当前位置： SCI文献检索 > JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY期刊下所有文献 > Incretin-Based Therapy for Diabetes: What a Cardiologist Needs to Know.

Incretin-Based Therapy for Diabetes: What a Cardiologist Needs to Know.

Abstract：

:Incretin-based therapies are effective glucose-lowering drugs that have an increasing role in the treatment of type 2 diabetes because of their efficacy, safety, and ease of use. Both glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors are commonly used for glycemic control as adjuncts to metformin, other oral antiglycemic agents, or insulin. Glucagon-like peptide-1 receptor agonists may have additional effects, such as weight loss, that may be advantageous in obese patients. There is a large body of evidence from randomized controlled clinical trials supporting the cardiovascular safety of dipeptidyl peptidase-4 inhibitors and some glucagon-like peptide-1 receptor agonists, at least in the short term. However, concerns have been raised, particularly regarding their safety in patients with heart failure. In this review, the authors provide a brief but practical evidence-based analysis of the use of incretin-based agents in patients with diabetes, their efficacy, and cardiovascular safety.

journal_name

J Am Coll Cardiol

journal_title

Journal of the American College of Cardiology

authors

Waldrop G,Zhong J,Peters M,Rajagopalan S

doi

10.1016/j.jacc.2015.12.058

subject

Has Abstract

pub_date

2016-03-29 00:00:00

pages

1488-1496

issue

12

eissn

0735-1097

issn

1558-3597

pii

S0735-1097(16)00320-X

journal_volume

67

pub_type

杂志文章,评审

相关文献

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY文献大全
  • Oxidation-specific biomarkers, prospective 15-year cardiovascular and stroke outcomes, and net reclassification of cardiovascular events.

    abstract：OBJECTIVES:This study sought to assess the long-term predictive value and net reclassification for risk of cardiovascular disease (CVD) of biomarkers reflecting oxidation-specific epitopes (OSEs). BACKGROUND:OSEs are immunogenic, proinflammatory, and proatherogenic. The long-term predictive value and net reclassificat...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2012.08.979

    authors： Tsimikas S,Willeit P,Willeit J,Santer P,Mayr M,Xu Q,Mayr A,Witztum JL,Kiechl S

    更新日期：2012-11-20 00:00:00

  • Suppression of endothelial progenitor cells in human coronary artery disease by the endogenous nitric oxide synthase inhibitor asymmetric dimethylarginine.

    abstract：OBJECTIVES:We tested the hypothesis that asymmetric dimethylarginine (ADMA) may be an endogenous inhibitor of endothelial progenitor cells (EPCs). BACKGROUND:Endothelial progenitor cells play a pivotal role in regeneration of injured endothelium, thereby limiting the formation of atherosclerotic lesions. Reduced numbe...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2005.04.066

    authors： Thum T,Tsikas D,Stein S,Schultheiss M,Eigenthaler M,Anker SD,Poole-Wilson PA,Ertl G,Bauersachs J

    更新日期：2005-11-01 00:00:00

  • Multislice computed tomography and magnetic resonance imaging for the assessment of reperfused acute myocardial infarction.

    abstract：OBJECTIVES:We evaluated the accuracy of in vivo delayed-enhancement multislice computed tomography (DE-MSCT) and delayed-enhancement magnetic resonance imaging (DE-MRI) for the assessment of myocardial infarct size using postmortem triphenyltetrazolium chloride (TTC) pathology as standard of reference. BACKGROUND:The ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2006.02.059

    authors： Baks T,Cademartiri F,Moelker AD,Weustink AC,van Geuns RJ,Mollet NR,Krestin GP,Duncker DJ,de Feyter PJ

    更新日期：2006-07-04 00:00:00

  • Chronic monotherapy with rosuvastatin prevents progressive left ventricular dysfunction and remodeling in dogs with heart failure.

