当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY期刊下所有文献 > Impact of Ischemic Heart Failure Etiology on Cardiac Recovery During Mechanical Unloading.

Impact of Ischemic Heart Failure Etiology on Cardiac Recovery During Mechanical Unloading.

Abstract：

BACKGROUND:Small-scale studies focused mainly on nonischemic cardiomyopathy (NICM) have shown that a subset of left ventricular assist device (LVAD) patients can achieve significant improvement of their native heart function, but the impact of ischemic cardiomyopathy (ICM) has not been specifically investigated. Many patients with acute myocardial infarction are discharged from their index hospitalization without heart failure (HF), only to return much later with overt HF syndrome, mainly caused by chronic remodeling of the noninfarcted region of the myocardium. OBJECTIVES:This study sought to prospectively investigate the effect of ICM HF etiology on LVAD-associated improvement of cardiac structure and function using NICM as control. METHODS:Consecutive patients (n = 154) with documented chronic and dilated cardiomyopathy (ICM, n = 61; NICM, n = 93) requiring durable support with continuous-flow LVAD were prospectively evaluated with serial echocardiograms and right heart catheterizations. RESULTS:In patients supported with LVAD for at least 6 months, we found that 5% of subjects with ICM and 21% of subjects with NICM achieved left ventricular ejection fraction ≥40% (p = 0.034). LV end-diastolic and end-systolic volumes and diastolic function were significantly and similarly improved in patients with ICM and NICM. CONCLUSIONS:LVAD-associated unloading for 6 months resulted in a substantial improvement in myocardial structure, and systolic and diastolic function in 1 in 20 ICM and 1 in 5 NICM patients. These specific incidence and timeline findings may provide guidance in clinical practice and research design for sequencing and prioritizing advanced HF and heart transplantation therapeutic options in patients with ICM and NICM.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Wever-Pinzon J,Selzman CH,Stoddard G,Wever-Pinzon O,Catino A,Kfoury AG,Diakos NA,Reid BB,McKellar S,Bonios M,Koliopoulou A,Budge D,Kelkhoff A,Stehlik J,Fang JC,Drakos SG

doi

10.1016/j.jacc.2016.07.756

subject

Has Abstract

pub_date

2016-10-18 00:00:00

pages

1741-1752

issue

16

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(16)34925-7

journal_volume

68

pub_type

杂志文章

相关文献

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY文献大全
  • Prognostic value of fractional flow reserve: linking physiologic severity to clinical outcomes.

    abstract：BACKGROUND:Fractional flow reserve (FFR) has become an established tool for guiding treatment, but its graded relationship to clinical outcomes as modulated by medical therapy versus revascularization remains unclear. OBJECTIVES:The study hypothesized that FFR displays a continuous relationship between its numeric val...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,meta分析

    doi：10.1016/j.jacc.2014.07.973

    authors： Johnson NP,Tóth GG,Lai D,Zhu H,Açar G,Agostoni P,Appelman Y,Arslan F,Barbato E,Chen SL,Di Serafino L,Domínguez-Franco AJ,Dupouy P,Esen AM,Esen OB,Hamilos M,Iwasaki K,Jensen LO,Jiménez-Navarro MF,Katritsis DG,Kocam

    更新日期：2014-10-21 00:00:00

  • Prevalence of aortic valve abnormalities in the elderly: an echocardiographic study of a random population sample.

    abstract：OBJECTIVES:This study was undertaken to elucidate the prevalence of aortic valve abnormalities in the elderly. BACKGROUND:The age of persons treated actively for valve disorders is increasing. More information is needed about the prevalence of aortic valve disease in old age. METHODS:Randomly selected men and women i...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(93)90249-z

    authors： Lindroos M,Kupari M,Heikkilä J,Tilvis R

    更新日期：1993-04-01 00:00:00

  • Effects of verapamil on experimental cardiomyopathy in the Bio 14.6 Syrian hamster.

    abstract：:The Bio 14.6 Syrian hamster provides a good model for experimental study of cardiomyopathy. Cardiac receptor binding sites (alpha-1-, beta- and calcium antagonists) were studied in early (21 days old) and late (70 days old) stages of cardiomyopathy. The effects of verapamil on histologic features and free radicals in ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(87)80356-x

    authors： Kobayashi A,Yamashita T,Kaneko M,Nishiyama T,Hayashi H,Yamazaki N

    更新日期：1987-11-01 00:00:00

  • Ventricular inversion with normal ventriculoarterial connection and left atrial isomerism: correction by the Mustard operation.

