Autosomal dominant polycystic kidney disease and the heart and brain.

abstract：:Transitions of care-when patients move from one health care facility to another or back home-that are poorly executed result in adverse effects for patients. Fortunately, programs can be implemented that enhance collaboration across care settings and improve outcomes including reducing hospital readmission rates. ...

journal_title：Cleveland Clinic journal of medicine

authors： Li J,Young R,Williams MV

更新日期：2014-05-01 00:00:00

abstract：:Because 1% to 9% of people without symptoms have elevated liver enzymes, extensive evaluation of all abnormal test results would expose many patients to undue risks and expenses. On the other hand, failure to evaluate minor liver enzyme elevations could mean missing the early diagnosis of potentially treatable disorde...

journal_title：Cleveland Clinic journal of medicine

authors： Aragon G,Younossi ZM

更新日期：2010-03-01 00:00:00

abstract：:The metabolic syndrome--the cluster of obesity, impaired fasting glucose, elevated triglycerides, low high-density lipoprotein cholesterol, and hypertension--may not be a "real" syndrome in the strict sense. It can, however, still be a useful concept if it prompts a physician to look for and treat additional risk fact...

journal_title：Cleveland Clinic journal of medicine

authors： Stolar M

更新日期：2007-03-01 00:00:00

abstract：:The effects of estrogenic steroid hormones in women are apparent, but the circulating androgen levels are much higher. Compared with serum estrone and estradiol levels, circulating testosterone levels are five to 10 times higher, androstenedione levels 30 times higher, dehydroepiandrosterone levels 100 times higher, a...

journal_title：Cleveland Clinic journal of medicine

authors： Cumming DC

更新日期：1990-03-01 00:00:00

abstract：:Gout management requires a comprehensive strategy that considers both acute and chronic aspects of the disease. Acute gout flares should be treated with anti-inflammatory agents as rapidly as possible. The underlying hyperuricemia may be treated with urate-lowering agents initiated at a time appropriate for the indivi...

journal_title：Cleveland Clinic journal of medicine

authors： Schumacher HR Jr,Chen LX

更新日期：2008-07-01 00:00:00

abstract：:Cardiac rehabilitation, consisting of prescribed exercise and counseling for risk modification, has proven benefits for patients with cardiovascular disease. Nevertheless, rates of referral and use remain low. Efforts to increase program referral and participation are ongoing. ...

journal_title：Cleveland Clinic journal of medicine

authors： Simon M,Korn K,Cho L,Blackburn GG,Raymond C

更新日期：2018-07-01 00:00:00

abstract：:Thrombotic thrombocytopenic purpura (TTP) is a spectrum of syndromes characterized by thrombocytopenia and microangiopathic hemolytic anemia, manifested by an elevated blood lactate dehydrogenase (LDH) concentration and red blood cell fragments. It classically occurs in patients with a hereditary or acquired lack of A...

journal_title：Cleveland Clinic journal of medicine

authors： Crowther MA,George JN

更新日期：2008-05-01 00:00:00

abstract：:Recommendations exist for preparticipation physical examinations, but there is no national standard, and the recommendations are not widely followed. The most common reasons for denying clearance to play are musculoskeletal conditions, hypertension, and visual acuity problems. Although detecting potentially life-threa...

journal_title：Cleveland Clinic journal of medicine

authors： Mick TM,Dimeff RJ

更新日期：2004-07-01 00:00:00

abstract：:The preoperative evaluation often includes more tests than are necessary. This article reviews the usefulness of and indications for nine commonly ordered preoperative tests. ...

journal_title：Cleveland Clinic journal of medicine

authors： Jones T,Isaacson JH

更新日期：1995-11-01 00:00:00

abstract：:Anticonvulsant hypersensitivity syndrome, a potentially fatal but rare reaction, manifests as rash, fever, tender lymphadenopathy, hepatitis, and eosinophilia. To manage hypersensitivity syndrome successfully, one must recognize the symptoms early, stop the offending drug immediately, and substitute a safe, alternativ...

