Abstract:
BACKGROUND:Fractional flow reserve (FFR) has become an established tool for guiding treatment, but its graded relationship to clinical outcomes as modulated by medical therapy versus revascularization remains unclear. OBJECTIVES:The study hypothesized that FFR displays a continuous relationship between its numeric value and prognosis, such that lower FFR values confer a higher risk and therefore receive larger absolute benefits from revascularization. METHODS:Meta-analysis of study- and patient-level data investigated prognosis after FFR measurement. An interaction term between FFR and revascularization status allowed for an outcomes-based threshold. RESULTS:A total of 9,173 (study-level) and 6,961 (patient-level) lesions were included with a median follow-up of 16 and 14 months, respectively. Clinical events increased as FFR decreased, and revascularization showed larger net benefit for lower baseline FFR values. Outcomes-derived FFR thresholds generally occurred around the range 0.75 to 0.80, although limited due to confounding by indication. FFR measured immediately after stenting also showed an inverse relationship with prognosis (hazard ratio: 0.86, 95% confidence interval: 0.80 to 0.93; p < 0.001). An FFR-assisted strategy led to revascularization roughly half as often as an anatomy-based strategy, but with 20% fewer adverse events and 10% better angina relief. CONCLUSIONS:FFR demonstrates a continuous and independent relationship with subsequent outcomes, modulated by medical therapy versus revascularization. Lesions with lower FFR values receive larger absolute benefits from revascularization. Measurement of FFR immediately after stenting also shows an inverse gradient of risk, likely from residual diffuse disease. An FFR-guided revascularization strategy significantly reduces events and increases freedom from angina with fewer procedures than an anatomy-based strategy.
journal_name
J Am Coll Cardioljournal_title
Journal of the American College of Cardiologyauthors
Johnson NP,Tóth GG,Lai D,Zhu H,Açar G,Agostoni P,Appelman Y,Arslan F,Barbato E,Chen SL,Di Serafino L,Domínguez-Franco AJ,Dupouy P,Esen AM,Esen OB,Hamilos M,Iwasaki K,Jensen LO,Jiménez-Navarro MF,Katritsis DG,Kocamdoi
10.1016/j.jacc.2014.07.973subject
Has Abstractpub_date
2014-10-21 00:00:00pages
1641-54issue
16eissn
0735-1097issn
1558-3597pii
S0735-1097(14)05831-8journal_volume
64pub_type
杂志文章,meta分析abstract:OBJECTIVES:The objective was to assess the prevalence of subclavian artery stenosis (SS) in four cohorts (two free-living and two clinical populations) and determine both risk factors for this condition and the association with other cardiovascular conditions. BACKGROUND:The prevalence of SS in the general population ...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,meta分析
doi:10.1016/j.jacc.2004.04.044
更新日期:2004-08-04 00:00:00
abstract::Low osmolar contrast agents produce less adverse electrophysiologic and hemodynamic alterations during cardiac catheterization. The nonionic agents probably reduce the risk of provoking myocardial ischemia during coronary arteriography or ventriculography. Patients also report less subjective sensation of discomfort d...
journal_title:Journal of the American College of Cardiology
pub_type: 指南,杂志文章
doi:10.1016/0735-1097(93)90747-o
更新日期:1993-01-01 00:00:00
abstract:OBJECTIVE:The goal of this study was to determine whether wall stress at rest and during stress could explain the influence of left ventricular (LV) morphology on the accuracy of dobutamine stress echocardiography (DSE). BACKGROUND:The sensitivity of DSE appears to be reduced in patients with concentric remodeling, bu...
journal_title:Journal of the American College of Cardiology
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doi:10.1016/s0735-1097(02)02105-8
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abstract:OBJECTIVES:To investigate the electromechanical consequences of nonsurgical septal reduction in a group of patients with hypertrophic obstructive cardiomyopathy (HOCM). BACKGROUND:Patients with HOCM may benefit symptomatically from nonsurgical septal reduction as an alternative to dual chamber pacing and sensing (DDD)...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/s0735-1097(99)00332-0
更新日期:1999-10-01 00:00:00
abstract::Forty years ago therapy for congestive heart failure was limited largely to the mercurial diuretics and a variety of cardiac glycoside preparations; these were often ineffective, and the common practice of "pushing" digitalis caused serious, sometimes lethal side effects. Today, a more complete understanding of the re...
journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章,评审
doi:10.1016/0735-1097(89)90586-x
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abstract::Retrospective data on the treatment of aortic dissection at the Massachusetts General Hospital from 1963 to 1978 are reported. During this period, 160 patients with spontaneous aortic dissection were treated by definitive medical or definitive surgical therapy. Patients were classified according to type (proximal vers...
journal_title:Journal of the American College of Cardiology
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doi:10.1016/s0735-1097(84)80363-0
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abstract::Kawasaki disease (KD) is an acute, self-limited vasculitis that typically occurs in young children and was first described by Japanese pediatrician Tomisaku Kawasaki in 1967. Although originally thought to be a rare condition, KD has become the most common cause of acquired heart disease in the pediatric age group in ...
journal_title:Journal of the American College of Cardiology
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doi:10.1016/j.jacc.2009.04.102
更新日期:2009-11-17 00:00:00
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journal_title:Journal of the American College of Cardiology
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doi:10.1016/s0735-1097(00)00617-3
更新日期:2000-06-01 00:00:00
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journal_title:Journal of the American College of Cardiology
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abstract::Venous thromboembolism (VTE) is a common disease associated with high risk for recurrences, death, and late sequelae, accounting for substantial health care costs. Anticoagulant agents are the mainstay of treatment for deep vein thrombosis and pulmonary embolism. The recent availability of oral anticoagulant agents th...
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journal_title:Journal of the American College of Cardiology
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pub_type: 杂志文章
doi:10.1016/s0735-1097(01)01659-x
更新日期:2001-12-01 00:00:00
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更新日期:2003-05-21 00:00:00
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更新日期:2012-10-16 00:00:00
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journal_title:Journal of the American College of Cardiology
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doi:10.1016/s0735-1097(84)80293-4
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更新日期:2002-06-05 00:00:00
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pub_type: 杂志文章
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journal_title:Journal of the American College of Cardiology
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更新日期:2016-08-30 00:00:00
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pub_type: 杂志文章
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更新日期:1984-12-01 00:00:00
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journal_title:Journal of the American College of Cardiology
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更新日期:1993-06-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/0735-1097(92)90191-o
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/s0735-1097(86)80396-5
更新日期:1986-11-01 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/j.jacc.2003.05.009
更新日期:2003-11-19 00:00:00
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journal_title:Journal of the American College of Cardiology
pub_type: 杂志文章
doi:10.1016/j.jacc.2012.09.037
更新日期:2013-01-08 00:00:00