    abstract：:A 2 year old boy with ventricular inversion and normal ventriculoarterial connection is described. Associated cardiac lesions included single atrium, absence of the coronary sinus, bilateral superior venae cavae, absence of the hepatic segment of the inferior vena cava with azygos and hemiazygos continuation, right ao...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(84)80331-9

    authors： Park SC,Siewers RD,Neches WH,Mathews RA,Fricker FJ,Beerman LB,Fischer DR,Zuberbuhler JR

    更新日期：1984-07-01 00:00:00

  • Sustained ventricular tachyarrhythmias within 2 months of acute myocardial infarction: results of medical and surgical therapy in patients resuscitated from the initial episode.

    abstract：:Sustained ventricular tachycardia or fibrillation that develops during the early recovery period after acute myocardial infarction is a common clinical problem whose management remains controversial. Fifty-three patients who survived an initial episode of sustained ventricular tachycardia or fibrillation occurring bet...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(85)80479-4

    authors： DiMarco JP,Lerman BB,Kron IL,Sellers TD

    更新日期：1985-10-01 00:00:00

  • Persistent impairment of endothelial vasomotor function has a negative impact on outcome in patients with coronary artery disease.

    abstract：OBJECTIVES:We assessed the hypothesis that changes in endothelial vasomotor function in response to optimized therapy for atherosclerotic coronary artery disease predict future cardiovascular events. BACKGROUND:Although endothelial vasomotor dysfunction is a predictor of cardiovascular events, it remains unclear wheth...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2008.08.074

    authors： Kitta Y,Obata JE,Nakamura T,Hirano M,Kodama Y,Fujioka D,Saito Y,Kawabata K,Sano K,Kobayashi T,Yano T,Nakamura K,Kugiyama K

    更新日期：2009-01-27 00:00:00

  • Complicated Carotid Artery Plaques as a Cause of Cryptogenic Stroke.

    abstract：BACKGROUND:The underlying etiology of ischemic stroke remains unknown in up to 30% of patients. OBJECTIVES:This study explored the causal role of complicated (American Heart Association-lesion type VI) nonstenosing carotid artery plaques (CAPs) in cryptogenic stroke (CS). METHODS:CAPIAS (Carotid Plaque Imaging in Acu...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2020.09.532

    authors： Kopczak A,Schindler A,Bayer-Karpinska A,Koch ML,Sepp D,Zeller J,Strecker C,Hempel JM,Yuan C,Malik R,Wollenweber FA,Boeckh-Behrens T,Cyran CC,Helck A,Harloff A,Ziemann U,Poli S,Poppert H,Dichgans M,Saam T

    更新日期：2020-11-10 00:00:00

  • Contractile Function During Angiotensin-II Activation: Increased Nox2 Activity Modulates Cardiac Calcium Handling via Phospholamban Phosphorylation.

    abstract：BACKGROUND:Renin-angiotensin system activation is a feature of many cardiovascular conditions. Activity of myocardial reduced nicotinamide adenine dinucleotide phosphate oxidase 2 (NADPH oxidase 2 or Nox2) is enhanced by angiotensin II (Ang II) and contributes to increased hypertrophy, fibrosis, and adverse remodeling....

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2015.05.020

    authors： Zhang M,Prosser BL,Bamboye MA,Gondim ANS,Santos CX,Martin D,Ghigo A,Perino A,Brewer AC,Ward CW,Hirsch E,Lederer WJ,Shah AM

    更新日期：2015-07-21 00:00:00

  • Transluminal carbon dioxide-laser catheter angioplasty for dissolution of atherosclerotic plaques.

    abstract：:Carbon dioxide laser energy was used for the dissolution of atheromatous plaques. Flexible, nontoxic infrared optical fibers were used for the transmission of the carbon dioxide laser beam intraarterially. Dissolution of plaques and recanalization of obstructed arteries were achieved both in vitro and in vivo with con...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(84)80439-8

    authors： Eldar M,Battler A,Neufeld HN,Gaton E,Arieli R,Akselrod S,Levite A,Katzir A

    更新日期：1984-01-01 00:00:00

  • Long-term retention of cardiac resynchronization therapy.

