Getting the iron out: preventing and treating heart failure in transfusion-dependent thalassemia.

abstract：:The history and physical examination, rather than routine laboratory, cardiovascular, and pulmonary testing, are the most important components of the preoperative evaluation. The history should include a complete review of systems (especially cardiovascular and pulmonary), medication history, allergies, surgical and a...

journal_title：Cleveland Clinic journal of medicine

authors： Michota FA,Frost SD

更新日期：2004-01-01 00:00:00

abstract：:Community-acquired bacterial meningitis is still a significant cause of morbidity and mortality. Clinicians should know how to quickly diagnose it, perform a lumbar puncture, order the necessary tests, and start appropriate empiric therapy promptly. ...

journal_title：Cleveland Clinic journal of medicine

authors： Bhimraj A

更新日期：2012-06-01 00:00:00

abstract：:Elevated serum urate levels are recognized as leading to gouty arthritis, tophi formation, and uric acid kidney stones. While serum urate elevations have long been associated with renal disease, they are not usually considered to have a causal role in kidney dysfunction. However, recent epidemiologic studies have iden...

journal_title：Cleveland Clinic journal of medicine

authors： Edwards NL

更新日期：2008-07-01 00:00:00

abstract：:Many infants, children, and adolescents exhibit unusual mannerisms, behaviors, and spells. These events cause concern to parents and are frequently brought to the attention of physicians. If the spells are infrequent and do not interfere with function, no intervention may be necessary. If they are severe and recurrent...

journal_title：Cleveland Clinic journal of medicine

authors： Rothner AD

更新日期：1989-01-01 00:00:00

abstract：:Informed consent in clinical research is a matter of both ethics and federal regulation. A research subject must enter a study voluntarily, be informed about risks and benefits, and understand the difference between experiment and treatment. ...

journal_title：Cleveland Clinic journal of medicine

authors： Bramstedt KA

更新日期：2004-11-01 00:00:00

abstract：:Because type 2 diabetes mellitus is a progressive disease, most patients eventually need insulin. When and how to start insulin therapy are not one-size-fits-all decisions but rather must be individualized. This paper reviews the indications, goals, and options for insulin therapy in type 2 diabetes. ...

journal_title：Cleveland Clinic journal of medicine

authors： Brateanu A,Russo-Alvarez G,Nielsen C

更新日期：2015-08-01 00:00:00

abstract：:COVID-19 infection is associated with several cardiac complications with high rates of adverse outcomes. Cardiac imaging has different utility in different clinical scenarios, and the importance of minimizing healthcare worker exposure should be considered. Cardiac imaging should only be ordered if its benefits outwei...

journal_title：Cleveland Clinic journal of medicine

authors： Wang TKM,Tang WHW,Flamm SD,Griffin B,Dugar S,Grimm RA,Kwon DH

更新日期：2020-05-14 00:00:00

abstract：:Observational studies indicate that aspirin may counteract the beneficial effect of angiotensin-converting enzyme (ACE) inhibitors, but the data are not yet sufficient for making firm recommendations. We review the available data and offer tentative conclusions. ...

journal_title：Cleveland Clinic journal of medicine

authors： Peterson JG,Lauer MS

更新日期：2001-06-01 00:00:00

abstract：:SCS is an efficacious, reversible, and safe therapy that improves quality of life, increases exercise tolerance, and relieves angina pectoris, but clinical trials in North America are needed to confirm the data coming from Europe. Neuronal convergence onto STT cells underlies the referred pain associated with angina p...

journal_title：Cleveland Clinic journal of medicine

authors： Foreman RD

更新日期：2007-02-01 00:00:00

abstract：:Treatment of anemia in the perioperative period of major orthopedic surgery decreases the need for blood transfusion and improves perioperative outcomes. Use of epoetin alfa in this setting is FDA-approved and provides significant benefit to qualified and carefully chosen patients. ...

journal_title：Cleveland Clinic journal of medicine

authors： Kumar A,Dimov V

更新日期：2006-09-01 00:00:00

abstract：:In 1988, a new do-not-resuscitate policy aimed at assisting professional staff, nurses, patients, and families in end-of-life choices replaced the existing policy at The Cleveland Clinic Foundation. We conducted a retrospective chart review to examine the effects of the new policy on length of stay. Data were collecte...