journal_title：Cleveland Clinic journal of medicine

authors： Hamer HM,Morris HH

更新日期：1999-04-01 00:00:00

abstract：:When a patient reports constipation, a careful history and physical examination may identify the underlying cause. In many patients, though, no underlying cause is identified. Empiric treatment with exercise, hydration, fiber supplementation, and mild laxatives is often effective. If constipation does not resolve with...

journal_title：Cleveland Clinic journal of medicine

authors： Soffer EE

更新日期：1999-01-01 00:00:00

abstract：:One of the most important deficiency states associated with chronic renal failure is profound anemia. While it has been possible to identify differing types of anemia in patients receiving dialysis support, and thus correct the secondary causes, most patients continue to exhibit symptoms and signs of the anemic state....

journal_title：Cleveland Clinic journal of medicine

authors： Paganini EP,Garcia J,Abdulhadi M,Lathim D,Giesman J,Weick JK

更新日期：1989-01-01 00:00:00

abstract：:Although the safety profiles of drug-eluting stents are similar to those of bare metal stents in the short term, concern has arisen about their potential for late thrombosis (occurring > 30 days after implantation). Stent thrombosis is rare but potentially devastating and can result in ST-segment elevation myocardial ...

journal_title：Cleveland Clinic journal of medicine

authors： Rabbat MG,Bavry AA,Bhatt DL,Ellis SG

更新日期：2007-02-01 00:00:00

abstract：:Tailored care will increasingly become the hallmark of treatment for patients with hypertension in the 1990s. In mildly hypertensive patients, treatment should begin with nonpharmacologic approaches to lower blood pressure and reduce the patient's cardiovascular risk profile. The ever-increasing array of antihypertens...

journal_title：Cleveland Clinic journal of medicine

authors： Vidt DG

更新日期：1991-05-01 00:00:00

abstract：:Antibiotics can be effective against acute exacerbations of chronic bronchitis and chronic obstructive pulmonary disease, but with bacterial resistance to multiple antibiotics increasing worldwide, appropriate antibiotic selection is critical. Categorizing patients with acute exacerbations according to age, number of ...

journal_title：Cleveland Clinic journal of medicine

authors： Adams SG,Anzueto A

更新日期：2000-09-01 00:00:00

abstract：:Observational studies indicate that aspirin may counteract the beneficial effect of angiotensin-converting enzyme (ACE) inhibitors, but the data are not yet sufficient for making firm recommendations. We review the available data and offer tentative conclusions. ...

journal_title：Cleveland Clinic journal of medicine

authors： Peterson JG,Lauer MS

更新日期：2001-06-01 00:00:00

abstract：:Although hypertension has been defined numerically as blood pressure levels above 140/90 mmHg, there is no doubt that a blood pressure level within the "normal" range increases the stress on a diseased heart. For this reason, vasodilator therapy is often successful in treating congestive heart failure. The authors pro...

journal_title：Cleveland Clinic journal of medicine

authors： Fouad-Tarazi FM,Hobbs RE

更新日期：1989-06-01 00:00:00

abstract：:Exercise, in conjunction with diet, is critical to losing weight and maintaining health in obese patients. While it can be challenging for an obese person to transition to a healthy lifestyle, the physical and emotional benefits of a regular exercise program make it worth the effort. ...

journal_title：Cleveland Clinic journal of medicine

authors： Higgins JP,Higgins CL

更新日期：2016-02-01 00:00:00

abstract：:Although a low level of high-density lipoprotein (HDL) cholesterol is a useful clinical predictor of coronary heart disease, raising the HDL cholesterol level does not necessarily lower this risk. Part of the explanation for this paradox may be that, under certain conditions, HDL either can be less functional as an an...

journal_title：Cleveland Clinic journal of medicine

authors： Ansell BJ

更新日期：2007-10-01 00:00:00

abstract：:Genetics may account for much of the variability in our patients' responses to drug therapies. This article offers the clinician an up-to-date overview of pharmacogenomic testing, discussing implications and limitations of emerging validated tests relevant to the use of warfarin (Coumadin), clopidogrel (Plavix), stati...

