Using biochemical markers of bone turnover in clinical practice.


:Biochemical markers of bone turnover provide clinically useful evidence of the normal and pathologic processes that reflect bone cell activity in the skeleton. Understanding the behavior of markers of bone formation and bone resorption should aid in managing patients with a variety of skeletal disorders.


Cleve Clin J Med


Singer FR,Eyre DR




Has Abstract


2008-10-01 00:00:00












  • Beyond cardiovascular risk: the impact of obesity on cancer death.

    abstract::Obesity is associated with higher rates of death due to cancer. Possible explanations for this association include physiological factors associated with obesity, lower cancer screening rates in obese people, and technical difficulties in treating obese patients. These problems represent opportunities to improve the ca...

    journal_title:Cleveland Clinic journal of medicine

    pub_type: 杂志文章,评审


    authors: Bordeaux BC,Bolen S,Brotman DJ

    更新日期:2006-10-01 00:00:00

  • Hepatocellular carcinoma: options for diagnosing and managing a deadly disease.

    abstract::Hepatocellular carcinoma (HCC) is an important cause of death in patients with liver disease, and its incidence appears to be rising in the United States. Because early diagnosis improves the chances of survival, it is important to identify patients who would benefit from surveillance. Once HCC is suspected on surveil...

    journal_title:Cleveland Clinic journal of medicine

    pub_type: 杂志文章,评审


    authors: Murali AR,Romero-Marrero C,Aucejo F,Menon KV

    更新日期:2013-10-01 00:00:00

  • Innovative models of home-based palliative care.

    abstract::The focus of palliative care is to alleviate pain and suffering for patients, potentially while they concurrently pursue life-prolonging or curative therapy. The potential breadth of palliative care is recognized by the Medicare program, but the Medicare hospice benefit is narrowly defined and limited to care that is ...

    journal_title:Cleveland Clinic journal of medicine

    pub_type: 杂志文章


    authors: Labson MC,Sacco MM,Weissman DE,Gornet B,Stuart B

    更新日期:2013-01-01 00:00:00

  • Overactive bladder: evaluation and management in primary care.

    abstract::Primary care physicians must initiate a discussion of overactive bladder and urinary incontinence with their patients who are at risk. A stepwise approach to evaluation and diagnosis and the use of systematic evaluation and treatment algorithms suitable to the primary care setting will improve identification and effec...

    journal_title:Cleveland Clinic journal of medicine

    pub_type: 杂志文章,评审


    authors: Rosenberg MT,Dmochowski RR

    更新日期:2005-02-01 00:00:00

  • Acute noncardiogenic pulmonary edema due to polymer fume fever.

    abstract:BACKGROUND:Certain fluorocarbon polymers can produce a clinical syndrome called polymer fume fever when the products of pyrolysis are inhaled. SUMMARY:A previously healthy 21-year-old white man presented with severe chest tightness, difficulty in breathing, pyrexia, nausea, vomiting, and a dry irritating cough. These ...

    journal_title:Cleveland Clinic journal of medicine

    pub_type: 杂志文章


    authors: Silver MJ,Young DK

    更新日期:1993-11-01 00:00:00

  • Medical devices and conflict of interest: unique issues and an industry code to address them.

    abstract::Development of medical devices requires interaction between physicians and industry that is considerably more intimate than that in pharmaceutical development. Progress in procedure-based medicine would be stalled if this collaboration were eliminated. This degree of interaction, however, creates conflicts of interest...

    journal_title:Cleveland Clinic journal of medicine

    pub_type: 杂志文章


    authors: LaViolette PA

    更新日期:2007-03-01 00:00:00

  • Cultural and clinical issues in the care of Asian patients.

    abstract::Special problems of Asian patients have considerable impact on diagnosis and treatment, and the number of persons of Asian ancestry seen in primary care in the United States is increasing. Knowledge of how to provide optimal care despite language barriers, low socioeconomic status, different health beliefs and practic...

    journal_title:Cleveland Clinic journal of medicine

    pub_type: 杂志文章,评审


    authors: Jin XW,Slomka J,Blixen CE

    更新日期:2002-01-01 00:00:00

  • Preoperative evaluation of the lung resection candidate.