    abstract：OBJECTIVES:This study examined the effects of long-term monotherapy with rosuvastatin (RSV) on the progression of left ventricular (LV) dysfunction and remodeling in dogs with heart failure (HF). BACKGROUND:3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors or "statins" possess other noncholesterol-lowering pr...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2007.04.050

    authors： Zacà V,Rastogi S,Imai M,Wang M,Sharov VG,Jiang A,Goldstein S,Sabbah HN

    更新日期：2007-08-07 00:00:00

  • Cardiopulmonary Exercise Testing: What Is its Value?

    abstract：:Compared with traditional exercise tests, cardiopulmonary exercise testing (CPET) provides a thorough assessment of exercise integrative physiology involving the pulmonary, cardiovascular, muscular, and cellular oxidative systems. Due to the prognostic ability of key variables, CPET applications in cardiology have gro...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jacc.2017.08.012

    authors： Guazzi M,Bandera F,Ozemek C,Systrom D,Arena R

    更新日期：2017-09-26 00:00:00

  • Reversal of calcium cycling defects in advanced heart failure toward molecular therapy.

    abstract：:Heart failure is a growing major cause of human morbidity and mortality worldwide. A wave of new insights from diverse laboratories has begun to uncover new therapeutic strategies that affect the molecular pathways within cardiomyocytes that drive heart failure progression. Using an integrative approach that employs i...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jacc.2006.06.070

    authors： Hoshijima M,Knöll R,Pashmforoush M,Chien KR

    更新日期：2006-11-07 00:00:00

  • Pharmacologic inhibition of poly(adenosine diphosphate-ribose) polymerase may represent a novel therapeutic approach in chronic heart failure.

    abstract：OBJECTIVES:We investigated the effects of a novel ultrapotent poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitor, PJ34, on cardiac and endothelial dysfunction in a rat model of chronic heart failure (CHF). BACKGROUND:Overactivation of the nuclear enzyme PARP importantly contributes to the development of ce...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(02)02062-4

    authors： Pacher P,Liaudet L,Mabley Jg,Komjáti K,Szabó C

    更新日期：2002-09-04 00:00:00

  • Quantification of absolute myocardial perfusion at rest and during exercise with positron emission tomography after human cardiac transplantation.

    abstract：:The maximal exercise capacity of cardiac transplant recipients is reduced compared with that of normal subjects. To determine if this reduced exercise capacity is related to inadequate myocardial perfusion during exercise, myocardial perfusion was measured noninvasively with use of positron emission tomography and nit...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(91)90608-c

    authors： Krivokapich J,Stevenson LW,Kobashigawa J,Huang SC,Schelbert HR

    更新日期：1991-08-01 00:00:00

  • High pressure assisted coronary stent implantation accomplished without intravascular ultrasound guidance and subsequent anticoagulation.

    abstract：OBJECTIVES:The purpose of this study was to determine the efficacy of treatment with antiplatelet therapy and no anticoagulation after high pressure assisted coronary stent implantation performed without intravascular ultrasound (IVUS) guidance. BACKGROUND:Previous studies have shown that during IVUS-guided Palmaz-Sch...

    journal_title：Journal of the American College of Cardiology

    pub_type： 临床试验,杂志文章,多中心研究

    doi：10.1016/s0735-1097(96)00431-7

    authors： Nakamura S,Hall P,Gaglione A,Tiecco F,Di Maggio M,Maiello L,Martini G,Colombo A

    更新日期：1997-01-01 00:00:00

  • Effects of supine and lateral recumbent positions on pulmonary venous flow in healthy subjects evaluated by transesophageal Doppler echocardiography.

    abstract：OBJECTIVES:This study attempted to evaluate the effects of supine and lateral recumbent positions on pulmonary venous flow by transesophageal Doppler echocardiography in healthy subjects. BACKGROUND:Although transesophageal echocardiographic examination is usually performed with the patient lying in the left lateral d...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(94)90154-6

    authors： Tanabe K,Yoshitomi H,Oyake N,Asanuma T,Ohta T,Ishibashi Y,Shimada T,Morioka S,Moriyama K

    更新日期：1994-11-15 00:00:00

  • Trans-septal catheterization in the electrophysiology laboratory: data from a multicenter survey spanning 12 years.

