Assessing cancer clinical trials: will your patient benefit from a 'breakthrough'?

abstract：:The history and physical examination, rather than routine laboratory, cardiovascular, and pulmonary testing, are the most important components of the preoperative evaluation. The history should include a complete review of systems (especially cardiovascular and pulmonary), medication history, allergies, surgical and a...

journal_title：Cleveland Clinic journal of medicine

authors： Michota FA,Frost SD

更新日期：2004-01-01 00:00:00

abstract：:Eating disorders are common in adolescents and young adults, including those with a history of overweight or obesity, and are associated with numerous systemic sequelae. Understanding the differences in presentation between these patients and those who have a more classic anorexia nervosa phenotype is critical to ensu...

journal_title：Cleveland Clinic journal of medicine

authors： Rastogi R,Rome Md ES

更新日期：2020-03-01 00:00:00

abstract：:Mild cognitive impairment (MCI) is a common heterogeneous syndrome that in some cases is transitional between normal age-related cognitive changes and dementia. Identifying it early may lead to prompt recognition of reversible causes and allows for timely future planning. This article describes definitions of MCI and ...

journal_title：Cleveland Clinic journal of medicine

authors： Patel BB,Holland NW

更新日期：2012-12-01 00:00:00

abstract：:Exercise, in conjunction with diet, is critical to losing weight and maintaining health in obese patients. While it can be challenging for an obese person to transition to a healthy lifestyle, the physical and emotional benefits of a regular exercise program make it worth the effort. ...

journal_title：Cleveland Clinic journal of medicine

authors： Higgins JP,Higgins CL

更新日期：2016-02-01 00:00:00

abstract：:Thrombotic thrombocytopenic purpura, Shiga toxin hemolytic uremic syndrome, atypical hemolytic uremic syndrome, and antiphospholipid syndrome are thrombotic microangiopathies that present similarly but arise from different causes. Management depends on distinguishing them promptly and providing targeted therapy. ...

journal_title：Cleveland Clinic journal of medicine

authors： Appel GB

更新日期：2017-02-01 00:00:00

abstract：:Evidence is mounting that depression is a risk factor for the development of cardiovascular disease and portends a worse outcome in cardiac patients. Depression can be easily diagnosed and safely treated in cardiac patients, but it is undertreated. ...

journal_title：Cleveland Clinic journal of medicine

authors： Kemp DE,Malhotra S,Franco KN,Tesar G,Bronson DL

更新日期：2003-09-01 00:00:00

abstract：:Although hypertension has been defined numerically as blood pressure levels above 140/90 mmHg, there is no doubt that a blood pressure level within the "normal" range increases the stress on a diseased heart. For this reason, vasodilator therapy is often successful in treating congestive heart failure. The authors pro...

journal_title：Cleveland Clinic journal of medicine

authors： Fouad-Tarazi FM,Hobbs RE

更新日期：1989-06-01 00:00:00

abstract：:Biochemical markers of bone turnover provide clinically useful evidence of the normal and pathologic processes that reflect bone cell activity in the skeleton. Understanding the behavior of markers of bone formation and bone resorption should aid in managing patients with a variety of skeletal disorders. ...

journal_title：Cleveland Clinic journal of medicine

authors： Singer FR,Eyre DR

更新日期：2008-10-01 00:00:00

abstract：:Interleukin 1 (IL-1) is a potential target of therapy in COVID-19 during the severe respiratory-inflammatory phase ("cytokine release syndrome"), when pulmonary macrophages are hyperactivated, releasing IL-1 and other cytokines. Preliminary evidence indicates that anakinra and canakinumab, drugs that block the action ...

journal_title：Cleveland Clinic journal of medicine

authors： Calabrese LH,Calabrese C

更新日期：2020-07-09 00:00:00

abstract：:Numerous immunomodulating agents are currently being studied in clinical trials for the treatment of COVID-19, including interferon therapies. Interferons are naturally occurring host antiviral proteins upstream of the inflammatory pathway that are released by host cells in response to the presence of viral pathogens....