    abstract::Lung resection provides the greatest likelihood of cure for patients with localized lung cancer, but is associated with a risk of mortality, decreased postoperative lung function, and other complications. Lung function testing using spirometry, diffusing capacity of the lung for carbon monoxide, and peak oxygen consum...

    journal_title:Cleveland Clinic journal of medicine

    pub_type: 杂志文章,评审


    authors: Mazzone P

    更新日期:2012-05-01 00:00:00

  • Improved outcomes in nephrotic syndrome.

    abstract::Nephrotic syndrome can now be treated effectively in most cases. All patients should be treated with a low-salt diet, diuretics to reduce edema, and statins to normalize serum lipid concentrations. Patients with nephrotic syndrome are prone to deep vein thrombophlebitis, renal vein thrombosis, and pulmonary emboli. De...

    journal_title:Cleveland Clinic journal of medicine

    pub_type: 杂志文章,评审


    authors: Appel GB

    更新日期:2006-02-01 00:00:00

  • Scleroderma: a treatable disease.

    abstract::Many effective treatments for scleroderma have emerged in recent years, including bosentan, an endothelin receptor antagonist, and epoprostenol, a prostacyclin, both of which target vasoconstriction. Cyclophosphamide may soon be proven effective against interstitial lung disease. ...

    journal_title:Cleveland Clinic journal of medicine

    pub_type: 杂志文章


    authors: Korn JH

    更新日期:2003-11-01 00:00:00

  • Treating acute exacerbations of chronic bronchitis in the face of antibiotic resistance.

    abstract::Antibiotics can be effective against acute exacerbations of chronic bronchitis and chronic obstructive pulmonary disease, but with bacterial resistance to multiple antibiotics increasing worldwide, appropriate antibiotic selection is critical. Categorizing patients with acute exacerbations according to age, number of ...

    journal_title:Cleveland Clinic journal of medicine

    pub_type: 杂志文章,评审


    authors: Adams SG,Anzueto A

    更新日期:2000-09-01 00:00:00

  • Transmission and risk factors of OF COVID-19.

    abstract::SARS-CoV-2, the virus that causes COVID-19, is transmitted through respiratory secretions and saliva. The virus can also live for short periods of time (1 to several hours) on fomites such as doorknobs, handrails, and tables. Aerosolization of the virus can occur during procedures including bronchoscopy, endotracheal ...

    journal_title:Cleveland Clinic journal of medicine

    pub_type: 杂志文章


    authors: Miller R,Englund K

    更新日期:2020-05-14 00:00:00

  • Aortic valve replacement in young patients: long-term follow-up.

    abstract::Thirty-four young patients (28 male and 6 female) underwent aortic valve replacement between 1972 and 1988. Ages ranged from 11 to 20 years (mean 17.7 years). Including reimplantation in the follow-up period, 40 valves were implanted, among which were 17 (43%) St. Jude, 7 (16%) Bjork-Shiley, and 4 (10%) Carpentier-Edw...

    journal_title:Cleveland Clinic journal of medicine

    pub_type: 杂志文章


    authors: Moodie DS,Hanhan U,Sterba R,Murphy DJ Jr,Rosenkranz ER,Kovacs AM

    更新日期:1992-09-01 00:00:00

  • Heart disease and depression: don't ignore the relationship.

    abstract::Evidence is mounting that depression is a risk factor for the development of cardiovascular disease and portends a worse outcome in cardiac patients. Depression can be easily diagnosed and safely treated in cardiac patients, but it is undertreated. ...

    journal_title:Cleveland Clinic journal of medicine

    pub_type: 杂志文章,评审


    authors: Kemp DE,Malhotra S,Franco KN,Tesar G,Bronson DL

    更新日期:2003-09-01 00:00:00

  • Allergy blood testing: A practical guide for clinicians.

    abstract::Blood tests are available that measure levels of immunoglobulin E (IgE) against specific allergens such as foods, inhalants, medications, latex, and venoms. These tests can confirm the diagnosis of an allergic disorder, supplementing a clinical history consistent with an immediate allergic reaction. They are particula...

