Abstract:
:Numerous immunomodulating agents are currently being studied in clinical trials for the treatment of COVID-19, including interferon therapies. Interferons are naturally occurring host antiviral proteins upstream of the inflammatory pathway that are released by host cells in response to the presence of viral pathogens. It is known that beta coronaviruses deploy anti-interferon defenses to escape host innate immunity early in the infection course, and thus interferons have become attractive candidates for treatment of COVID-19. Questions surrounding timing, type of interferon, and route of administration all remain unanswered. Here we discuss the role of interferons in host antiviral immunity, and review the current data surrounding use of interferons in COVID-19.
journal_name
Cleve Clin J Medjournal_title
Cleveland Clinic journal of medicineauthors
Calabrese LH,Lenfant T,Calabrese Cdoi
10.3949/ccjm.87a.ccc066subject
Has Abstractpub_date
2020-12-03 00:00:00eissn
0891-1150issn
1939-2869pii
ccjm.87a.ccc066pub_type
杂志文章abstract::The decline in testosterone with age has been associated with specific physical changes that affect quality of life and life expectancy, although a cause-and-effect relationship is yet to be established. While female menopause is rapid and well described, "male menopause" or androgen decline in older men is gradual an...
journal_title:Cleveland Clinic journal of medicine
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journal_title:Cleveland Clinic journal of medicine
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abstract::Nephrotic syndrome can now be treated effectively in most cases. All patients should be treated with a low-salt diet, diuretics to reduce edema, and statins to normalize serum lipid concentrations. Patients with nephrotic syndrome are prone to deep vein thrombophlebitis, renal vein thrombosis, and pulmonary emboli. De...
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journal_title:Cleveland Clinic journal of medicine
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journal_title:Cleveland Clinic journal of medicine
pub_type: 杂志文章,评审
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