The role of hyperuricemia and gout in kidney and cardiovascular disease.

Abstract:

:Elevated serum urate levels are recognized as leading to gouty arthritis, tophi formation, and uric acid kidney stones. While serum urate elevations have long been associated with renal disease, they are not usually considered to have a causal role in kidney dysfunction. However, recent epidemiologic studies have identified serum urate elevations as an independent risk factor for chronic kidney disease. Hyperuricemia has also been found to be an independent risk factor for cardiovascular disease and hypertension. An animal model of mild hyperuricemia has shed new light on a potential mechanism of microvascular changes leading to endothelial dysfunction, a precursor to both coronary artery disease and hypertension. Additional animal studies and recent epidemiologic findings have provided further evidence that soluble urate is a risk factor for nonarticular disease.

journal_name

Cleve Clin J Med

authors

Edwards NL

doi

10.3949/ccjm.75.suppl_5.s13

subject

Has Abstract

pub_date

2008-07-01 00:00:00

pages

S13-6

eissn

0891-1150

issn

1939-2869

journal_volume

75 Suppl 5

pub_type

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