Abstract:
BACKGROUND:Ovarian cancer can be cured if detected early enough, but usually has already metastasized when diagnosed. A family history of ovarian cancer is still the strongest known risk factor. OBJECTIVE:To identify women at risk for ovarian cancer and design a program of surveillance. METHODS:Prospective registry of women with a family history of ovarian cancer. RESULT:From April 1991 to July 1993, 137 women (119 families), mean age 43, registered with the Familial Ovarian Cancer Registry. The 119 pedigrees revealed 171 cases of ovarian cancer. Only one family is undocumented by pathology. Forty of 137 registrants have more than one relative with ovarian cancer. Six percent of pelvic examinations were abnormal for potential adnexal disease. In 4% of registrants, initial CA125 concentrations were abnormal. Ultrasound examinations were abnormal in ovarian size (5%), in morphology (3%), and by resistive indices (4%). Four ultrasounds were repeated earlier than routine. Using "standard" fees, the total cost to diagnose the one case of ovarian cancer discovered was $68,848. CONCLUSIONS:This approach still cannot be considered cost-effective. We are continuing to search for genetic and molecular markers of disease in women at greatest risk and in their affected relatives.
journal_name
Cleve Clin J Medjournal_title
Cleveland Clinic journal of medicineauthors
Belinson JL,Okin C,Casey G,Ayoub A,Klein R,Hart WR,Franco K,Litt Rdoi
10.3949/ccjm.62.2.129subject
Has Abstractpub_date
1995-03-01 00:00:00pages
129-34issue
2eissn
0891-1150issn
1939-2869journal_volume
62pub_type
杂志文章abstract::Weight-loss drugs are being evaluated for their role in obesity management. This article reviews the available weight-loss drugs, their efficacy and side effects, and their best clinical use. ...
journal_title:Cleveland Clinic journal of medicine
pub_type: 杂志文章,评审
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abstract::Percutaneous transluminal coronary angioplasty (PTCA) of stenotic saphenous vein grafts is less invasive than repeat coronary bypass grafting; however, this procedure is complicated by atheromatous embolization in 2.5%-3.0% of cases, an incidence significantly higher than in angioplasty of native coronary vessels. We ...
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abstract::Cancer patients and their families often ask their primary care physicians if a new treatment reported in the news can help them. Physicians familiar with the long and complicated process of oncologic clinical trials are in the best position to assess the potential for clinical benefit from a new antineoplastic therap...
journal_title:Cleveland Clinic journal of medicine
pub_type: 杂志文章
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journal_title:Cleveland Clinic journal of medicine
pub_type: 杂志文章,评审
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abstract::Although atrial fibrillation is well tolerated by most patients, in some patients the consequences may be severe. The Maze procedure is a new open-heart operation that creates a carefully designed maze of incisions in the atrial myocardium; this maze then acts as an electrical conduit to channel atrial impulses from t...
journal_title:Cleveland Clinic journal of medicine
pub_type: 杂志文章
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abstract::The importance of glycemic control in preventing the chronic and devastating complications of diabetes is well established. Insulin administration is an important therapeutic option for managing diabetes, particularly for patients with profound insulin deficiency. Many insulin formulations are on the market, including...
journal_title:Cleveland Clinic journal of medicine
pub_type: 杂志文章,评审
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abstract::Although most patients with emphysema are managed medically, a small subset of severely disabled patients may become candidates for surgery. This paper discusses for the internist who works with emphysema patients the risks, benefits, patient selection criteria, and outcome data for three procedures in current use: bu...
journal_title:Cleveland Clinic journal of medicine
pub_type: 杂志文章,评审
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journal_title:Cleveland Clinic journal of medicine
pub_type: 杂志文章,评审
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journal_title:Cleveland Clinic journal of medicine
pub_type: 杂志文章,评审
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journal_title:Cleveland Clinic journal of medicine
pub_type: 已发布勘误
doi:
更新日期:2015-02-01 00:00:00
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journal_title:Cleveland Clinic journal of medicine
pub_type: 杂志文章,评审
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journal_title:Cleveland Clinic journal of medicine
pub_type: 杂志文章
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journal_title:Cleveland Clinic journal of medicine
pub_type: 杂志文章
doi:10.3949/ccjm.71.1.63
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journal_title:Cleveland Clinic journal of medicine
pub_type: 已发布勘误
doi:
更新日期:2016-09-01 00:00:00
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journal_title:Cleveland Clinic journal of medicine
pub_type: 杂志文章,评审
doi:10.3949/ccjm.85a.17037
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journal_title:Cleveland Clinic journal of medicine
pub_type: 杂志文章,评审
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journal_title:Cleveland Clinic journal of medicine
pub_type: 杂志文章,评审
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journal_title:Cleveland Clinic journal of medicine
pub_type: 杂志文章,评审
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pub_type: 杂志文章,评审
doi:10.3949/ccjm.84a.16107
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journal_title:Cleveland Clinic journal of medicine
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journal_title:Cleveland Clinic journal of medicine
pub_type: 杂志文章,评审
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journal_title:Cleveland Clinic journal of medicine
pub_type: 杂志文章,评审
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journal_title:Cleveland Clinic journal of medicine
pub_type: 杂志文章
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journal_title:Cleveland Clinic journal of medicine
pub_type: 杂志文章,评审
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journal_title:Cleveland Clinic journal of medicine
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journal_title:Cleveland Clinic journal of medicine
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journal_title:Cleveland Clinic journal of medicine
pub_type: 杂志文章,评审
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journal_title:Cleveland Clinic journal of medicine
pub_type: 杂志文章,评审
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更新日期:2018-03-01 00:00:00
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journal_title:Cleveland Clinic journal of medicine
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journal_title:Cleveland Clinic journal of medicine
pub_type: 杂志文章,评审
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