journal_title：Cleveland Clinic journal of medicine

authors： Kitzmiller JP,Groen DK,Phelps MA,Sadee W

更新日期：2011-04-01 00:00:00

abstract：:Patients with alcohol use disorder (AUD) are at higher risk of pneumonia and of poor outcomes. This article reviews the etiology of pneumonia in patients with AUD, its impact on mortality and resource utilization, and its implications for treatment. ...

journal_title：Cleveland Clinic journal of medicine

authors： Gupta NM,Deshpande A,Rothberg MB

更新日期：2020-07-31 00:00:00

abstract：:The antidiuretic hormone arginine vasopressin (AVP) is primarily responsible for regulating osmotic and volume homeostasis of body fluids, largely through binding to vasopressin type 1A (V(1A)) and type 2 (V2) receptors. Increased AVP secretion leads to decreased free water excretion with resulting water retention, an...

journal_title：Cleveland Clinic journal of medicine

authors： Verbalis JG

更新日期：2006-09-01 00:00:00

abstract：:Women with heart failure differ from their male counterparts in a number of ways, including etiology, pattern of cardiac remodeling, and prognosis. They may even respond differently to medical therapy. But until prospective, sex-specific studies show that we should do otherwise, we recommend that women with heart fail...

journal_title：Cleveland Clinic journal of medicine

authors： Mezu U,Bott-Silverman C,Hsich E

更新日期：2007-06-01 00:00:00

abstract：:Complications of chronic gastroesophageal reflux disease (GERD) run the gamut from erosive esophagitis to esophageal cancer, but all are linked to repeated exposure of the esophagus to caustic gastric and duodenal acid. Progression from one complication to another is not clearly established across the GERD continuum, ...

journal_title：Cleveland Clinic journal of medicine

authors： Fennerty MB

更新日期：2003-11-01 00:00:00

abstract：:Heart failure is the most important public health problem in cardiovascular medicine, and is increasing in both prevalence and expense. Programs that use an interdisciplinary team to improve outpatient treatment and prevent hospitalizations will help improve care and control costs. But the most important long-term str...

journal_title：Cleveland Clinic journal of medicine

authors： Starling RC

更新日期：1998-07-01 00:00:00

abstract：:Many drugs can injure the kidneys, but they cause renal injury via only a few common mechanisms. Many patients who develop renal injury after drug exposure have identifiable risk factors that could be modified or that should preclude the use of these drugs in the first place. ...

journal_title：Cleveland Clinic journal of medicine

authors： Guo X,Nzerue C

更新日期：2002-04-01 00:00:00

abstract：:The focus of palliative care is to alleviate pain and suffering for patients, potentially while they concurrently pursue life-prolonging or curative therapy. The potential breadth of palliative care is recognized by the Medicare program, but the Medicare hospice benefit is narrowly defined and limited to care that is ...

journal_title：Cleveland Clinic journal of medicine

authors： Labson MC,Sacco MM,Weissman DE,Gornet B,Stuart B

更新日期：2013-01-01 00:00:00

abstract：:Congestive heart failure is the most common cause of death in patients with thalassemia, as chronic accumulation of iron due to regular blood transfusions leads to biventricular systolic dysfunction and death at a very young age. The quantity of iron deposited in the heart is a key determinant of outcome. Early diagno...

journal_title：Cleveland Clinic journal of medicine

authors： Jabbar DA,Davison G,Muslin AJ

更新日期：2007-11-01 00:00:00

abstract：:To date, there are no effective antiviral medications for COVID-19. Drug repurposing, a strategy that uses existing drugs, offers potential prevention and treatment options for COVID-19. We discuss one treatment strategy that combines anti-inflammatory (melatonin) and antiviral (toremifene) agents for patients infecte...

journal_title：Cleveland Clinic journal of medicine

authors： Cheng F,Rao S,Mehra R

更新日期：2020-06-30 00:00:00

abstract：:A surprising number of apparently healthy people harbor unsuspected pituitary tumors, which are being discovered incidentally on computed tomography (CT) or magnetic resonance imaging (MRI) performed for other reasons. The majority can be safely observed; for others, medical therapy or surgical resection is necessary....

journal_title：Cleveland Clinic journal of medicine

authors： Serhal D,Weil RJ,Hamrahian AH

更新日期：2008-11-01 00:00:00