    abstract：OBJECTIVES:The purpose of this study was to determine the frequency and causes of intermittent and permanent loss of cardiac resynchronization therapy (CRT) in patients who have undergone the successful implantation of a transvenous defibrillator that delivers CRT (CRT-D). BACKGROUND:The causes of loss of CRT have not...

    journal_title：Journal of the American College of Cardiology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/j.jacc.2004.03.054

    authors： Knight BP,Desai A,Coman J,Faddis M,Yong P

    更新日期：2004-07-07 00:00:00

  • The challenge of cardiomyopathy.

    abstract：:The combined clinical and pathophysiologic characteristics and diagnostic features as well as current concepts of pathogenesis, therapy and prevention of the principal forms of cardiomyopathy are reviewed. These include hypertrophic cardiomyopathy, dilated cardiomyopathy, restrictive cardiomyopathy and specific cardia...

    journal_title：Journal of the American College of Cardiology

    pub_type： 历史文章,杂志文章,评审

    doi：10.1016/0735-1097(89)90293-3

    authors： Abelmann WH,Lorell BH

    更新日期：1989-05-01 00:00:00

  • Multivessel Palmaz-Schatz stenting: early results and one-year outcome.

    abstract：OBJECTIVES:To determine whether the benefits outlined in Background might extend to patients with multivessel disease, we examined the short- and long-term outcome of multivessel Palmaz-Schatz stenting. BACKGROUND:Percutaneous transluminal coronary angioplasty (PTCA) has become the dominant treatment for most patients...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(97)00146-0

    authors： Laham RJ,Ho KK,Baim DS,Kuntz RE,Cohen DJ,Carrozza JP Jr

    更新日期：1997-07-01 00:00:00

  • Valvular heart disease and pregnancy: part II: prosthetic valves.

    abstract：:A large number of prosthetic heart valves (PHV) are being implanted in patients with both congenital and acquired valvular disease. Many of the recipients of such valves are women of childbearing age who desire to have children. The main issues involved with pregnancy in a patient with PHV include the selection of PHV...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jacc.2005.02.087

    authors： Elkayam U,Bitar F

    更新日期：2005-08-02 00:00:00

  • Outcome of patients with nonischemic dilated cardiomyopathy and unexplained syncope treated with an implantable defibrillator.

    abstract：OBJECTIVES:The purpose of this study was to determine the outcome of patients with nonischemic dilated cardiomyopathy, unexplained syncope and a negative electrophysiology test who are treated with an implantable defibrillator. BACKGROUND:Patients with nonischemic cardiomyopathy and unexplained syncope may be at high ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(99)00148-5

    authors： Knight BP,Goyal R,Pelosi F,Flemming M,Horwood L,Morady F,Strickberger SA

    更新日期：1999-06-01 00:00:00

  • A randomized multicenter study comparing a paclitaxel drug-eluting balloon with a paclitaxel-eluting stent in small coronary vessels: the BELLO (Balloon Elution and Late Loss Optimization) study.

    abstract：OBJECTIVES:The aim of this study was to evaluate the efficacy of drug-eluting balloons (DEB) compared with paclitaxel-eluting stents (PES) for the reduction of restenosis in small vessels. BACKGROUND:DEB have been shown to be effective in the treatment of coronary in-stent restenosis, but data are limited regarding th...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.jacc.2012.09.020

    authors： Latib A,Colombo A,Castriota F,Micari A,Cremonesi A,De Felice F,Marchese A,Tespili M,Presbitero P,Sgueglia GA,Buffoli F,Tamburino C,Varbella F,Menozzi A

    更新日期：2012-12-18 00:00:00

  • Percutaneous mitral valvuloplasty in surgical high risk patients.

    abstract：:Among 126 consecutive patients undergoing percutaneous mitral valvuloplasty, 34 were judged to be at high risk for surgery on the basis of age greater than 70 years (n = 13), New York Heart Association functional class IV (n = 11), ejection fraction less than or equal to 35% (n = 3), severe pulmonary hypertension (n =...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(10)80098-1

    authors： Lefèvre T,Bonan R,Serra A,Crépeau J,Dyrda I,Petitclerc R,Leclerc Y,Vanderperren O,Waters D

    更新日期：1991-02-01 00:00:00

  • High prevalence of antibodies against beta 1- and beta 2-adrenoceptors in patients with primary electrical cardiac abnormalities.