    abstract：OBJECTIVES:We report the data from the Italian Survey on trans-septal catheterization (TSP-C) for catheter ablation of arrhythmias in the left heart that covered 2003 and previous years. BACKGROUND:Over the last decade the use of TSP-C in the electrophysiology laboratory has greatly increased. Recent data on number of...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jacc.2005.10.046

    authors： De Ponti R,Cappato R,Curnis A,Della Bella P,Padeletti L,Raviele A,Santini M,Salerno-Uriarte JA

    更新日期：2006-03-07 00:00:00

  • Adhesion molecules in nonrheumatic aortic valve disease: endothelial expression, serum levels and effects of valve replacement.

    abstract：OBJECTIVES:We studied the expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1) and endothelial selectin (E-selectin) on aortic valve endothelium in patients undergoing valve replacement. We also assessed the relation between serum levels and endothelial expression and als...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(00)00998-0

    authors： Ghaisas NK,Foley JB,O'Briain DS,Crean P,Kelleher D,Walsh M

    更新日期：2000-12-01 00:00:00

  • Computed Tomography and Cardiac Magnetic Resonance in Ischemic Heart Disease.

    abstract：:Ischemic heart disease is a complex disease process caused by the development of coronary atherosclerosis, with downstream effects on the left ventricular myocardium. It is characterized by a long preclinical phase, abrupt development of myocardial infarction, and more chronic disease states such as stable angina and ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jacc.2016.08.047

    authors： Dweck MR,Williams MC,Moss AJ,Newby DE,Fayad ZA

    更新日期：2016-11-15 00:00:00

  • Sympathetic stimulation produces a greater increase in both transmural and spatial dispersion of repolarization in LQT1 than LQT2 forms of congenital long QT syndrome.

    abstract：OBJECTIVES:The study compared the influence of sympathetic stimulation on transmural and spatial dispersion of repolarization between LQT1 and LQT2 forms of congenital long QT sYndrome (LQTS). BACKGROUND:Cardiac events are more associated with sympathetic stimulation in LQT1 than in LQT2 or LQT3 syndrome. Experimental...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(00)01200-6

    authors： Tanabe Y,Inagaki M,Kurita T,Nagaya N,Taguchi A,Suyama K,Aihara N,Kamakura S,Sunagawa K,Nakamura K,Ohe T,Towbin JA,Priori SG,Shimizu W

    更新日期：2001-03-01 00:00:00

  • Effect of lesion characteristics on outcome of directional coronary atherectomy.

    abstract：:Directional coronary atherectomy, a new transluminal procedure for treatment of obstructive lesions in coronary arteries by excision and removal of tissue, was performed on 447 lesions in 382 procedures. Successful outcome, defined as a reduction of stenosis by greater than or equal to 20% with a less than 50% residua...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(91)90840-6

    authors： Hinohara T,Rowe MH,Robertson GC,Selmon MR,Braden L,Leggett JH,Vetter JW,Simpson JB

    更新日期：1991-04-01 00:00:00

  • Pregnancy-associated plasma protein-A levels in patients with acute coronary syndromes: comparison with markers of systemic inflammation, platelet activation, and myocardial necrosis.

    abstract：OBJECTIVES:The goal of this study was to determine the predictive value of pregnancy-associated plasma protein-A (PAPP-A) in patients with acute coronary syndromes (ACS). BACKGROUND:Pregnancy-associated plasma protein-A is a zinc-binding matrix metalloproteinase abundantly expressed in eroded and ruptured plaques and ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2004.09.060

    authors： Heeschen C,Dimmeler S,Hamm CW,Fichtlscherer S,Simoons ML,Zeiher AM,CAPTURE Study Investigators.

