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Treatment of Venous Thromboembolism With New Anticoagulant Agents.

Abstract：

:Venous thromboembolism (VTE) is a common disease associated with high risk for recurrences, death, and late sequelae, accounting for substantial health care costs. Anticoagulant agents are the mainstay of treatment for deep vein thrombosis and pulmonary embolism. The recent availability of oral anticoagulant agents that can be administered in fixed doses, without laboratory monitoring and dose adjustment, is a landmark change in the treatment of VTE. In Phase III trials, rivaroxaban, apixaban, edoxaban (antifactor Xa agents), and dabigatran (an antithrombin agent) were noninferior and probably safer than conventional anticoagulation therapy (low-molecular-weight heparin followed by vitamin K antagonists). These favorable results were confirmed in specific patient subgroups, such as the elderly and fragile. However, some patients, such as those with cancer or with intermediate- to high-risk pulmonary embolism, were underrepresented in the Phase III trials. Further clinical research is required before new oral anticoagulant agents can be considered standard of care for the full spectrum of patients with VTE.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Becattini C,Agnelli G

doi

10.1016/j.jacc.2016.01.072

subject

Has Abstract

pub_date

2016-04-26 00:00:00

pages

1941-55

issue

16

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(16)00818-4

journal_volume

67

pub_type

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