    abstract：OBJECTIVES:This study sought to determine the prevalence of autoantibodies directed against the beta-adrenoceptors in patients with primary electrical cardiac abnormalities, including atrial arrhythmias, ventricular arrhythmias and conduction disturbances, in the absence of any other cardiac abnormality. BACKGROUND:Us...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(95)00262-2

    authors： Chiale PA,Rosenbaum MB,Elizari MV,Hjalmarson A,Magnusson Y,Wallukat G,Hoebeke J

    更新日期：1995-10-01 00:00:00

  • Zotarolimus-eluting peripheral stents for the treatment of erectile dysfunction in subjects with suboptimal response to phosphodiesterase-5 inhibitors.

    abstract：OBJECTIVES:This study sought to evaluate the safety and feasibility of zotarolimus-eluting stent implantation in focal atherosclerotic lesions of the internal pudendal arteries among men with erectile dysfunction (ED) and a suboptimal response to phosphodiesterase-5 inhibitors. BACKGROUND:ED, a common condition, is of...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,多中心研究,随机对照试验

    doi：10.1016/j.jacc.2012.08.1016

    authors： Rogers JH,Goldstein I,Kandzari DE,Köhler TS,Stinis CT,Wagner PJ,Popma JJ,Jaff MR,Rocha-Singh KJ

    更新日期：2012-12-25 00:00:00

  • Effect of stenosis geometry on the Doppler-catheter gradient relation in vitro: a manifestation of pressure recovery.

    abstract：OBJECTIVES:This study investigated the effect of stenosis geometry on the Doppler-catheter gradient relation. BACKGROUND:Although gradient estimation by Doppler ultrasound has been shown to be accurate in various clinical and in vitro settings, there have also been reports of substantial discrepancies between Doppler ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(93)90362-5

    authors： Baumgartner H,Schima H,Tulzer G,Kühn P

    更新日期：1993-03-15 00:00:00

  • Subclinical Atherosclerosis Burden by 3D Ultrasound in Mid-Life: The PESA Study.

    abstract：BACKGROUND:Detection of subclinical atherosclerosis improves risk prediction beyond cardiovascular risk factors (CVRFs) and risk scores, but quantification of plaque burden may improve it further. Novel 3-dimensional vascular ultrasound (3DVUS) provides accurate volumetric quantification of plaque burden. OBJECTIVES:T...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jacc.2017.05.033

    authors： López-Melgar B,Fernández-Friera L,Oliva B,García-Ruiz JM,Peñalvo JL,Gómez-Talavera S,Sánchez-González J,Mendiguren JM,Ibáñez B,Fernández-Ortiz A,Sanz J,Fuster V

    更新日期：2017-07-18 00:00:00

  • Subclinical peripheral arterial disease and incompressible ankle arteries are both long-term prognostic factors in patients undergoing coronary artery bypass grafting.

    abstract：OBJECTIVES:This study was designed to determine the prevalence of peripheral arterial disease (PAD) in candidates for coronary artery bypass grafting (CABG) and to assess the predictive value of different types of subclinical PAD (peripheral occlusive disease and medial arterial calcification [incompressible ankle arte...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2005.05.066

    authors： Aboyans V,Lacroix P,Postil A,Guilloux J,Rollé F,Cornu E,Laskar M

    更新日期：2005-09-06 00:00:00

  • Narrowing of the superior vena cava-right atrium junction during radiofrequency catheter ablation for inappropriate sinus tachycardia: analysis with intracardiac echocardiography.

    abstract：OBJECTIVES:The study explored the potential for tissue swelling and venous occlusion during radiofrequency (RF) catheter ablation procedures using intracardiac echocardiography (ICE). BACKGROUND:Transient superior vena cava occlusion has been reported following catheter ablation procedures for inappropriate sinus tach...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(99)00047-9

    authors： Callans DJ,Ren JF,Schwartzman D,Gottlieb CD,Chaudhry FA,Marchlinski FE

    更新日期：1999-05-01 00:00:00

  • Cardiac tamponade and pericardial effusion: respiratory variation in transvalvular flow velocities studied by Doppler echocardiography.

    abstract：:Cardiac tamponade has been associated with an abnormally increased respiratory variation in transvalvular blood flow velocities. To determine whether this finding is consistently present in cardiac tamponade, seven patients were studied prospectively with Doppler echocardiography before and after pericardiocentesis an...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/s0735-1097(98)90060-2

    authors： Appleton CP,Hatle LK,Popp RL

    更新日期：1988-05-01 00:00:00

  • Assessment of single vessel coronary artery disease: results of exercise electrocardiography, thallium-201 myocardial perfusion imaging and radionuclide angiography.