journal_title：Cleveland Clinic journal of medicine

authors： Calabrese LH,Lenfant T,Calabrese C

更新日期：2020-12-03 00:00:00

abstract：:Decisions about whether and how long to treat seizures in children and adolescents should be based on rational criteria and knowledge of the natural history of epileptic syndromes, rather than on the presumption that all seizures should be treated at any cost. ...

journal_title：Cleveland Clinic journal of medicine

authors： Zacharowicz L,Moshé SL

更新日期：1995-05-01 00:00:00

abstract：:Platelet activation is one of the essential steps in the genesis and propagation of atherothrombosis. Accumulating clinical evidence suggests that an elevated platelet count, platelet activation, and platelet hyperreactivity (defined as residual platelet activity despite antiplatelet drug therapy) may be associated wi...

journal_title：Cleveland Clinic journal of medicine

authors： Kottke-Marchant K

更新日期：2009-04-01 00:00:00

abstract：:Exercise stress electrocardiography is unreliable as a test for obstructive coronary artery disease (CAD) if the patient has left bundle branch block. The authors provide an algorithm for using alternative tests: exercise stress echocardiography, dobutamine echocardiography, computed tomographic (CT) angiography, and ...

journal_title：Cleveland Clinic journal of medicine

authors： Xu B,Cremer P,Jaber W,Moir S,Harb SC,Rodriguez LL

更新日期：2018-03-01 00:00:00

abstract：:Lifestyle modifications in conjunction with antidiabetes medications can produce near-normal blood glucose concentrations in patients with type 2 diabetes mellitus (T2DM). Because these patients have increased cardiovascular morbidity and mortality, treatment strategies should also address the cardiovascular aspects o...

journal_title：Cleveland Clinic journal of medicine

authors： Peters AL

更新日期：2009-12-01 00:00:00

abstract：:Studies published during the past year on the treatment of several infectious diseases provide valuable information that should enable us to treat our patients more effectively. Among those findings: Oral vancomycin (Vancocin) is superior to oral metronidazole (Flagyl) for treating patients with severe Clostridium dif...

journal_title：Cleveland Clinic journal of medicine

authors： Longworth DL

更新日期：2008-08-01 00:00:00

abstract：:Consensus panel guidelines advocate for the judicious use of antipsychotic drugs to manage delirium in hospitalized patients when nonpharmacologic measures fail and the patient is in significant distress from symptoms, poses a safety risk to self or others, or is impeding essential aspects of his or her medical care. ...

journal_title：Cleveland Clinic journal of medicine

authors： Thom RP,Mock CK,Teslyar P

更新日期：2017-08-01 00:00:00

abstract：:Glomerulonephritis (GN) is a common manifestation of the antineutrophil cytoplasmic antibody-associated systemic vasculitides (AASV), which include granulomatosis with polyangiitis and microscopic polyangiitis. The level of renal involvement at presentation is highly predictive of survival and should be assessed early...

journal_title：Cleveland Clinic journal of medicine

authors： de Groot K

更新日期：2012-11-01 00:00:00

abstract：:Because 1% to 9% of people without symptoms have elevated liver enzymes, extensive evaluation of all abnormal test results would expose many patients to undue risks and expenses. On the other hand, failure to evaluate minor liver enzyme elevations could mean missing the early diagnosis of potentially treatable disorde...

journal_title：Cleveland Clinic journal of medicine

authors： Aragon G,Younossi ZM

更新日期：2010-03-01 00:00:00

abstract：:The elderly are at increased risk for dehydration and associated fluid and electrolyte imbalances. Changes in functional and mental status, medication effects, and changes in the aging renal system all may be factors. Furthermore, hypodipsia, or insensibility to thirst, may be a physiologic process of aging. These and...

journal_title：Cleveland Clinic journal of medicine

authors： Silver AJ

更新日期：1990-06-01 00:00:00

abstract：:An over-the-counter at-home test for human immunodeficiency virus (HIV) infection has been approved and will likely be available soon. It is intended to decrease the percentage of HIV-infected people unaware of their infection (estimated at 18% of the 1.2 million people infected in the United States). Since early and ...