    journal_title:Cleveland Clinic journal of medicine

    pub_type: 杂志文章,评审


    authors: Siles RI,Hsieh FH

    更新日期:2011-09-01 00:00:00

  • Liver biopsy 2005: when and how?

    abstract::Clinical imaging and serologic testing are increasingly replacing biopsy for diagnosing hepatic diseases. However, more biopsies are being done to stage and grade hepatitis C and fatty liver disease, to diagnose space-occupying lesions (typically with fine-needle aspiration biopsy), and to assess response to therapy. ...

    journal_title:Cleveland Clinic journal of medicine

    pub_type: 杂志文章,评审


    authors: Siegel CA,Silas AM,Suriawinata AA,van Leeuwen DJ

    更新日期:2005-03-01 00:00:00

  • Constipation: an approach to diagnosis, treatment, referral.

    abstract::When a patient reports constipation, a careful history and physical examination may identify the underlying cause. In many patients, though, no underlying cause is identified. Empiric treatment with exercise, hydration, fiber supplementation, and mild laxatives is often effective. If constipation does not resolve with...

    journal_title:Cleveland Clinic journal of medicine

    pub_type: 杂志文章,评审


    authors: Soffer EE

    更新日期:1999-01-01 00:00:00

  • Giant cell arteritis: An updated review of an old disease.

    abstract::Giant cell arteritis is a common systemic vasculitis that affects the elderly and has a variable clinical presentation. Physicians should be aware of its different clinical phenotypes so that they can recognize it early and promptly initiate glucocorticoids, the mainstay of therapy. Clinicians should also be familiar ...

    journal_title:Cleveland Clinic journal of medicine

    pub_type: 杂志文章,评审


    authors: Rinden T,Miller E,Nasr R

    更新日期:2019-07-01 00:00:00

  • COX-2-selective inhibitors in the treatment of arthritis.

    abstract::Therapy with nonselective nonsteroidal anti-inflammatory drugs (NSAIDs) has long been the cornerstone of pharmacologic management of patients with osteoarthritis (OA) and rheumatoid arthritis (RA). Many patients with OA or RA, however, are at increased risk of developing clinically significant adverse events associate...

    journal_title:Cleveland Clinic journal of medicine

    pub_type: 杂志文章,评审


    authors: Schnitzer TJ,Hochberg MC

    更新日期:2002-01-01 00:00:00

  • Sudden unexpected death in epilepsy: impact, mechanisms, and prevention.

    abstract::Patients with refractory epilepsy face an elevated risk of sudden death, with rates as high as 1% per year. This phenomenon, known as sudden unexpected death in epilepsy (SUDEP), is believed to be a seizure-related occurrence, but the exact underlying mechanisms are uncertain. Both pulmonary and cardiac pathophysiolog...

    journal_title:Cleveland Clinic journal of medicine

    pub_type: 杂志文章,评审


    authors: Jehi L,Najm IM

    更新日期:2008-03-01 00:00:00

  • Prescribing exercise to help your patients lose weight.

    abstract::Exercise, in conjunction with diet, is critical to losing weight and maintaining health in obese patients. While it can be challenging for an obese person to transition to a healthy lifestyle, the physical and emotional benefits of a regular exercise program make it worth the effort. ...

    journal_title:Cleveland Clinic journal of medicine

    pub_type: 杂志文章,评审


    authors: Higgins JP,Higgins CL

    更新日期:2016-02-01 00:00:00

  • Preventing ischemic stroke in the older adult.

    abstract::Stroke is a deadly and disabling disease that preferentially afflicts older adults. It shares common risk factors with myocardial infarction (MI), such as hypertension, diabetes, and hyperlipidemia. Blood pressure control, cholesterol reduction with statins, and glucose control reduce the risk for both stroke and MI. ...

    journal_title:Cleveland Clinic journal of medicine

    pub_type: 杂志文章,评审


    authors: Ling GS,Ling SM

    更新日期:2005-10-01 00:00:00

  • Disseminated aspergillosis presenting as a skin abscess.

