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High serum erythropoietin level is associated with smaller infarct size in patients with acute myocardial infarction who undergo successful primary percutaneous coronary intervention.

Abstract：

OBJECTIVES:We investigated whether a higher serum erythropoietin (EPO) level in patients with acute myocardial infarction (MI) subjected to successful primary percutaneous coronary intervention (PCI) can predict a smaller infarct size determined by creatine kinase (CK) release. BACKGROUND:Erythropoietin has been shown to protect cardiomyocytes from ischemia-reperfusion injury in rodents. METHODS:We prospectively studied 101 patients with first MI who received successful primary PCI within 12 h from the onset of MI. Blood samples were collected to examine the serum EPO level after the primary PCI and within 24 h from the onset of MI. RESULTS:The peak CK level and cumulative CK release were significantly lower in the above-median EPO group than in the below-median EPO group. Thrombolysis In Myocardial Infarction (TIMI) grades and collateral grades before PCI, infarct-related coronary arteries, time to the successful reperfusion from the onset of MI, and serum creatinine levels were similar in the two EPO groups. A stepwise multiple regression analysis revealed that the absolute serum EPO level (mU/ml) as well as TIMI grades after PCI and preinfarction angina was an independent predictor for the cumulative CK release. CONCLUSIONS:These data suggest that a high endogenous EPO level can predict a smaller infarct size in patients with acute MI subjected to successful primary PCI. This might be attributed to the potentially protective effect of endogenous EPO against ischemia-reperfusion injury in humans.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Namiuchi S,Kagaya Y,Ohta J,Shiba N,Sugi M,Oikawa M,Kunii H,Yamao H,Komatsu N,Yui M,Tada H,Sakuma M,Watanabe J,Ichihara T,Shirato K

doi

10.1016/j.jacc.2005.01.043

subject

Has Abstract

pub_date

2005-05-03 00:00:00

pages

1406-12

issue

9

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(05)00419-5

journal_volume

45

pub_type

杂志文章

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