journal_title：Cleveland Clinic journal of medicine

authors： Koval CE

更新日期：2012-10-01 00:00:00

abstract：:The ongoing outbreak of Zika virus infection that began in South America and Central America in 2014 is worrisome because of associations with fetal microcephaly and with Guillain-Barré syndrome. Here we summarize what has happened and what is known so far. As the outbreak continues to evolve, we urge clinicians to wa...

journal_title：Cleveland Clinic journal of medicine

authors： Flores MS,Burgess TH,Rajnik M

更新日期：2016-04-01 00:00:00

abstract：:Although atrial fibrillation is well tolerated by most patients, in some patients the consequences may be severe. The Maze procedure is a new open-heart operation that creates a carefully designed maze of incisions in the atrial myocardium; this maze then acts as an electrical conduit to channel atrial impulses from t...

journal_title：Cleveland Clinic journal of medicine

authors： McCarthy PM,Castle LW,Trohman RG,Simmons TW,Maloney JD,Klein AL,White RD,Cox JL

更新日期：1993-03-01 00:00:00

abstract：:Recent studies have significantly broadened understanding of immunoglobulin production and T-cell receptor formation at the gene level. A limited number of genes can be rearranged during the course of B-cell or T-cell development to yield unique DNA sequences that will code for specific antibodies and T-cell receptor ...

journal_title：Cleveland Clinic journal of medicine

authors： Fishleder AJ

更新日期：1989-10-01 00:00:00

abstract：:Heart failure is the most important public health problem in cardiovascular medicine, and is increasing in both prevalence and expense. Programs that use an interdisciplinary team to improve outpatient treatment and prevent hospitalizations will help improve care and control costs. But the most important long-term str...

journal_title：Cleveland Clinic journal of medicine

authors： Starling RC

更新日期：1998-07-01 00:00:00

abstract：:Therapeutic hypothermia in acute resuscitation medicine has a long history, but its currently recommended use dates back to work in the mid-1960s by the late Dr. Peter Safar and colleagues. Compared with normothermia, mild therapeutic hypothermia, induced right after restoration of spontaneous circulation in comatose ...

journal_title：Cleveland Clinic journal of medicine

authors： Kochanek PM

更新日期：2009-04-01 00:00:00

abstract：:Overactive bladder (OAB) is a prevalent condition in both men and women that imposes significant burdens on the patient and his or her quality of life. Nevertheless, only a small percentage of patients with OAB receive diagnosis and treatment. The identification of OAB is well within the scope of the primary care prov...

journal_title：Cleveland Clinic journal of medicine

authors： Rosenberg MT,Newman DK,Tallman CT,Page SA

更新日期：2007-05-01 00:00:00

abstract：:The metabolic syndrome is likely to develop in patients in whom genetic predisposition, chronic stress, negative emotion, and unhealthy lifestyle habits converge. In light of the psychophysiologic aspect of most of these factors, biofeedback, relaxation, and other psychophysiologic interventions have been studied and ...

journal_title：Cleveland Clinic journal of medicine

authors： McGrady A

更新日期：2010-07-01 00:00:00

abstract：:To date, there are no effective antiviral medications for COVID-19. Drug repurposing, a strategy that uses existing drugs, offers potential prevention and treatment options for COVID-19. We discuss one treatment strategy that combines anti-inflammatory (melatonin) and antiviral (toremifene) agents for patients infecte...

journal_title：Cleveland Clinic journal of medicine

authors： Cheng F,Rao S,Mehra R

更新日期：2020-06-30 00:00:00

abstract：:Up to two-thirds of patients who have had a stroke have obstructive sleep apnea (OSA) afterward. These patients have worse outcomes than those without OSA in terms of short-term morbidity, functional and cognitive recovery, and mortality rates over the long term. Following a stroke, identifying OSA and treating it wit...

journal_title：Cleveland Clinic journal of medicine

authors： McKee Z,Auckley DH

更新日期：2019-06-01 00:00:00

abstract：:The decline in testosterone with age has been associated with specific physical changes that affect quality of life and life expectancy, although a cause-and-effect relationship is yet to be established. While female menopause is rapid and well described, "male menopause" or androgen decline in older men is gradual an...

journal_title：Cleveland Clinic journal of medicine

authors： McGill JJ,Shoskes DA,Sabanegh ES

更新日期：2012-11-01 00:00:00