate t...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1034887
更新日期:1998-05-01 00:00:00
abstract::Several authors regard early vitrectomy as the best guarantee of success in cases of severe ocular injury. The present authors reviewed their own group of 27 patients, which included 13 cases with intraocular foreign bodies, 6 cases of blunt trauma and 8 with perforating injuries. Aside from cases which later develope...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1046190
更新日期:1990-05-01 00:00:00
abstract:BACKGROUND:The successful development of cataract operation and IOL implantation in the last decade has resulted in progressive shortening of the incision length as well as in developing safer and simpler anesthetic techniques. The purpose of the present study was to evaluate whether cataract surgery with scleral incis...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1055/s-2008-1035332
更新日期:1996-12-01 00:00:00
abstract::The author presents a set of colored pictures which permits to delimitate 3 kinds of zonular fibers. 1. Short anterior fibers. 2. Short posterior or medial fibers, and 3. long posterior fibers. Describe also 3 irregular rings where the zonular fibers are firmly attached to the hyaloids and vitreous. 1. The Wieger's or...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1977-07-01 00:00:00
abstract::Clinico-virologic investigations and the availability of the new antiviral drug Acyclovir have changed our therapeutic approach to deep herpetic diseases. Treatment of the symptoms alone with steroids should now be avoided. Basic treatment should consist of optimal dosages of Acyclovir. However, additional steroid the...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1050949
更新日期:1985-06-01 00:00:00
abstract::There are three forms of lens dislocation in the posterior segment: intravitreal, prebasal, and intrabasal. The location of the dislocated lens depends on gravity and the condition of the vitreous body. As a rule the dislocated lens lies at the bottom of the vitreous cavity; it may be completely embedded in the vitreo...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1050310
更新日期:1988-12-01 00:00:00
abstract::A very rare combination of congenital malformations of the eyelids and eyes in a 6-month-old boy is reported. The main symptoms are a bilateral microblepharon associated with ectropion and bilateral aphakic microphthalmus. The pathogenesis of these changes is discussed. ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1057334
更新日期:1981-11-01 00:00:00
abstract::Optimal vision requires an ocular surface with vital epithelial coverage and a stable tear film. A multitude of endogenous and external factors may alter this delicate balance. Studies over the last decade have established that Ca2+ is an important factor in the control of ocular surface epithelial function and has le...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/a-1120-8754
更新日期:2020-05-01 00:00:00
abstract::a) Punctum plasty (eversion of the lacrimal point): This simple method results in a permanently enlarged punctum. A 4-0 silk suture is passed through the vertical part of the canaliculus and the conjunctiva, drawing them together very tightly. The thread falls out after 4-6 weeks. b) Management of trichiasis: Electrol...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1046212
更新日期:1990-05-01 00:00:00
abstract::A report on 3 instances of accidental injection of lidocaine into the eye. Among the immediate reactions were (1) development of corneal edema due to an abrupt rise in intraocular pressure, (2) dilatation and paralysis of the pupil, (3) decrease of visual acuity to light perception. In 2 of the patients pupillary reac...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1050595
更新日期:1986-02-01 00:00:00
abstract::The authors report on an 11-month-old child in whom subcutaneous fatty tissue covered with normal skin was found instead of a cornea. Since the lid and conjunctiva were intact this developmental anomaly may be designated cryptophthalmos solum corneae. ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1046162
更新日期:1990-04-01 00:00:00
abstract::As a model for our study we selected 11 pseudophacic patients with secondary cataracts who experienced good postoperative visual acuity after extracapsular cataract extraction. Besides best visual acuity and contrast sensitivity Pattern-ERG (PERG) and Contrast-Transfer-Ratio (CTR) were measured before and after YAG-Ka...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1045788
更新日期:1992-05-01 00:00:00
abstract:BACKGROUND:A meticulous fundoscopy is an essential examination before administering an orthoptic occlusion therapy (patching), even in cases with a "clear indication" for patching. In this case of an 8-year-old hyperopic boy the subsequent fundoscopy revealed a bilateral maculopathy that explained the stagnation of the...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1027270
更新日期:2008-05-01 00:00:00