    更新日期：2005-01-18 00:00:00

  • Ergonovine maleate testing during cardiac catheterization: a 10-year perspective in 3,447 patients without significant coronary artery disease or Prinzmetal's variant angina.

    abstract：:The utility of ergonovine testing for coronary artery spasm was assessed in 3,447 patients with angiographically insignificant (less than 50% diameter stenosis) or no coronary artery disease. No patients clinically had Prinzmetal's variant angina. Overall, 4% had a positive ergonovine test result, defined by spasm cau...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(92)90145-d

    authors： Harding MB,Leithe ME,Mark DB,Nelson CL,Harrison JK,Hermiller JB,Davidson CJ,Pryor DB,Bashore TM

    更新日期：1992-07-01 00:00:00

  • Gender-related differences in the central arterial pressure waveform.

    abstract：OBJECTIVES:This study investigated the effect of age and gender on central arterial hemodynamic variables derived from noninvasive tonometric carotid pressure waveforms. BACKGROUND:Women have a greater age-related increase in left ventricular (LV) mass than do men and are more likely to experience symptomatic heart fa...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(97)00378-1

    authors： Hayward CS,Kelly RP

    更新日期：1997-12-01 00:00:00

  • Gaps in referral to cardiac rehabilitation of patients undergoing percutaneous coronary intervention in the United States.

    abstract：BACKGROUND:Rates of referral to cardiac rehabilitation after percutaneous coronary intervention (PCI) have been historically low despite the evidence that rehabilitation is associated with lower mortality in PCI patients. OBJECTIVES:This study sought to determine the prevalence of and factors associated with referral ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.jacc.2015.02.063

    authors： Aragam KG,Dai D,Neely ML,Bhatt DL,Roe MT,Rumsfeld JS,Gurm HS

    更新日期：2015-05-19 00:00:00

  • Relationship between renal function and plasma brain natriuretic peptide in patients with heart failure.

    abstract：OBJECTIVES:This study sought to evaluate the relationship between brain natriuretic peptide (BNP), renal function, and the severity of congestive heart failure (CHF). BACKGROUND:Both BNP and renal function are prognostic predictors in CHF patients. METHODS:We measured the plasma BNP level in the aortic root and coron...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/j.jacc.2005.10.038

    authors： Tsutamoto T,Wada A,Sakai H,Ishikawa C,Tanaka T,Hayashi M,Fujii M,Yamamoto T,Dohke T,Ohnishi M,Takashima H,Kinoshita M,Horie M

    更新日期：2006-02-07 00:00:00

  • Determinants of the spontaneous ectopic activity in repetitive monomorphic idiopathic ventricular tachycardia.

    abstract：:Twenty-four hour ambulatory electrocardiographic tape recordings of 30 patients (16 men and 14 women, mean age 42 +/- 17 years) with repetitive monomorphic idiopathic ventricular tachycardia were analyzed using a new computerized system designed to study 15 RR cycles and mean heart rate of the 3 minutes preceding any ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(86)80139-5

    authors： Zimmermann M,Maisonblanche P,Cauchemez B,Leclercq JF,Coumel P

    更新日期：1986-06-01 00:00:00

  • Doppler echocardiographic measurement of aortic valve area in aortic stenosis: a noninvasive application of the Gorlin formula.

    abstract：:Thirty adult patients with aortic stenosis had Doppler echocardiography within 1 day of cardiac catheterization. Noninvasive measurement of the mean transaortic pressure gradient was calculated by applying the simplified Bernoulli equation to the continuous wave Doppler transaortic velocity recording. Stroke volume wa...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(86)80382-5

    authors： Teirstein P,Yeager M,Yock PG,Popp RL

    更新日期：1986-11-01 00:00:00

  • Immediate effects of lung transplantation on right ventricular morphology and function in patients with variable degrees of pulmonary hypertension.

    abstract：OBJECTIVES:This study sought to determine the immediate effects of lung transplantation on right ventricular morphology and function in patients with variable degrees of pulmonary hypertension and to evaluate these features as potential markers of immediate outcome. BACKGROUND:Selected lung transplant recipients with ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(95)00502-1

    authors： Katz WE,Gasior TA,Quinlan JJ,Lazar JM,Firestone L,Griffith BP,Gorcsan J 3rd

    更新日期：1996-02-01 00:00:00

  • Prolongation of isovolumetric relaxation time as assessed by Doppler echocardiography predicts doxorubicin-induced systolic dysfunction in humans.