journal_title：Cleveland Clinic journal of medicine

authors： Kanoti GA,Gombeski WR Jr,Gulledge AD,Konrad D,Collins R,Medendorp SV

更新日期：1992-11-01 00:00:00

abstract：:Several theories have been put forth to explain the pathogenesis of syringomyelia, the formation of longitudinal, fluid-filled cavities within the spinal cord. Chief among them is Gardner's hydrodynamic theory, widely accepted for more than two decades. Gardner attributed the genesis of syringomyelia to craniospinal p...

journal_title：Cleveland Clinic journal of medicine

authors： Pillay PK,Awad IA,Hahn JF

更新日期：1992-07-01 00:00:00

abstract：:Patients with muscle diseases are often seen initially by general practitioners. This article reviews how to evaluate and manage such patients, including those taking a statin, how to interpret creatine kinase (CK) test results, and how to recognize common as well as potentially dangerous myopathies. ...

journal_title：Cleveland Clinic journal of medicine

authors： Oddis CV

更新日期：2019-10-01 00:00:00

abstract：:Lifestyle modifications in conjunction with antidiabetes medications can produce near-normal blood glucose concentrations in patients with type 2 diabetes mellitus (T2DM). Because these patients have increased cardiovascular morbidity and mortality, treatment strategies should also address the cardiovascular aspects o...

journal_title：Cleveland Clinic journal of medicine

authors： Peters AL

更新日期：2009-12-01 00:00:00

abstract：:The treatment of hepatitis C has evolved rapidly since the identification of the hepatitis C virus (HCV) in 1989. Since the first accepted therapy for HCV infection, recombinant interferon, received marketing approval a little more than a decade ago, it has come to be used in combination with ribavirin for improved ra...

journal_title：Cleveland Clinic journal of medicine

authors： Saadeh S,Davis GL

更新日期：2004-05-01 00:00:00

abstract：:Early restoration of patency of the infarct-related artery is a universally accepted goal in the treatment of acute myocardial infarction. However, even with the most successful fibrinolytic regimen only approximately 50% of patients achieve restoration of normal flow at 90 minutes. "Rescue" angioplasty, the mechanica...

journal_title：Cleveland Clinic journal of medicine

authors： Mukherjee D,Ellis SG

更新日期：2000-05-01 00:00:00

abstract：:Thirty-four young patients (28 male and 6 female) underwent aortic valve replacement between 1972 and 1988. Ages ranged from 11 to 20 years (mean 17.7 years). Including reimplantation in the follow-up period, 40 valves were implanted, among which were 17 (43%) St. Jude, 7 (16%) Bjork-Shiley, and 4 (10%) Carpentier-Edw...

journal_title：Cleveland Clinic journal of medicine

authors： Moodie DS,Hanhan U,Sterba R,Murphy DJ Jr,Rosenkranz ER,Kovacs AM

更新日期：1992-09-01 00:00:00

abstract：:Although a low level of high-density lipoprotein (HDL) cholesterol is a useful clinical predictor of coronary heart disease, raising the HDL cholesterol level does not necessarily lower this risk. Part of the explanation for this paradox may be that, under certain conditions, HDL either can be less functional as an an...

journal_title：Cleveland Clinic journal of medicine

authors： Ansell BJ

更新日期：2007-10-01 00:00:00

abstract：:Patients with systemic lupus erythematosus (SLE, lupus) have a markedly better survival rate today than they did 50 years ago, but they face a greater risk of cancer, cardiovascular disease, and osteoporosis at early ages. With better understanding of the immunological mechanisms of the disease, new avenues of therapy...

journal_title：Cleveland Clinic journal of medicine

authors： Manzi S

更新日期：2009-02-01 00:00:00

abstract：:Increased levels of human growth hormone (HGH) may correlate with the severity of psoriasis and native somatostatin (SRIF) may improve it by inhibiting HGH release. The synthetic SRIF analog, SMS 201-995, is a potent and long-lasting HGH inhibitor. Nine patients with chronic plaque psoriasis completed 12 weeks of open...