    abstract::An immunocompromised patient presented with chronic low back pain as the initial symptom and a subcutaneous abscess as the initial sign of disseminated aspergillosis. With the rising incidence of immunocompromised patients, cutaneous manifestation of aspergillosis may become more common. ...

    journal_title:Cleveland Clinic journal of medicine

    pub_type: 杂志文章


    authors: Helm TN,Mazanec D

    更新日期:1990-01-01 00:00:00

  • Depression: a shared risk factor for cardiovascular and Alzheimer disease.

    abstract::Depression has been linked to cardiovascular disease and cognitive impairment, including Alzheimer disease, but the exact nature of the relationship is poorly understood. Although depression seems to progress little after the onset of Alzheimer disease, depression in earlier life increases the risk of dementia and cog...

    journal_title:Cleveland Clinic journal of medicine

    pub_type: 杂志文章,评审


    authors: Wint D

    更新日期:2011-08-01 00:00:00

  • The continuum of GERD complications.

    abstract::Complications of chronic gastroesophageal reflux disease (GERD) run the gamut from erosive esophagitis to esophageal cancer, but all are linked to repeated exposure of the esophagus to caustic gastric and duodenal acid. Progression from one complication to another is not clearly established across the GERD continuum, ...

    journal_title:Cleveland Clinic journal of medicine

    pub_type: 杂志文章,评审


    authors: Fennerty MB

    更新日期:2003-11-01 00:00:00

  • Neurological mechanisms of chest pain and cardiac disease.

    abstract::SCS is an efficacious, reversible, and safe therapy that improves quality of life, increases exercise tolerance, and relieves angina pectoris, but clinical trials in North America are needed to confirm the data coming from Europe. Neuronal convergence onto STT cells underlies the referred pain associated with angina p...

    journal_title:Cleveland Clinic journal of medicine

    pub_type: 杂志文章,评审


    authors: Foreman RD

    更新日期:2007-02-01 00:00:00

  • Renal disease in small-vessel vasculitis.

    abstract::Glomerulonephritis (GN) is a common manifestation of the antineutrophil cytoplasmic antibody-associated systemic vasculitides (AASV), which include granulomatosis with polyangiitis and microscopic polyangiitis. The level of renal involvement at presentation is highly predictive of survival and should be assessed early...

    journal_title:Cleveland Clinic journal of medicine

    pub_type: 杂志文章


    authors: de Groot K

    更新日期:2012-11-01 00:00:00

  • The challenge of irritable bowel syndrome: creating an alliance between patient and physician.

    abstract::The most important component of the treatment of irritable bowel syndrome (IBS) is to establish a therapeutic physician-patient relationship, coupled with patient education. We describe a stepwise approach to management, including judicious use of invasive tests, and setting realistic treatment goals that address the ...

    journal_title:Cleveland Clinic journal of medicine

    pub_type: 杂志文章,评审


    authors: Shen B,Soffer E

    更新日期:2001-03-01 00:00:00

  • The heart failure pandemic: changing patterns, costs, and treatment strategies.

    abstract::Heart failure is the most important public health problem in cardiovascular medicine, and is increasing in both prevalence and expense. Programs that use an interdisciplinary team to improve outpatient treatment and prevent hospitalizations will help improve care and control costs. But the most important long-term str...

    journal_title:Cleveland Clinic journal of medicine

    pub_type: 杂志文章,评审


    authors: Starling RC

    更新日期:1998-07-01 00:00:00

  • Managing knee osteoarthritis before and after arthroplasty.

    abstract::Primary care physicians play a key role in the diagnosis and the nonoperative management of knee osteoarthritis (OA), including monitoring for problems in patients who have undergone knee replacement surgery. This article reviews key clinical and radiographic findings of knee OA, options for conservative management, a...

    journal_title:Cleveland Clinic journal of medicine

    pub_type: 杂志文章,评审


    authors: Rosneck J,Higuera CA,Tadross N,Krebs V,Barsoum WK

    更新日期:2007-09-01 00:00:00