    abstract：:The sensitivity of the commonly used stress tests for the diagnosis of coronary artery disease was analyzed in 46 patients with significant occlusion (greater than or equal to 70% luminal diameter obstruction) of only one major coronary artery and no prior myocardial infarction. In all patients, thallium-201 perfusion...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(85)80256-4

    authors： Port SC,Oshima M,Ray G,McNamee P,Schmidt DH

    更新日期：1985-07-01 00:00:00

  • The histology of viable and hibernating myocardium in relation to imaging characteristics.

    abstract：OBJECTIVES:This study characterizes the histology of myocardium predicted to be hibernating using three different imaging techniques to explain the discordance among them. BACKGROUND:Both radionuclide and functional imaging techniques were used to assess myocardial hibernation. The former have high sensitivity and the...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(01)01766-1

    authors： Gunning MG,Kaprielian RR,Pepper J,Pennell DJ,Sheppard MN,Severs NJ,Fox KM,Underwood SR

    更新日期：2002-02-06 00:00:00

  • Lorcainide in patients with refractory ventricular tachyarrhythmia.

    abstract：:Lorcainide, a new antiarrhythmic agent with local anesthetic or membrane-stabilizing properties similar to those of quinidine, was tested in 76 patients with diverse types of heart disease and recurrent ventricular tachycardia or ventricular fibrillation. Lorcainide was administered for 72 to 96 hours in a dose rangin...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(84)80293-4

    authors： Chesnie B,Lampert S,Podrid P,Lown B

    更新日期：1984-06-01 00:00:00

  • Nonpharmacological lipoprotein apheresis reduces arterial inflammation in familial hypercholesterolemia.

    abstract：BACKGROUND:Patients with familial hypercholesterolemia (FH) are characterized by elevated atherogenic lipoprotein particles, predominantly low-density lipoprotein cholesterol (LDL-C), which is associated with accelerated atherogenesis and increased cardiovascular risk. OBJECTIVES:This study used (18)F-fluorodeoxygluco...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2014.01.088

    authors： van Wijk DF,Sjouke B,Figueroa A,Emami H,van der Valk FM,MacNabb MH,Hemphill LC,Schulte DM,Koopman MG,Lobatto ME,Verberne HJ,Fayad ZA,Kastelein JJ,Mulder WJ,Hovingh GK,Tawakol A,Stroes ES

    更新日期：2014-10-07 00:00:00

  • Vascular function and carotid intimal-medial thickness in children with insulin-dependent diabetes mellitus.

    abstract：OBJECTIVES:The objective of this study was to evaluate endothelium-dependent vasodilation and carotid intimal-medial thickness (IMT) in children with insulin-dependent diabetes mellitus. BACKGROUND:Diabetes mellitus is an established risk factor for atherosclerosis. Vascular complications of diabetes are not clinicall...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(02)02894-2

    authors： Singh TP,Groehn H,Kazmers A

    更新日期：2003-02-19 00:00:00

  • Repeat interventions as a long-term treatment strategy in the management of progressive coronary artery disease.

    abstract：OBJECTIVES:This study investigates whether repeat coronary interventions, applied over an extended time period, can successfully curtail the progression of ischemic symptoms and angiographic lumen narrowing. BACKGROUND:Coronary artery disease is a chronic and generally progressive disorder, and potential treatment str...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(96)00002-2

    authors： Lehmann KG,Maas AC,van Domburg R,de Feyter PJ,van den Brand M,Serruys PW

    更新日期：1996-05-01 00:00:00

  • Comparison of angioscopy, intravascular ultrasound imaging and quantitative coronary angiography in predicting clinical outcome after coronary intervention in high risk patients.

    abstract：OBJECTIVES:The purpose of this study was to identify qualitative or quantitative variables present on angioscopy, intravascular ultrasound imaging or quantitative coronary arteriography that were associated with adverse clinical outcome after coronary intervention in high risk patients. BACKGROUND:Patients with acute ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(96)00102-7

    authors： Feld S,Ganim M,Carell ES,Kjellgren O,Kirkeeide RL,Vaughn WK,Kelly R,McGhie AI,Kramer N,Loyd D,Anderson HV,Schroth G,Smalling RW

    更新日期：1996-07-01 00:00:00