journal_title：Cleveland Clinic journal of medicine

authors： Camisa C,O'Dorisio TM,Maceyko RF,Schacht GE,Mekhjian HS,Howe BA

更新日期：1990-01-01 00:00:00

abstract：:Many patients are donating their own blood before surgery to avoid blood-borne infections, often on the advice of their physicians. But autologous blood transfusion, while safer than allogeneic transfusion, is not completely risk-free. It is also expensive, its benefits are difficult to assess, and its increasing popu...

journal_title：Cleveland Clinic journal of medicine

authors： Domen RE

更新日期：1996-09-01 00:00:00

abstract：:In patients with morbid obesity, surgery is the only treatment known to produce sustained weight loss and to reduce comorbidities. Traditional (open) gastric bypass surgery is associated with postoperative complications that include wound infection, pulmonary embolism, and pneumonia. Laparoscopic techniques achieve si...

journal_title：Cleveland Clinic journal of medicine

authors： Brody F

更新日期：2004-04-01 00:00:00

abstract：:The preoperative evaluation often includes more tests than are necessary. This article reviews the usefulness of and indications for nine commonly ordered preoperative tests. ...

journal_title：Cleveland Clinic journal of medicine

authors： Jones T,Isaacson JH

更新日期：1995-11-01 00:00:00

abstract：:The neurohormone arginine vasopressin (AVP) is a promising target in the treatment of heart failure because AVP promotes congestion and hyponatremia, each of which is associated with poor outcomes. Diuretics are standard therapy for heart failure, but they have several limitations, including worsening renal function a...

journal_title：Cleveland Clinic journal of medicine

authors： Gheorghiade M

更新日期：2006-06-01 00:00:00

abstract：:Cyclospora cayetanensis, an emerging pathogen with worldwide distribution, causes diarrhea in both immunocompetent and HIV-infected patients. We review the epidemiology of Cyclospora infection and how to diagnose and treat it. ...

journal_title：Cleveland Clinic journal of medicine

authors： Gumbo T,Gordon SM,Adal KA

更新日期：1997-06-01 00:00:00

abstract：:We reviewed the population of a surgical intensive care unit from July 1, 1987 to June 30, 1988, adjusting for severity of illness using the APACHE II system. Nineteen different departments admitted a total of 613 patients to the surgical intensive care unit. Predicted mortality was 22.9%; actual mortality was 15.7%. ...

journal_title：Cleveland Clinic journal of medicine

authors： Lockrem JD,Lopez E,Gallagher J,Church GE,Estafanous FG

更新日期：1991-11-01 00:00:00

abstract：:Special problems of Asian patients have considerable impact on diagnosis and treatment, and the number of persons of Asian ancestry seen in primary care in the United States is increasing. Knowledge of how to provide optimal care despite language barriers, low socioeconomic status, different health beliefs and practic...

journal_title：Cleveland Clinic journal of medicine

authors： Jin XW,Slomka J,Blixen CE

更新日期：2002-01-01 00:00:00

abstract：:Tailored care will increasingly become the hallmark of treatment for patients with hypertension in the 1990s. In mildly hypertensive patients, treatment should begin with nonpharmacologic approaches to lower blood pressure and reduce the patient's cardiovascular risk profile. The ever-increasing array of antihypertens...

journal_title：Cleveland Clinic journal of medicine

authors： Vidt DG

更新日期：1991-05-01 00:00:00

abstract：:Most patients find some relief with current agents, even though a poor understanding of the causes of chronic primary headache limits prophylaxis and treatment. The author reviews current preventive and treatment strategies for migraine, chronic tension headache, cluster headache, and substance withdrawal headache. ...

journal_title：Cleveland Clinic journal of medicine

authors： Solomon GD

更新日期：2001-11-01 00:00:00

abstract：:In hospitalized medical patients, randomized trials have established that anticoagulant prophylaxis has an acceptable benefit-to-risk ratio: ie, it lowers the incidence of clinically silent and symptomatic venous thromboembolism (VTE), including fatal pulmonary embolism, more than it raises the risks of bleeding and o...

journal_title：Cleveland Clinic journal of medicine

authors： Pai M,Douketis JD

更新日期：2010-02-01 00:00:00