abstract:BACKGROUND:The treatment of late age-related Macular Degeneration (AMD) according to the results of prospective clinical studies is indicated in classical choroidal neovascularisations (NV), which can be delineated from the center of the fovea. To evaluate the effectiveness of this therapy, the knowledge of the frequen...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1035324
更新日期:1996-11-01 00:00:00
abstract::Whereas by far not all properties of the crystalline lens can be realized with an artifical intraocular lens, maximal stability of such a device is its most important feature. The latter can be achieved by the adherence of the lens to the capsular membrane, left behind after extra-capsular cataract extraction. In this...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1979-06-01 00:00:00
abstract::In this paper 21 cases of branch vein thrombosis and 15 cases of central retinal vein thrombosis treated by argon laser photocoagulation are compared with an untreated control group. The visual prognosis after photocoagulation was no better in the treated group than in the control group. After central retinal vein occ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1057347
更新日期:1981-12-01 00:00:00
abstract:BACKGROUND:Causes of transient vertical diplopia include myasthenia, dysthyroid orbitopathy, multiple sclerosis, decompensation of a pre-existing state. PURPOSE:To describe an unusual cause of transient diplopia, silent sinus syndrome. METHODS:Clinical, radiological and pathology findings from a 55-year-old man with ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1034917
更新日期:1998-05-01 00:00:00
abstract::In spite of modern optical examination techniques such as sonography, nuclear magnetic resonance tomography (NMR) and x-ray computer tomography up to now the meningioma of the optic nerve sheath still poses a problem in respect of differential diagnosis. This problem is illustrated by two case reports. In both patient...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1045712
更新日期:1992-01-01 00:00:00
abstract::Four serologically-proved cases of intraocular toxocara infections are demonstrated. Three different manifestations in the following way were found: 1. Solitary granuloma on the posterior pole (2 patients). 2. Anterior and posterior uveitis of both eyes with granuloma near the ora (1 patient). 3. Iridocyclitis of both...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1978-12-01 00:00:00
abstract:BACKGROUND:Computer programmes for visual stimulation may give new impulses to the field of amblyopia treatment by offering an option to shift the apparative visual training into the domestic sphere. Regarding this aspect we report on a placebo controlled study on a newly developed vision training consisting of a backg...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 临床试验,杂志文章
doi:10.1055/s-2001-14921
更新日期:2001-04-01 00:00:00
abstract::In addition to photopic visual acuity both mesopic vision and sensitivity to glare play an important role in road traffic safety. It is known since the comprehensive investigations by Harms and Aulhorn that mesopic vision and sensitivity to glare are subjected to interindividually different changes with increasing age...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1057572
更新日期:1980-05-01 00:00:00
abstract::Julius Hirschberg of Berlin was one of the most brilliant ophthalmologists of his time. As a surgeon and as the editor of the "Centralblatt für praktische Augenheilkunde" (1877-1919) he enjoyed a world-wide reputation. He devised an electrical hand magnet for the extraction of intraocular foreign bodies (1879 - see Du...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 传,历史文章,杂志文章
doi:
更新日期:1976-01-01 00:00:00
abstract::The author describes the genuine indications for the preventive treatment of retinal detachment. He was above all guided by the minute observations of the eye fundus of two eyes with the Goldmann-glass. The author's long experience and his auto-observation of the retinal detachment operation and of preventive treatmen...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:
更新日期:1977-06-01 00:00:00
abstract::This paper reports on 6 cases of keratoconjunctivitis caused by the latex of Euphorbiaceae, one of them with slight systemic intoxication. Phorbolesters are considered to be responsible for the toxicity of the latex of Euphorbiaceae, e.g., in the case of Euphorbia helioscopia, 12-Desoxyphorbol-13-phenylacetate-2-O-ace...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1050944
更新日期:1985-05-01 00:00:00
abstract::The position of the implanted posterior chamber lens (Shearing type) in human cadaver eyes was photographed from the rear. We were especially interested in the position of the loops. ...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-2008-1057359
更新日期:1981-12-01 00:00:00
abstract:PURPOSE:Choroidal neovascularization (CNV) secondary to pathological myopia (PM) occurs in up to 10 % of PM and the natural course often leads to a considerable deterioration of visual acuity. Treatment options like laser or PDT can stabilize visual acuity. Alternatives like ranibizumab are new treatment options that s...
journal_title:Klinische Monatsblatter fur Augenheilkunde
pub_type: 杂志文章
doi:10.1055/s-0031-1273210
更新日期:2011-04-01 00:00:00