    abstract：:A reasonably sensitive and specific noninvasive test for doxorubicin cardiotoxicity is needed. In addition, few data exist on the short- and long-term effects of doxorubicin on diastolic filling. To determine if pulsed Doppler indexes of diastolic filling could predict doxorubicin-induced systolic dysfunction, 26 pati...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(92)90138-d

    authors： Stoddard MF,Seeger J,Liddell NE,Hadley TJ,Sullivan DM,Kupersmith J

    更新日期：1992-07-01 00:00:00

  • Endothelium-derived relaxing factor is important in mediating the high output state in chronic severe anemia.

    abstract：OBJECTIVES:We evaluated the endothelial and vascular smooth muscle function in patients with chronic severe anemia to determine whether increased basal nitric oxide levels contribute to the systemic vasodilation and high cardiac output seen in these patients. BACKGROUND:Patients with chronic severe anemia have a high ...

    journal_title：Journal of the American College of Cardiology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0735-1097(95)00007-Q

    authors： Anand IS,Chandrashekhar Y,Wander GS,Chawla LS

    更新日期：1995-05-01 00:00:00

  • The evolving management of acute right-sided heart failure in cardiac transplant recipients.

    abstract：:Avoidance of the clinical syndrome of acute right-sided heart failure after heart transplantation is, unfortunately, not possible. Clinical experience and the literature certainly suggest that a significant factor in the successful management of right ventricular (RV) failure is recipient selection. Moreover, threshol...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/s0735-1097(01)01486-3

    authors： Stobierska-Dzierzek B,Awad H,Michler RE

    更新日期：2001-10-01 00:00:00

  • Severe renal impairment and stroke prevention in atrial fibrillation: implications for thromboprophylaxis and bleeding risk.

    abstract：:The prevalence of atrial fibrillation (AF) in end-stage renal failure is high, with an increased risk of stroke among these patients with AF compared with the AF population without severe renal impairment. Many trials have shown the net clinical benefit of oral anticoagulation therapy for primary and secondary prevent...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jacc.2010.12.013

    authors： Marinigh R,Lane DA,Lip GY

    更新日期：2011-03-22 00:00:00

  • Paired comparisons of efficacy of intravenous and oral procainamide in patients with inducible sustained ventricular tachyarrhythmias.

    abstract：:Thirty-eight patients who had inducible sustained ventricular tachycardia during baseline programmed electrical stimulation underwent electrophysiologic testing after both intravenous and oral administration of procainamide. Each had presented clinically with documented sustained ventricular tachycardia or out of hosp...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/0735-1097(91)90651-o

    authors： Interian A Jr,Zaman L,Velez-Robinson E,Kozlovskis P,Castellanos A,Myerburg RJ

    更新日期：1991-06-01 00:00:00

  • Current evidence on treatment of patients with chronic systolic heart failure and renal insufficiency: practical considerations from published data.

    abstract：:Chronic kidney disease (CKD) is increasingly prevalent in patients with chronic systolic heart failure. Therefore, evidence-based therapies are more and more being used in patients with some degree of renal dysfunction. However, most pivotal randomized clinical trials specifically excluded patients with (severe) renal...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章,评审

    doi：10.1016/j.jacc.2013.11.031

    authors： Damman K,Tang WH,Felker GM,Lassus J,Zannad F,Krum H,McMurray JJ

    更新日期：2014-03-11 00:00:00

  • Right coronary artery-pulmonary artery arteriovenous fistula secondary to open heart surgery.

    abstract：:A patient is described who underwent atrial septal defect repair at age 12 and presented 16 years later with angina. Coronary angiography revealed a right coronary artery to pulmonary artery fistula that had developed at the site of the previous thoracotomy. This is the first report of an acquired fistula of this type...

    journal_title：Journal of the American College of Cardiology

    pub_type： 杂志文章

    doi：10.1016/s0735-1097(85)80509-x

    authors： Rothschild AH,Adatepe MH,Magovern GJ,Rothschild MA,Joyner CR

    更新日期：1985-10-01 00:00:00